Total No.
of Printed Pages-2 SS/MBBS-II/1* IA/PATHO/06-23
2023
(June)
PATHOLOGY
Full Marks: 100
Time: 3 hours
indicate full marks
The fiqures in the margin
for the questions
Answer all questions
skin and mental
was admitted in ICU with dyspnea, pale cool
kA 30 years female examination,
history of self-induced abortion two days back. On
confusion. She had a Lab investigation
pulse.
pressure was reduced with tachycardia and fecble
her blood presence of toxic granules in
leukocytosis (TC 30,000/cumm) with left shift and 2+4+4=10
revealed
neutrophils and reduced platelet count.
diagnosis?
a) What is the most probable
the disease.
b) Write the pathogenesis of
discase.
c Write four complications of the cellular events
inflammation. Classify inflammation with examples. Describe the
Ve. Define inflammation. 2+3+6+4=15
chemical mediators of
of inflammation. Narme some pathogenesis of septic shock.
of shock? Describe the
.3. Define shock. What are the types 2+4+9=15
5x7-35
(short essay question)
,4 Write briefly on the following:
Different routes of metastasis of tumour.
inflammation.
5 Role of macrophages in chronic
o Virchow's triad in thrombosis.
changes in pernicious anaemia.
i Pathogenesis and morphological
AMicrobiological carcinogens.
metastatic classification with examples.
-A Distinguish between dystrophic and
attendant- Discuss briefly about
A)Importance of cornnunication by a doctor to the
it.
2x10-20
5. Short answer question:
producing it.
Enumerate six tumour markers and the tumours
, List the stains of amyloid. (Turn Over)
Jree differences between dry angene and et
panggene
Oive two examples of physinlopcal hyperglasia
Role af telomerase in cellular agng
tuo cxamples each of
autosamal dominant and autoscal recesse diseder
GPathogenesis of megaloblastic anaemia
G Draw the histologcal picture of tuberculold granuloma
Trisomy 21.
Four clinical fcaturcs of
Hypersensitivity reaction with example.
correct option:
6. Choose the
Nutmeg liver is found in
A congestion.
b infarction.
embolism.
d baemorrhage
Liquifactive necrosis is found in
s) kidney
K brain.
c lymph node.
d) hcart tumuur cells?
line of defense against
Which cell acts as tie irst
a) Macrophages.
bj Neutrophils.
a NKoells and Tcells.
d) Basophils
CD 95 is a marker of
a) MHC complex.
b) NK cell.
Death Receptor.
d) T helper cell.
Serum ferritin level is reduced in
a) haemolytic anaemía
b) megaloblastic anaenia.
aplastic anaemia.
anacmia.
) iron deficiency
TRBS-II/ [* IA/PATHO/O6-23
Total No. of Printed Pages -2
SS/MBBS-II/ 1t IA/MIC/06-23
2023
(June)
MICROBIOLOGY
Rull Marks: 100
Time. 3 hours
The figures in the margin indicate full marks
for the questions
alternate day for last
1. A 30 year old male presented with fever and chills and rigor in every
2+3+6+4-15
7 days. On physical examination, there was anaemia and palpable spleen.
a) What is your probable clinical diagnosis?
b) Enumerate the causative agent with species.
s) Confirm your probable diagnosis in laboratory.
c) Outline the preventivc measures against the disease.
1. Define immunity. Describe different types of immunity with example. Discuss the
differential features of actie and passive immunity. 2+4+4= 10
the isolation of
3. Describe the mechanism of replication in viruses. Discuss briefly about
virus by tissue culture. What is an inclusion body? 7+5+3=15
4. Write brielly on the following: 5x6-30
t Differentiate between innate and acquired imunity.
b) Post Kala-azar Dermal Leishmaniasis.
c) Bacterial spores and their practical applications.
d) Role of bacterial conjugation in drug resistance.!
c) Koch's postulates,
9 Heterophile antigen.,
5. Give reasoning: 4x5-20
a) Gram stain is a differential stain.
b) Blood agar is an enriched medium.
c) Ig Eis a reagin.e
d) LoefMer's syndrome may be scen in a patient with ascariasis.
