Depression (Major Depressive Disorder) : Mental Health Notes™
Depression (Major Depressive Disorder) : Mental Health Notes™
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Overview
Depression is a mood disorder that causes a persistent feeling of sadness and loss of
interest. Also called major depressive disorder or clinical depression, it affects how you
feel, think and behave and can lead to a variety of emotional and physical problems.
You may have trouble doing normal day-to-day activities, and sometimes you may feel
as if life isn't worth living.
More than just a bout of the blues, depression isn't a weakness and you can't simply
"snap out" of it. Depression may require long-term treatment. But don't get discouraged.
Most people with depression feel better with medication, psychotherapy or both.
Symptoms
Although depression may occur only once during your life, people typically have multiple
episodes. During these episodes, symptoms occur most of the day, nearly every day
and may include:
Loss of interest or pleasure in most or all normal activities, such as sex, hobbies
or sports
Tiredness and lack of energy, so even small tasks take extra effort
Reduced appetite and weight loss or increased cravings for food and weight gain
For many people with depression, symptoms usually are severe enough to cause
noticeable problems in day-to-day activities, such as work, school, social activities or
relationships with others. Some people may feel generally miserable or unhappy without
really knowing why.
Common signs and symptoms of depression in children and teenagers are similar to
those of adults, but there can be some differences.
Depression is not a normal part of growing older, and it should never be taken lightly.
Unfortunately, depression often goes undiagnosed and untreated in older adults, and
they may feel reluctant to seek help. Symptoms of depression may be different or less
obvious in older adults, such as:
Fatigue, loss of appetite, sleep problems or loss of interest in sex — not caused
by a medical condition or medication
Often wanting to stay at home, rather than going out to socialize or doing new
things
Suicidal thinking or feelings, especially in older men
If you feel depressed, make an appointment to see your doctor or mental health
professional as soon as you can. If you're reluctant to seek treatment, talk to a friend or
loved one, any health care professional, a faith leader, or someone else you trust.
If you think you may hurt yourself or attempt suicide, call 911 or your local emergency
number immediately.
Call a suicide hotline number — in the U.S., call the National Suicide Prevention
Lifeline at 1-800-273-TALK (1-800-273-8255). Use that same number and press
"1" to reach the Veterans Crisis Line.
If you have a loved one who is in danger of suicide or has made a suicide attempt,
make sure someone stays with that person. Call 911 or your local emergency number
immediately. Or, if you think you can do so safely, take the person to the nearest
hospital emergency room.
Causes
It's not known exactly what causes depression. As with many mental disorders, a variety
of factors may be involved, such as:
Risk factors
Depression often begins in the teens, 20s or 30s, but it can happen at any age. More
women than men are diagnosed with depression, but this may be due in part because
women are more likely to seek treatment.
Factors that seem to increase the risk of developing or triggering depression include:
Certain personality traits, such as low self-esteem and being too dependent, self-
critical or pessimistic
Serious or chronic illness, including cancer, stroke, chronic pain or heart disease
Certain medications, such as some high blood pressure medications or sleeping
pills (talk to your doctor before stopping any medication)
Complications
Depression is a serious disorder that can take a terrible toll on you and your family.
Depression often gets worse if it isn't treated, resulting in emotional, behavioral and
health problems that affect every area of your life.
Excess weight or obesity, which can lead to heart disease and diabetes
Social isolation
Prevention
There's no sure way to prevent depression. However, these strategies may help.
Take steps to control stress, to increase your resilience and boost your self-
esteem.
Research suggests that depression doesn't spring from simply having too much or too
little of certain brain chemicals. Rather, there are many possible causes of depression,
including faulty mood regulation by the brain, genetic vulnerability, stressful life events,
medications, and medical problems.Apr 11, 2017
Irritability, anger, and agitation are often the most noticeable symptoms in depressed
teens—not sadness. They may also complain of headaches, stomachaches, or other
physical pains.May
What Is Depression?
Depression (major depressive disorder) is a common and serious medical illness that
negatively affects how you feel, the way you think and how you act. Fortunately, it is
also treatable. Depression causes feelings of sadness and/or a loss of interest in
activities once enjoyed. It can lead to a variety of emotional and physical problems and
can decrease a person’s ability to function at work and at home.
Depression symptoms can vary from mild to severe and can include:
Also, medical conditions (e.g., thyroid problems, a brain tumor or vitamin deficiency) can
mimic symptoms of depression so it is important to rule out general medical causes.
