Dr.

Priti Vaidyanathan
Sabinsa Europe GmbH
16 April 2015
In-Cosmetics 2015

Sabinsa Corporation | Confidential | [Link]

What is DCosmix?
DCosmix is the outcome of over 2 decades of
unrivalled competence of the Sabinsa research team to
pioneer and innovate, novel dermaceuticals from
natural sources.
DCosmix is an intelligent fusion of science and
performance.
DCosmix caters to the broad palette of applications in
the Cosmeceutical and Personal care range.
Sabinsa Corporation | Confidential | [Link]

Why DCosmix ?
Provides innovative solutions to create unique formulations.
Helps unravel multiple facets with the powerhouse of
synergistic naturals.
Brings balance to your search of novelty in formulations.
Offers solutions to the boundless challenges that your
formulations face.
Helps your products stand out in the fiercely competitive
market.
Positively influences the ease of formulations.
Uplifts the spirit of formulationsNaturally !
Sabinsa Corporation | Confidential | [Link]

DCosmix Application Focus.

Skin firming
Skin regeneration
Skin hydration
Skin protection
Skin calming
Skin nourishing
Skin energizing

Sabinsa Corporation | Confidential | [Link]

Skin lightening
Skin brightening
Skin conditioning
Skin de-stress
Hair growth
Hair fall control
Hair conditioning

DCosmix Range

Sabinsa Corporation | Confidential | [Link]

DCosmix Range
Blend

Broad range of application

1 AgeLess Complex DCx Skin firming, Skin regeneration

2 AcNil DCx

Anti-acne, Skin protection, Skin calming

3 CosmeVit DCx

Skin conditioning, Skin energizing, Skin

lightening and Skin de-stress

4 DermaSoothe DCx

Skin conditioning, Skin calming

5 DerMoist DCx

Skin hydration, Skin nourishing

6 DHeal DCx

Skin protection, Skin calming

7 KeraCon DCx

Hair growth, Hair fall control

8 MelaLite DCx

Skin lightening, Skin brightening

Sabinsa Corporation | Confidential | [Link]

AgeLess Complex DCx

Sabinsa Corporation | Confidential | [Link]

1. AgeLess Complex DCx

AgeLess Complex DCx effective ingredients
that offer pro-active protection against time
and
environmental
aggression
and
synergistically help to repair, rejuvenate and
condition the skin naturally!!

Sabinsa Corporation | Confidential | [Link]

Ageless Complex DCx Ingredient Rationale

Barley Beta Glucans - Recognized for their role in maintaining collagen
balance, it helps protect the integrity of the skin matrix
N-Acetyl Glucosamine Maintains the natural reserve of skin moisture
Niacinamide - Clinically validated to balance skin moisture and manage
hyperpigmentation. It inhibits melanosome transfer to keratinocytes
pTeroWhite - Known for its melanogensis inhibition potential
Tocopheryl Acetate- Cell membrane protectant and potent antioxidant
Cosmoperine - Patented and proven dermal penetration enhancer
Cosmoperine U.S Patent No. 6,849,645. Japanese Patent No. JP4098985. Great Britain Patent No. GB2380675
Sabinsa Corporation | Confidential | [Link]

Ageless Complex DCx In vitro study

Activity

Result

Anti-collagenase activity

13.56% inhibition at 1000 g/ml

Anti-elastase activity

11.5% inhibition at 1000 g/ml

Sabinsa Corporation | Confidential | [Link]

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AgeLess Complex DCx - Deliverables

Efficient control of wrinkles
Increase collagen formation
Enhance elasticity of the skin
Promote evenness of skin tone

Sabinsa Corporation | Confidential | [Link]

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AgeLess Complex DCx - Suggested Usage and Dosage

Range

Anti aging

Anti Wrinkle
After Suncare

Sabinsa Corporation | Confidential | [Link]

Dosage Form

Cream
Translucent Serum
Cream
Cream, Lotion

Dose

1-3 %
1-3%
0.5-2%
1-2%

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AcNil DCx
Sabinsa Corporation | Confidential | [Link]

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2. AcNil DCx
AcNil DCx provides an effective nutrient
composite offering a multi-pronged approach
to acne management by addressing different
skin concerns such as P acne activity,
inflammation, irritation and increase sebum
secretion.

Sabinsa Corporation | Confidential | [Link]

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Causes of acne
Some of the common causes of acne
Growth and multiplication of acne causing
bacterium Propionibacterium acnes.
Higher
levels
of
the
hormone
Dihydrotestosterone by the activity of the
enzyme 5-alpha reductase.
Increase in androgens during puberty and
adolescence which in turn, triggers an
enlargement of the sebaceous glands.

