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Crystallization Principle and Objectives

Crystallization is a process used to isolate or purify solid crystals from a uniform solution. More than 80% of substances used in pharmaceuticals, chemicals, foods and cosmetics undergo crystallization as the final purification step before being formulated into a solid product. The properties of the solid material obtained, such as its polymorphism, can dramatically impact the resulting product's performance. Crystallization involves mass transfer of a solute from a liquid solution into a pure solid crystalline phase.

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2K views1 page

Crystallization Principle and Objectives

Crystallization is a process used to isolate or purify solid crystals from a uniform solution. More than 80% of substances used in pharmaceuticals, chemicals, foods and cosmetics undergo crystallization as the final purification step before being formulated into a solid product. The properties of the solid material obtained, such as its polymorphism, can dramatically impact the resulting product's performance. Crystallization involves mass transfer of a solute from a liquid solution into a pure solid crystalline phase.

Uploaded by

Priya Sharma
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Crystallization Principle and Objectives

Crystallization is the (natural or artificial) process for the formation of solid crystals from a uniform solution.
More than 80% of the substances used in pharmaceuticals, fine chemicals, agrochemicals, food and cosmetics
are isolated or formulated in their solid form. Crystallization is in general the last chemical purification step in the
production of ingredients.
Since the properties of a solid material (polymorphism) can dramatically affect the process or the products
compliance and effect (dissolution rate for example), monitoring and controlling the isolation of solids for the
various applications through crystallization is of paramount interest.
Crystallization is also a chemical solid-liquid separation technique, in which mass transfer of a solute from the
liquid solution to a pure solid crystalline phase occurs.

Crystallization Technologies
Draft tube baffle technology:
This type of crystallization is especially designed for low viscosity products when a narrow crystal size distribution is
expected.
Super saturated product enters into a chamber containing the massecuite (mixture of solids and solution).
Instantaneously, the product crystallizes around the crystals that are already inside the vessel so that the solution
reaches the saturation point. Inside the chamber, a stirrer creates a high circulation flow in order to give a good
repartition of the crystals in the massecuite.
On the side of the vessel, baffles create a quiet zone where an upward flow brings the smallest crystals out of the
vessels. They are re-melted and put back in the vessel.

Forced circulation crystallization:


The design of such a crystallization unit is very similar to a forced circulation evaporator. A vertical tubular heat
exchanger is only preferred due to the high viscosity of the massecuite.
This type of crystallization unit is designed for the crystallization of salts out of effluent.

Crystallization Plant
A complete crystallization plant includes a crystallization unit, centrifuge, vacuum group and condenser. The
installation requires the integratation of crystallization technologies into a well adapted thermic scheme.
As with evaporation, it is also possible to organize different steps of crystallization in a multiple-effect crystallization
unit to be combined with mechanical vapor compression or thermo-compression.
Browse the crystallization technology developed by Novasep for food applications.

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