Shivaji University, Kolhapur
Question Bank for March 2022 (Summer) Examination
Subject Code: 69897 Subject Name: Industrial Pharmacy-I
OBJECTIVE TYPE QUESTIONS(02 Marks)
1. Define preformulation. What are goals of preformulation studies?
2. Enlist different physicochemical properties of drug to be studied in preformulation.
3. Define preformulation and give its objectives.
4. Give BCS classification of drug.
5. What is intrinsic solubility of drugs? Give its significance.
6. What are hydrates and solvates give examples?
7. Define partition coefficient. Give its significance in preformulation study.
8. Give importance of polymorphism in preformulation study.
9. “Preformulation is first step in rationale development of dosage form”: Justify the
sentence.
10. Enlist different IPQC tests for liquid orals.
11. Give difference between syrup and elixir.
12. Define is granulation? Why it is necessary?
13. Why wet granulation technique is widely used in pharmaceutical industry?
14. Define capping, sticking, lamination and mottling as a defects in tablet making.
15. Define lubricant, anti-adherant and glidant with example of each.
16. What is disintegration time for uncoated and film coated tablet?
17. Define sublingual, effervescent, enteric coated and hypodermic tablet.
18. Enlist different types of tablet tooling? Define: Head flat (Dwell Flat) and Dwell
time.
19. Differentiate between sugar coating and film coating.
20. Enlist different compendial and non-compendial tests for tablet.
21. Classify different types of tablets.
22. Give ideal characteristics of tablet dosage form.
23. What is mean by enteric coating. List examples of enteric coating polymers.
24. Why mannitol is widely used diluent in chewable tablet?
25. Give importance of hardness test on tablet.
26. What are acceptable limits for weight variation test as per Indian Pharmacopoeia?
27. What are acceptable limits for weight variation test as per USP?
28. How flow properties of granules determined?
29. Differentiate disintegrant and super disintegrant with examples.
30. What are chewable tablets and lozenges?
31. Define extrusion and spheronization?
32. What is bloom strength? Give its significance.
33. Give difference between hard gelatin and soft gelatin capsules.
34. Enlist i) Components of hard gelatin capsule shell, ii) Manufacturing Steps for hard
gelatin Capsule shell.
35. What is pellet? Enlist different methods of pelletization.
36. What is storage condition for tablet?
37. Define minim per gram factors? Give its formula.
38. Write on different sizes of hard gelatin capsule.
39. Define ophthalmic products? List ideal requirements for ophthalmic formulations.
40. Enlist tests used to investigate quality of ophthalmic products
41. Classify clean room area with different grades.
42. What is HEPA? Give its efficiency.
43. Define parenteral products. List advantages and disadvantages of parenteral
administration.
44. What is importance of isotonicity in parenteral formulation?
45. What is Sham test?
46. Differentiate between LVPs and SVPs.
47. List out non-aqueous vehicles used in prarenterals.
48. Write different methods of sealing of ampoules.
49. What do you mean by „class 100‟ clean area?
50. Name the methods of adjustment of isotonicity.
51. What is LAL test?
52. Name sterilization methods for eye drop.
53. What is in-situ emulsification? Give its example.
54. Why is KOH widely used as alkali for soap formation in vanishing cream?
55. What is SPF? Give its importance.
56. Define simulative and palliative suntan preparations.
57. What is breaking and softening point of lipstick?
58. List different types of hair dyes with example.
59. Write formula to prepare toothpaste.
60. Enlist evaluation tests for aerosol.
61. Designate following propellant numerically: i) Heptafluoropropane,
ii) Trichloromonofluoromethane.
62. Give name of following numerically designated propellant: i) 227, ii) 11
63. Give name of following numerically designated propellant: i) 134, ii) 114
64. Define primary and secondary packaging material with examples.
65. Enlist factors influencing choice of containers.
SHORT ANSWER QUESTIONS (05 Marks)
1. Explain solubility analysis in preformulation study.
2. Elaborate chemical properties of drug substance studied in preformulation.
3. Why preformulation is first step in rational development of dosage form? Discuss
impact of preformulation study on stability of dosage form.