Sabinsa Corporation | Confidential | [Link]

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AcNil DCx Ingredient Rationale

Monolaurin - A produce from Cocus nucifera with proven antiacne benefits
Olive oil Contains natural squalene and affords skin soothing benefits
Policosanol Clinically evaluated to reduce sebum production
Coleus Oil Potent antimicrobial
Aloe vera Clinically validated to promote wound healing and soothing
Niacinamide - Clinically validated to manage depigmentation and acne
breakouts. It inhibits melanosome transfer to keratinocytes
Zinc Monomethionine Improves skin immunity
Ginger SCFE 20%- Anti-inflammtory, Antimicrobial
Mandelic acid- Mild exfoliate and anti acne
Policosanol U.S Patent No. 7,217,546. Indian Patent No. IN229695.
Sabinsa Corporation | Confidential | [Link]

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AcNil DCx In vitro Antimicrobial activity

Inhibitory activity against P acnes bacteria

Minimal Inhibitory Concentration 500 g/ml

Sabinsa Corporation | Confidential | [Link]

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AcNil DCx - Deliverables

Reduce sebum production
Inhibit P. acnes proliferation
Minimize recurrence of acne break outs
Reduce inflammation
Diminish acne scars

Sabinsa Corporation | Confidential | [Link]

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AcNil DCx - Suggested Usage and Dosage

Range

Anti-Acne

Dosage Form

Cream
Gel (Spot applicator)
Creamy Face Wash
Face pack

Sabinsa Corporation | Confidential | [Link]

Dose
2-5%
4-6%
2-4%
2-3%

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CosmeVit DCx
Sabinsa Corporation | Confidential | [Link]

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3. CosmeVit DCx
CosmeVit DCx is a power house of skin
nutrients that supports a healthy and glowing
skin with a multifaceted approach to skin
lightening, skin moisturizing and skin
protection.
CosmeVit DCx is generally recommended for
use in combination with core actives intended
for the specific application.
Sabinsa Corporation | Confidential | [Link]

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CosmeVit DCx - Ingredient Rationale

Retinol / Vitamin A - Effective as an antioxidant, skin-cell regulator and
helps skin repair
Vitamin E acetate - Stable form of Vitamin E, acts as a cell membrane
protectant
Niacinamide / Vitamin B3 Clinically validated to manage hyper
pigmentation and moisture balance. It inhibits melanosome transfer to
keratinocytes
Vitamin F - Linoleic acid and Linolenic acids well recognized to promote
skin vitality
Ascorbyl glucoside - Stabilized form of Vitamin C with antioxidant benefits
Sabinsa Corporation | Confidential | [Link]

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CosmeVit DCx - Deliverables

Nourishes skin with vital nutrients to make it
bright and radiant
Protects skin against harmful UV radiation
production
Visibly lightens complexion
Evens out skin tone

Sabinsa Corporation | Confidential | [Link]

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CosmeVit DCx - Suggested Usage and Dosage

Range

Skin lightening
Depigmentation
Anti-aging
Anti-Wrinkle
Anti-acne
After Sun-care
Hair Care

Dosage Form

Dose

Cream, Lotion, Translucent Serum 0.5-1%

Cream
1-2%
Cream, Translucent Serum
1-2%
Cream
0.5-2%
Cream, Face Wash
0.5-1%
Creams and Lotions
0.5-1%
Creams
0.3-0.5%

Sabinsa Corporation | Confidential | [Link]

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CosmeVit DCx used in commercial formulation

Johara PhytoBright Skin Lightening Range

Sabinsa Corporation | Confidential | [Link]

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DermaSoothe DCx
Sabinsa Corporation | Confidential | [Link]

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4. DermaSoothe DCx
Dermasoothe DCx is a composite of potent
ingredients to replenish the skins natural
moisture reserves and placate the skin
naturally.

Sabinsa Corporation | Confidential | [Link]

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DermaSoothe DCx - Ingredient Rationale

Allantoin A proven moisturizing, healing, anti-irritating, soothing
nutrient
N-Acetyl Glucosamine Helps preserve the natural moisture reserves of
the skin
CovaFresh IV - Water soluble Menthyl lactate to offer cooling effects
Chamomile extract Proven anti-irritant phytonutrients
Olive oil Skin soothing oil

Sabinsa Corporation | Confidential | [Link]

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DermaSoothe DCx - Deliverables

Soothe and calm the skin
Moisturizes to restore visibly healthier skin
Helps calm minor skin itch / irritations

Sabinsa Corporation | Confidential | [Link]

