QRM Phantoms
QRM Phantoms
A milestone in the history of both companies QRM phantoms are professionally designed and manufac-
In 1922, PTW started being a pioneer in medical radiation tured with highest precision. The components are carefully
measurements. Since then, PTW has always been and selected and adapted to the specific imaging modality. Our
will continue to be at the forefront of advancing patient machinery uses the latest technology to produce and manu-
safety through innovation and cutting-edge measurement facture phantoms with high accuracy.
technology.
In 1994, QRM (Quality Assurance in Radiology and Medicine) Standard as well as custom-made phantoms undergo a
was founded by Professor Willi A. Kalender as a university quality control test according to their use. Therefore, differ-
spin-off of the Institute of Medical Physics in Erlangen, ent types of medical imaging devices (e.g. DXA, CT, C-arm,
Germany, for the development, design, construction, and Micro-CT, MRI, etc.) are used for our test setups.
production of phantoms for quality assurance in X-ray
imaging and associated procedures. Our core competence is the development and production of
Since April 2020 QRM is a subsidiary of PTW Freiburg GmbH. customized phantoms in cooperation with our customers.
We successfully collaborate with manufacturers in medical
Phantoms for your needs and industrial X-ray markets as well as with scientists and
We look back on more than 25 years of experience in design- physicians working on research projects and studies world-
ing and manufacturing phantoms for medical imaging mo- wide. All standard phantoms can be modified according to
dalities. Our first products were designed for lung imaging in your needs. We also offer customized phantoms for: PET,
Computed Tomography (CT) and bone densitometry in DXA SPECT, radiation therapy, and for other modalities.
and CT. Since starting manufacturing phantoms in the early
‘90s, our range of phantoms has increased substantially over Are you interested in a completely new, specially designed
the years. Today, we offer products for different imaging phantom for a specific study, project, or new application?
modalities in clinical routine, research, development, and
science, as well as customized and OEM products. Contact us - we provide phantoms for your needs.
2
Contents
} Introduction 2
} Customized Solutions 4
} Diagnostic Imaging 5
Image Quality Phantoms 5
Anthropomorphic Phantoms 27
Tissue-Equivalent Materials 39
Dosimetry Phantoms 45
Bone Densitometry Phantoms 49
Micro-CT and Micro-PET/SPEC Phantoms 61
} Radiation Therapy 77
} Codes of Practice 81
Introduction 82
CT Image Quality 83
CT Dose Index (CTDI) 89
Multi-Energy and Photon Counting CT 90
CT Value Calibration in RT Planning Systems 91
Bone Mineral Density 92
Pre-clinical Imaging (Micro-CT) 94
} Product Index 95
3
Customized Solutions
QRM additionally offers customized phantoms for: MRI, PET, Just follow these steps to get your specific phantom:
SPECT, radiation therapy, and other imaging modalities. - Send an inquiry
If you send us a request for a custom-made phantom, we
Are you interested in a completely new, specially designed will provide a proposal of what is technically possible and
phantom for a specific study, project or new application? what would be the best way to realize your ideas. This will
Or do you need a special OEM product? be the basis for the following discussion or you will accept
our first draft.
Contact us - we provide phantoms for your needs. - Mention the imaging modality
Please let us know the modality where the phantom will be
used.
For dedicated imaging modalities we have to use different
components or materials for the phantom.
- Give a brief description
Give us a brief description of the phantom. The more
details we know prior, the better our draft/proposal will be.
- Send a short drawing or line sketch
Provide us a short drawing or a line sketch. This will be the
easiest way to understand what you are looking for. You
can simply use MS® Word® or Powerpoint® to draw your
phantom. Or just send us a scanned manual sketch. We
also acccept CAD-files (e.g. .dxf or .stl).
- Please feel free to contact us by E-mail or give us a call to
discuss the design of your specific phantom.
4
Image Quality Phantoms
} Multi-Energy QA Phantom 6
} Wire Phantom 18
} MAM Phantoms 25
5
Multi-Energy QA Phantom
6
Spectral CT Phantom
Specification Options
Phantom diameter 100 mm QRM-10145 Fillable Rod, D20
Phantom height 103 mm QRM-30101 ICRU Tissue rod, soft tissues
Phantom weight 1.0 kg QRM-30102 ICRU Tissue rod, bone
Body material Water-equivalent (CTwater, QRM-10143 D100 CTwater insert, 8 boreholes
approx. 0 HU at (80 ... 140) kV1) QRM-20100 Thorax Phantom
Holes (Ø 20 mm) 4 pcs. (QRM-10139) or QRM-20118 Abdomen Phantom
8 pcs. (QRM-10147) QRM-20115 Oval Body Phantom, Tissue
Insert diameter 20 mm QRM-20116 Oval Body Phantom, CTwater
Insert height 103 mm QRM-10141 Extension Ring CTwater, 160mm
QRM-10142 Extension Ring CTwater, 320mm
7
Dual-Energy Phantom, V2
imaging device.
There are several options available to be used with the D100
compatible QRM-10107 as, for example, our Thorax or Ab-
domen Phantom. Ordering Information
QRM-10107 Dual Energy CT Phantom, V2
Specification
Phantom diameter 100 mm Options
Phantom height 100 mm QRM-20100 Thorax Phantom
Phantom weight 1.0 kg QRM-20118 Abdomen Phantom
QRM-20115 Oval Body Phantom, Tissue
Inserts QRM-20116 Oval Body Phantom, CTwater
8 cylindrical targets Ø 10 mm / H 10 mm QRM-10141 Extension Ring CTwater, 160mm
8 cylindrical targets Ø 5 mm / H 5 mm QRM-10142 Extension Ring CTwater, 320mm
1 calibration cylinder Ø 25 mm / H 10 mm
Material
Phantom body CTwater, 0 HU at (80 ... 140) kV1
8
Dual-Energy Phantom, V5
9
Cone-Beam Phantom,
Expert and Basic
Ordering Information
QRM-10103 Cone-Beam Phantom, Expert
For further infomation please visit [Link]. QRM-10120 Cone-Beam Phantom, Basic
10
Breast CT QA Phantom,
Expert
Specification
Phantom diameter 140 mm
Phantom height 180 mm
Body material CTwater (water-equivalent)
Inserts length 17.5 mm
Ordering Information
QRM-10136 Breast CT QA Phantom, Expert
11
2D Low Contrast Phantom
Specification
Phantom diameter 100 mm
Phantom height 103 mm
Phantom weight 0.9 kg
Body material tissue-equivalent plastic at 120 kV
Contrast Inserts
Contrast values -10 HU and -20 HU relative to
background1
Dimensions Ø 5, 10, 15 mm / H 100 mm
12
2D Medium Contrast
Phantom
Specification
Phantom diameter 100 mm
Phantom height 103 mm
Phantom weight 0.9 kg
Body material tissue-equivalent plastic at 120 kV
Cylindrical Inserts
Contrast values -25, -50, -75 and -100 HU relative
to background1
Dimensions Ø 2, 4, 6, 8 and 15 mm / H 100 mm
13
3D Low Contrast Phantom
Specification
Phantom diameter 100 mm
Phantom height 103 mm
Phantom weight 0.9 kg
Body material tissue-equivalent plastic
Contrast Inserts
Contrast values -10 HU (QRM-10109) or
-20 HU (QRM-10110)
relative to background1
Cylindrical contrast insert Ø 20 mm / H 25 mm
Spherical contrast inserts 9 spheres Ø 3 mm
9 spheres Ø 4 mm
9 spheres Ø 5 mm
9 spheres Ø 6 mm
7 spheres Ø 8 mm
14
Slice Sensitivity Phantom
Specification
Phantom diameter 23 mm
Phantom height 100 mm
Phantom material tissue-equivalent plastic
Metal (Au) foil: Ø 1 mm,
thickness: 0.025 mm
Ordering Information
QRM-10114 Slice Sensitivity Phantom
15
3D Spatial Resolution
Phantom, D100
16
3D Spatial Resolution
Phantom
Table:
Diameter (mm) Line pairs/cm
4.0 1.25
3.0 1.66
2.0 2.50
1.5 3.33
1.2 4.16
1.0 5.00
0.9 5.55
0.8 6.25
0.7 7.14
0.6 8.33
0.5 10.0
0.4 12.5
17
Wire Phantoms
Specification
Wire Phantom, resin (QRM-10104)
Phantom diameter 45 mm
Phantom height 60 mm
Phantom material Proprietary resin
Ordering Information
QRM-10104 Wire Phantom, resin
QRM-10105 Wire Phantom, D100
QRM-10138 Wire Phantom, air
18
Beam Stop Phantom
The Beam Stop array is placed between the object and the
X-ray source or between the object and detector.
