~

-+--4-+--t-l- -+- I I - _,

t
- -
 I
'

-© IC\.\ushi
I Kctsqf .
I I I I I '
 1'
{3 ceili-
f(LUT-♦ (panc-rw ("' t off-in¾]
~\1uost <.t\U,H.Q!O 1<inase • ~[Link]- ,_ Phosphate
l") "TP ADP
·tt - induciblev PhQSfhO He~o-se
- comm, ea sttp .....- [Link]-rase
PhOSfh~ F'Juao)
[Link]-1,,. 8iS P. ~ rc,ncase ~
(cc>
~ F-ructose - ,- p, UC)
fltTP ~PP

I
Aldolase
DHAP
'"-'-s ""
HN pn0
T-riose.
tton1e,a
@R)
6-l~ceTaldeh~d.e-3-P c3c)
PREP
PHAS E
(1C)
NA:j '-l Cr\y,-3-P. Dehgcl-ro9en..sc PAY OF
PH AS E
2·5 F\TP x z @TP NAO?
I, 3- Bis pt,ospho 91yctY(tte
AOf ~ 1,3 8Prir ldtiQSe
ATP

3 Phospho9l~ce-rQte
l 3 P<t [Link].se
2. Phospho91y,e-rat,
EnolQ&e - ► (:)Fluorride
Hi/
PEP
l M5&+ / Mrf't' cJ Mr+ I 1Yln7.+ [Link]
Na.F : OXl\\oJ-e
ADP ) I P~u--rvate
@n ATP VJ kiNSe.
i
BloC? 3lucose
rrctained .
1- F\T p P~U-r'JAte
 ~\U(OSe
'1,
Ot, LAt1Ar&
2 <.tl~c.e-ratcAehijc(e ?> P

Net ATP" 0) + Lo + 2. t- 2. ) = 2 J lT P
; n p7ep
J
- - ~ ( _ _ _ f~
- -
~_c1_e_,_/_2 3_
_, B_P_a-_Sh_u_m-_; ~ ~ ly R~~
{"-R_a-:.,p_~,.;..p_o1_t_L_eu_b_e_,.i_n,
___ glucose
en t( M

1,3 8 ~
[Link] . . . Sl111l), ,sRt(.r
U',f- 02 C W t,t U
1 '1 BP~ . . . I -{ HT

1,3
I ;J
ADP
\ ,? 2, ~ 8 P~ · u n lo a ~
~
o,_

.
Hb .
&- / ' ~ ~ ~ ;~....1
Ki na,e ~ A rP .x 2-.
BP y, 'ij
== '
2,3 8 ~ -
h o9IC jC N Q t~ Pta~hotQJe
3 Phosp

l [No NET AT~

'
I
I
I
- -[Fate o f PYURVAre]
TCA ~d e.
Acet~\ CoA

PDH
tompl,,c
,~U1VA~e
OXQlO C lY ~I ~.
Q([Link]~ 6'oHn n '\ PYUR'JATE
ftTP ADP CO2.

Alanine Amino
TTC1nsf tT'lse
Alanint
C&tt1'VO..te. Deh~d-ro9 e nQ S! Rxi] .·- - ti@
PDH - Mu I -
complex
{ oxidative De.-ca'tbox~l®'&tt J 4 ()1/~
7
f, PPH TPP
•
Oih~dYo llpo~I C•A
f1 11'~nsacet~tqse Lif)OMitle 1

C?> Dih'dDlYO lipomidt FAD

'
NAot I

TPP - t+h~I 1PP l2 t)

[Link] Ac.et1s I
lipomid.e Lipomiae
j Co A·SH

[Link]( [Acel-y I loA]