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DermaSoothe DCx - Usage and Dosage

Range

After Suncare
Soothing - Calamine
Skin Care
Hair Care

Sabinsa Corporation | Confidential | [Link]

Dosage Form

Lotion, cream
Lotion
Shave and After shave cream or
Translucent Gel
Leave on Hair cream

Dose
1-3%
1-3%
2-3%
2-3%

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DermaSoothe DCx used in commercial

formulation Glenmarks Elosmooth

Sabinsa Corporation | Confidential | [Link]

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DerMoist DCx
Sabinsa Corporation | Confidential | [Link]

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5. DerMoist DCx
DerMoist DCx is a balanced composite of
proven nutrients that help to gently calm
sensitive skin while keeping it moist,
nourished and healthy.

Sabinsa Corporation | Confidential | [Link]

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DerMoist DCx - Ingredient Rationale

Cococin CG - Supports skin hydration and rejuvenation
Dexapanthenol Helps maintain hydration balance
Hyaluronic acid- Potent moisturizer and humectant for dry skin
Zinc Gluconate Boosts skin immunity
Jojoba Oil - Affords a protective sheath to the skin

Cococin U.S Patent No. 7,300,682 & 8,247,003. European Patent No. EP1341547.
New Zealand Patent No. NZ598630. and NZ600307. Eurasian Patent No. EA20368
Sabinsa Corporation | Confidential | [Link]

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DerMoist DCx Human User Study

*After using DerMoist DCx 3% Moisturizing Cream for 4 weeks by 20 volunteers (6 men and 14 women), during a
study conducted by an independent agency
Sabinsa Corporation | Confidential | [Link]

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DerMoist DCx - Deliverables

Affords hydration of skin
Moderate and modulate sebum production
Improve skin immunity
Support skin rejuvenation

Sabinsa Corporation | Confidential | [Link]

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DerMoist DCx - Usage and Dosage

Range

Anti-acne
Anti-aging
Day Care
Skin conditioning

Dosage Form

Cream, Face Wash

Cream, Serum
Creams, Lotions
Creams, Lotions

Sabinsa Corporation | Confidential | [Link]

Dose

5-15%
5-10%
3-5%
2-5%

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DHeal DCx
Sabinsa Corporation | Confidential | [Link]

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6. DHeal DCx
DHeal DCx is a scientifically validated
composite of natural nutrients that provide a
healing touch and soothe the skin while
protecting it from microbial infections.

Sabinsa Corporation | Confidential | [Link]

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DHeal DCx - Ingredient Rationale

Cococin CG - Supports skin hydration and promotes wound healing
Centellin CG Wound and scar management
1,2 Diols Antimicrobial, hydration support
Chamomile extract Proven anti-irritant phytonutrients
Aloe vera Clinically validated to promote wound healing and soothing
Allantoin A proven moisturizing, healing, anti-irritating, soothing nutrient
Betaine Monohydrate - Helps strengthen skin barrier and maintain waterbalance of the skin
Cococin U.S Patent No. 7,300,682 & 8,247,003. European Patent No. EP1341547.
New Zealand Patent No. NZ598630. and NZ600307. Eurasian Patent No. EA20368
Sabinsa Corporation | Confidential | [Link]

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DHeal DCx - In vitro study

Activity

Result

MTT cell proliferation assay 24.15% cell proliferation at 50 g/ml

SRB cell proliferation assay

Sabinsa Corporation | Confidential | [Link]

21.50% cell proliferation at 50 g/ml

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DHeal DCx - Deliverables

Promotes cell renewal and restores skin vitality
Helps reduce inflammation
Stimulates collagen production
Prevents microbial infection
Provides antioxidant support
Gently nourishes the skin

Sabinsa Corporation | Confidential | [Link]

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DHeal DCx - Usage and Dosage

Range

Cuts/Burns & Wounds

Cleansers
Skin conditioning

Sabinsa Corporation | Confidential | [Link]

Dosage Form

Cream
Face wash
Hand wash
Creams, Lotions

Dose
3-5%
2-4%
3-5%
2-5%

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KeraCon DCx
Sabinsa Corporation | Confidential | [Link]

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7. KeraCon DCx
KeraCon DCx is composed of ingredients which
helps to strengthen hair, promote hair growth
and keeps the hair healthy and soft.

