Section: 1BPH
Group No.: II
Date of Preparation: 27/ 01/ 23
I. Category: AMANDA
Capsule________________________________________________________________
II. Synonym/s:
The synonym of aspirin is Acetylsalicylic Acid (ACA)._____________________________
III. Description of the Final Product:
The powdered aspirin is placed inside the capsule, sealed and polished with a clean
cloth or gauze.
IV. Use/s:
__ Aspirin is used to treat mild to moderate pain from headaches, menstrual cramps,
arthritis, toothaches, and muscle pains as well as to lower fever.
V. Formula: RAYEE
Ingredients Original Amount Computed Amount
Active ingredient: Aspirin 300 mg / cap 600 mg / 2 caps
Diluent: Lactose
● for cap size #1——> ● 0.024 g of lactose/cap ● 0.048 g / 2 caps
● for cap size #0——> ● 0.186 g of lactose/cap ● 0.372 g / 2 caps
VI. Computations:
*note lahat ng slash (/) ay fractionnn malipan sa mga “/ cap”, slash talaga un*
Capsule Size
300 mg x 1 g/ 1000 mg x 15.432 gr/ 1g = 4.6296 gr -> Capsule #1
Diluent content (gr to g)
● For Capsule #1: 5 gr - 4.6296 gr = 0.3704 gr x 1 g / 15.432 gr = 0.024 g of
Lactose per cap
● For Capsule #0 (if size #1 is unavailable): 7.5 gr - 4.6296 gr = 2.8704 x 1 g /
15.432 gr = 0.186 g of Lactose per cap
Ingredients for 2 capsules
Aspirin: 300 mg or 4.6296 gr x 2 caps = 600 mg or 9.2592 gr / 2 caps
Lactose (#1): 0.0240 g x 2 = 0.048 g / 2 caps
Lactose (#0): 0.1860 g x 2 = 0.372 g / 2 caps
VII. Label: ___white___________________________________________________
VIII. Container: _Hard gelatin capsule of aspirin placed inside the wide mouth bottle_______
Post-laboratory Exercises
1. Describe the punch method. ELLAAA
In the process of filling hand-fill capsules, the pharmacist uses the punch method, which
entails repeatedly pounding the open end of the base of the capsule into the powder
while making sure that the level is half the size of the capsule body. Finally, the cap or
other half of the capsule will be reapplied to seal the capsule. The weight of each
capsule is then measured using an empty capsule, and powders are then added or
subtracted from the weight until the desired weight is achieved.
2. Give the different sizes of hard gelatin capsules and their approximate capacity by
capsule size. Give examples of diluents and disintegrants that are frequently added
during capsule formulation. ERINN
Hard capsules come in a range of standard sizes, which are denoted by numerals
ranging from 000 to 5. The standard size capsules and their respective contents (in mg)
are as follows: 00 (950 mg), 00 (650 mg), 0 (450 mg), 1 (300 mg), 2 (250 mg), 3 (200
mg), 4 (150 mg), and 5. (100mg). Microcrystalline cellulose (MCC) is frequently utilized
in tablet and capsule formulations as a binder/diluent. Starch is an example of a classic
disintegrant, while croscarmellose sodium, crospovidone, and sodium starch glycolate
are examples of "super disintegrants."
3. Compare the procedures for compounding hard gelatin capsules with tablets and
compounding hard gelatin capsules with liquid ingredients. JAYYY
When we compound hard gelatin capsules with tablets we use the punch method to produce the
capsules. The powder is placed on a clean surface like a sheet of paper or glass and is formed
and gathered together by a spatula. Taking the capsule you punch the tablet vertically to fill the
powder. When the capsule is finished we then take the cap and cover the top of the capsule and
then push until you hear a click sound. For gelatine capsules with liquid ingredients we’ll use a
micropipette so that an accurate measurement can be obtained for the capsule. We then placed
the capsule in a machine where the base and the cap are separated. The machine will then
completely mix the liquid which will eventually spread over the bases and fill the capsules
evenly.