Depression affects an estimated one in 15 adults (6.7%) in any given year. And one in
six people (16.6%) will experience depression at some time in their life. Depression can
strike at any time, but on average, first appears during the late teens to mid-20s.
Women are more likely than men to experience depression. Some studies show that
one-third of women will experience a major depressive episode in their lifetime.
Depression Is Different From Sadness or Grief/Bereavement
The death of a loved one, loss of a job or the ending of a relationship are difficult
experiences for a person to endure. It is normal for feelings of sadness or grief to
develop in response to such situations. Those experiencing loss often might describe
themselves as being “depressed.”
But being sad is not the same as having depression. The grieving process is natural
and unique to each individual and shares some of the same features of depression.
Both grief and depression may involve intense sadness and withdrawal from usual
activities. They are also different in important ways:
o In grief, painful feelings come in waves, often intermixed with positive memories
of the deceased. In major depression, mood and/or interest (pleasure) are
decreased for most of two weeks.
o In grief, self-esteem is usually maintained. In major depression, feelings of
worthlessness and self-loathing are common.
o For some people, the death of a loved one can bring on major depression.
Losing a job or being a victim of a physical assault or a major disaster can lead to
depression for some people. When grief and depression co-exist, the grief is
more severe and lasts longer than grief without depression. Despite some
overlap between grief and depression, they are different. Distinguishing between
them can help people get the help, support or treatment they need.
Depression can affect anyone—even a person who appears to live in relatively ideal
circumstances.
Antidepressants may produce some improvement within the first week or two of use.
Full benefits may not be seen for two to three months. If a patient feels little or no
improvement after several weeks, his or her psychiatrist can alter the dose of the
medication or add or substitute another antidepressant. In some situations other
psychotropic medications may be helpful. It is important to let your doctor know if a
medication does not work or if you experience side effects.
Psychiatrists usually recommend that patients continue to take medication for six or
more months after symptoms have improved. Longer-term maintenance treatment may
be suggested to decrease the risk of future episodes for certain people at high risk.
Psychotherapy may involve only the individual, but it can include others. For example,
family or couples therapy can help address issues within these close relationships.
Group therapy involves people with similar illnesses.
Depending on the severity of the depression, treatment can take a few weeks or much
longer. In many cases, significant improvement can be made in 10 to 15 sessions.
Depression
Persistent Sadness & Loss of Interest in Life
Article by:
Dina Cagliostro, PhD
Jump to: Statistics Causes of Depression Types Signs & Symptoms Treatment
What Is Depression?
Being depressed often feels like carrying a very heavy burden, but you are not alone in
this struggle. Millions of Americans suffer from some form of depression every year,
making it one of the most common mental disorders in the country.
Gaining a deeper understanding of depression can help begin the journey to recovery.
Taking some time to learn more about the causes and symptoms of depression will assist
you greatly when it comes time to consider methods of treatment.
Depression is more than just feeling sad. Everyone feels upset or unmotivated from time
to time, but depression is more serious. It is a mood disorder characterized by prolonged
feelings of sadness and loss of interest in daily activities. If these symptoms persist for a
period of at least two weeks, it is considered a depressive episode.
Patient Statistics
According to the National Institute of Mental Health (NIMH), major depression is one of
the most common mental disorders in the United States. 1
Data from the Substance Abuse and Mental Health Services Administration (SAMHSA)
shows that in 2017, an estimated 17.3 million adults in the United States reported having
at least one major depressive episode in the previous 12 months. That’s 7.1% of all US
adults ages 18 and older. Adult females have a higher prevalence of experiencing a major
depressive episode than their male counterparts—8.7% compared to 5.3% in adult males.
Depression in the adolescent population (ages 12 to 17) has also increased. An estimated
3.2 million adolescents had at least one major depressive episode—a number that
represents 13.3% of the adolescent population.
Not only is depression prevalent, but it also creates the heaviest burden of disability
among mental and behavior disorders. According to a 2010 World Health Organization
(WHO) report, depression accounted for 3.7% of all U.S. disability-adjusted life years
and 8.3% of all U.S. years lived with disability.
Causes of Depression
There is no one cause for depression, as it depends on a unique combination of an
individual’s genetic makeup and environmental conditions. There are many factors to
take into account:
Types of Depression
Just as there is no one cause for depression, there isn’t only one type of depression. It can
take many forms. The fifth edition of the Diagnostic and Statistical Manual of Mental
Health Disorders lists nine distinct types:
Experiencing some combination of these symptoms for a period of at least two weeks
likely signifies that you are in the midst of a depressive episode.
