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Atropine: Classification Trade Name (S) Desired Effects

Atropine is an anticholinergic drug that works by blocking parasympathetic nervous system activity. It increases heart rate by blocking vagal nerve activity to the heart. It is used to treat symptomatic bradycardia and organophosphate or nerve agent poisoning by drying mucous membranes. Common side effects include flushed skin, tachycardia, dry mouth, and blurred vision. It should be administered rapidly by IV push to prevent reflex bradycardia and may worsen ischemia.

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34 views2 pages

Atropine: Classification Trade Name (S) Desired Effects

Atropine is an anticholinergic drug that works by blocking parasympathetic nervous system activity. It increases heart rate by blocking vagal nerve activity to the heart. It is used to treat symptomatic bradycardia and organophosphate or nerve agent poisoning by drying mucous membranes. Common side effects include flushed skin, tachycardia, dry mouth, and blurred vision. It should be administered rapidly by IV push to prevent reflex bradycardia and may worsen ischemia.

Uploaded by

gugicevdzoce
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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ATROPINE

CLASSIFICATION Anticholinergic, parasympatholytic

TRADE NAME(S) Atropine

DESIRED EFFECTS Accelerates heart rate in bradycardia, thus improving


cardiac output and decreases chance of ventricular
ectopy.
Dries mucous membranes in organophosphate
poisoning.

MECHANISM OF ACTION By blocking parasympathetic (vagal) action of the heart,


atropine increases the rate of discharge by the sinus
node, enhances conduction through the AV junction, and
accelerates the heart rate, thereby improving cardiac
output.

INDICATIONS • Symptomatic bradycardia


• Narrow complex (Mobitz Type I) AV block
• Cholinergic poisoning (organophosphate or nerve
agents)

CONTRAINDICATIONS • Afib / Aflutter with rapid ventricular response


(RVR)
• Mobitz Type II AV Blocks
• Wide Complex 3rd degree AV blocks
• Myocardial ischemia

ADVERSE REACTIONS • Flushed skin


• Tachycardia
• Dry mouth
• Dilated pupils
• Delirium
• Blurred vision
• headache

DRUG INTERACTIONS • Incompatible with sodium bicarbonate


• Effects enhanced by antihistamines,
procainamide, quinidine, benzodiazepines, and
antidepressants

PRECAUTIONS • Renal disease


• CHF
• Down’s Syndrome

Effective 5/1/21 Drug Index Atropine


Replaces 7/1/11
ATROPINE
SPECIAL CONSIDERATIONS Administration should be rapid IV push to prevent reflex
bradycardia. Atropine may result in an increased oxygen
demand in patients suffering myocardial ischemia, thus
worsening the ischemia or infarction size. Ineffective for
bradycardia in heart transplant patients (denervated
heart), proceed to pacing.

DOSING REGIMEN • Adult


o Bradycardia: 1 mg rapid IV push every
3-5 minutes (max dose 3 mg)

o Cholinergic Poisoning:

ƒ 2mg IV push every 15 minutes


until decreased secretions;
ƒ 2mg IM every 15 minutes if NO
IV
-----------------------------------------------------------------------
• Pediatric
o Bradycardia: 0.02 mg/kg rapid IV
push every 5 minutes, minimum dose
0.1 mg
ƒ Max dose: 1mg child; 2mg
adolescent

o Cholinergic Poisoning:

ƒ 0.05mg/kg IV push every 15


minutes until decreased
secretions;
ƒ 1mg IM every 15 minutes if NO
IV

PROTOCOL LOCATION • Dysrhythmias


• Toxic Exposure – Nerve Agent &
Organophosphate Poisoning

Effective 5/1/21 Drug Index Atropine


Replaces 7/1/11

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