BC-6800
Auto Hematology Analyzer
Small Cube, Big Difference
Small Cube, Big Difference
2D
Forward scatter
EOS
NEU
+ Side scatter
MON
LYM
3D
Forward scatter
MON
NEU
LYM
EOS
+ Side scatter
+ Fluorescence
In 2D scattergram, the cell clusters appear close to each
other. Whereas with the 3D scattergram, clusters are well
separated which helps in detecting abnormal cells, if any.
SF Cube
Small Cube,
Big Difference
Cell Analysis Technology
DIFF
HFC%*
MON%
IMG%
DIFF scattergram of BC-6800 differentiates WBCs into
4 parts and also provides valuable parameters like
HFC*, IMG* InR* and Abnormal Flags such as Left shift,
NRBC, PLT Clump, Atypical Lymphocyte.
Left shift
(flag)
IMG(#, %) provide information about the presence of
immature granulocytes, if any, including
promyelocytes, myelocytes, metamyelocytes,
(NEU+BAS)% immature eosinophils and immature basophils.
BC-6800 extends WBC diff to 6-part, on every sample,
by including immature granulocyte.
LYM%
EOS%
NRBC
(flag)
PLT Clump
(flag)
InR*
HFC*(#, %) parameters alert the user of the presence
of high fluorescent cell population, if any, such as
blasts and atypical lymphocytes.
BASO
Basophils are counted in a dedicated channel that
detects information about cell volume and cellular
complexity. This provides more accurate and
reliable basophil results.
BAS%
* For research use only
BC-6800
Auto Hematology Analyzer
Malaria screening
Angle of view 1
Angle of view 2
DIFF
DIFF
Plasmodium
BC-6800 provides dedicated flags called infected RBC? and InR*(#,) parameters to represent
the number and ratio of the infected red blood cells in the blood sample respectively. BC-6800
users can obtain information about the possible presence of plasmodium parasite, the causative
agent of malaria infection.
DIFF
Normal sample
DIFF
Few
1-4 infected RBC per
4 microscopy view
DIFF
Some
2-3 infected RBC per
microscopy view
DIFF
Many
>4 infected RBC per
microscopy view
With the rising number of red cells infected with malaria parasites, the number of dots in the "InR"
area increase proportionately. This creates the possibility to not only screen but also judge the
severity of malarial infection.
Patients with
fever
BC-6800Infected
RBC flag and
results
Confirm Malaria by
microscopy and/or
rapid immuno tests
Malaria
treatment
Correct decision
helps patient with
early recovery
Since blood examination is almost always required for patients with fever, and given the increasingly
wider use of automated hematology analyzers, an automated method with good sensitivity & specificity
to screen for the presence of malaria parasites would be highly desirable and would prove to be
practical and economical as it could lead to eventual detection of malaria even in unsuspected cases.
BC-6800 increases the laboratorys efficiency for malaria detection and facilitates an earlier therapeutic
intervention leading to quicker recovery for the patient.
* For research use only
Interference prevention
WBC: fluorescence
DIFF
In DIFF scattergram, lipid particles are not stained by
fluorescent dye while WBCs are. This difference prevents
interference and ensures more accurate WBC results.
Lipid particle: no fluorescence
Angle of view 1
Angle of view 2
DIFF
The PLT clump
seems mixed up
with Neutrophil
The PLT clump
seems mixed up
with Eosinophil
DIFF
The PLT clump
is well separated
from Neutrophil
The PLT clump is
well separated
from Eosinophil
The combination of 3D information helps in the separation of PLT clumps from clusters of WBCs.
Extended count time
DIFF
Regular count time
DIFF
Extended count time
For leucopenic samples (WBC<1.5 x 109/ L) or capillary blood samples, BC-6800 is designed to
automatically extend count time to 3 folds. This increases the number of cells counted and
significantly improves the accuracy and reliability of WBC counts and WBC 5-part differential results.
NRBC flag & detection
In routine CBC test, BC-6800 can flag "NRBC", if they are present in the sample. The actual number of
NRBCs can then be measured in a dedicated counting channel to obtain accurate quantitive NRBC#.
This helps reduce the cost of counting NRBCs in the samples without the NRBC flag.