Treatment
Any treatment for depression should coincide with a healthy diet and a regular sleep
schedule. It may sound simplistic, but the importance of taking care of your body cannot
be overstated.
There are various methods you could use to sooth the symptoms of depression. All of us
could stand to exercise more often, but exercise is especially helpful for the depressed
mind. It enables you to better handle stress, and the endorphins released during exercise
give you a mental boost. Aside from the mental health benefits, the Centers for Disease
Control and Prevention (CDC) report that physical activity helps you sleep better at night.
Yoga is a more accessible form of exercise, because it doesn’t require equipment and
because many of the moves and poses do not require much effort. Meditation is a highly
effective way of clearing your head and calming your body. It’s also easy to do, with
guided meditations available through phone apps, online in text and videos, and in books.
If you enjoy keeping a journal, you may find that it helps to express your thoughts on
paper instead of bottling them inside. It’s helpful to have close friends and family who
you can confide in, but they’re not always available or may be dealing with stress of their
own. This makes keeping a journal a good idea to have an alternate way to vent.
Therapy with anyone from a guidance counselor to a certified therapist can work
wonders, and many may prefer therapy over the medication route. Situational depression
especially can be relieved by having a way to get everything off your chest and receive
practical advice.
For a more hands-on approach, try experts like psychiatrists or psychologists. They offer
many types of therapy, from light therapy for Seasonal Affective Disorder to cognitive
behavioral therapy that works to change your thought processes.
Other alternatives include drinking special teas or taking supplements. The properties of green
tea and chamomile tea give them a calming effect, and some have found success drinking St.
John’s Wort tea to treat depression. It can also be taken as a supplement. While there is no proof
that St. John’s Wort improves depression symptoms, fish oil, and SAM-e are supplements with a
proven impact.
There is no shame in taking medication to manage your depression. People routinely take
medication for physical ailments, and having a mental illness isn’t any different. If you’re
worried about the possible side effects, call your doctor to discuss them. Any medication can be
tapered down or ceased, and there are different types available to suit your individual needs and
chemistry.
Remember that recovery is a journey, not a destination. Bad days will still come, but with well-
targeted treatment, you should be able to overcome extreme lows. While science has yet to find a
cure for mental disorders such as depression, it is entirely possible to live a happy and fulfilling
life in spite of it.
If you are experiencing a mental health crisis, or someone you love is in danger, we
strongly suggest that you reach out to to a qualified mental health professional. To aid in
your search please consider our directory of emergency mental health resources.
9 Types of Depression
and How to Recognize
Them
Major depression
Persistent depression
Bipolar disorder
Depressive psychosis
Perinatal depression
PMDD
Seasonal depression
Situational depression
Atypical depression
Diagnosis
Understanding depression
Everyone goes through periods of deep sadness and grief. These feelings
usually fade away within a few days or weeks, depending on the
circumstances. But profound sadness that lasts more than two weeks and
affects your ability to function may be a sign of depression.
But if they start to impact your day-to-day life, they may be the result of
depression.
There are many types of depression. While they share some common
symptoms, they also have some key differences.
Here’s a look at nine types of depression and how they affect people.
1. Major depression
Major depression is also known as major depressive disorder, classic
depression, or unipolar depression. It’s fairly common — about 16.2 million
adults in the U.S. have experienced at least one major depressive episode.
People with major depression experience symptoms most of the day, every
day. Like many mental health conditions, it has little to do with what’s
happening around you. You can have a loving family, tons of friends, and a
dream job. You can have the kind of life that others envy and still have
depression.
Even if there’s no obvious reason for your depression, that doesn’t mean it’s
not real or that you can simply tough it out.
These symptoms can last weeks or even months. Some people might have a
single episode of major depression, while others experience it throughout their
life. Regardless of how long its symptoms last, major depression can cause
problems in your relationships and daily activities.
2. Persistent depression
Persistent depressive disorder is depression that lasts for two years or more. It’s
also called dysthymia or chronic depression. Persistent depression might not
feel as intense as major depression, but it can still strain relationships and
make daily tasks difficult.
