Compare the Top Advanced Threat Protection (ATP) Software for Mac as of November 2025

What is Advanced Threat Protection (ATP) Software for Mac?

Advanced threat protection (ATP) software is designed to detect, prevent, and respond to sophisticated cyber threats in real-time. It employs advanced techniques such as machine learning, behavioral analysis, and threat intelligence to identify and mitigate potential security risks. The software offers comprehensive protection across various endpoints, networks, and cloud environments, ensuring a multi-layered defense strategy. It also provides detailed reporting and analytics, enabling organizations to understand threat patterns and improve their security posture. By integrating these capabilities, advanced threat protection software helps organizations safeguard sensitive data, maintain regulatory compliance, and enhance overall cybersecurity resilience. Compare and read user reviews of the best Advanced Threat Protection (ATP) software for Mac currently available using the table below. This list is updated regularly.

  • 1
    ThreatLocker

    ThreatLocker

    ThreatLocker

    The ThreatLocker suite of security tools are powerful and designed so that everyone from businesses to government agencies to academic institutions can directly control exactly what applications run on their networks. We envision a future in which all organizations can chart their own course free from the influence of cybercriminals and the damage their incursions cause, and our team of veteran cybersecurity professionals created ThreatLocker to make this vision a reality. The team at ThreatLocker has been developing cybersecurity tools for decades, including programs to enhance email and content security, and this is our most innovative and ambitious cybersecurity solution yet. We developed this unique cybersecurity system because we believe that organizations should have complete control of their networks and should not have to live in fear of the next malware attack. To learn more, visit ThreatLocker.com.
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  • 2
    ESET PROTECT Advanced
    ESET Protect Advanced is a comprehensive cybersecurity solution designed for businesses of all sizes. It offers advanced endpoint protection against ransomware, zero-day threats, and sophisticated attacks with ESET LiveSense technology. It includes full disk encryption for legal compliance and data protection. The solution features proactive cloud-based threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent new threats. Mobile threat defense secures Android and iOS devices with anti-malware, anti-theft, and mobile device management. It also provides cloud app protection, mail server security, and vulnerability and patch management. Extended detection and response (XDR) enhances threat detection and response, while multi-factor authentication adds security. The solution offers single-pane-of-glass remote management for visibility into threats and users, along with advanced reporting and custom notifications.
    Starting Price: $275/month/5 devices
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  • 3
    ESET PROTECT Complete
    ESET PROTECT Complete is a comprehensive cybersecurity solution designed to safeguard business endpoints, cloud applications, and email systems. It offers advanced protection against ransomware and zero-day threats through cloud-based sandboxing technology and machine learning-driven detection. It includes full disk encryption capabilities, aiding compliance with data protection regulations. ESET PROTECT Complete also provides robust security for mobile devices, file servers, and email servers, incorporating anti-malware, anti-phishing, and anti-spam measures. Its centralized, cloud-based management console allows for streamlined deployment, monitoring, and response to security incidents across the organization. Additional features include vulnerability and patch management, ensuring that software vulnerabilities are promptly identified and addressed.
    Starting Price: $287.72 one-time payment
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    ESET PROTECT Elite
    ESET PROTECT Elite is an enterprise-grade cybersecurity solution that integrates extended detection and response with comprehensive multilayered protection. It offers advanced threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent zero-day threats and ransomware. The platform includes modern endpoint protection for computers and smartphones, server security for real-time data protection, and mobile threat defense. It also features full disk encryption, helping organizations comply with data protection regulations. ESET PROTECT Elite provides robust email security, including anti-phishing, anti-malware, and anti-spam technologies, along with cloud app protection for Microsoft 365 and Google Workspace. Vulnerability and patch management capabilities allow for automatic tracking and patching of vulnerabilities across all endpoints.
    Starting Price: $275 one-time payment
  • 5
    FortiSandbox
    Unlike previous generation of viruses that were non-sophisticated and low in volume, antivirus tools were sufficient to provide reasonable protection with their database of signatures. However, today’s modern malware entails new techniques such as use of exploits. Exploiting a vulnerability in a legitimate application can cause anomalous behavior and it’s this behavior that attackers take advantage of to compromise computer systems. The process of an attack by exploiting an unknown software vulnerability is what is known as a zero-day attack aka 0-day attack, and before sandboxing there was no effective means to stop it. A malware sandbox, within the computer security context, is a system that confines the actions of an application, such as opening a Word document, to an isolated environment. Within this safe environment the sandbox analyzes the dynamic behavior of an object and its various application interactions in a pseudo-user environment and uncovers any malicious intent.
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