1st step
2nd step
NRBC
DIFF
NRBC flag
NRBC counting
4 WBC counting channels
BASO
DIFF
WBC-D* WBC-B*
NRBC
RET
WBC-N* WBC-R*
NRBC sample
6
4
3
2
Report WBC
WBC value
WBC value
Normal sample
6
4
3
2
Flag
1
0
WBC-D*
WBC-B*
WBC-N*
WBC-R*
WBC-D*
Counting channel
4
3
2
Flag
Report WBC
WBC value
WBC-N*
WBC-R*
Lyse-resistant RBC sample
WBC-B*
Counting channel
Fragile WBC sample
WBC value
Report
corrected WBC
4
3
2
Flag
Report WBC
WBC-D*
WBC-B*
WBC-N*
WBC-R*
Counting channel
WBC-D*
WBC-B*
WBC-N*
WBC-R*
Counting channel
BC-6800 has 4 dedicated counting channels for the WBC measurement to prevent
interference caused by the presence of lipid particles, lyse-resistant RBCs, PLT clumps
and NRBCs. This increases the reliability of WBC data.
* For research use only
Reticulocyte detection
RET
RBC analysis with SF Cube technology helps
differentiation of Reticulocytes from mature red cells
IRF
LFR MFR HFR
by their reaction with fluorescent stain. Besides the
conventional parameters such as RET# and RET%,
BC-6800 also provides additional data concerning
immature reticulocytes (IRF), which assists in early
diagnosis of anemia and monitoring the bone
marrow response to hematinic therapy.
RBC-O*
Macro%*
Macro#*
Micro%*
Micro#*
Microcytic RBC
Normal RBC
MRV*
RHE*
Reticulocyte Hemoglobin
Expression
Macrocytic RBC
Mean Reticulocyte Volume
Reticulocyte
Micro* (#, %) parameters point to number & % of microcytic (small) RBCs while Macro* (#, %) parameters
reflect the number & % of macrocytic (large) RBCs. MRV* parameter represents the mean volume of
reticulocyte while RHE* parameter indicates the hemoglobin content for reticulocytes.
These parameters provide clues and more clinical information on anemia type, especially while
differentiating iron deficiency from other causes of anemia.
* For research use only
BC-6800
Auto Hematology Analyzer
RBC/PLT detection
Counting
aperture
Reagent rotational mixing
Bubble
Impulse
Traditional bubble mixing
Reagent outlet
Counting
aperture
Reagent inlet
Impulse
Reagent rotational mixing
The rotational mixing avoids bubble formation, a persistent problem with traditional mixing, to ensure
more accurate RBC result.
Focusing Flow-DC
Number
Method
Traditional DC
Impedance Method
Volume
Focusing Flow-DC method
optimizes RBC histogram
The Focusing Flow-DC process minimizes the interference traditionally encountered in DC technology
and produces a near Gaussian histogram. Because of this, histogram related parameters like MCV,
RDW-CV, RDW-SD are more accurate and provide clinically useful information.
PLT-O* result is free from the interference from
PLT-O
microcytic & fragmented RBCs, and large
platelets because of fluorescent staining. This
IPF
Immature Platelet Fraction
enhances data accuracy and sensitivity. PLT
numeric result is corrected automatically when
PLT-O*
PLT-O* counting mode is employed.
IPF parameter indicates the thrombopoiesis
status in thrombocytopenia cases. It may also be
used as an index of thrombopoietic activity in
Optical + Fluorescence measurement
bone marrow, similar to the use of reticulocyte
count in the evaluation of anemia.
HGB detection
Stronger LH lyse
Prevents interferences from:
high WBC counts or presence of
lipid in sample
Bigger size detector
WBC or lipid particle
LED
525nm
WBC or lipid particle
The lens converts divergent rays of the incident light to parallel, which increases precision of
HGB measurement. Combined with stronger LH lyse and bigger detector that minimizes the
interference from high WBC and lipids, BC-6800 provides more reliable HGB result.
* For research use only
Interlaboratory quality control
CBC-MonitorTM is the inter-laboratory quality control process which is essential for higher lab quality
assurance system.
CBC-MonitorTM can provide user labs with evaluations on its analytical performance and comparison
with other peer labs using the same measurement instrument/process.
i-Message
No Flag
Cut off value?
Value
20
40
60
Flag
i-Message provides more quantitive and comprehensive information about the severity of the abnormality for
corresponding suspect flags. This helps the BC-6800 users, not only to identify the blood samples that are flagged,
but also to judge the extent of abnormality.
Body fluid analysis
BC-6800 can analyze CSF and serous fluid samples to provide reportable parameters for RBC, WBC, WBC
differential (polymorphonuclear & mononuclear) and total cell count (TC-BF).