Specification
Phantom dimension 240 mm x 240 mm
Phantom height (5.5 ... 6) mm
Body material PMMA
Ordering Information
QRM-10115 Beam Stop Phantom
19
Dental CBCT QA Phantom,
Basic
3 defined sections:
Section 1: 4 inserts in water: air, -3% contrast, +3% contrast
and bone arranged concentrically
Section 2: Homogeneous water-equivalent slice
Section 3: Centrally placed high-attenuating sphere
20
Dental CBCT QA Phantom,
Expert
21
Water Tank Phantom
} D100 compatible
} Evaluate noise and homogeneity of a 3D scan
} Samples and small phantoms can be placed in water
Specification
Phantom height 200 mm
Phantom width 120 mm
Phantom length 228 mm
Phantom weight 0.6 kg
Phantom material PMMA
Cylinder diameter 100 mm
Cylinder length 108 mm
Cylinder wall thickness 3.0 mm
Ordering Information
QRM-10113 Water Tank Phantom
Options
QRM-20100 Thorax Phantom
QRM-20118 Abdomen Phantom
QRM-20115 Oval Body Phantom, Tissue
QRM-20116 Oval Body Phantom, CTwater
QRM-10141 Extension Ring CTwater, 160mm
QRM-10142 Extension Ring CTwater, 320mm
22
Calcium Scoring Phantom,
D100
In order to obtain absolute values for the calcium mass, a Ordering Information
calibration measurement with the central calibration insert QRM-10146 Calcium Scoring Phantom, D100
of known CaHA density of 200 mg CaHA/cm³ can be carried
out. The water-equivalent insert serves as a further calibra-
tion standard. In practice the CT number of water should
always be checked in the given set up. If the measured value
deviates from zero, the known deviation can be taken into
account in the applied scoring method.
23
High Contrast Resolution
Phantom, D100
24
MAM Phantoms
Specification
Technician set for MAM 6868-163 (QRM-10148):
1x Test plate 150 mm x 150 mm x 6 mm
2x Absorber plate 150 mm x 150 mm x 20 mm
2x Absorber plate 150 mm x 150 mm x 10 mm
1x Absorber plate 150 mm x 150 mm x 6 mm
1x Absorber plate 150 mm x 150 mm x 4 mm
All plates have two bore holes, such that they can be
attached to the aluminum holder (two rods, diameter: 6 mm,
length: 120 mm)
Ordering Information
QRM-10148 Technician set for MAM 6868-163
QRM-10149 Operator set for MAM 6868-163
25
Notes
26
Anthropomorphic Phantoms
} Thorax Phantom 28
} Abdomem Phantom 29
} Extension Rings 31
} Cranial CT Phantom 35
27
Thorax Phantom
} D100 compatible There are multiple standard cylinders for image quality pur-
} Includes spine and lung lobes poses available. The following D100 Insert are available:
} Customizable
QRM-10108 D100 Soft Tissue Insert
The phantom comprises artificial lung lobes and a bone-like QRM-10112 2D Low Contrast Phantom
spine insert (spongiosa and corticalis) surrounded by soft QRM-10100 2D Medium Contrast Phantom
tissue-equivalent material. QRM-10109 3D Low Contrast Phantom (-10 HU)
The plastics used in this phantom mimic human tissues in the QRM-10110 3D Low Contrast Phantom (-20 HU)
thorax with respect to density and X-ray attenuation charac- QRM-10101 3D Spatial Resolution Phantom, D100
teristics of a human thorax. QRM-10140 High Contrast Resolution Phantom, D100
QRM-10105 Wire Phantom, D100
The QRM-20100 is a compact functional phantom as it can QRM-10113 Water Tank Phantom
be easily positioned on the patient couch in order to success- QRM-10107 Dual Energy Phantom, V2
fully conduct all measurement tasks. QRM-10123 Dual Energy Phantom, V5
QRM-10139 Spectral CT Phantom
Specification QRM-10147 Spectral CT Phantom II
Phantom dimension 200 mm x 300 mm QRM-10143 D100 CTwater insert, 8 boreholes
Phantom height 103 mm QRM-10146 Calcium Scoring Phantom, D100
Phantom weight 2.7 kg QRM-40106 Dose Insert D100
Diameter of borehole 100 mm QRM-90110 Electron Density Phantom, D100
28
Abdomen Phantom
} D100 compatible There are multiple standard cylinders for image quality pur-
} Includes organs (liver, spleen) poses available. The following D100 Insert are available:
The phantom comprises a bone-like spine insert (spongiosa QRM-10108 D100 Soft Tissue Insert
and corticalis) and fixed liver and spleen inserts providing the QRM-10112 2D Low Contrast Phantom
appropriate CT values of real tissues. All organs are embed- QRM-10100 2D Medium Contrast Phantom
ded in soft tissue-equivalent material. QRM-10109 3D Low Contrast Phantom (-10 HU)
QRM-10110 3D Low Contrast Phantom (-20 HU)
The plastics of this phantom mimic human tissues with QRM-10101 3D Spatial Resolution Phantom, D100
respect to density and X-ray attenuation characteristics of a QRM-10140 High Contrast Resolution Phantom, D100
human abdomen. QRM-10105 Wire Phantom, D100
QRM-10113 Water Tank Phantom
There are multiple standard cylinders (D100) for image quality QRM-10107 Dual Energy Phantom, V2
purposes available (see options section). QRM-10123 Dual Energy Phantom, V5
QRM-10139 Spectral CT Phantom
Customizable: The phantom can be manufactured with QRM-10147 Spectral CT Phantom II
exchangeable/removable liver and spleen inserts. QRM-10143 D100 CTwater insert, 8 boreholes
QRM-10146 Calcium Scoring Phantom, D100
Specification QRM-40106 Dose Insert D100
Phantom dimension 200 mm x 300 mm QRM-90110 Electron Density Phantom, D100
Phantom height 103 mm
Phantom weight 3.2 kg
Diameter of borehole 100 mm Further, there are extension rings available to mimic obese
Body material Soft tissue-equivalent, patients:
approx. 30 HU at (80 ... 140) kV
Liver/Spleen tissue-equivalent, QRM-20104 Extension Ring Soft Tissue, M
approx. 60 HU at 120 kV QRM-20105 Extension Ring Soft Tissue, L
Spine corticalis / spongiosa, bone-like, QRM-20106 Extension Ring Soft Tissue, XL
approx. 550 HU / 200 HU QRM-20107 Extension Ring Fat, M
at 120 kV QRM-20108 Extension Ring Fat, L
QRM-20109 Extension Ring Fat, XL
Ordering Information
QRM-20118 Abdomen Phantom
Options
The Abdomen Phantom is also available with drilled holes
according to CTDI specifications:
29
Oval Body Phantom
A (semi-)anthropomorphic surrounding
for multiple D100 inserts to investigate
the influence of scan parameters in CT
and CBCT
30
Extension Rings
31
Calcium Scoring Phantom
Set
32
Liver Nodule Phantom
The shape and density of the nodules in the Liver insert can
be customized upon request.
Specification
Phantom dimension 200 mm x 300 mm
Phantom height 103 mm
Phantom weight 4.2 kg
33
Pediatric Thorax and Pediat-
ric Abdomen Phantom
Specification
Phantom dimensions:
34
Cranial CT Phantom
Specification
Phantom dimension 140 mm x 180 mm
Phantom height 88 mm
Phantom weight 2.0 kg
Body material Brain tissue,
approx. 35 HU at (80 ... 140) kV1
Low contrast structures + 7 HU above surrounding tissue1
Medium dense bone HA 400 (400 mg CaHA / cm3)
Dense bone HA 1000 (1000 mg CaHA / cm3)
Ordering Information
QRM-20113 Cranial CT Phantom
35
Lung Nodule Phantom
20 HU 1 2 1 1 1
It houses multiple spherical nodules of different densities 50 HU 2 1 1 1 1
and dimensions arranged randomly within both lung lobes. 80 HU 1 1 2 1 2
The nodules are designed to cover various imaging scenari-
-650 HU 1 2 1 1 1
os with respect to nodule type and grey value (e.g., ground
-750 HU 1 1 1 2 1
glass opacity). The enclosed lung material consists of homo-
geneous and heterogeneous lung granulate which can be -850 HU 2 1 1 1 1
optionally filled into the lung lobes by the end user.
Nodules with core and shell:
In order to mimic a (semi-)anthropomorphic surrounding it Nodule No. Core Shell D Core D Shell
contains a bone-like spine (corticalis and spongiosa). The 1 50 HU -750 HU 2 4
body is made of soft tissue-equivalent material. 2 50 HU -750 HU 2 6
3 50 HU -750 HU 4 8
The QRM-20114 is a compact functional phantom and can
be easily positioned on the patient couch.
