cobas c 311 analyzer

Host Interface Manual

New Mode
Roche/Hitachi cobas c 311 analyzer

Document Information
Manual Software Revision Date Changes
Version Version
Draft 2007/09/14 All
Version 0.1 Based on the “cobas e411
HostCommunication_Version_1.[Link]”
and “HOST-MAN_V01_c311_3c.DOC”
Version 1.0 2007/10/22
Version 1.1 2008/02/25 Revised.
Version 1.2 2008/06/10 Revised.
Version 1.3 2011/05/24 Function addition of Host
Communication setting.
Change by function addition of Host
Communication setting.
Change of result data flags.
Version1.4 2013/07/24 Communication Text
"Note" for the case that no inquiry is
sent in sequence number mode is added.
Test order record
Field: Universal Test ID
"Note" for the limitation of the dilution
for HbA1c full blood is added.
Result record
Field: instrument identification
Module "ISE11" is changed into "ISE1".
Version 1.5 2014/07/01 (1)Layout modification to Roche
corporate design
(2)Comment Record, that follows the
order record
(3)Note for the characters to send from
Host is added.
(4)Note for S.B.S Mode is added.
(5)Naming of Table 20 and reference
adapted
(6)Figure 3: Text Settings Screen is
improved.
New Mode check box is "checked".

Version 1.6 2015/09/30 Correction of the description for "How

to store a host communication trace file"
Press "Floppy Disk Write"
-> Press "Backup Disk Write"
Insert Floppy Disk to store the trace
-> Insert DVD or USB media to store the
trace
Version 1.7 2015/10/23 Correction of the host flag code on
List of Result Data Flags(Data Alarm
List). The code for "Serum index
multiple interference" was modified
from 59 to 58.

Edition notice This Users Guide is for users of cobas c 311 analyzer.

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Every effort has been made to ensure that all the information contained in
this document is correct at the time of printing. However, Roche
Diagnostics International Ltd reserves the right to make any changes
necessary without notice as part of ongoing product development.
Any customer modification to the software will render the warranty or
service agreement null and void.

Intended use This document describes communication procedure related to

communication method that enables intercommunication between
Laboratory Host System, hereinafter referred to as HOST, and cobas c
311 analyzer. Specification and software described herein comply with
the following ASTM communication protocol: (HOST communication
ASTM higher-layer: High-Level, lower-layer: Low-Level I/F
specification)

Specification X12 of ASTM (American Society of Testing and Materials)

ASTM E1381-91: Specification for Low-Level Protocol to Transfer
Messages Between Clinical
Laboratory Instruments and Computer System
ASTM E1394-91: Standard Specification for Transferring Information
between Clinical Instruments and Computer Systems based dependency
of sample results from calibration- and control.

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Copyright © 2015 Roche Diagnostics GmbH. All rights reserved.

Trademarks The following trademarks are acknowledged:

COBAS, COBAS C, COBAS INTEGRA, ELECSYS and LIFE NEEDS
ANSWERS are trademarks of Roche.

All other trademarks are the property of their respective owners.

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Table of Content
List of Result Data Flags ( Data Alarm
Specification of interface 6 List ) ........................................................................ 51

Specification of Communication.......................... 7
Communication trace 53
Host Communication Setting ............................... 8
Communication Setting.................................................. 9 Test Selection Information in Real Time .......... 54
Text Setting .................................................................. 11 Real Time Test Results ......................................... 55
Host Text Code Setting ................................................ 15
Batch Test Selection Information ...................... 56
Result Upload Settings ................................................. 16
Communication Cable ......................................... 17 Appendix 57

Communication text 19 Appendix A: Instrument Alarms ........................ 58

Appendix B: ASCII Table ..................................... 70
Communication Text ........................................... 20
Control Characters ....................................................... 70
Printable Characters .................................................... 71
ASTM communication protocol 21

Communication Data Structure ......................... 22

Frame Structure .................................................... 23
Definition of Communication Protocol ............ 24
Establish phase ............................................................. 24
Transfer phase .............................................................. 26
Termination phase ........................................................ 26

Record structure 27

Syntax..................................................................... 29
Message Header Record ...................................... 32
Message Termination Record ............................. 33
Request Information Record .............................. 34
Patient Information Record ................................ 36
Test Order Record ................................................ 37
Comment Record, that follows the order
record (used for patient demographic
data) ....................................................................... 41
Result Record ........................................................ 42
Comment Record, that follows the result
record (result data flag) ...................................... 45
Photometric Calibration Result Record ............ 46
ISE Calibration Result Record ............................. 48
Photometric Absorbance Data Record.............. 50

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Specification of interface 1

1. Specification of Communication ................................................................................ 7

2. Host Communication Setting ...................................................................................... 8

3. Communication Cable ................................................................................................. 17

Roche/Hitachi cobas c 311 analyzer

Specification of Communication

Communication between cobas c 311 analyzer and HOST is based on

RS-232C connection.
Item Specification Recommendation Note

Communication Protocol ASTM -

Communication Speed 19200bps/9600bps/4800bps 9600bps Selectable from GUI

Character Configurations See Table B-2. 8bit,NONE,1Stopbit Selectable from GUI

Protocol Type cobas type cobas type Selectable from GUI

Frame Length 247 bytes -

Communication Port 1 port -

Cable Length 15m -

Communication method Half duplex

Table 1: Specification of Serial Interface

Character Configuration is selected from table 2.