Moreover, for research use only, BC-6800 provides differential results for eosinophils, neutrophils as well as
high fluorescent cells (HF-BF*), which may include histiocytes, epithelial cells, spleen cells, ex-foliated cells etc.
Such additional information improves the possibility of better clinical diagnosis.
HF-BF* (high fluorescent cells)
HF-BF* may contain: histiocyte, epithelial cell,
spleen cell, exfoliated cell, etc.
MN (Mononuclear cell)
TC-BF
WBC
PMN (Polymorphonuclear cell)
Eos*(Eosinophil)
Nue-BF* (Neutrophils)
* For research use only
SF Cube
Cell Analysis Technology
Easy to use
SPU with touch screen is used for sample processing, including QC, calibration &
maintenance. DMU by PC is used for data management only. the PC software allows
easier operation and wider application.
Easy to maintain
Replacement of the fluorescent reagents in BC-6800 is very convenient as the reagent
compartment is located on the left front of the analyzer.
The only maintenance expected from the end user is either a daily shut down using
Probe cleanser or using it once per day in case the instrument is not shut down.
Moreover, in case of 'no shut down' the "auto-protect" program reminds the user when
the maintenance is due.
SPU
Sample Processing Unit
DMU
Data Managing Unit
BC-6800
Auto Hematology Analyzer
Technical Specifications:
Principles
SF Cube cell analysis technology for WBC, 5-Part diff, NRBC, RET and PLT-O
Focusing Flow-DC method for RBC and PLT
Cyanide free hemoglobin measurement
Parameters
36 reportable parameters (whole blood): WBC, Lym%, Mon%, Neu%, Bas%,
Eos%, IMG%, Lym#, Mon#, Neu#, Eos#, Bas#, IMG#; RBC, HGB, HCT, MCV,
MCH, MCHC, RDW-CV, RDW-SD, RET%, RET#, IRF, LFR, MFR, HFR, NRBC#,
NRBC%; PLT, MPV, PDW, PCT, P-LCR, P-LCC, IPF
18 research parameters (whole blood): HFC#, HFC%, WBC-R, WBC-D, WBC-B,
WBC-N, RBC-O, PLT-O, PLT-I, PDW-SD, InR#, InR, Micro%, Micro#, Macro%,
Macro#, MRV, RHE
7 reportable parameters (body fluid): WBC-BF, TC-BF#, MN#, MN%, PMN#,
PMN%, RBC-BF
7 research parameters (body fluid): Eos-BF#, Eos-BF%, Neu-BF#, Neu-BF%,
HF-BF#, HF-BF%, RBC-BF
Sample Volume
Predilute mode (capillary blood), Open vial
Manual mode (whole blood), Open vial
Autoloader mode (whole blood), Closed vial
Manual mode (body fluid), Open vial
40L
150L
200L
150L
Throughput
Up to 125 samples per hour (CBC+DIFF)
Up to 90 samples per hour (CBC+DIFF+RET)
Up to 40 samples per hour (body fluid)
Loading capacity
Up to 100 sample tubes
Mode
CBC, CBC+DIFF, CBC+RET, CBC+NRBC, CBC+DIFF+RET,
CBC+DIFF+NRBC, CBC+DIFF+RET+NRBC, RET
2 histograms for RBC and PLT
3 scattergrams (3D) for DIFF, NRBC and RET
6 scattergrams (2D) for DIFF, BASO, NRBC, RET, RET-EXT, PLT-O
Data storage capacity
Up to 100,000 patient results including all numeric and graphical
information
Performance
Parameter Linearity Range
WBC
0-50010/L
RBC
0-810/L
HGB
0-250g/L
HCT
0-75%
PLT
0-500010/L
RET#
0-0.810/L
Printout
Various printout formats and user-defined formats available
Precision
2.5% (410/L)
1.5% (3.510/L)
1.0% (110-180g/L)
1.5% (30%-50%)
4.0% (10010/L)
15% (RBC310/L;
1%RET%4%)
Carryover
1.0
1.0
1.0
1.0
1.0
/
Operating environment
Temperature: 15C~32C
Humidity: 30%~85%
680mm
700mm
Weight (kg)125
850mm
Mindray Building, Keji 12th Road South,
High-tech Industrial Park, Nanshan, Shenzhen 518057, P.R. China
Tel: +86 755 8188 8998 Fax: +86 755 26582680
E-mail: intl-market@[Link] [Link]
Mindray is listed on the NYSE under the symbolMR
2013 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. All rights reserved. Specifications subject to changes without prior notice.
P/N:ENG-BC6800-210285x16-20130829