Persistent depression lasts for years at a time, so people with this type of
depression may start to feel like their symptoms are just part of their normal
outlook on life.
high energy
reduced sleep
irritability
racing thoughts and speech
grandiose thinking
increased self-esteem and confidence
unusual, risky, and self-destructive behavior
feeling elated, “high,” or euphoric
There are several types of bipolar disorder. Read more about them and how
they’re diagnosed.
4. Depressive psychosis
Some people with major depression also go through periods of losing touch
with reality. This is known as psychosis, which can involve hallucinations and
delusions. Experiencing both of these together is known clinically as major
depressive disorder with psychotic features. However, some providers still
refer to this phenomenon as depressive psychosis or psychotic depression.
Hallucinations are when you see, hear, smell, taste, or feel things that aren’t
really there. An example of this would be hearing voices or seeing people who
aren’t present. A delusion is a closely held belief that’s clearly false or doesn’t
make sense. But to someone experiencing psychosis, all of these things are
very real and true.
5. Perinatal depression
Perinatal depression, which is clinically known as major depressive disorder with
peripartum onset, occurs during pregnancy or within four weeks of childbirth.
It’s often called postpartum depression. But that term only applies to
depression after giving birth. Perinatal depression can occur while you’re
pregnant.
Hormonal changes that happen during pregnancy and childbirth can trigger
changes in the brain that lead to mood swings. The lack of sleep and physical
discomfort that often accompanies pregnancy and having a newborn doesn’t
help, either.
Symptoms of perinatal depression can be as severe as those of major
depression and include:
sadness
anxiety
anger or rage
exhaustion
extreme worry about the baby‘s health and safety
difficulty caring for yourself or the new baby
thoughts of self-harm or harming the baby
Women who lack support or have had depression before are at increased risk
of developing perinatal depression, but it can happen to anyone.
6. Premenstrual dysphoric
disorder
Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual
syndrome (PMS). While PMS symptoms can be both physical and
psychological, PMDD symptoms tend to be mostly psychological.
These psychological symptoms are more severe than those associated with
PMS. For example, some women might feel more emotional in the days
leading up to their period. But someone with PMDD might experience a level
of depression and sadness that gets in the way of day-to-day functions.
Some women dismiss PMDD as just a bad case of PMS, but PMDD can
become very severe and include thoughts of suicide.
7. Seasonal depression
Seasonal depression, also called seasonal affective disorder and clinically known
as major depressive disorder with seasonal pattern, is depression that’s
related to certain seasons. For most people, it tends to happen during the
winter months.
Symptoms often begin in the fall, as days start to get shorter, and continue
through the winter. They include:
social withdrawal
increased need for sleep
weight gain
daily feelings of sadness, hopelessness, or unworthiness
Seasonal depression may get worse as the season progresses and can lead
to suicidal thoughts. Once spring rolls around, symptoms tend to improve.
This might be related to changes in your bodily rhythms in response to the
increase in natural light.
8. Situational depression
Situational depression, clinically known as adjustment disorder with depressed
mood, looks like major depression in many respects.
Of course, it’s normal to feel sad and anxious during events like these — even
to withdraw from others for a bit. But situational depression happens when
these feelings start to feel out of proportion with the triggering event and
interfere with your daily life.
Situational depression symptoms tend to start within three months of the initial
event and can include:
frequent crying
sadness and hopelessness
anxiety
appetite changes
difficulty sleeping
aches and pains
lack of energy and fatigue
inability to concentrate
social withdrawal
9. Atypical depression
Atypical depression refers to depression that temporarily goes away in response
to positive events. Your doctor might refer to it as major depressive disorder
with atypical features.
Despite its name, atypical depression isn’t unusual or rare. It also doesn’t
mean that it’s more or less serious than other types of depression.
Having atypical depression can be particularly challenging because you may
not always “seem” depressed to others (or yourself). But it can also happen
during an episode of major depression. It can occur with persistent depression
as well.
If you’ve never had depression before, start with your primary care physician.
Some symptoms of depression can be related to an underlying physical
condition that should be addressed.
Try to give your doctor as much information about your symptoms as you can.
If possible, mention:
It might feel uncomfortable, but try to tell your doctor everything. This will help
them give you a more accurate diagnosis and refer you to the right type of
mental health professional.
Worried about the cost of mental health services? Here are five ways to access
therapy for every budget.
Suicide prevention
If you think someone is at immediate risk of self-harm or hurting another
person:
• Call 911 or your local emergency number.