36
D100 Insert Phantoms
Ordering Information
QRM-10108 D100 Soft Tissue Insert
QRM-10112 2D Low Contrast Phantom
QRM-10100 2D Medium Contrast Phantom
QRM-10109 3D Low Contrast Phantom (-10 HU)
QRM-10110 3D Low Contrast Phantom (-20 HU)
QRM-10101 3D Spatial Resolution Phantom, D100
QRM-10140 High Contrast Resolution Phantom, D100
QRM-10105 Wire Phantom, D100
QRM-10113 Water Tank Phantom
QRM-10107 Dual Energy Phantom, V2
QRM-10123 Dual Energy Phantom, V5
QRM-10139 Spectral CT Phantom
QRM-10147 Spectral CT Phantom II
QRM-10143 D100 CTwater insert, 8 boreholes
QRM-10146 Calcium Scoring Phantom, D100
QRM-40106 Dose Insert D100
QRM-90110 Electron Density Phantom, D100
37
Notes
38
Tissue-Equivalent Materials
} CTwater 40
} Bone 41
} ICRU Tissues 42
} CTIodine 43
39
CTwater
Specification
Material proprietary water-equivalent plastic
Accuracy 0 HU ± 5 HU in the range of
(80 ... 140) kV tube voltage
Density 1.03 mg / cm3
Ordering Information
Please contact qrmphantoms@[Link]
40
Bone
Specification
Material Calcium hydroxyapatite (CaHA)
Density (0 ... 1000) mg HA / cm³,
for Computed Tomography
(0 ... 1200) mg HA / cm³,
for Micro-CT
Ordering Information
Please contact qrmphantoms@[Link]
41
ICRU Tissues
Water 1 1 7.4 0 Besides the standard dimensions (rods or slab, see specifica-
Adipose 0.95 0.95 6.3 -95 ... -70 tions), all materials can be manufactured in various shapes as
Skin 1.09 1.08 7.3 71 ... 75 rods, slaps, cubes, spheres, and custom designs. Therefore,
our materials are ideal for custom phantom design as well as
Brain 1.04 1.03 7.4 40 ... 37
single samples dedicated to calibration and research purposes
Breast 1.02 1.01 6.9 -9 ... 3 in diagnostic X-ray imaging and radiation therapy.
(fibroglandular)
Breast (50/50) 0.96 0.96 6.7 -70 ... -53 Furthermore, we design materials which exhibit specific ener-
Eye lens 1.07 1.05 7.2 45 ... 50 gy-dependent CT-values (defined by the customer).
Blood (whole) 1.06 1.05 7.5 60 ... 55
GI tract (intestine) 1.03 1.02 7.4 22 ... 23 Specification
ICRU Soft tissue/bone rod (QRM-30101, QRM-30102)
Heart (blood filled) 1.06 1.05 7.5 60 ... 55
Diameter 20 mm
Kidney 1.05 1.04 7.4 45 ... 43 Height 100 mm
Liver 1.06 1.05 7.5 56 ... 53
Spleen 1.06 1.05 7.5 57 ... 54 ICRU Soft tissue/bone slab (QRM-30101, QRM-30102)
Testis 1.04 1.03 7.4 37 ... 35 Dimension 300 mm x 300 mm x 10 mm
Thyroid 1.05 1.04 7.9 112 ... 73
Ordering Information
Please contact qrmphantoms@[Link]
42
CTIodine
Specification
Following base materials can be selected:
- CTwater
- Blood-equivalent material
- ICRU Tissue-equivalent materials
Ordering Information
Please contact qrmphantoms@[Link]
43
Notes
44
Dosimetry Phantoms
} CTDI CTwater Phantom 46
} Extension Rings 48
45
CTDI CTwater Phantom
There are two different versions available, both in a modular Oval CTDI CTwater Phantom (QRM-40101):
design with a removable head phantom fitting tightly into a Phantom dimension (body) 380 mm x 220 mm
circular body (QRM-40100) or oval body (QRM-40101, spe- Phantom diameter (head) Ø 160 mm
cially designed to mimic the human body shape). Phantom height 150 mm
Borehole diameter Ø 13 mm
The phantoms are designed according to the guidelines for Center position of 10 mm from phantom’s margin
CTDI measurements (IEC 61223-3-5 and IEC 60601-2-44) peripheral holes
and are equipped with nine dose bore holes. The head cyl- Body material CTwater
inder offers one central and four peripheral holes to accom-
modate standard ion chambers. The body has four peripheral Ordering Information
bores. The phantom is delivered with nine CTwater solid rods QRM-40100 CTDI CTwater Phantom
to plug the holes not in use, and one adapter plug to house QRM-40101 Oval CTDI CTwater Phantom
a standard pencil shaped ion chamber.
46
Thorax and Abdomen
Dosimetry Phantoms
Specification
Phantom dimension 200 mm x 300 mm Further, there are extension rings available to mimic obese
Phantom height 103 mm patients:
Phantom weight 2.7 kg (Thorax), 3.2kg (Abdomen),
0.9 kg (Insert) QRM-40113 Ion chamber adapter D13
Diameter of borehole 100 mm QRM-40107 Dosimetry Extension Ring Soft Tissue, M
Phantom materials: QRM-40108 Dosimetry Extension Ring Soft Tissue, L
Body/Insert material Soft tissue-equivalent, QRM-40109 Dosimetry Extension Ring Soft Tissue, XL
approx. 30 HU at (80 ... 140) kV QRM-40110 Dosimetry Extension Ring Fat, M
Lung approx. -800 HU at 120 kV QRM-40111 Dosimetry Extension Ring Fat, L
Liver/Spleen tissue-equivalent, QRM-40112 Dosimetry Extension Ring Fat, XL
approx. 60 HU at 120 kV
Spine corticalis / spongiosa, bone-like,
approx. 550 HU / 200 HU at
120 kV
47
Extension Rings
48
Bone Densitometry Phantoms
} European Spine Phantom (ESP) 50
49
European Spine Phantom
(ESP)
50
European Forearm Phantom
(EFP)
and on different machines, but also to compare axial and I 200 800 25.6 28 15
peripheral bone measurements. II 100 800 18.6 19.8 15
III 50 800 11.6 14 15
A circular cross-section with flattened sides was chosen to
IV Water-equivalent 800 5 10 15
model the forearm. The inserts simulate trabecular bone and
provide the basis for linearity checks in qCT. There are two V Water-equivalent 800 12 14 45
inserts with multiple sections mimicking large, medium and VI Water-equivalent 800 5 10 15
small bone with different calcium hydroxyapatite (CaHA) den-
1
Accuracy ± 5 HU of specified values
sities (according to the ESP).