No. Data bit Parity bit Stop bit
1 7bit EVEN 2Stopbit
2 7bit ODD 2Stopbit
3 7bit EVEN 1Stopbit
4 7bit ODD 1Stopbit
5 8bit NONE 2Stopbit
6 8bit NONE 1Stopbit
7 8bit EVEN 1Stopbit
8 8bit ODD 1Stopbit
Table 2: Character Configuration

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Host Communication Setting

Select Yes/No at “Host Communication” on Start Conditions screen.

Figure 1: Start Conditions Screen

Select condition of HOST communication on the Utility > System >

Host Communication Setting window. The setting is only changeable
when “Host Communication” is off.

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Communication Setting

Figure 2: Communication Setting Screen

RS232C Setting

Speed 19200/9600/4800 Select speed.

Parity 7bit, EVEN,2Stopbit/
7bit, ODD,2Stopbit/
7bit, EVEN,1Stopbit/
7bit, ODD,1Stopbit/
8bit, NONE,2Stopbit/
8bit, NONE,1Stopbit/
8bit, EVEN,1Stopbit/
8bit, ODD,1Stopbit Select Parity.

Automatic Recovery of Session Check box On/Off

During the initial setup of the host, it is recommended that this function
not be enabled so errors can be detected. After the host interface has been
successfully established, this function can be enabled, and can help
resolve occasional interface errors without requiring operator intervention.

Communication Trace Check box On/Off

This function applies to all host communications. When this function is

enabled, the content of the communication with the host can be stored at
the analyzer. The Communication Trace report can be printed from the
global Print screen. This report can be used as an analysis tool if a
problem occurs.
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Note Due to the trace file size, it is recommended that the Communication Trace
report not be routinely used. When enabled for troubleshooting purposes, it is
recommended that the print buffer be printed prior to printing this report, as the
size of it might overwrite other buffered printouts.

How to store a host communication trace file.

• It is possible to get a host communication trace by the following

procedure.
• Touch the Print button.
• Select Utility tab.
• Select the Communication Trace in the list box.
• Select the radio button „Print“
• Press View
• Press " Backup Disk Write"
• Enter Filename for Tracefile
• Select Page Range
• Insert DVD or USB media to store the trace
• Touch OK button.
Ignore host orders for samples Check box On/Off
with already existing 1st
results

If this function is enable, when orders are sent from Host, orders for tests
with already existing 1st run results are ignored and not measured again.
Additional orders are detected and processed and Automatic rerun
triggered by system instrument is possible.
Rerun and 3rd result orders from host are not possible.
If this function is disabled, all orders are detected and measured even if
not necessary.
For example, during S.B.S. mode, the inquiry of orders to Host is
performed repeatedly. When this function is enable, orders sent from
Host which have 1st result are not measured.

Note S.B.S means "scan before sample stop".

The S.B.S mode is activated on the Barcode Setting window(Utility>System).
In case of SBS mode is activated, at the end of the run, when all first and rerun
results are available, the analyzer checks the internal sample database to collect
open test [Link] database can be checked up to six times.
So even if the first database check has already been performed, additional tests
or samples will be measured in the next cycle

System Name used on reports and in communications for the cobas c 311
analyzer.

Host Name used on reports and in communications for the host system.

System ID The ID number used to identify the system in communications with the
host.

Host ID The ID number used to identify the host in communications with the
analyzer.

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Text Setting

Figure 3: Text Settings Screen

Result Only Check box On/Off

This function applies to all Realtime Communications. This does not

apply to the Batch Mode. When this function is enabled, communication
during analysis is limited only to the analytical data transmissions.
Inquiries for the Test Selection Information or Auto Rerun Selection
Information are not made. Test selections would need to be made either
manually by the operator at the analyzer, by Batch Mode from the host,
or by use of the Default Profile.

TS Timeout Check box On/Off and input 10-9999

This function allows the operator to set a timeout interval for Test
Selection Information Inquiry for Realtime Communications and for
routine, Stat and rerun samples. The specified timeout interval determines
how long the analyzer will wait for a ‘Response from the host’. The range
is 10-9999 seconds (depending on TS Priority Mode), with a default of 18
seconds. Enabling this function optimizes the throughput of the system. If
the function is not enabled, the analyzer will wait indefinitely for Test
Selection Information.

Auto Rerun TS Check box On/Off

This function applies to Auto Rerun TS inquiry within the Realtime

Communications if the upload setting is not “by sample. When this
function is enabled in the Auto Rerun mode during analysis, an inquiry is
made for the Auto Rerun selections. When this function is not enabled,
no inquiry for the Auto Rerun Selection is made.
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Auto Rerun TS Timeout Check box On/Off and input 10-9999

This function applies to the reception of Auto Rerun Test Selection

Information in Realtime Communications. The range is 10-9999 seconds,
with a default of 18 seconds (depending on TS Priority Mode). If the
function is not enabled, the analyzer waits indefinitely for Rerun Test
Selection Information.

