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40 views1 page

Text

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agyapongp626
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Robert Koch developed guideline association particular microorganism with specific

infectious diseases. A microorganism can be accepted as the causative agent of an


infectious disease only following postulates, known as Koch’s postulates, are
satisfied:

1. A specific organism can always be found in association with a given disease.

2. The organism can be isolated and grown in pure culture in the laboratory.

3. The pure culture will produce the disease when inoculated into a susceptible
animal.

4. It is possible to recover the organism in pure culture from the experimentally


infected
animal.

Koch’s postulate has remained a mainstay of microbiology; however, many


microorganisms that do not meet the criteria of postulates have been shown to cause
disease. For example, Treponema pallidum and Mycobacterium leprae, causative agents
of syphilis and leprosy respectively.
Work with viruses could not be effectively performed until instruments were
developed

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