The bone-like structure is completed with a thin cortical wall
surrounding each section. Ordering Information
QRM-50111 European Forearm Phantom (EFP)
The following quantities can be determined:
- Spongiouse/trabecular and cortical volume bone mineral
density (vBMD) in g/cm³
- Thickness of cortical bone in mm
- Measures of bone equivalent inserts
- Bone Mineral Content (BMC)
51
Forearm Phantom (BMF)
Specification
Phantom dimension 70 mm x 25 mm
Phantom height 150 mm
Phantom weight 225 g
Body material soft tissue-equivalent plastic
Inserts
Diameter 14 mm
Height 150 mm
Center-to-center distance 28 mm
between two inserts
Material Water-equivalent1, CTwater,
approx. 0 HU at (80 ... 140) kV
Bone-like2, 200 mg CaHA/cm³
Specified values. Nominal values can vary with respect to manufacturing method
2
Ordering Information
QRM-50112 Forearm Phantom (BMF)
52
DXA Spine QA Phantom,
3 HA
Specification
Phantom dimension 260 mm x 180 mm (± 2 mm)
Phantom height 110 mm
Phantom weight 4.3 kg
Body material soft tissue-equivalent at 120 kV
Phantom accuracy All HA materials are within ± 5%
of specified values
Accuracy of calibrated ± 5 mg/cm2
aBMD
53
Bone Density Calibration
Phantom, 3
The flat and slightly bent design allows the most convenient
positioning of the phantom directly under an object on the Ordering Information
couch. This easy-to-use geometry of the phantom facilitates QRM-50115 Bone Density Calibration Phantom, 3 H200
the evaluation of the bone mineral density (BMD). QRM-50118 Bone Density Calibration Phantom, 3 H300
QRM-50120 Bone Density Calibration Phantom, 3 H400
Each phantom is separately calibrated to the reference stan- QRM-50116 Bone Density Calibration Phantom, 3 H500
dard BDC, containing analytically confirmed bone mineral QRM-50117 Bone Density Calibration Phantom, 3 H600
densities. QRM-50119 Bone Density Calibration Phantom, 3 H700
Specification
Phantom dimension 120 mm x 25 mm
(slightly bent)
Body material soft tissue-equivalent at 120 kV
Phantom accuracy All CaHA materials are within
± 5% of specified values
Accuracy of calibrated ± 2 mg/cm³
vBMD
54
Bone Density Calibration
Phantom, 6
55
HIP Calibration Phantom, V2
Specification
Phantom dimension 360 mm x 160 mm
Phantom height 103 mm Ordering Information
Distance between inserts 200 mm QRM-50113 HIP Calibration Phantom, V2
Body material soft tissue-equivalent
(approx. 30 HU at (80 ... 140) kV1
56
DXA Femur Phantom
Specification
Phantom dimension 150 mm x 180 mm x 170 mm
Body material tissue-equivalent plastic at 120 kV
Ordering Information
QRM-50146 DXA Femur Phantom
57
JIS Forearm Phantom
Ordering Information
QRM-50139 JIS Forearm Phantom
58
JIS Heel Phantom
Ordering Information
QRM-50143 JIS Heel Phantom
59
Notes
60
Micro-CT and Micro-PET/SPECT Phantoms
} Micro-CT Wire Phantom 62
} Micro-CT HA Phantoms 66
61
Micro-CT Wire Phantom
Specification
Micro-CT Wire Phantom air
Phantom diameter 20 or 32 mm
Phantom height (inner) 40 mm
Phantom height (total) 58 mm
Phantom weight 7.5 g
Body material protective housing,
wall thickness of 0.3 mm
Wire material tungsten
Wire diameters 3, 10 or 25 micron
62
Micro-CT Multi Disk
Phantom
Specification
Phantom diameter 20 mm
Phantom height 49 mm
Phantom weight 19 g
High-density disk
Diameter 20 mm
Thickness 1.0 mm
Density 1.38 g/cm³
Low-density disk
Diameter 20 mm
Thickness 3.0 mm
Density 1.18 g/cm³
Tolerances ± 0.15 mm
Ordering Information
QRM-70104 Micro-CT Multi Disk Phantom
63
Micro-CT Contrast Scale
Phantom
Specification
Phantom diameter 32 mm
Phantom height 43 mm
Phantom weight 35 g
Body material resin
Inserts:
Concentration
Iodine approx. 10 mg I / cm³
CaHA approx. 1200 mg CaHA/cm³
Density
Iodine approx. 1.13 g/cm³
CaHA approx. 1.9 g/cm³
Dimension
Iodine Ø 5 mm
CaHA Ø 5 mm
Height
Iodine 20 mm
CaHA 20 mm
Ordering Information
QRM-70105 Micro-CT Contrast Scale Phantom
64
Micro-CT Dose Phantom
Specification
Phantom diameter 32 mm
Phantom height 120 mm
Phantom weight 105 g
Central borehole diameter 9 mm1
Body material soft tissue-equivalent plastic
Ordering Information
QRM-70106 Micro-CT Dose Phantom
65
Micro-CT HA Phantoms
66
Micro-CT Mouse Phantom
Specification
Phantom width 32 mm
Phantom height 24 mm
Phantom length 40 mm
Phantom weight 35 g
Body material soft tissue-equivalent
Ordering Information
QRM-70137 Micro-CT Mouse Phantom
67
Micro-CT Low Contrast
Phantom
Specification
Micro-CT Low Contrast Phantom, V1 (QRM-70108)
Phantom diameter 32 mm
Phantom height approx. 41 mm
Phantom weight 35 g
Body material soft tissue-equivalent resin
Low contrast inserts:
Inserts diameter 1 mm / 2.5 mm
Contrast levels approx. - 4 % / - 8 %
Ordering Information
QRM-70108 Micro-CT Low Contrast Phantom, V1
QRM-70124 Micro-CT Low Contrast Phantom, V2
68
Micro-CT Slice Sensitivity
Phantom
Specification
Phantom diameter 32 mm
Phantom height approx. 43 mm
Phantom weight 35 g
Body material soft tissue-equivalent resin
Insert (Au) diameter 1 mm
Insert (Au) thickness 0.01 mm
Ordering Information
QRM-70109 Micro-CT Slice Sensitivity Phantom
69
Micro-CT Bar Pattern
Phantom, air or resin
A 5, 10, 25, 5
Each 5 x 5 mm² chip contains bar (trenches) and point 50, 100,
structures with a width of 5 to 150 microns. The depth of the 150
structures varies between 70 and 150 microns. The different B 5, 10, 15, 5 5, 10, 15, 18
structures on the chip are arranged over the chip in such a 20, 25, 20, 25,
way that the spatial resolution can be evaluated in a single 30 30
measurement both in the center and in the periphery of the C 5, 10, 15, 5 5, 10, 15, 18
image/chip. 20, 25, 20, 25,
30 30
The Micro-CT Bar Pattern resin (QRM-70114) is available in
D 5, 10, 25, 18
other diameters upon request. Besides, adapter/extension cyl-
50, 100,
inders are available upon request. Please note that the chips
150
are not intended to be used for planar radiography.
E 5, 10, 25, 5
50, 100,
For further information please visit [Link].
150
Specification
Micro-CT Bar Pattern Phantom, air (QRM-70113) Ordering Information
Phantom diameter 20 mm QRM-70113 Micro-CT Bar Pattern, air
Phantom height 40 mm QRM-70114 Micro-CT Bar Pattern, resin
Phantom wall thickness 0.2 mm
Phantom material air / plastic
Contrast of pattern silicon / air
70
Micro-CT Bar Pattern
Phantom, NANO
Each 3 mm x 3 mm chip contains bar (trenches) and point Table 2: Line and point pattern
structures with a width of 1 to 10 microns. The depth of the Row Line thickness Lines per Dots (µm)
structures varies between 5 and 15 microns. The different (µm) pattern
structures on the chip are arranged over the chip in such a A 2, 4, 6, 8, 10 50 ... 250
way that the spatial resolution can be evaluated in a single B 2, 4, 6, 8, 10
measurement both in the center and in the periphery of the C 1, 2, 3, 4, 5 100 ... 500
image/chip.
D 1, 2, 3, 4, 5 100 ... 500
E 2, 4, 6, 8, 10
In addition, a slented edge and a so-called Siemens-star
(actinomorphic star) are placed on the chip. Specific mount/ F 2, 4, 6, 8, 10 50 ... 250
holder for your micro-CT system is available upon request.
Table 3: Line and point pattern
Specification Row Line thickness Line pairs/mm Points (µm)
Phantom diameter 5.4 mm (µm)
Ordering Information
QRM-70119 Micro-CT Bar Pattern Phantom, NANO
For further information please visit [Link].
71
Micro-CT Water Phantom
Specification
Micro-CT Water Phantom, D60 (QRM-70110)
Phantom inner diameter 60 mm
Phantom height 135 mm
Phantom inner height 110 mm
Phantom wall thickness 0.5 mm
Body material durable plastic or PMMA
72
Micro-PET IQ Phantom,
NEMA NU4
For evaluation of the IQ, attenuation
accuracy and to perform scatter
corrections in micro-PET systems
in accordance with the NEMA
NU 4-2008 standard
Specification
Phantom (outer) diameter 33.5 mm
Phantom height 63 mm
Body material PMMA
Phantom cavities:
73
Micro-PET Scatter Phantom
Specification
Micro-PET Scatter Phantom Mouse (QRM-70116)
Phantom diameter 25 mm
Phantom height 70 mm
Phantom material high-density polyethylene (HD PE)
Borehole diameter 3.2 mm
Borehole position 10 mm off-center (parallel to the
central axis)
74
Micro-PET Hot Rod
Phantom
Specification
Phantom (outer) diameter 35 mm
Phantom height 70 mm
Body material PMMA
Hot rod Insert (see table)
Hole pattern resolution 0.6, 0.8, 1.0, 1.2, 1.5, 2.0 mm
inserts diameter
Insert (outer) diameter 29 mm
Insert height 12 mm
Table:
Ø (mm) Quantity Center-to-center (mm)
0.6 43 1.2
0.8 26 1.6
1.0 19 2.0
1.2 13 2.4
1.5 8 3.0
2.0 6 4.0
Ordering Information
QRM-70121 Micro-PET Hot Rod Phantom
75
Notes
76
Radiation Therapy
} Comprehensive Electron Density Phantom 78
} CTwater slabs 80
77
Comprehensive Electron
Density Phantom
An excellent tool for the calibration
of Hounsfield Unit (HU) vs. electron
density of radiotherapy treatment
plans to optimize the dose delivered
to the patient (CT/CBCT)
78
Electron Density Phantom,
D100
An important tool for the calibration of
Hounsfield Unit (HU) vs. electron
density of radiotherapy treatment plans
to optimize the dose delivered to the
patient (CT/CBCT)
Specification
Phantom diameter 100 mm
Phantom height 103 mm
Phantom weight 0.9 kg
Body material Water-equivalent (CTwater),
approx. 0 HU at (80 ... 140) kV1
79
CTwater Slabs
Specification
Phantom dimension 300 mm x 300 mm
Phantom height 5 mm (QRM-90111),
10 mm (QRM-90112),
20 mm (QRM-90113)
80
Codes of Practice
} 1 Introduction 82
} 2 CT Image Quality 83
Disclaimer
Although the information in this document has been care-
fully assembled. PTW Freiburg does not guarantee that this
document is free of errors. PTW Freiburg shall not be liable in
any way for any consequence of using this document.