~ADHa. LifOTn/tU,
~o

NADH
 PDH ~ A,et~I coA
I P~ \A"t vate
(~C,) CO2-
NADH
J
 cit-ric --add ~,k. /[Link] cycCE-/ KRE-8s CYCLE -- ---
"con l k:e~p Sellin [Link],mce .fo7 ~oneg, ,Eff,~,..
- -:tc
D - AU Co
'---...s.:-......,, CoA-S~
----ot....;i e
at..:.!,. OAA -~~---
~umcrro~ ~tt._o NADfi-w ii/~'¥:~ + Cihra.-te
Aconitase
E)Ftu-ro-ac~
cf IA m Q 91ti@ snng~ :
Suc,i~ t:,, FAVH2 3 NADH X ~-s: f·S Ar (I SOcih"c:tfe)
(:) ,Plj (\ Fl\ D / r:A DH~: I• 5 ATP
1OcTP ~ 1 ATP
.:t so GI hate
tv'ialoriate @[Link]~ NAOl-1
DH
,,_ _ . Thiol<iM&e Io ATP +H~
U:-TP CoA -SH @
~~[Link]XQ7.-:I0:-•-:S~U--,t._f_n____~
GtDP Ute n~ ~.-.... CO2-<:-/ - -
oA , ctCoA-SH o<. Ke~o ✓ rsocH7o:J-e OJ.I
NAO(}?
+H+ NAD+
6tlUtQ"'1Clte.
lHJ e A"rsen ite
 -
-~hA(OSe fYOfft r:ro,ion~ I
Co A (odd [Link] F~)
-
----
,,.. "t\lA!ose f-Yom Amino Addi
~IA'TV«i'e,.. Ala nine
~ly, ine
se-rine
c~steine

~\utamCAtc
ol-t<eto ~ Gtl\Atomi r,e
CrlWNTAtf ~:,gininc
Mis+idinc
/
su,,i~I
PToline
.isoltutint
Co A - Methlonint
Valine
 ~ [ U\ LYCO(d NO LY .S IS ]
I 'cu:L'/(OU7ENEsrsJ (.iflUtose

CKLYCO~EN
~cos •
ATP J. Ct1u,okinc1ie
RtMOVQI <Pf-
l@ It\ foYm ~ Ca: I ®
~lvcose- 6 - ®
t [Link]. L
LIMIT DEXTRIN fom,1t
~-I-{! )
uTP I UDP- ~IU(os, f~Yo- ~·u-~- er-er-<i-6'- &- ez- ~-:-0
\
~ PhOsph~v::,l~e
~J
~
UDP- utucose I
-<li..f4) .:. t<l l·lf)
✓I ~1~c.o9,n ~[Link] 4 5l~t~
vor J. I TTon Sf eT(Ut
Add" of ociivattd 91<.[Link] -lo (Ji~
[Link] p"lirtln (CkP) / ~l~togenih J, .
T-ran sft1t of -nisaccJ,-ride urut to
~-u-~-~-~-~-~-~-@
t
cx:ci,~)
linK°'Be ...
1 . (tlycog~~
• ·
~nthase
lir>eoY

J~
[Link]~
'~-(r-(t'.. (r•Cr-~ -~-<R-~ - ( r - ~ - ~ - ~
o<(l,6)1i n~

Elon,cw°" [Link]
~·Ct· Ci-~-~ -~- Cr-df-G t- GI:-~ ~
10·12. jr,u~Je 't(u:!We,
~
®
1 Deb-ranching en&ymt -
tt (1 .. ,) 9 '"cosidos~
s,,anchfn1, Enz~rne
1
+Telnsf(,11, '® ii foYMi:atW
SltAldn9 of o<lt• 6) linkQ't
~ .. (t ..(r-~- ~- Gt-Ct- ~ - c.--et- €)
~ poir,t
{t•(i-(t-(i -'4\-Ca-& --6'· ~
I'\ oZ(l-6) Vnkage
~
. l <i'l!IW9e11 PhOSphoTg/llJe

