TOTAL PARENTERAL NUTRITION
Definition:
Total parenteral nutrition is defined as method of nutrition given for total
nutritional needs of infants or children where lives are threatened because feeding
by ways of the GI tract is impossible, inadequate or hazardous.
TPN combines highly concentrated solution of glucose, amino acids, vitamins and
minerals and is given through a central line.
Indications:
Neonates
Absolute Indications: Intestinal failure, necrotizing enterocolitis, congenital
anomalies like tracheo-esophageal fistula.
Relative Indications: Hyaline membrane disease, promotion of growth in
preterm infants, possible prevention of necrotizing enterocolitis.
Infants and children:
Intestinal Failure: Short gut, protracted diarrhea, chronic intestinal pseudo-
obstruction, post-operative abdominal or cardiothoracic surgery.
Organ Failure: Acute renal failure, acute liver failure.
Hyper catabolism: extensive burns, severe trauma.
Contraindications:
Hyperbilirubinemia
Azotemia
Shock
Thrombocytopenia
RDS
Nutrients:
Calories: Newborn-110-125 kcal/day and children 100-110 kcal/kg/day.
Glucose: 10-30 g/kg/day at 6 mg/kg/min rate of infusion.
Lipids: Intralipid with 10% soyabean oil 1-3 g/kg/day.
Aminoacid: crystalline aminoacids 2-5 g/kg/day.
Vitamins and mineral: Standard multivitamin are usually given.
Fluids: 70-150 ml/kg.