81
1 Introduction
This chapter aims to briefly explain the physics and the as- Safety warnings and instructions
sessment methods of image quality parameters for multiple Please read these safety warnings and instructions carefully
QRM-phantoms dedicated to various X-ray applications. For a before use and keep them well for your future reference.
more detailed description we recommend relevant literature,
e.g. (book) ‘Computed Tomography – Fundamentals, System 1. Do not place the phantoms in direct sunlight or near
Technology, Image Quality, Applications – Willi A. Kalender, chemicals. Make sure that the environment does not expe-
Publicis 2011’ rience abrupt changes in temperature or humidity.
2. Do not put the product on a cart, table, or desk, which is
Although this chapter provides the reader with a concise not stable, to avoid falling off.
overview for the evaluation of the X-ray system’s imaging 3. Do not clean the phantom with solvents. Just use a mild
performance, it should be noted that QRM phantoms are soap and rinse with clear water.
NOT registered as medical devices. Hence, the procedures 4. Transportation is only recommended if a transport case is
outlined in this chapter are recommended only for research available.
and development purposes and do not replace relevant pro-
tocols and publications and shall not be used for the accep-
tance tests and constancy tests of X-ray imaging devices used
for the diagnosis or treatment of patients.
82
2 CT Image Quality
Image quality parameters are of utmost importance for For the acquisition of the spatial resolution using the PSF
evaluating the performance of imaging systems and are and MTF as described above, phantoms with thin wires are
affected by different factors. The physics and the assessment commonly used.
techniques of the common CT image quality checks defined The spatial resolution along the longitudinal direction (z-axis)
in the literature, guidelines, and reports are briefly described can be investigated using slice sensitivity profiles employing
below. The models name of the appropriate QRM phantoms phantoms with thin high absorbing metal inserts.
for which these tests can be performed are indicated in each Alternatively/Similarly, instead of using the PSF, the 3D MTF
section. can also be calculated using the edge spread function (ESF)
obtained from measurements of phantoms including sharp
edges or spheres. Phantoms including such inserts hence
1. Spatial Resolution and Modulation allow to assess spatial resolution in all planes by evaluating
Transfer Function (MTF) the 3D MTF.
83
Figure 1: Cone-Beam Phantom CT Image (Test pattern sec- Figure 3: Wire Phantom CT Image - Resin, PSF and MTF
tion)
Suitable Phantoms
- QRM-10103 Cone-Beam Phantom, Expert
- QRM-10120 Cone-Beam Phantom, Basic
- QRM-10131 Dental CBCT QA Phantom, Expert
- QRM-10130 Dental CBCT QA Phantom, Basic
- QRM-10136 Breast CT QA Phantom, Expert
- QRM-10104 Wire Phantom, resin
- QRM-10105 Wire Phantom, D100
- QRM-10138 Wire Phantom, air
- QRM-10114 Slice Sensitivity Phantom
84
One important quantity to describe the low contrast detect-
ability is the contrast-to-noise ratio (CNR). The CNR depends
on the differences in the mean HU values, CT#contrast insert and
CT#background, and the background signal noise, sbackground:
The CNR can be assessed with phantoms containing sever- Suitable Phantoms
al spherical (3D measurements) or cylindrical low contrast - QRM-10103 Cone-Beam Phantom, Expert
inserts (2D measurements) which provide different contrast - QRM-10120 Cone-Beam Phantom, Basic
values and insert diameters. - QRM-10112 2D Low Contrast Phantom
- QRM-10100 2D Medium Contrast Phantom
Evaluation of the low-contrast resolution with - QRM-10109 3D Low Contrast Phantom (-10 HU)
QRM Phantoms - QRM-10110 3D Low Contrast Phantom (-20 HU)
We describe the assessment/evaluation of the low-contrast
resolution here using the QRM Cone Beam Phantom (Low
Contrast Section).
For the assessment of the CNRs of different contrast values
provided in the phantom only the largest inserts (seen as cir-
cles/disks) should be considered. Smaller inserts should only
be evaluated according to their visibility. Regions of Interest
(ROIs) smaller than the diameter of the insert should be used
to exclude cupping/edge effects from the analysis.
85
3. CT Value Accuracy (Linearity) CT Value Accuracy (Linearity) evaluation with
QRM Phantoms
After collecting/obtaining the projection data the 3D image Thick slices (approx. 5 mm slice thickness) and a soft kernel
matrix is calculated/reconstructed. The physical quantity shall be used to reduce the image noise. In order to exclude
affecting the intensity of the projection data and hence, cre- cupping/edge effects (in particular in the highly absorbing
ating the image contrast is the linear attenuation coefficient, bone insert) ROIs smaller than the inserts’ diameter should
μmaterial, of the irradiated material or patient. However, μmaterial be used to evaluate the HU values. Within this limit, the ROIs
is an energy- dependent quantity and, hence, the intensity should be chosen as large as possible to average over many
of the projection data depends not only on the material image pixels.
composition, but also on multiple other parameters as X-ray
spectrum (i.e. tube voltage), filtration, detector configuration, - Draw circular ROIs of appropriate size and place them in the
beam hardening etc. Further, the image contrast is affected scaling inserts
by the data processing, i.e. reconstruction kernel, pre-filtering - Read out mean CT values within the ROIs and compare
etc. In order to ensure the comparability between different them to data acquired in prior quality assurance checks/
scanners and protocols in the clinical routine, CT values (grey measurements.
values, CT#) are commonly quantified in Hounsfield Units
(HU). The Hounsfield scale is defined by setting the grey val-
ue of water to 0 HU and the grey value of air to -1,000 HU,
regardless of the used tube voltage or scan protocol. The CT
value of an arbitrary material is calculated as follows:
µmaterial - µwater
CT# = · 1000 HU
µwater
86
4. Signal-to-Noise Ratio (SNR) Suitable Phantoms
QRM-10103 Cone-Beam Phantom, Expert
In imaging systems, there are several sources of noise as, for QRM-10120 Cone-Beam Phantom, Basic
example, thermal noise in the detector or scattered pho- QRM-10131 Dental CBCT QA Phantom, Expert
tons that do not pass straight through the tissue due to the QRM-10130 Dental CBCT QA Phantom, Basic
Compton effect, but still contribute to the signal. QRM-10136 Breast CT QA Phantom, Expert
The higher the SNR, the lower the noise in the image. The
SNR is directly related to the (low) contrast separation: the
higher the SNR, the better the low contrast separation (see
section 2.2)
The SNR is affected by various parameters. Generally, the Figure 7: CT Image showing SNR analysis
SNR is scales with the number of X-ray photons contributing
to the image. Therefore, a high dose favors a high value of
the SNR:
87
5. CT Value Uniformity (Homogeneity) 6. Geometric Accuracy
Uniformity is an important image quality parameter that In radiotherapy or interventional applications, treatments are
determines how uniform the CT values of a homogeneous based on the accuracy of the patient’s anatomy obtained by
test object are depicted in an [Link] to artifacts such CBCT, i.e. sensitively depend on the exact localization/spatial
as beam hardening, cupping artifacts or detector-specific positions of the internal structures. The treatment isocenter
issues that often arise in clinical practice, uniformity should and the imaging isocenter must match each other, and the
be inspected regularly to ensure that the CT value deviation reproducibility of the spatial positioning of movable internal
between the center and periphery of the image is not higher structures should be checked regularly. Different parame-
than the tolerances. The tolerance value is defined according ters such as reconstruction algorithms and spatial resolution
to international and national guidelines, and the difference in affect the geometric accuracy. While monthly geometric ac-
the mean CT values between the center and the periphery of curacy tests are recommended in Radiotherapy Units, annual
the image should not exceed ± 4 HU. The deviation from the controls are sufficient for dental and interventional CBCT.
baseline values should not exceed ± 2 HU.