Manual Rerun T S Check box On/Off

This function applies to the Test Selection Information inquiry for

Manual Rerun samples in Realtime Communication. When this function
is enabled, an inquiry is made for the test selections for rerun samples
during analysis. Any samples that have previously been processed create
a TS inquiry to the host. When this function is not enabled, no TS inquiry
for Manual Rerun samples is made.

Stat TS Check box On/Off

This function applies to the Test Selection Information inquiry for Stat
samples in Realtime Communications. When this function is enabled, an
inquiry is made for the test selections for Stat samples during analysis.
When this function is not enabled, no TS inquiry for Stat samples is made.

TS Inquire Always Check box On/Off

This function applies to the Test Selection Information inquiry for routine
and Stat samples in Realtime Communications. This does not apply to TS
information inquiry for rerun samples, Auto Rerun and Manual Rerun.
When this function is enabled, an inquiry is made whether the TS
information is in the analyzer or not. When not enabled, an inquiry is
made only for the samples that do not have test selections.

TS Ask in Barcode Read Error Check box On/Off

If this function is enabled, and the analyzer cannot read a sample barcode,
“***...” (13 or 22 characters of ‘*’) is sent as the sample ID, and the rack
ID and position are sent to the host as key information to identify the
sample. If the host has the table of the rack ID, position and Sample ID,
the host can send back to the analyzer the correct Sample ID instead of
‘***...’

Note Because Host protocol and text field is same as cobas6000, Rack ID field is used
in cobas c 311 analyzer communication text.

The only currently known use for this function is with a Sample Handling
System that ‘manufactures’ sample aliquots for the analyzer. This type of
system would track samples by position on [Link]. Unless the Sample
Handling System can perform this function, it is strongly recommended
that it not be used
This function is not visible, if the Sample Barcode Reader is switched off.

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TS Priority Mode Check box On/Off

If this function is enabled, after a Test Selection inquiry the analyzer will
stop sending any information, i.e. result data, until the analyzer receives
the answer to the inquiry from the host or the TS timeout period passes.
This option applies to both the inquiry at the bar code reader and the
implied inquiry after Result upload in “By Sample” setting.
The range of the TS Timeout and Auto Rerun TS Timeout is from 1 to 18
seconds with this mode on. With this mode off the TS Timeout options
remain at 10 to 9999 seconds. If this mode is enabled and the TS Timeout
checkbox is off, TS timeout is handled as 18 seconds.

Sample ID 22 Digits Check box On/Off

The maximum length of the sample ID is increased from 13 to max. 22

characters.

New Mode Check box On/Off

The host interface protocol description in this manual is based on this

'New Mode' setting enabled.
If disabled the protocol is identical with the protocol of the CC Modular
software for purpose of 100% compatibility with already connected
Analyzer systems.
Concerning detail of the CC Modular host interface specification refer to
Roche/Hitachi MODULAR System Host Interface Document Version 1.0
Ident. No. 011632701 (US ID)

Send 1st/Rerun Information Check box On/Off

With this mode enabled additional information that shows whether a

query is 1st or rerun measurement is added to Request Information
Record. This mode is applied to only “Inquiry for the Requested Tests”
message from the analyzer to the host, but not applied to “Inquiry of
Result” from the host to the analyzer.
If the function is not enabled, no information is added to Request
Information Record.

Send Comments Check box On/Off

This function applies to host communications. When this function is

enabled, the host can send patient comments to the analyzer. Patient
comments stored in the analyzer can also be transmitted to the host along
with analytical data and Reaction Monitor data. When this function is not
enabled, no patient comments are accepted or sent.

Send Concentration Of Check box On/Off

Chemistry Qualitative Test

This function is available for Result transfer and Reaction Monitor

transfer.

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When this function is selected, measurement results are also send to Host
with Qualitative result in photometric test result record.

Send Time stamp of Check box On/Off

pipetting of Sample

When this function is enabled, pipetting date and time for each test result
is sent to the host.

Chemistry Test Calibration Check box On/Off

Results Detail

When this function is enabled, the detail information (reagent lot number,
reagent bottle sequence number, expired flag, calibrator lot number and
pipetting date and time) corresponding to the calibration result is sent to
the host.

Control Results Mode Check box On/Off

Incremental

With this mode enabled, the control results are sent test oriented; i.e. as
soon as one test result is available it is sent to the host.

QC Additional Information Control Name/Lot No

With this function it is possible to select if ‘Control Name’ or ‘Lot

Number’ shall be sent in field 3 of the Test Order record within a control
result message.

Host Test Code Use the Host Test Code Setting window to edit the test code sent to the
host

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Host Text Code Setting

Figure 4: Host Text Code Setting

Host Code Input 1-99999

Use this text box to edit the host code for the test selected in the Test list.
After editing the code, touch Update to save the change.

Update Changes are saved and the updated contents of the list are displayed.

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Result Upload Settings

Figure 5: Result Upload Settings

Routine Sample Result By Sample / ISE/Chemistry

upload setting

With this function it is possible to select how the routine sample results
are uploaded to the host in real time. When By Sample is selected, all
results of routine sample are uploaded by round.
When ISE/Chemistry is selected, ISE results and Chemistry results of
routine sample are uploaded separately. And to indicate the last result
upload an automatic Query is sent to the host and to indicate the last
result upload an automatic Query is sent to the host.

