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Fosfomycin: Interpretation of Inhibition Zones Obtained With The Bauer-Kirby Agar Disk Diffusion Susceptibility Test

The document describes testing fosfomycin antibiotic susceptibility of 430 bacterial strains using disk diffusion and dilution methods. Tentative criteria are proposed to interpret inhibition zone diameters for staphylococci and Enterobacteriaceae/Pseudomonas aeruginosa as sensitive, intermediate, or resistant based on MIC breakpoints.

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64 views2 pages

Fosfomycin: Interpretation of Inhibition Zones Obtained With The Bauer-Kirby Agar Disk Diffusion Susceptibility Test

The document describes testing fosfomycin antibiotic susceptibility of 430 bacterial strains using disk diffusion and dilution methods. Tentative criteria are proposed to interpret inhibition zone diameters for staphylococci and Enterobacteriaceae/Pseudomonas aeruginosa as sensitive, intermediate, or resistant based on MIC breakpoints.

Uploaded by

nosila_oz854
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© © All Rights Reserved
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Chapter IV

RESULTS AND DISCUSSION

A total of 430 strains representing diverse gram-positive and gram-negative bacterial


species were examined for susceptibility to fosfomycin utilizing the Bauer-Kirby agar disk
diffusion and the Steers’ agar dilution methods. Tentative criteria are proposed for the
interpretation of the diameters of resultant inhibition zones (50 μg fosfomycin disks plus 50
μg glucose-6-phosphate) on Mueller-Hinton agar, based on MIC breakpoints of d 16 μg/ml =
sensitive (S), 32–64 μg/ml = intermediate susceptible (I), and ≥ 128 μg/ml = resistant (R).
For staphylococci: ≥ 20 mm = S; 14–19 mm = I; ≤ 13 mm = R;
for Enterobacteriaceae and Pseudomonas aeruginosa: ≥ 16 mm = S; 11-15 mm = I; ≤
10mm = R.

© 1983 S. Karger AG, Basel

Fosfomycin: Interpretation of
Inhibition Zones Obtained with the
Bauer-Kirby Agar Disk Diffusion
Susceptibility Test
Traub W.H. · Spohr M.

Author affiliations
Institut für Hygiene und Mikrobiologie, Universität des Saarlandes, Homburg a. d. Saar, FRG
Corresponding Author
Walter H. Traub, Institut für Hygiene und Mikrobiologie, Haus 43, Universität des
Saarlandes, Homburg a. d. Saar (FRG)

Published online: September 08, 2009

Number of Print Pages: 5


Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)


eISSN: 1421-9794 (Online)

For additional information: https://www.karger.com/CHE

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