Geometric accuracy evaluation with QRM Phantoms
CT Value Uniformity (Homogeneity) evaluation with - Use thin slices (approx. 1 mm thickness) and a suitable
QRM Phantoms reconstruction kernel, e.g. a regularly/frequently used scan
- Place the homogeneous phantom at the isocenter and protocol and high-resolution kernel.
scan the phantom with the largest dose (mAs) and most - Measure the dimensions of the holes at each position using
frequently used tube voltage. Use relative thick slices of at a ruler or equivalent tool of your DICOM Viewer to deter-
least 2 mm thickness. mine a distortion of the hole matrix. An overestimation of
- Insert several ROIs (central, top, right, bottom and left) of hole size depends on scanner settings and beam harden-
roughly 20 % of the phantom diameter in the axial image ing in the image. The holes may appear larger than they
of the homogeneous phantom and examine the mean CT are. Measure the positions of the holes within the regular
values to assess the homogeneity of the CT values within hole grid to uncover a distortion of the hole matrix in the
the image. periphery.
- Avoid placing the peripheral ROIs too close to the edge of
the phantom.
- Evaluate how much the mean CT values of the peripheral Suitable Phantoms
ROIs deviate from the value at the center. - QRM-10103 Cone-Beam Phantom, Expert
- If necessary, repeat the analysis using different ROI sizes - QRM-10120 Cone-Beam Phantom, Basic
and locations, as well as slice thicknesses, scan protocols
and reconstruction kernels.
Suitable Phantoms
- QRM-10103 Cone-Beam Phantom, Expert
- QRM-10120 Cone-Beam Phantom, Basic
- QRM-10131 Dental CBCT QA Phantom, Expert
- QRM-10130 Dental CBCT QA Phantom, Basic
- QRM-10136 Breast CT QA Phantom, Expert
88
3 CT Dose Index (CTDI)
The Computed Tomography Dose Index (CTDI100) indicates The summation with index i accounts for all scanning
the air-kerma readings in mGy across a 100 mm long cali- sequences of the examination. Ni indicates the number of
brated pencil-shaped ionization chamber in CT systems. The simultaneously acquired slices, Nrot,i is the number of sequen-
CTDI100 is defined as the integral of the dose profile (z axis) tial scans or spiral rotations and Ti is the collimation (slice
along a line perpendicular to the tomographic plane (x-y thickness) in examination i. Ci is the mAs value of the ith
plane). scan. Typically, the standard value of 100 mAs is used for the
determination of the DLP.
1
∫
+50 mm
CTDI100 = D (z) dz
N·T -50 mm
The volumetric CTDI (CTDIvol) is another important metric
D (z): dose profile along the axis perpendicular to the axial/ used for dose evaluations particularly for helical CT scans
scan plane (z-direction) which takes the pitch factor into account. Each CT scan pro-
T: slice thickness tocol indicates the CTDIvol as part of the scan report. It is an
N: number of slices acquired per single axial rotation important indicator for comparing patient scans and proto-
cols during clinical routine.
Although the CTDI100 does not represent the patient dose It is calculated from the ratio of weighted CTDI over pitch:
and does not yield information about the radiation attenu-
ation within real tissue it is a important parameter for dose CTDIvolume = CTDI100,weight / pitch
comparison between different CT systems and scan proto-
cols. By default cylindrical PMMA phantoms (usually with
a diameter of 32 cm/16 cm for the adult body/head section CTDI and DLP assessment with QRM Phantoms
and 16 cm/10 cm for the pediatric body/head section) are -A fter placing the phantom on the couch, it should be
used in clinical routine during the acceptance and constan- positioned accurately at the isocenter by using the internal
cy tests. However, for a more realistic investigation of the alignment lasers.
radiation dose , semi-anthropomorphic water-equivalent - Insert the 100 mm pencil-shaped ion chamber in the phan-
phantoms that exhibit the same x-ray attenuation properties tom (using the adapter) and connect it to the calibrated
as liquid water in for tube voltages of 80 kV to 140 kV can electrometer.
also be a useful tool for dose evaluation. -A cquire the values first of from the central position and
then from the peripheral positions (top, right, bottom, left).
Since the chamber has a homogeneous response along its - S canning parameters (kVp, mAs, collimation, pitch etc.) are
axis, it not only integrates over radiation within the slice, but recorded for each scan protocol.
also detects scattered radiation along its entire length. The -D uring the measurement of one position, all other bore
weighted CTDI (CTDIweight) more reflects the real absorption of holes must be filled with plugs
x-rays in the examined body and is an established metric to
quantify the dose. It is the weighted sum of the central and
peripheral CTDI values: Suitable Phantoms
- QRM-40100 CTDI CTwater Phantom
1 2
CTDI100,weight = CTDI100,center + CTDI100,periphery - QRM-40101 Oval CTDI CTwater Phantom
3 3
- QRM-40104 Thorax Dosimetry Phantom
where CTDI100,c is the CTDI measured in the center hole of - QRM-40105 Abdomen Dosimetry Phantom
the phantom and CTDI100,p is the average value of the four - QRM-20120 Pediatric Thorax Phantom, newborn
peripheral CTDIs. - QRM-20137 Pediatric Thorax Phantom, 1 year
Even though the CTDI characterizes the particular CT system - QRM-20138 Pediatric Thorax Phantom, 3 years
it is not a direct measure of the real patient dose as it de- - QRM-20121 Pediatric Thorax Phantom, 6 years
pends on scan range, patient size and anatomy etc. - QRM-20123 Pediatric Thorax Phantom, 12 years
- QRM-20139 Pediatric Thorax Phantom, 15 years
Therefore, the dose-length-product (DLP) is commonly con- - QRM-20125 Pediatric Abdomen Phantom, newborn
sidered to estimate the patient dose resulting from a com- - QRM-20140 Pediatric Abdomen Phantom, 1 year
plete examination: - QRM-20141 Pediatric Abdomen Phantom, 3 years
- QRM-20142 Pediatric Abdomen Phantom, 6 years
DLP = Si CDTI100,weight,i · Ni · Nrot,i · Ti · Ci - QRM-20143 Pediatric Abdomen Phantom, 12 years
- QRM-20144 Pediatric Abdomen Phantom, 15 years
89
4 Multi-Energy and Photon Counting CT
Multi-Energy CT (MECT) the energy of the individual X-ray photons can be detected.
The linear attenuation coefficient and, hence, the CT value Therefore, photons can be sorted according to their energy.
depends on the material’s effective atomic number, effective Selecting appropriate energy thresholds possibly yields the
X-ray energy (poly-energetic spectrum) and mass density. separation of multiple contrast media or elements (e.g. Ca, I,
Therefore, in conventional CT imaging materials with dif- Fe, Gd) with a single scan. Being challenging at the moment,
ferent atomic numbers might appear with similar CT values this new technique paves the way to various new/future
at a particular tube voltage making material differentiation applications. For material decomposition, the CT values of
difficult. As the linear attenuation coefficient depends on the different materials at low tube voltage (e.g. 80 kV) is plotted
X-ray energy, this limitation can be circumvented by measur- against the CT value at high tube voltage (e.g. 140 kV).
ing at different tube voltages, i.e., different (poly-energetic) With this method, materials can be differentiated from each
spectra and the materials can be separated. This approach other according to their position on the graph.
is called Dual- or Multi-energy imaging. The most common Modern dual- or multi-energy or PC post-processing proto-
example is the separation of Calcium and Iodine, but recently cols offer the possibility to create so-called virtual non-con-
also other materials and contrast media gain importance (e.g. trast images or iodine/calcium maps which automatically
Gd, Fe, etc.). disentangle tissues rich in Iodine (or other contrast agents) or
calcium. These images can be combined to color-maps with
The basic principle behind dual- or multi-energy imaging is different colors indicating the presence of a specific element
the energy-dependence of the linear attenuation coefficient: in the tissue (calcium, iodine or other contrast agents).
the dominant interactions between X-ray radiation and
tissue occurring at the energies used in diagnostic imaging
are Compton scattering and Photoelectric absorption. As Multi-energy CT postprocessing and material
the tube voltage, and hence, the X-ray energy increases, the decomposition with QRM Phantoms
cross-section of photoelectric effect decreases, while the - Position the phantom accurately at the isocenter by using
Compton interaction gains importance. the internal alignment lasers.