STAT Sample Result upload By Sample / ISE/Chemistry / By Test

setting

With this function it is possible to select how the stat sample results are
uploaded to the host in real time. When [By Sample] is selected, all
results of STAT sample are uploaded by round.
When ISE/Chemistry is selected, ISE results and Chemistry results of Stat
sample are uploaded separately. And when By Test is selected, as soon as
one test result is available it is sent to the host. In the
modes ISE/Chemistry and By Test an automatic Query is sent to the host,
to indicate the last result upload.

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No Automatic Result Upload By Sample / ISE/Chemistry / By Test

This function is applied to Realtime communication for routine and Stat

samples.
When this function is enabled, no result is uploaded in real time. In this
case, the results can be uploaded manually by selecting samples from the
Workplace/Data Review screen.

Communication Cable

Connect RS-232C communication cable to the connector at

the cobas c 311 analyzer. The connector is D-SUB9.
Figure 6 shows connector and communication cable. Figure 7 shows
connection diagram.

Connector for external

communication

Figure 6: Connector

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Figure 7: Connection Diagram

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Communication text 2

4. Communication Text .................................................................................................... 20

Roche/Hitachi cobas c 311 analyzer

Communication Text

cobas type
Text Direction
Real Time Batch
Upload
Inquiry for Order Yes No
cobas c 311->HOST
Download
Order for Test Request Yes Yes
HOST-> cobas c 311
Upload
Result Report Yes Yes
cobas c 311 ->HOST
Download
Inquiry of Result No Yes
HOST-> cobas c 311
Yes: equipped
No: not equipped
Table 3: List of Communication Text

Note Patient sample and quality control sample and calibration result are sent as result
data..
There is no Inquiry for Order of a control sample and Calibration..
In sequence number mode, there is no inquiry for Patient samples whose
sequence numbers and positions are not registered on the Test Selection screen.

Text Real/Batch Cause

Inquiry for the Requested Real • After sample ID is read, inquire of HOST for test selection
Tests information of patient sample to which test selection
(Upload) information is not registered.
• Wait for reply from HOST for test selection information for
a certain length of time after the inquiry. If not replied even
after a certain length of time, cancel the inquiry.
Order for Test Request Real • Specify the test selection information for a sample when the
(Download) test selection information is inquired.
Batch • HOST specifies the test selection information of a patient
sample at a given timing. Register test selection information
before reading sample ID to use this function.
Result Report Real Send result data of patient sample and quality control
(Upload) sample when test data of the sample is collected.
Batch • Send result data of patient sample and quality control sample
specified on [Data Review] window.
Inquiry for result Batch • Send result data of patient sample requested by Host. It is
not possible to select result from Host if 1st and rerun result
exists, because the selection is done at the Analyzer on Test
Review screen. (Workplace / Data Review / Test Review-
Test result list).
The result is selected by the rules below from (1) to (3).
(1) There is a result.
(2) The result does not have alarm, which is listed on Review by
Exception screen.
(3) Result is selected if 1st and rerun result is existed in Data
Review screen or the only one result exists for a test.
Table 4: Causes of Communication Text

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ASTM communication protocol 3

5. Communication Data Structure ............................................................................... 22

6. Frame Structure ..............................................................................................................23

7. Definition of Communication Protocol .................................................................. 24

Roche/Hitachi cobas c 311 analyzer

Communication Data Structure

cobas c 311 analyzer employs ASTM communication protocol.

ASTM communication protocol consists of three layered data structure
such as message, record, and frame. In the application layer, data is
communicated by message. Further, data is communicated by frame
actually in the data link layer. Data structure of a frame varies by protocol.
A message consists of several records. A record consists of one or more
frames. If a message exceeds 240 bytes, a frame is divided into middle
frames and a last frame. [ETB] is used for the middle frame and [ETX] is
used for the last frame.
[Message] [Record] [Frame] Communication

Application Layer Presentation Layer Data Link Layer

[ETB]

[ETB]
Creating Message

[ETB]
Analyzing Message

[ETB]

[ETB]

[ETX]

Figure 8: Data Structure

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Frame Structure

Frame structure is shown below.

Middle frame when a frame is divided into more than one.
[STX] FN text [ETB] CS1 CS2 [CR] [LF]

When the last frame or a frame is single frame.

[STX] FN text [ETX] CS1 CS2 [CR] [LF]

Field ASCII Code Content character Note

[STX] 0x02 Start of Text 1byte
FN - Frame No. 1byte 1
text - Communication data Max240byte 2
[ETX]/[ETB] 0x03/0x17 End of Text/ End of Communication Block 1byte 3
CS1 - 1byte
Check Sum 4
CS2 - 1byte
[CR] 0x0d Carriage Return 1byte
[LF] 0x0a Line Feed 1byte

Notes 1: Way to assign frame No. (FN) is starting from No.1 to No.7. When exceeding
No. 7, start from No.0 to No.7.
2: Codes except the following ASCII code are available for text.