A Glutaraldehyde is the most common high-level disinfectant used for an
cndoscope.
(Tum Ouer)
practicc."
6. ive an account on "Role of ethics in medical 1x5-5
7. Choose the correct answer:
fulGl the Koch's postulates?
Which of the following organism does not
a) Chlamydia pneumoniae
Lepra bacilli
c) Rickettsia
d) Klebsiella pneumoniae
ii. Who is the Father of Microbiology?
a) Antonie Philips van leeuwenhoek
b) Edward Jenner
Le Louis Pasteur
d) Joseph Láster
Lipopolysacchuride is a component of cell wall of
a) Gram positive bacteria
b) Gram negative bacteria
c) Virus
d) Fungi
free DNA is
Mechanism of direct transfer of
, transformation.
conjugation.
c) transduction,
d) transposition.
aparasite is called
harboring adult or sexual stage of
Host
(definitive host.
b) intermediate host.
reservoir host.
) None of the above.
ss/MBBs-II/ 1« IA/MIC/06-23
Total No. of Printed Pages - 2
sS/MBBS-II/ 1 LA/PHAR/06-23
2023
(June)
PHARMACOLOGY
Ful! Marks: 100
Time: 3 hours
The figures in the margin indicate full marks
for the questions
Answer all questions
,I. Choose the correct answer from the choices given:
1x5-5
Which of the following is a local route of drug administration?
Sublingual
J Intra-articular
c) Oral
d) Intravenou8
Majority of drugs cross biological membranes primarily by
passive diffusion.
bl facilitated diffusion.
c) active transport.
d) pinocytosis.
Absorption of a drug is aflected by
a) solubility.
b) route of administration.
c) vascularity.
) AlI of the above.
iv. In competitive antagonisn
P Efficacy decreases, potency remains same.
decreases.
b) Efficacy remains same, potency
c) Eficacy and potency both decrease.
in the presence of
d) There is leftward shift of the curve of the agonist
competitive antagonist
Therapeutic index is not
t ameasure of eflicacy.
(Turn Over)
b) a neasure of safety.
) the ratio of LD SO and ED 50.
ag
d) of concern when it is narrow.
2. What is biotransformation of drugs? Explain briely the phase-1l and phase-2 reactions with
one example of cach. Name one microsomal inducing drug and one therapeutic use based
on this action. 2+6+2=10
wntgshort notes on fany fiue):
3. Write 5x5-25
ratogenicity
ilocarpine
YOver the counter drugs
Pharmacovigilance program of India
Dose response curves
Antimicrobial agcnt resistance
S. Explain why: 3x5-15
car c Amoxycillin is combined with clavulenic acid as fixed dose combination.
s.Ot Low molecular weight heparin is preferred to conventional heparin.
Beta blockers are contraindicated in bronchial asthma.
)
d Adrenaline is preferred over noradrenaline in the management of anaphylactic shock.
Physostigrnine is used in atropine poisoning and not neostigrnine.
Aman aged 45 yrars presented with gradual onset diplopia, drooping eyelids, difficulty in
chewing food and weakness of limbs, which is accentuated by exercise. The symptoms
efin
1fer fluctuate in intensity over time. A provisional diagnosis of myasthenia gravis is made.
Des a What pharmacological test can be done to confirm the diagnosis? 3
What drugs can be given to reduce the syn1ptoms? 3
yir
What is myasthenia crisis and cholinergic crisia? 4
,W
6. Explain briefly: 5x6-30
aY Uses of atropine and its substitutes.
5 Volume of distribution.
g Tetracyclines are contraindicated in children and pregnant women.
) Management of common poisoning.
Y Timolol is used in the treatment of glaucoma.
Type Aadverse drug reactions.
. Write the question on AETCOM: 5
Healthcare as a ight.
Rights of a patient, duties of a doctor.
Ss/MBBS-II/ 1 IA/PHAR/06-23