~
l

I
RtMO'J4l '1 Ct 1 ® one b~ one
U"
~ 6@1uco$e j 6:IIJCO~II f'hosphOY !f llllt
I
(It ~llUO$t I ®
l
I
((
Muta&e
~
etong<1Hon-+ 8-ran cnin~ ~ [Link]( ' ®
<Kl~to9e11 \~n.._.,_ , BY(Afiehins ~ J 6'1UtO.$t- , • PhosphaltJlt

[Link]
~LYCO<rEN. "'
.. -
 fHMP Shunt)
[Peniqse pnosphoJe pathway l thospho3luconaJ:t-
P~itiW~]
6 X @ 6 Phosphate (6c]
OX\Df\TI\JE
PHASE
NADP+
NADPH/
~1 <Jt\[Link] - 6- Phosprnatc.
[Link]~d-ro9•na~ - Ra.t-e urni l-in-9 Step

- Swe\/e...[Link] , >< ,_ Phospho-~luconQte

- I ive:r, qcHpose
+issue) RBC. NAopt ~ ~ 6•Phospho-91w,on~
- c~toplasrn NADPH~· • DH
Oa
6 >< Ribulose - , - Phos,hMe CscJ
- NON
tTd~e
fTQSe
0
;x
~ibose s ® D
I
[5CJ A
~'l..
T
etola" (TPP~ M,a+) l
V
E

Stdoheptul(»e =t (f) 6-l~tnaltAth~d, 3 ® PHA~

[lCJ
)( 2..
c~,J)( 2-
a,u
7ev.
s+4>s
Bft\
Skin.)
.rnt.
O\J e10\l R:t n:
6 Y. fsrn«t:uJ:se 6© • ,s x ar_,:ucose 6 ~
= 3lLtto~e
12. NADPH -t-12-1-f+
+
12. NADP+ +
6COL,
+
. 6 Hz.O
 LI PIO METABOLISM
."
0 ~ -oxic t ~ '?i: F ~ Ac.u:uOlli"v @ [Link] cl'[Link] FA OX/ :-

- in MIT. (Odd uiairt FA, W)AatFA ) [Link]

- o<. oxi II : ER/ Pwoxiso rne ~ ® JSuc"ssive Steps
CDA CJ,)
~ O)(i" : ERi Mic:[Link]"1e
1-on.9 [Link] FA •
- • • , _ •.1/""·~
: ,fl,.
~ ,. ,, ,
A~I <.oA -t hopion yl
Ut.
~ l PRO,,/ON~L. S6
e11,eox~LA

--. /iv o.~pose ti~sue, !>I<· M:] M~/ ~ I loA

( FA ~ ~ I ... [Link]
···o- eo A...
ArPJ .J!J1. .J.,{M·M [Link] ,.,11
® AC..TIVAl/ON OF F•A· ---, .[Link]~f c.o(I - TC/t
F-A li-cooH) / o
~[Link] D~-NOVO F·A- ......;;..;::.;._
l R-i -s~ @ :.:::,_~:..;.;:. S~N rHESlS u~NE N's
A~ I GM ......:....::.;... _ _ _ {,. SP l~AL. -

- ~ L - _ , . - ~~ ~:-:='.'-:-. - U3taso I .
OMM .s THA ~~ I ~ w.c..[Link]\g ~ I .
~ TRAf'lSP ofr Of '1UIVI\T£ D FA 'TO M I T.. ~lcw.d., ~pt!! r .
~ _4' .
~r~-=o:;-F--AAllftt'f~~4c~?b'
:::@
@T_i_A_:Ns=-fO

~
1- l
- -'6•
c A
O
[Link]. ITINE
---.-- ~~
(.UH 1.
N:i LI PA, M/T(lt L
7iANSFEtl l5
CfT.J.)

e) Malon!f I ~ MIT
[Link]};J,
-,·· - ~
[il c.,1~~
/3·0XI ~
.,J.
wl
~ lJ, tasllflj .sttlle) ! Oflll
~ Cin ftd S'fQ!tJ c;.{f-.Q.t:t