- Measure the phantom with standard scan protocols and
In clinical practice, there are different technical approaches to evaluate different post-processing techniques and algo-
multi-energy imaging invlolving photon counting detectors , rithms regarding the correct material separation, concentra-
dual-layer CT, kV-switching or dual-source CT. All these mate- tion etc.
rial-specific imaging techniques provide valuable information - If necessary, repeat the measurement with varied positions
regarding the contribution, concentration, and chemical of the test rods (possible for QRM-10150, QRM-10147 and
composition of the materials in specific tissues and enables QRM-10139).
separate visualization these materials.
Suitable Phantoms
Photon-Counting CT - QRM-10150 Multi-Energy QA Phantom
Among all established approaches of Multi- or Dual-energy - QRM-10147 Spectral CT Phantom II
imaging, the new generation of CT scanners using pho- - QRM-10139 Spectral CT Phantom
to-counting detectors is particularly promising. - QRM-10123 Dual Energy CT Phantom, V5
X-ray detectors used in conventional CTs integrate over the - QRM-10107 Dual Energy CT Phantom, V2
energy of all radiation deposited in the detector, i.e. the
signal comprises all photons absorbed in the detector. By
contrast, X-rays absorbed in photon counting detectors are
directly converted into electrical signals and hence, counted
individually. Especially, it is possible to detect the energy of
the individually detected photons as the amplitude of the
electrical signal in the detector scales with the energy of the
incident photon. This new approach offers multiple benefits
with respect to conventional detectors.
Due to the way the new detectors are constructed, PC detec-
tors exhibit smaller pixels compared to conventional detec-
tors leading to enhanced spatial resolution. Further, as PC
detectors are not susceptible to electronic noise, high con-
trast-to-noise ratio, low dose and reduced image artifacts can
be achieved. The main advantage of PC technology is that Figure 10: CT# of Iodine and CaHA-enriched material
90
5 CT Value Calibration in RT Planning Systems
CT Value calibration in Radiotherapy Treatment Electron Density Calibration Curve assessment
Planning Systems with QRM Phantoms
In radiotherapy, it is crucial to deliver the prescribed dose to - Although the tissue-equivalent electron density rods can
the target volume with high precision. Therefore, different be arranged in various ways depending on the research
algorithms are used in treatment planning systems (TPSs), purpose, it is recommended to be place them according to
which take elemental composition, stopping power, and the manufacturer’s recommendation to minimize artifacts
electron density relative to water (ρwe ) into account when de- and achieve the best possible results.
termining tumor and OAR (organs at risk) dose distribution. - It is possible to compare results obtained in body geometry
In order to perform pixel-by-pixel heterogeneity correction (phantom body and head insert) and using the head insert
based on the estimated attenuation within the non-uniform as stand-alone phantom.
tissue, an electron density map is generated corresponding to - Place the phantom on the couch and insert the tis-
the CT values for all clinically used photon energies. Since the sue-equivalent electron density rods according to the manu-
predominant tissue-photon interaction at typical X-ray ener- facturer’s recommendation.
gies in CT is Compton scattering and Photoelectric effect, - Position the phantom accurately at the isocenter by using
the linear attenuation coefficient is considered to be pro- the internal alignment lasers.
portional to the relative electron density of the tissues. The - Acquire CT images within 3 different slices, one at centrally
electron densities are calculated from the mass density and within the phantom and two slightly off-centered (approx.
the elemental composition of each material. By scanning a ± 1 cm ). To have a good SNR, a 5+ mm slice thickness
phantom containing different tissue-equivalent materials with should be appropriate
known electron densities on the tomography device, the CT - Place ROIs withing the tissue-equivalent inserts and evaluate
values of each tissue-equivalent material can be determined the mean CT values. Use ROIs smaller than the inserts’ di-
and an electron density map (calibration curve) is created, ameter in order to exclude cupping/edge effects (in particu-
which visualizes the relation between the relative electron lar in the highly absorbing bone insert).
densities and the corresponding CT values. Treatment plan- - Create a calibration curve using the measured CT values
ning systems use the linear fitting equation for heterogeneity (average of three slices) and the corresponding electron
corrections. The linear fitting equation is adapted to the CT density relative to water (ρwe ) provided by the manufacturer.
models and acquisition parameters such as tube voltage,
mAs, reconstruction algorithms, filters etc.
Suitable Phantoms
- QRM-90114 Comprehensive Electron Density Phantom
- QRM-90110 Electron Density Phantom, D100
91
6 Bone Mineral Density
Osteoporosis is a condition that develops more rapidly in As the accuracy of the analysis, for both, DXA systems and
women after menopause than in men and increases fracture CT systems, is very prone to beam hardening effects, amount
risk due to bone mineral loss and decrease in bone structure. of adipose tissue around the investigated area, the exact
Dual energy X-ray absorptiometry (DXA, DEXA) is the most spectrum used, etc.
often used method to measure bone mineral density. The Hence, the actual value of the BMD can drastically vary be-
method has gained acceptance for screening osteoporosis tween systems. In addition, different manufacturers use their
patients. DXA systems are widely used in hospitals and med- own calibration methods which also lead to varying BMD
ical practices. values.
Quantitative CT (qCT) is beside DXA a standard method in Therefore, it is crucial to calibrate the CT or DXA systems
bone densitometry. Due to its ability to acquire 3-dimension- using phantoms containing well-defined BMDs.
al images and its higher image quality, bone mineral density
assessment is more accurate than DXA. Different body regions are commonly used for BMD analysis.
Regions of highest interest are the lumbar spine, and the
Calcium hydroxyapatite (CaHA) is the main component of distal forearm. Other areas of interest are the Hip-region, the
bone. Because of its relatively high effective atomic number femoral neck and the distal legs (heel).
(Zeff) and high mass density CaHA has a high linear attenua-
tion coefficient compared to soft tissues. This can be exploit- There are different phantoms available satisfying the re-
ed to measure the bone mineral density by methods such quirements of DXA or qCT (or both) for the different body
as dual energy X-ray absorptiometry (DXA) or quantitative CT regions mentioned above. In qCT, one can create a calibra-
(qCT). tion between CT values and BMD using specifically designed
phantoms. DXA systems can be calibrated by phantoms spe-
Dual energy absorptiometry is a planar X-ray technique to cially designed for DXA applications. Furthermore, there are
assess bone mineral density. Considering the X-ray attenu- phantoms that are suitable for a cross-calibration between
ation using two different poly-energetic spectra allows to different DXA systems (e.g. for multi-center studies).
separate the attenuation by bone from that of soft tissue.
In addition to the assessment of Bone Mineral Density in fe-
While DXA gives information about the area bone miner- male or male population, it is also possible to evaluate BMD
al density (aBMD) in g CaHA/cm2 , the volumetric density of small animals using Micro-CT systems. For more informa-
(vBMD) in g CaHA/cm3 can be acquired with qCT. Further, tion, please read the Micro-CT Section.
as 3D cross-sectional images are obtained, this approach
facilitates to evaluate the vBMD of cortical bone and trabec-
ular bone separately. Bone Mineral Density assessment with QRM Phantoms
in qCT
In BMD examinations, there are specific criteria determined - Position the phantom accurately on the couch in the de-
by the World Health Organization to assess the BMD which sired configuration.
are the T score and the Z score. The T score is the standard - Acquire CT images in the region(s) of interest (e.g. in the
deviation of the individual’s BMD value to the average BMD different vertebrae of the ESP). To have a good SNR, use at
of the young population of the same sex. This quantity serves least 5 mm slice thickness.
for the diagnosis of osteoporosis: a value above -1 implicates - Place several ROIs within the bone inserts (spongious/tra-
a BMD in the normal range, a T score between -1 to -2.5 in- becular part) and measure the mean CT values. Important-
dicates osteopenia (low BMD) and a value below -2.5 implies ly, use ROIs smaller than the inserts’ diameter in order to
osteoporosis. The Z score is the standard deviation relative to exclude edge effects.
the average BMD of the same age group providing a com- - Create a calibration curve (linear fit) using the measured CT
parison to the average population of the same age. values and the corresponding electron vBMD values provid-
ed by the manufacturer.
- This calibration curve can be used to determine the vBMD
value of any bone under investigation.