Code Code Code Code Code

[SOH]0x01 [STX]0x02 [ETX]0x03 [EOT]0x04 [ENQ]0x05
[ACK]0x06 [LF]0x0A [DLE]0x10 [DC1]0x11 [DC2]0x12
[DC3]0x13 [DC4]0x14 [NAK]0x15 [SYN]0x16 [ETB]0x17

Notes 3: When a frame is 240 bytes or less, use [ETX].

When exceeding 240 bytes, use [ETB].
4: Add each character code which frame No. is (FN) to [ETB] or [ETX]. Display
the sum in hexadecimal format. Convert the last two digits into ASCII code.
Code used for Check Sum is ’0’ to ’9’ and ’A’ to ’F.’

Ex. Check Sum Calculation Method

[STX] ‘1’ ‘T’ ‘e’ ‘s’ ‘t’ [ETX]

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Field Character Hex. format Sum

[STX] [STX] 02h -
FN ‘1’ 31h 31h
text ‘T’ 54h 85h
‘e’ 65h EAh
‘s’ 73h 15Dh
‘t’ 74h 1D1h
[ETX] [ETX] 03h 1D4h
Last two digits of the sum.
D4h
CS1 ‘D’ 44h
CS2 ‘4’ 34h
[CR] 0Dh
[LF] 0Ah

[STX] ‘1’ ‘T’ ‘e’ ‘s’ ‘t’ [ETX] ‘D’ ‘4’ [CR] [LF]

Definition of Communication Protocol

Low-Level Protocol of ASTM communication protocol is one-way.

Response is generated after the information is sent. Response is not
generated simultaneously with communication. Unlike the other
communication protocols, it does not have master-slave relation.
Both cobas c 311 analyzer and HOST enable to initialize the
communication.
When establishing send system and receive system, or when having the
action of both the sender and the receiver arranged properly, the
information is communicated by the following three phases.
• Establish phase
• Transfer phase
• Termination phase

Establish phase
In Data/Link layer, both sender and receiver go into one the following
status.
• Idle state: status waiting for becoming receiver.
• Starting Establish phase at the transmitting side, transmitting record
information by frame, and completing by Termination phase.
• Receiving receiver’s frame, and sending [ACK].
Number of sender or receiver is one at a time. Both sender and receiver
enable to be in idle status. When the presentation layer requires the data
link layer to send record, one need to change its status from idle to sender.
To have one been sender and the other been waited, or receiver, the
sender needs to start Establish phase. Therefore inform that the other

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changed its status from idle to receiver by sending ASCII code 05h[ENQ]
from the sender and sending ASCII code 06h[ACK] from the receiver.
Transfer phase starts when Establish phase is completed by receiving
[ACK]. Reception other than [ENQ] is ignored in idle status. Reception
of [ENQ] is replied by [ACK] and receiver is turned to receiving status.
Establish phase Transfer
phase

Retry Retry Retry

10sec 1sec 15sec
ENQ ENQ ENQ ENQ ENQ
Sender

Receiver
XXX ENQ ACK

(1) (2) (3)

Figure 9: Establish Phase

Normal procedure of Establish phase is mentioned above. In case of

error, there are additionally three options for the receiver to respond
[ENQ].
(1) Receiver sends characters These characters are normally sent by using ASCII
other than [ACK]. code 15hex [NAK] when the receiver is busy.
The sender waits for a certain length of time, e.g.,
cobas c 311 analyzer waits for 10 seconds, and
tries to establish with the other [ENQ].
The cobas c 311 analyzer repeats this cycle until
the number of retries after error reaches six.
(2) Sender sends [ENQ]. The status in which both sender and receiver are
trying to change their status to the sender is called
“Link contention” in ASTM.
When in link contention, it is defined that
communication information of cobas c 311
analyzer has a priority. So that HOST has to stop
sending [ENQ] and has to respond simultaneously
by [ACK] or [NAK] when the link contention is
detected.
On the other hand, the cobas c 311 analyzer waits
for more than 1 second and replies [ENQ]. The
sender repeats this cycle until receiving characters
such as [ACK] or [NAK].
(3) No response from receiver. The sender starts Termination phase by sending
ASCII code 04hex [EOT] after waiting for
15 seconds, and displays an error message.

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Transfer phase
After receiving frame, sender discontinues communication until receiving
the response or occurrence of time-out. Usually the receiver notifies by
sending [ACK] that it successfully received the last frame and completes
its preparations to receive the next frame. The receiver notifies by
sending [NAK] that the last frame was not received and it is waiting for
receiving the frame. According to the above, there are three options for
HOST to respond the communication of the frame.
HOST sends [ACK] or [EOT]. cobas c 311 analyzer sends the next record.
cobas c 311 analyzer has data that is to be
communicated. cobas c 311 analyzer continues
to send records. (It is started with Establish
phase.)
HOST sends characters other than cobas c 311 analyzer repeatedly sends record.
[ACK] or [EOT]. This cycle is repeated until “number of retry in
case of error” reaches six. At this moment, cobas
c 311 analyzer starts Termination phase and
displays an error message by sending [EOT].
No response from HOST cobas c 311 analyzer starts Termination phase by
sending [EOT] after 15 seconds and displays an
error message.