' "'"' '°"''I. («n.<J;. / J, <>IU2J C~ , • .., L 1117 Z, 1- I I I ZZ z, >

AG!:f 1 ~ cl h [Link]
~
.-1i ([Link] /lP r- .Jr )
IHP

~ CD· ~ o~id•tion ~ ~ ~ ~~:---:-'.:-;;, OAA

?H~ ~,. ri
© ~-ox1r>A TION PROPe ~ - oxi" 0
....._. [Link].9e C. ® AlTIYATfON OF [Link]~L Co A ·

)
lQ) AefhJJ_
~ {J)A +~ -qS-SH 1,i,r
l~c.c 1 ~L 1RIINSAc:~ [Link] J ~~ PP (1oc..)
[Link],.,
~-En~~ CoA - SH J; ..--, txu [Link] 511n11iu.4
lb) ,,.- [Link] I [Link](J().1/t p;l11J.M1, Fuu, w.f r f' CIs c..)
Mal~ loA t ~ - 5 11 N~~l-' FPrc.,sc.) r-s-ijN- -11-4 ~-e--]
JEALON}t L t!AN§f\C~LAS6 )
s q,~(30c)
1'1:Qt~AC-1+ WA ·SH NADPH-. / lfoltl)A.)5, ~~~ltO>t~l,.A~,
0~ --4 -l, G Cl.Al5
~-~nl +-~-Alf J..aKios+ e,c,a), { 3ot:)
NADP'1.., f-- ~,g_oJf
~ ,..~ l kETOAc.~L S~NTHMi)J iOl -- -C- ~
0
CfiOLE$ TROL ( 2-:rc)
~-~o~ AtP (ID 01..SSTROI.. DE CxRADATION-
NADPHtt-trl -f -
1,seroAc.~1.. [Link]..rA~et • 3imp comp : '1) Bile Acid
~ b) Vit D
~ -~dXoX!fWf, A, C-, e,) SteToic:l Ho-r mone
~o 1,[oe H!:tD~ATASEJ 5
 {;!;{00.,
® HDL Metal)o/ ism _, ~
O"fciJ. ~ ·7 'fWlOSt
J.J. vv.
-~ [Link] ¥ ¢ ~
I
If
oiscoicbl HDL - - -
[Link],L.e

[Link] £'-
J((.,
[Link]( ~ [Link]£\Gt ~/ h

1 0 T-ro.K\O{f'I ~ .dal· -to, H DL

® utw. (I [Link],(,(Yr, ~ [Link],l .+'1'1
HDL
,~-
[Link],s,
Gr [Link].O
~~
IuLucoss - At,ANINE
f>!j(4TV4b-

c'jciE I
~~
L"'~";

~lid GHYI ate

c) .sto1'"d~ 4 1'70JWfW -
Ilda

~
NH .1
~
 4 T~[Link] J'lt : -

♦
0/T

fo-rm~
..-'I,l, IFo"ll"f\Ql1\ldClst )
l(~r, - IA"lt.1411\e

Dop~rrunt
JI"
\lit c. R.,.~_,,..,,-x,...~.../•'"1"•...,!
fBIJ (>lo Mtttiyl u tp)

wn-;, IIM~lt:!(t TTI1,1o,£ ru-l

51111 ,l,

0
~ 5EROTONIN PATHWAY_
 N UGLEOTIDf MET.
0 De -1'\0\JO s ~ n [Link] Pu.-r i ne N~cte· ~ (Y'\,{· d)O ~ v U:V,b(rr,r~ -
0