92
Suitable Phantoms for qCT
- QRM-50100 European Spine Phantom (ESP)
- QRM-50111 European Forearm Phantom (EFP)
- QRM-50112 Forearm Phantom (BMF)
- QRM-50113 HIP Calibration Phantom, V2
- QRM-50131 HIP-QC120 Phantom
- QRM-50121 Spine-QC120 Phantom
- QRM-50137 Knee-QC Phantom
- QRM-50115 Bone Density Calibration Phantom, 3 H200
- QRM-50118 Bone Density Calibration Phantom, 3 H300
- QRM-50120 Bone Density Calibration Phantom, 3 H400
- QRM-50116 Bone Density Calibration Phantom, 3 H500
Figure 12: Cross-calibration example (ESP with BDC Phantom) - QRM-50117 Bone Density Calibration Phantom, 3 H600
- QRM-50119 Bone Density Calibration Phantom, 3 H700
- QRM-50124 Bone Density Calibration Phantom, 6 H200
- QRM-50125 Bone Density Calibration Phantom, 6 H300
- QRM-50129 Bone Density Calibration Phantom, 6 H400
- QRM-50126 Bone Density Calibration Phantom, 6 H500
- QRM-50127 Bone Density Calibration Phantom, 6 H600
- QRM-50128 Bone Density Calibration Phantom, 6 H700
93
7 Pre-clinical Imaging (Micro-CT)
Micro-CT enables non-destructive material testing (NDT) at Assessment with QRM Phantoms
industrial sites and visualization and analysis of the internal The assessment methods explained above in the clinical CT
structures of small animals (mouse, rat, etc.) for preclinical part of this document can be applied to Micro-CT phantoms
research purposes. Depending on the desired application, as well. Therefore, please read the corresponding section for
there are various systems offering a wide range of possible clinical CT for more details of these different measurement
sample size and resolution. Nowadays spatial resolution in tasks. Instead of quantifying the CT values in Hounsfield
the sub-micrometer range can be reached. units, use the grey value scale of your Micro-CT.
In clinical CT scanners the gantry with X-ray tube and Suitable Phantoms for Micro-CT
detector rotates around the patient. In micro CT, there are Spatial resolution:
also other setups that can be found. E.g. the sample can be - QRM-70109 Micro-CT Slice Sensitivity Phantom
directly rotated around its axis (z-axis) between a fixed X-ray - QRM-70113 Micro-CT Bar Pattern Phantom, air
tube and detector (mostly for industrial applications). By - QRM-70114 Micro-CT Bar Pattern Phantom, resin
varying the distances between sample, detector and X-ray - QRM-70119 Micro-CT Bar Pattern Phantom, NANO
tube the magnification can be adjusted. While rotating the - QRM-70100 Micro-CT Wire Phantom air, D20, 10 micron
sample, multiple projections at different angles are obtained - QRM-70101 Micro-CT Wire Phantom air, D20, 25 micron
and reconstructed in order to get a 3D image of the sample. - QRM-70102 Micro-CT Wire Phantom air, D32, 10 micron
- QRM-70103 Micro-CT Wire Phantom air, D32, 25 micron
Compared to clinical CT, the X-ray beam originates from - QRM-70117 Micro-CT Wire Phantom air, D20, 3 micron
a very small focal spot (microfocus) enabling the superior - QRM-70118 Micro-CT Wire Phantom air, D32, 3 micron
spatial resolution. - QRM-70130 Micro-CT Wire Phantom resin, D32, 25 micron
- QRM-70131 Micro-CT Wire Phantom resin, D32, 10 micron
Micro-CT systems are usually no medical devices and are - QRM-70133 Micro-CT Wire Phantom resin, D20, 25 micron
not calibrated to the Hounsfield scale. There are not strict-
ly pre-defined and calibrated scan protocols as in clinical Grey value accuracy (linearity):
systems, but rather various scan geometries as the user can - QRM-70105 Micro-CT Contrast Scale Phantom
adjust multiple settings (tube voltage, tube current, focal
spot, distance between detector, sample and X-ray tube, ac- Low-contrast resolution:
quisition time per projection, number of projections, etc.) in - QRM-70108 Micro-CT Low Contrast Phantom, V1
order to get the best imaging result. Unlike in clinical devices, - QRM-70124 Micro-CT Low Contrast Phantom, V2
there are no prescribed daily, weekly or monthly standard
quality assurance test procedures. Especially, due to the spe- Signal-to-noise ratio, Uniformity (homogeneity):
cific scan geometry (Cone-beam) and detector type (usually - QRM-70110 Micro-CT Water Phantom, D60
flat-panel detectors are used), Micro-CTs are very prone to - QRM-70111 Micro-CT Water Phantom, D32
image artifacts. - QRM-70112 Micro-CT Water Phantom, D20
Therefore, QA test procedures are essential to ensure Geometric accuracy (distortion) and post-processing
constant quality and comparability of results obtained at a techniques:
specific system or at several systems. - QRM-70104 Micro-CT Multi Disk Phantom (Defrise)
In principle, the image quality parameters/metrics and cali- - QRM-70137 Micro-CT Mouse Phantom
bration procedures recommended for Micro-CT systems are
the same as for clinical CT devices and can be assessed using Bone mineral density calibration:
high-tech phantoms specially developed for Micro-CT. - QRM-70107 Micro-CT HA Phantom D32
There are various phantoms available addressing different - QRM-70129 Micro-CT HA Phantom D25
tasks: spatial resolution (directly by line patterns or indirectly - QRM-70126 Micro-CT HA Phantom D20
by evaluation of the MTF), low-contrast resolution (CNR), - QRM-70127 Micro-CT HA Phantom D10
signal-to-noise ratio (SNR), uniformity, grey value accuracy - QRM-70128 Micro-CT HA Phantom D4.5
(linearity), geometric accuracy, in-vivo or in-vitro bone miner- - QRM-70134 Micro-CT HA set of 5 single rods
al density calibration and dose evaluation (CTDI and DLP).
Dose phantoms (CTDI and DLP):
- QRM-70106 Micro-CT Dose Phantom
94
Product Index
Product Page Product Page
2D Low Contrast Phantom 12 High Contrast Resolution Phantom, D100 24
2D Medium Contrast Phantom 13 HIP Calibration Phantom, V2 56
3D Low Contrast Phantom 14 ICRU Tissues 42
3D Spatial Resolution Phantom 17 JIS Forearm Phantom 58
3D Spatial Resolution Phantom, D100 16 JIS Heel Phantom 59
Abdomem Phantom 29 Liver Nodule Phantom 33
Beam Stop Phantom 19 Lung Nodule Phantom 36
Bone 41 MAM Phantoms 25
Bone Density Calibration Phantom, 3 54 Micro-CT Bar Pattern Phantom, air or resin 70
Bone Density Calibration Phantom, 6 55 Micro-CT Bar Pattern Phantom, NANO 71
Breast CT QA Phantom, Expert 11 Micro-CT Contrast Scale Phantom 64
Calcium Scoring Phantom, D100 23 Micro-CT Dose Phantom 65
Calcium Scoring Phantom Set 32 Micro-CT HA Phantoms 66
Comprehensive Electron Density Phantom 78 Micro-CT Low Contrast Phantom 68
Cone-Beam Phantom, Expert and Basic 10 Micro-CT Mouse Phantom 67
Cranial CT Phantom 35 Micro-CT Multi Disk Phantom 63
CTDI CTwater Phantom 46 Micro-CT Slice Sensitivity Phantom 69
CTIodine 43 Micro-CT Water Phantom 72
CTwater 40 Micro-CT Wire Phantom 62
CTwater slabs 80 Micro-PET Hot Rod Phantom 75
D100 Insert Phantoms 37 Micro-PET IQ Phantom, NEMA NU4 73
Dental CBCT QA Phantom, Basic 20 Micro-PET Scatter Phantom 74
Dental CBCT QA Phantom, Expert 21 Multi-Energy QA Phantom 6
Dual Energy CT Phantom, V2 8 Oval Body Phantoms 30
Dual Energy CT Phantom, V5 9 Pediatric Thorax and Abdomen Phantoms 34
DXA Femur Phantom 57 Slice Sensitivity Phantom 15
DXA Spine QA Phantom, 3 HA 53 Spectral CT Phantom (Set) 7
Electron Density Phantom, D100 79 Thorax and Abdomen Dosimetry Phantom 47
European Forearm Phantom (EFP) 51 Thorax Phantom 28
European Spine Phantom (ESP) 50 Water Tank Phantom 22
Extension Rings 31, 48 Wire Phantom 18
Forearm Phantom (BMF) 52
95
Phantoms for your needs.
PTW is a global market leader for dosimetry and quality Since April 2020 QRM is a subsidiary of PTW Freiburg GmbH.
control solutions in radiation medicine, serving the needs QRM looks back on more than 25 years of experience in
of medical radiation experts in more than 160 countries designing and manufacturing phantoms for medical imaging
worldwide. Starting with the famous Hammer dosemeter in modalities. QRM phantoms are professionally designed and
1922, the German manufacturer is the pioneer in medical manufactured with highest precision.
radiation measurement, known for its unparalleled quality
and precision.
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D987.211.00/00 2023-09