Sabinsa Corporation | Confidential | [Link]

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KeraCon DCx - Ingredient Rationale

Cococin CG - Helps promote hair growth while moisturizing the scalp
Barley Beta Glucans - Helps to improve the hair vitality and protect it from
environmental stressors
Caffeine A phosphodiesterase inhibitor, helps prevent hair loss and also
promotes hair growth
Betaine Monohydrate - Increase the moisture content of the hair, protects
the scalp and produces brighter hair gloss
Trehalose Moisture retention property
Cococin U.S Patent No. 7,300,682 & 8,247,003. European Patent No. EP1341547.
New Zealand Patent No. NZ598630. and NZ600307. Eurasian Patent No. EA20368
Sabinsa Corporation | Confidential | [Link]

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KeraCon DCx - In vitro study

Activity

Result

MTT cell proliferation assay 22.35% cell proliferation at 50 g/ml

SRB cell proliferation assay

Sabinsa Corporation | Confidential | [Link]

26.00% cell proliferation at 50 g/ml

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KeraCon DCx - Deliverables

Strengthens hair shaft
Protects from hair shaft damage
Protects hair from environmental stressors

Sabinsa Corporation | Confidential | [Link]

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KeraCon DCx - Usage and Dosage

Range

Hair care

Sabinsa Corporation | Confidential | [Link]

Dosage Form

Hair conditioner
Shampoo
Conditioning Creams
Gels

Dose
5-8%
2-5%
1-2%
1-2%

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MelaLite DCx
Sabinsa Corporation | Confidential | [Link]

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8. MelaLite DCx
MelaLite DCx is a natural composite of melanin
suppressors that helps to lighten the skin tone and
eliminate pigmentation problems.

Sabinsa Corporation | Confidential | [Link]

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MelaLite DCx - Ingredient Rationale

SabiWhite - Clinically proven to be a safe and effective alternative to
Hydroquinone for its skin lightening property
pTeroWhite - Potent melanogenesis inhibitor, UV protectant

Licorice Extract 40% CA Potential tyrosinase and melanogenesis

inhibitor

Tetrahydrocurcuminoids (SabiWhite) U.S Patent No. 6,653,327. European Patent No. EP1171144
& EP1328263. New Zealand Patent No. NZ514884. Australian Patent No. AU2006235807
Sabinsa Corporation | Confidential | [Link]

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MelaLite DCx - In vitro study

Skin lightening potential of MelaLite DCx vs Kojic acid

IC50 (g/ml)

100
80

MelaLite DCx

100

Kojic Acid

60
40
20
0

3.62

Tyrosinase inhibition

10.19

Melanogenesis inhibition

Lower the IC50 value, higher the activity

Sabinsa Corporation | Confidential | [Link]

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MelaLite DCx Human User Study

Users also reported an improvement in skin clarity, skin tone and glow
on using MelaLite DCx cream.
*After using MelaLite DCx 1% Skin Lightening Cream for 4 weeks by 20 volunteers (10 men and 10 women), during a
study conducted by an independent agency
Sabinsa Corporation | Confidential | [Link]

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MelaLite DCx - Deliverables

Improves fairness to the skin
Supports an even skin tone
Nourishes skin to make it bright and radiant
Protects skin against harmful UV radiation

Sabinsa Corporation | Confidential | [Link]

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MelaLite DCx - Usage and Dosage

Range

Skin lightening
Depigmentation
Anti-aging
Sun care
After suncare

Sabinsa Corporation | Confidential | [Link]

Dosage Form

Cream,Lotion,Serum
Cream
Cream, Serum
Cream, Lotions
Cream, Lotion

Dose
3-5%
5-8%
1-3%
1-2%
3-5%

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DCosmix Application Areas.

Application Focus

Skin firming
Skin regeneration
Skin conditioning
Skin hydration
Skin protection
Skin calming
Skin nourishing

DCosmix

AgeLess Complex DCx

AgeLess Complex DCx
CosmeVit DCx, DermaSoothe DCx
DerMoist DCx
AcNil DCx, DHeal DCx
DermaSoothe DCx, DHeal DCx, AcNil DCx
DerMoist DCx

Contd.,
Sabinsa Corporation | Confidential | [Link]

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DCosmix Application Areas.

Application Focus

Skin energizing
Skin lightening
Skin brightening
Skin de-stress
Hair growth
Hair fall control

Sabinsa Corporation | Confidential | [Link]

DCosmix

CosmeVit DCx
MelaLite DCx, CosmeVit DCx
MelaLite DCx
CosmeVit DCx
KeraCon DCx
KeraCon DCx

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DCosmix
DCosmix is an intelligent integration of science and
performance.
DCosmix is suitable for use in a broad range of dosage
forms that include creams, lotions, gels, serums, tonics
and more.
DCosmix The formulators choice

Sabinsa Corporation | Confidential | [Link]

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[Link]

participating members of:

THANK YOU
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