4. Discuss formulation components commonly used for liquid orals. Add a note on
filling and packaging of oral liquids.
5. Give formulation consideration of suspension.
6. Discuss defects in tablet coating with their causes and remedies.
7. What is difference between sugar and film coating? Explain different steps of sugar
coating.
8. Discuss primary bonding mechanism and mechanism of granule formation.
9. Elaborate various excipient used in tablet formulation.
10. Explain compression cycle of rotary tablet press.
11. Discuss wet granulation technique with special emphasis on high shear granulation.
12. Classify tablet coating equipment. Explain any one of them.
13. Explain compression cycle of single punch tablet machine.
14. Describe disintegration test for tablet.
15. Discuss film coating of tablet.
16. Elaborate quality control tests for granules.
17. Discuss formulation of different types of suspension.
18. Write a note on chilsonator.
19. Classify pelletization techniques. Discuss different methods of extrusion.
20. Discuss IPQC tests for Capsule.
21. Classify different hard gelatine capsule filling techniques. Explain any one of your
choices.
22. Enlist properties of gelatin. Discuss manufacturing of hard gelatin capsule shell.
23. Enlist components of soft gelatin capsule shell. Explain rotary die method of soft
gelatin capsules production.
24. What is base adsorption (BA) and minim per gram (M/g) factors? Give its
significance in capsule manufacturing.
25. Explain rotary die process for manufacturing of soft gelatin capsule.
26. Describe in brief formulation of eye drops, what are various adjuvants used in
preparation of eye drops?
27. List production facilities required for parenteral products. Explain in short
formulation of lyophilized products.
28. Write a note on HVAC.
29. Enlist quality control tests for parenteral preparations. Explain in-vitro test for
pyrogens.
30. List production facilities required for parenteral products. Explain in short
formulation of lyophilized products.
31. Enlist production facilities of parenteral products. Explain in short formulation of
sterile powders.
32. What are ophthalmic products? Discuss formulation components of eye drops.
33. Write a note on environmental control during manufacture of parenteral products.
34. Write the specifications and methods of preparation of WFI.
35. Explain different types of aerosol system.
36. Classify different types of glass used in pharmaceutical packaging. Add a note on
hydrolytic resistance test for glass.
37. What do you mean by palliative and simulative suntan preparations? Give
importance of SPF and sunscreen index in such formulations.
38. Elaborate note on three phase systems of aerosols with examples.
39. Write detailed note on propellants.
40. Discuss and differentiate the pressure filling and cold filling of aerosols.
41. Elaborate on excipients used in shampoo.
42. Discuss different types of hair dyes.
43. Explain in short different components of aerosol system.
44. Explain different factors influencing choice of containers.
45. Discuss on stability aspects of packaging materials.
LONG ANSWER QUESTIONS(10 Marks)
1. Give an account of the Physico-chemical characteristics of drugs inPreformulation
studies and explain its importance.
2. Discuss compression cycle of rotary tablet press. Explain in brief IPQC tests for
tablet.
3. Discuss on processing problems of tablet making with their causes and remedies.
4. Elaborate excipient used for tablet formulation with examples. Add a note on tablet
tooling.
5. Elaborate on granulators used in pharmaceutical industry.
6. Explain types, formulation, and evaluation of emulsion.
7. Give classification of clean room area and explain HVAC system for parenterals.
8. Explain in detail containers and closures used for parenteral preparation.
9. Elaborate aseptic processing of large volume parenteral.
10. Discuss various raw materials used in shampoo preparation. Give formulation of
anti-dandruff shampoo.
11. Elaborate raw materials used; method of preparation and quality control test for
lipstick.
12. Discuss manufacturing process and quality control test for pharmaceutical aerosol.
13. Discuss stability aspects of pharmaceutical packaging materials. Add a note on legal
and official requirements for containers.
14. Elaborate different raw materials used in formulation of cosmetic creams. Give
formulation of cold cream.
15. Elaborate different components of aerosol package. Add a note on different types of
aerosol system.