Response depends on how HOST responds to frame communication from

cobas c 311 analyzer. When cobas c 311 analyzer is in the receiving
status and is waiting communication from HOST, there are the following
three scenarios.
HOST sends frame characters. After the complete frame is received, the frame
No. and the checksum are checked if they are
correct. When the frame is correct, cobas c 311
analyzer responds by [ACK]. When the frame is
incorrect, the incorrect frame is rejected and
[NAK] is returned.
HOST does not complete frame Time-out occurs when receiving unfinished frame
communication. and at the same time [EOT] is not received after
15 seconds counted from the last communication
of [ACK] or [NAK] from cobas c 311 analyzer.
cobas c 311 analyzer is turned into idle status by
deleting the last incomplete message. The line is
deemed to be neutral status.
HOST sends [EOT]. The cobas c 311 analyzer is turned into idle
status. Only completely received frame is
deemed to be effective.

Termination phase
Both sender and receiver change their status into idle in Termination
phase. This phase only starts when the sender sends [EOT]. Response
from the receiver to this message is none. When [EOT] is detected at the
receiver, it is turned to be idle and the line is required to be changed to
neutral.

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Record structure 4

8. Syntax .................................................................................................................................29

9. Message Header Record .............................................................................................. 32

10. Message Termination Record .................................................................................... 33

11. Request Information Record....................................................................................... 34

12. Patient Information Record ........................................................................................ 36

13. Test Order Record ..........................................................................................................37

14. Comment Record, that follows the order record

(used for patient demographic data) ...................................................................... 41

15. Result Record ...................................................................................................................42

16. Comment Record, that follows the result record (result data flag) ............. 45

17. Photometric Calibration Result Record.................................................................. 46

18. ISE Calibration Result Record .................................................................................... 48

19. Photometric Absorbance Data Record ................................................................... 50

20. List of Result Data Flags .............................................................................................. 51

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Syntax

Syntax used in message (records) communicated by cobas c 311 analyzer

is shown below.
Message Syntax
Communication Text Real/Batch cobas Type
Comment or Special Instructions
H
Inquiry for the Requested Tests
Real Q TSREQ^REAL
(Upload)
L
Real H TSDWN^REPLY
P
Order for Test Request
O
(Download) Batch TSDWN^BATCH
C-CMM
L

H RSUPL^REAL
P
Real
O
Result Report
C-CMM RSUPL^REPLY
(Upload)
{R
C-RES } n
Batch L RSUPL^BATCH

H
Inquiry of Result Real Q RSREQ ^REAL
L
Photometry Calibration Result Report H
Real M-PCR PCUPL^REAL
L
ISE Calibration Result Report H
Real M-ICR ICUPL^REAL
L
H
P
O
C-CMM
Photometric Raw Data Report Batch ABUPL^BATCH
R
C-RES
M-ABS
L
Table 5: Message Syntax

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Communication sequences (message flow) of communication message by

application layer are shown below.
cobas c 311 analyzer [HOST]
(1) Order for Test Request: real- Inquiry for the Requested Tests ->
time (TSREQ^REAL)
<- Order for Test Request
(TSDWN^REPLY)
(2) Order for Test Request: batch <- Order for Test Request
(TSDWN^BATCH)
(3) Result Report: real-time Result Report ->
(RSUPL^REAL)
(4) Result Report: batch Result Report ->
(RSUPL^BATCH)
(5) Inquiry of Result: real-time <- Inquiry of Result
(RSREQ^ REAL)
Result Report ->
(RSUPL^REAL)
(6) Photometric Calibration Result Photometric Calibration Result Report ->
Report: real-time (RCUPL^REAL)
(7) ISE Calibration Result Report: ISE Calibration Result Report ->
real-time (ICUPL^REAL)
(8) Photometric Raw Data Report: Photometric Raw Data Report ->
Batch (ABUPL^BATCH)
Table 6: Communication Sequences

ASTM syntax is shown below.

(a) Terminating character of record: Indicates completion of record. ASCII CR
character (0Dhex) is required.
(b) Field separator character = vertical Separates adjacent fields in record. Also
bar ‘ | ’: separates the first record ID, the character
appeared at the top of record, and the next field.
Depending on the second character of message
title record, a record appeared at the top of the
message, it enables to define the field separator
character randomly. However ‘ |’ is
recommended.
(c) Repetition field separator character When fields consist of repetition of the same
= backslash ‘ \ ’: data, it is called “repeated field.” Repeated field
separator character is a separator between tests of
repeated field. Depending on the message title
code, it enables to define the repeated field
separator character randomly. However ‘ \ ’ is
recommended.
(d) Component separator character = When fields consist of multiple components, it is
caret ‘ ^ ’: called “component field.” Component separate
or character is a separator between the
components. Depending on the message title
code, it enables to define the component separator
character randomly. However ‘ ^ ’ is
recommended.
(e) Escape character = ampersand Escape character is defined to represent a
‘ & ’: separator character in the field including normal
text. Appearance of this character in such field
indicates that the following character has special
meaning. Depending on the message title code, it
enables to define the escape character randomly.
However ‘ & ’ is recommended.

