Sexual
dysfunction in women
with
cancer
,.b Sandy J. Falk, M.D. and Don S. Dizon, M.D. .d
b c
a Sexual Health Program, Dana Farber Cancer In titute! De"artment o# $b tetric , %ynecology, and &e"roducti'e Medicine, Har'ard Medical School, Har'ard (ni'er ity, De"artment o# Internal Medicine, Har'ard Medical School, Har'ard (ni'er ity, and $ncology Sexual Health, Ma achu ett %eneral Ho "ital Cancer Center, )o ton, Ma achu ett
d
*""roximatel +, million "eo"le ha'e a hi tory o# cancer in the (nited State alone, and the number i ex"ected to increa e -ith time. .hi ha "rom"ted an a""reciation o# the /uality o# li#e ur'i'or . 0omen treated #or cancer identi#y gynecologic i u a a ma1or concern for both general health and the negati'e im"act on exual #unction that #ollo- the cancer diagno i and ub e/uent treatment. Unfortunately, issues related to sexual health continue to be undera""reciated. *lthough com"rehen i'e cancer center ha2e ado"ted specialized centers for survivorship issues, including tho e in'ol'ing exual health, con ultation are not -idely a'ailable in mo t communities. We provide background information on treatment exual health, examine the im"act 13 1 ! c a n t s t r e a t m e n t t O n " s e x uand a l # f u n c t i o n , s o the m e o # C m a 1 o rhealth i ue 3+ $omen $ho have received a cancer diagnosis and been ub e/uently treated. 4Forti Steril5 !%1"&1%%'1()!1. %!%1" by *merican +ociety for &e"roducti'e Medicine.6
y #or e
J
Discuss, 7ou can di cu sfunefiom)canmd)2 22
thi article -ith it author and -ith other *S&M member at htt"899 #ert tert#orum. c%m9#alk 2 exual2dy2
,
: Do-nload a,#ree ;& code canner by earching #or<;& canner= in your mart"hone< a"" tore or a"" market"lace.
With ad'ance in early detec2 t i o n a n d t r e a t m e n t # o r c a n c e r , t h e n u m b e r o # u r ' i ' o r rnntinues to increase) and accordingly there has been an increased a$areness of survivorship issues. It i e timated that a o# January >3+> there -ere +?.@ million "eo"le -ith a hi tory o# cancer in the (nited State , and the number i ex"ected to increa e to +A million by >3>> 4+6. For #emale cancer ur'i'or , gynecologic i ue are a ma1or concern, and man y o# the e i ue im"act exual #unction. Some tertiary care center ha'e de'elo"ed exual health "rogram "eci#ically #or thi "atient "o"ulation, but ex"ert con ultation are not -idely a'ailable. In addition, mo t oncologi t are un able or un-illing to di cu exuality a n d i n t i m a c y i n t h e c o n t e x t o # a #ollo-2u" oncology 'i it becau e o# their lack o# training in thi area, "er
onal di com#ort, or time con traint . In te ad, the e i ue are rarel y ad dre ed, and -hen "atient a k about exual dy #unction, it i generally to the primary care physician or gynecologi t, -ho may be un#amiliar -ith the e i ue a they "ertain to -omen "re'iou ly treated #or cancer. In thi article, -e -ill re'ie- exual health i ue in -omen -ho ha'e had a cancer diagno i and ub e/uent treatment, and -e -ill #ocu in greater de"th on dy "areunia and 'aginal teno i , t-o o# the mo t common or igni #icant clinical cenario .
2
OVERVIEW OF SEXUAL DYSFUNCTION IN WOMEN TREATED FOR CANCER
Sexual health condition that a##ect -omen during or a#ter cancer treatment may be con idered according to the a m e c a t e go ri e a #e m a l e e xu a l dy #unction in the general "o"ulation. .he *merican P ychiatric * ociation de#ine the #ollo-ing #emale exual di orde r 8 e xual i nte re t9arou al, orga mic, and genito"el'ic "ain9"enetration 4>6. Cancer and it treatment can directly cau e all o# the e condition . Surgical treatment can re ult in di tortion o# #emale anatomy, "articularly #or "atient -ith brea t or gynecologic cancer . In addition, the remo'al o # t h e o ' a r i e i n " r e m e n o " a u a l -omen lead to "remature meno"au e -ith re ultant hormonal and "hy ical change that can alter e'eral domain o# exual #unction. Surgical treatment can re ult in exual dy #unction #or -omen diagno ed -ith other tumor a -ell! a an exam"le, exual dy #unct i o n i o c c u r i n + A B a n d C D B o # -omen treated #or early tage rectal cancer 4?6.
Chemothera"y can re ult in y temic e##ect that dam"en both exual de ire and arou al. In addition, chemothera"y may induce o'arian #ailure -ith an acute and udden loss of e trogen. Eear total alo"ecia re ulting #rom the u e o# ome agent 4 uch a the anthracycline and taxane 6 can