• Stay with the person until help arrives.
• Remove any guns, knives, medications, or other things that may
cause harm.
• Listen, but don’t judge, argue, threaten, or yell.
If you or someone you know is considering suicide, get help from a
crisis or suicide prevention hotline. Try the National Suicide Prevention
Lifeline at 800-273-8255.
7 Common Types of
Depression
By Nancy Schimelpfening | Medically reviewed by a board-certified physician | Updated June 24,
2019
Depression
Overview
Types
Symptoms
Causes & Risk Factors
Diagnosis
Treatment
Coping
ADA & Your Rights
Depression in Kids
When people think about depression, they often divide it into one of two things—either clinical
depression which requires treatment or "regular" depression that pretty much anyone can go
through. As a condition, depression can be a difficult concept to grasp since we refer to it as both
the symptom of a condition and a condition itself.
From a medical standpoint, depression is defined as a mood disorder which causes a persistent
feeling of sadness and the often profound loss of interest in things that usually bring you
pleasure.
It affects how you feel, think, and behave and can interfere with your ability to function and
carry on with daily life. There are many different causes of depression, some of which we don't
fully understand. Seven of the more common types include the following.
Verywell / JR Bee
1
Major Depressive Disorder (MDD)
When people use the term clinical depression, they are generally referring to major depressive
disorder (MDD)1. Major depressive disorder is a mood disorder characterized by a number of
key features:
Depressed mood
Lack of interest in activities normally enjoyed
Changes in weight
Changes in sleep
Fatigue
Feelings of worthlessness and guilt
Difficulty concentrating
Thoughts of death and suicide2
If a person experiences the majority of these symptoms for longer than a two-week period, they
will often be diagnosed with MDD.
2
Bipolar Disorder
Bipolar disorder is a mood disorder characterized by periods of abnormally elevated mood
known as mania. These periods can be mild (hypomania) or they can be so extreme as to cause
marked impairment with a person's life, require hospitalization, or affect a person's sense of
reality. The vast majority of those with bipolar illness also have episodes of major depression.4
In addition to depressed mood and markedly diminished interest in activities, people with bipolar
depression often have a range of physical and emotional symptoms which may include:
The risk of suicide in bipolar illness is up to 20 to 30 times greater than in the general
population. Psychosis (including hallucinations and delusions) can also occur in more extreme
cases.
4
Postpartum Depression
Pregnancy can bring about significant hormonal shifts that can often affect a woman's moods.
Depression can have its onset during pregnancy or following the birth of a child.6 Postpartum
depression is more than that just the "baby blues."
It can range from a persistent lethargy and sadness that requires medical treatment all the way up
to postpartum psychosis, a condition in which the mood episode is accompanied by
confusion, hallucinations or delusions.
5
Extreme fatigue
Feeling sad, hopeless, or self-critical
Severe feelings of stress or anxiety
Mood swings, often with bouts of crying
Irritability
Inability to concentrate
Food cravings or binging
Atypical Depression
Do you experience signs of depression (such as overeating, sleeping too much, or extreme
sensitivity to rejection) but find yourself suddenly perking up in face of a positive event?
Based on these symptoms, you may be diagnosed with atypical depression, a type of depression
which does not follow what was thought to be the "typical" presentation of the disorder. Atypical
depression is characterized by a specific set of symptoms related to:
It is actually more common than the name might imply. Unlike other forms of depression,
people with atypical depression respond better to a type of antidepressant known as
a monoamine oxidase inhibitor (MAO).10
Major depressive disorder has two subtypes: “atypical depression” and “melancholic
depression.” People who fall into the former category tend to sleep and eat a lot. They
are emotionally reactive and very anxious, Dr. Noble explains. Those in the latter
category have trouble sleeping and tend to ruminate over guilt-ridden thoughts, she
says. Young adults tend to present with atypical depression, and the melancholic type
is seen more often in seniors.
Treatment-resistant depression
Sometimes people with major depressive disorder don’t readily respond to treatment.
Even after trying one antidepressant and then another–and maybe a third or fourth–
their depression stubbornly hangs on. “Maybe it’s genetic, maybe it’s environmental,”
Dr. Noble says. “Their depression is just tenacious.”
Subsyndromal depression
A person who has depressive symptoms but doesn't quite check all the boxes for a
diagnosis of major depression may be deemed “subsyndromal.” Maybe she has three
or four symptoms, not five, or maybe she’s been depressed for a week, not two, Dr.