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(f) Expression of special characters by Escape sequence, character string starts and ends
escape characters: with &, is defined as follows. When these
sequences are detected in the field, it is
interpreted the corresponding character string.
&F& Field separator character
&S& Component separator character
&R& Repetition separator character
&E& Escape character

Escape sequences other than the above are skipped and handled as null
value.
The table below describes attributes of each field in each record shown in
chapter Patient Information Record.
No Name of Attributes Description
1 Order (No.) Sequence of the field. Sequence of the fields in record.
2 Name of Field (Field) Name of relevant field.
3 Type (Type) Typing characters for the fields are any of the following.
ST Character string.

TX Character string group that end is printable.

NM Numeric value. ‘+‘ or ‘-‘ is attached at the top. If not, the value is deemed to be
’+.‘ When without decimal point, the value is deemed to be integer. Prefix
attached to ’0,’ and suffix attached to ‘0’ of numeric value with decimal point can
be anything.
DT Date. Four digits of dominical year. YYYYMMDD (YYYY: dominical year,
MM: month, DD: day) Ex. September 5, 1995 is displayed as “19950905.”
TM Set time in 24 hours. HHMMSS (HH: hour, MM: minute, SS: second)
TS Time stamp. Display DT and TM together such as “YYYMMDDHHMMSS.”
CM Field of combined multiple data by component section separator character.
4 Maximum length (Max) Maximum number of effective characters except escape characters in the relevant field.
Table 7: Field description

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Message Header Record

cobas type (Upload, Download)

H|\^&|||cobas c 311^1|||||host|RSUPL^BATCH|P|1[CR]
(1) (2) (3) (4) (5) (6) (7)

No Field Comments
Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘H’ fixed.
(2) 2 Delimiter Definition ST 4 Four characters such as field separator character, repeat separator character,
component separator character, and escape character are defined. The first
character is defines as a field separator character and Record Type ID
separator as well. These four characters are ‘|\^&.’
3 Message Control ID Field does not contain data
4 Access Password Field does not contain data
(3) 5 Sender Name or ID CM 36 .
Setting is as follows:
<Sender’s device name>^<Communication program version>

<Sender’s device name> Type:TX Max: 30

Any characters within alphanumeric and ‘-.‘
<Communication program version> Type: NM Max: 5
‘1’ fixed.
6 Sender Street Address Field does not contain data
7 Reserved Field Field does not contain data
8 Sender Telephone Field does not contain data
Number
9 Characteristics of Field does not contain data
Sender
(4) 10 Receiver ID ST 30 Receiver’s name.
Sending from cobas c 311 analyzer.
Sending from HOST: any characters within alphanumeric and ‘-.‘
(5) 11 Comment or Special CM 11 Setting is as follows:
Instructions <Meaning of message>^< Mode of message >

<Meaning of message> Type: ST Max: 5

‘TSREQ’: TS inquiry.
‘TSDWN’: Test selection download.
‘RSUPL‘: Result report
‘PCUPL‘: Photometry calibration report
‘ICUPL‘: ISE calibration report
‘ABUPL’: Absorbance report
‘RSREQ’: Inquiry for the result

<Mode of message> Type: ST Max: 5

‘REAL’: communication in real time.
‘BATCH’: communication based on request from cobas c 311/HOST.
‘REPLY’: reply to the request.
(6) 12 Processing ID ST 1 ‘P’ fixed.
(7) 13 Version No. NM 1 ‘1’ fixed.
14 Date and Time of Field does not contain data
Message
Table 8: Message Header Record

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Message Termination Record

cobas type (Upload, Download)

L|1|N [CR]
(1)(2) (3)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘L’ fixed.
(2) 2 Sequence Number NM 1 Indicates sequence No. Normally it is ‘1’
(3) 3 Termination Code ST 1 ‘N’ fixed. (normal end)
Table 9: Message Termination Record

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Request Information Record

cobas type (Upload, Download)

Q|1|^^ 000663^32^50002^002^^S1^SC||ALL||||||||O[CR]
(1)(2) (3) (4) (5)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘Q’ fixed.
(2) 2 Sequence Number NM 6 Indicates sequence No. Normally it is ‘1’
(3) 3 Starting Range ID CM 45 Indicates inquired sample. Setting is as follows:
Number
^^<SampleID>^<SequenceNo>^< Rack ID No >^
<PositionNo>^^<SampleType>^<ContainerType>^

<SampleID> Type: ST Max: 22

indicates Sample No. (Sample ID.)
<SequenceNo> Type: NM Max: 5
indicates cobas c 311 analyzer internal sequence No. The range is 1-
60000
< Rack IDNo> Type: ST Max: 5
indicates carrier No. (Disk/Rack.)
At the c311 analyzer, Rack ID contains two kinds of information:
Type of sample - 2 digits
20: Calibration
30: Control
40: STAT
50: Routine
+ Disk Position - 3 digits
Note
Because Host protocol and text field is same as cobas6000, Rack ID
field is used in cobas c 311 analyzer communication text.