1 p~
{ .SU(U™f"
l 4 ,c5, N~ ➔ ~\~[Link]
( S Al CAR)
C1,NiN' ➔ M ~
0

THI= .,.,l rwc;J

Ft..1..tMy-- i~
~ -ifl'1' . a;·o. ~ ,c,o.;,b0?<.,(),Y/Ud.L R 5@

l
lA l CAR )
1,3,s,, , f
ATP, ~~[Link]
fo1'tn.y I QYQO$foT?:11ici.J
Tl1f 10
Z, S- CtlvJorn,· ne Fo..- rn'.A • Ml'WY'l(J- •,[Link] a'(UL c,cv.-[Link]..1 P s ·
~ r
3- 4-1~ c.i ne
(F Al CAR)
4 1 10 - THI=
1
lO; :J - l O~
l- Asp. ....
II) ✓1II
0

lMP
' r_y GUM I
~ , II - Noi+-.t ", .
( ~ ~ ,pr~o.;u)
,uh~ s ® ~,-.o,
A Tp l '"'~,..R"'"'PP~S-!::frrtn-:-:-et-:--~-
-o e~l ~ Dr

"[Link] ISlcvu.
p~ ~ P'(-0- f'K'IJ4fht:Ml ~~.a
( PRPP) ~YM
,., ....a .
"' ,.... m,rie. vu~lJ.';! ~1 on!
Amid 0 TT
0 L - ---C~ IMP
, _ Mt Adcnylo- -_'!'~. j c,.,,.,_,AAJ
p~ ~ 6rrwnt ~MP Furn 5ut GiM,1,C.
( PR A) ~ - ---
Q"to.,t.l

Ct\~~ n,
AT P
1,s~nl-htlCU,1
~
~ ~~
cc.,.,_rnp)
3 ( AMP)
'(~ ~ ll· 5 · ®
( ~AR) 11Ci~t --------- l Kinole

N~ NIO
~
1[~'1'1'cmsf(/\M(.J A DP ttiboo [Link]
lkl~t f/110-
-YtdO)lill J
[Link]$~

F~ ~[Link]- ine R 5 () NAOP>i (,.; T f

A1P
( r~AR. )

- ~~Qi ,~~[Link]~J '5,,

Deo~RJ bq'\Ltc)[Link]<d,,
tc). ADP , ol.t,;DP)
¢{Ty\Vfl0' - i ml · ell Cl~ R s®
l.t1hi b·,1 O'l.J :

~1~Jiox~I~ \
<Oi.
( AIR)

x&io+i,.. "rf-1.,
(j)~Dt\Ql'IWU
@ IV\lt.t\Ait 'Y t )(G\,{J
l',1'tr\l rV). rni - tii q 2,cli ,c,cv.b6i.x.,~ ¼V.l
1 11. s@ @ 6 IY\Vt~tc ruw:,u
t ( AC AIRJ ® A~•$<Mh
A
sf
N·
 [Link]
AMP
-
OH O O
~
a,~.

€l
H ~[Link] th'1ne , zMP
HIf po)(on IN Ile' -C.14P,1,W
( f/{Tos

. - lt1h N~ l\an ~~nd ·

.
6;
I
•
• •
• I
• .. , • ,
 ;:::>i Bili
'
I) HfMf: S':1NTH£SIS (~~~lit ~ m£»ion)J.l
(Y<)C~ {
.
Vr,Tdi,11 t~a.e
~ome _~ _pt9'(l;t(Q)(d _f'ol/X,V1, J:!µvt); > rn~IJ!"'. _ _.;.,,.....=~
Utndvt f._OV(,,'( ~ PWU - ~ · IYricu;c JB/t.1 RUBIN\ l!jeJIOW)
(. tAKwe~)

-rRF½NSPOR.T l + A/1,wnin

Albumin- Bi li -[Link] UJ~

J,
L. l'I E It . [Link].
!;) ~l<e % 8i/i-tubl" bAj Hep • ....
@J;g- TBC-100~
~ - .!<-3 ~ lotaA.J, Irl6W- O •S"-2 fYJ8/dru,
~am [Link], v.ii1~ snat ~ 1 FruU:- Nu.t
@J- WllSCNI..S' 1J>IS EASE ' ,