Noble explains.
“Rather than look at symptoms, I usually look at functionality,” she says. Is the
patient able to go to work and take care of day-to-day responsibilities? If the person is
struggling, they may still benefit from treatment, including with medication, she says.
People with persistent depressive disorder (PDD) have a low, dark, or sad mood on
most days and at least two additional symptoms of depression lasting two years or
more. In children and teens, PDD (also called dysthymia) may be diagnosed if
symptoms of irritability or depression persist for a year or more. “It may wax and
wane in intensity, but generally it’s a low level of depression,” Dr. Noble explains.
To be diagnosed with this type of depression, people must also have two of the
following: sleep problems (too much or too little); low energy or fatigue; low self-
esteem; poor appetite or overeating; poor concentration or difficulty making
decisions; and feelings of hopelessness.
Usually PDD requires treatment with a combination of medication and psychotherapy.
“It can be really uncomfortable, disabling, and interfere with a woman’s day-to-day
life,” says Dorothy Sit, MD, associate professor of psychiatry and behavioral sciences
at Northwestern University’s Feinberg School of Medicine in Chicago.
Bipolar depression
Wide swings in mood and energy, from elation to hopelessness, are the signature of
bipolar depression, also called bipolar disorder or manic-depressive illness. To be
diagnosed with this form of depression, a person must have experienced at least one
bout of mania. Bipolar usually shows up in young adulthood. While women and men
are diagnosed in equal numbers, studies point to possible gender differences: Men
appear to have more manic behavior; women tend toward depressive symptoms.
Bipolar usually worsens without treatment but can be managed with mood stabilizers,
antipsychotic medicines, and talk therapy.
While further research is needed, a recent study by Dr. Sit and colleagues
suggests light therapy may be a potential treatment for bipolar depression too.
Compared with dim placebo light, daily exposure to bright light at midday may reduce
symptoms of depression and improve functioning in people with bipolar disorder, the
study found.
“These are the kids with strong emotional outbursts,” Dr. Noble says. “They’re just
not able to contain their emotions,” so they “act out and act on” their feelings.
The birth of a baby brings enormous joy but can sometimes lead to postpartum
depression (PPD), a type that affects one in four women and one in eight men. In
women, postpartum depression is likely triggered by shifts in hormones, fatigue, and
other factors. In men, it’s environmental, brought on by shifting roles and lifestyle
changes that come with parenting.
Postpartum depression can begin any time in the first year following a child’s birth,
although it usually appears soon after the new arrival. Intense feelings of sadness,
anxiety, and exhaustion become overwhelming and can interfere with daily life. It can
provoke thoughts of hurting yourself or your baby.
Women and younger adults are at higher risk of developing SAD. It can also run in
families. SAD is diagnosed after at least two years of recurring, seasonal symptoms.
While the exact cause is unclear, research suggests it may be related to an imbalance
of the brain chemical serotonin. An overabundance of the sleep hormone melatonin
and insufficient levels of vitamin D may also play a role.
SAD is typically treated with a daily dose of light therapy and sometimes medication.
RELATED: 8 Ways to Cope With Seasonal Affective Disorder
Using or abusing sedating drugs can change your mood. Symptoms, such as
depression, anxiety, and loss of interest in pleasurable activities, typically appear
shortly after taking or abusing a substance or during withdrawal.
Substances that can lead to this type of depression include alcohol (if you drink too
much), opioid painkillers, and benzodiazepines (which act on the central nervous
system).
To diagnose someone with a substance-induced mood disorder, doctors must rule out
other potential causes of depression, and the depression must be severe enough to
interfere with daily activities.
Psychotic depression
One of Dr. Noble’s patients, two years after beginning treatment, confessed that she
had a year during which she would not eat anything her father cooked because she
thought he was poisoning her. The woman was otherwise lucid; she simply suffered
from psychotic depression that had not been fully treated.
Doctors usually prescribe antidepressants and antipsychotic medicines together to
treat psychotic depression.
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newsletter
Adding insult to injury, there’s now evidence that disease-related inflammation may
also play a role in the onset of depression. Inflammation causes the release of certain
chemicals by the immune system that cross into the brain, leading to brain changes
that can trigger or worsen depression in certain people, Dr. Noble explains.
Antidepressants may help prolong their life and improve their ability to function, she
says, and therapy can help many patients cope with mental and physical illnesses.
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