<PositionNo> Type: NM Max: 3 Position range is 001 to 110.

indicates position No. in carrier.
<SampleType> Type: ST Max: 2
indicates sample type.
Position type is identified by S0 ~ S5.
S1: Blood Serum/Plasma
S2: Urine
S3: CSF
S4: Suprnt
S5: Others
S0: None type sample (for TS inquiry)
QC: Control (only for Control Result Inquiries from Host)
S0 is used only in Sample ID mode.
.
<ContainerType> Type: ST Max: 7
indicates sample cup type.
‘SC’: test tube or sample cup.
‘MC’ : Microcup
<Kind>
R1: For 1st measurement
R2: For rerun measurement
This information is sent to the host only when an option of “Send 1st
/ Rerun Information” is specified
4 Ending Range ID Field does not contain data
Number
(4) 5 Universal Test ID ST 3 ‘ALL’ fixed.
6 Nature of Request Field does not contain data.
Time Limits

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Field Comments
No Field Type Max
No. cobas Type
7 Beginning Request Field does not contain data.
Results Date and
Time
8 Ending Request Field does not contain data.
Results Date and
Time
9 Requesting Field does not contain data.
Physician Name
10 Requesting Field does not contain data.
Physician Telephone
Number
11 User Field No.1 Field does not contain data
12 User Field No.2 Field does not contain data
(5) 13 Request Information ST 1 Indicates the objective of the record. Setting is as follows:
Status Codes
‘O’: Order query (to Host)
‘A’: Cancel the last request (to Host)
‘F’: The final result
Table 10: Request Information Record

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Patient Information Record

cobas type (Upload, Download)

P|1||||||20070921|M||||||35^Y[ C R ]
(1)(2) (3) (4) (5)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘P’ fixed.
(2) 2 Sequence Number NM 6 Indicates sequence No. Normally it is ‘1’
3 Practice Assigned Field does not contain data.
Patient ID
4 Laboratory Assigned Field does not contain data.
Patient ID
5 Patient ID No. 3 Field does not contain data.
6 Patient Name Field does not contain data.
7 Mother’s Maiden Field does not contain data.
Name
(3) 8 Birthdates DT 8 Date as defined by ASTM 6.6.2
(4) 9 Patient Sex ST 1 Field Value Description
M Male
F Female
U Unknown
10 Patient Race Field does not contain data.
11 Patient Address Field does not contain data.
12 Reserved Field Field does not contain data.
13 Patient Phone No Field does not contain data.
14 Attending Physician Field does not contain data.
ID
(5) 15 Special Field 1 CM 5 Format <Age>^<Age Unit>

Element Max Length Format

Age 3 NM
Age Unit 1 ST

Element Description
Age Age of the Patient from whom the sample was collected.
Range 1-200
Age Unit Specify ‘Y’, ‘M’ or ‘D’. Indicates unit of the age. ‘Y’ is
the year, ‘M’ is the month, and ‘D’ is the day.
Table 11: Patient Information Record

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Test Order Record

cobas type (Upload)

O|1| 000663|6^50002^002^^S1^SC|^^^10^3|R||20050705093416
(1)(2) (3) (4) (5) (6) (7)
||||N||||1|||||||20050705095504|||F[CR]
(8) (9) (10) (11)
cobas type (Download)

O|1| 000663|6^50002^002^^S1^SC|^^^10^3|R||20050705093416
(1) (2) (3) (4) (5) (6) (7)
||||A||||1||||||||||O[CR]
(8) (9) (11)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘O’ fixed.
(2) 2 Sequence Number NM 6 Indicates sequence No. Normally it is ‘1’
Indicates the sequence number of the Test Order Record at the
current layer. This record is in the layer following the Patient
Information Record and is reset to 1 for each occurrence of a new
Patient Information Record. It is numbered consecutively; 1, 2, etc.,
for each occurrence of this record.
(3) 3 Specimen ID ST 13 Indicates sample No. (Sample ID.)
or For control sample, set name or lot No. of control on communication
22 setting screen.
Note:
In [Link]. mode, becomes patient comment
Control: Control name or Lot-Number

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Field Comments
No Field Type Max
No. cobas Type
(4) 4 Instrument CM 22 Indicates ordered sample. Setting is as follows:
Specimen ID < SequenceNo>^<Rack ID>^<PositionNo>^ ^
<SampleType>^<ContainerType>

<SequenceNo> Type: NM Max: 5

indicates cobas c 311 analyzer. internal sequence No.
Confirmation number when samples are numbered in sequence in
order of input. In case of QC material, ‘Control Number * 1000+
Sequence No. sample’ is used.
ex. Control No. = 1, Sequence No. = 2 is written as 1002
In ID mode, the number is reserved.
In S. No. mode, the range is 1 – 60000.
Control No. range is 1-100.
Control Seq. No. range is 1-150
<Rack ID> Type: ST Max: 5
indicates carrier No. (Disk/Rack.)
At the c311 analyzer, Rack ID contains two kinds of information:
Type of sample - 2 digits
20: Calibration
30: Control
40: STAT
50: Routine
+ Disk Position - 3 digits
Note
Because Host protocol and text field is same as cobas6000, Rack ID
field is used in cobas c 311 analyzer communication text
<PositionNo> Type: NM Max: 3
indicates position No. in carrier.
Values 001 ~ 110
<SampleType> Type: ST Max: 2
indicates sample type.
S1: Serum / Plasma
S2: Urine
S3: CSF
S4: Suprnt
S5: Others
QC: Control
<ContainerType> Type: ST Max: 7
indicates type of sample cup.
‘SC’: Standerd cup.
‘MC’:Micro cup.
no value Priority is given to the information inputted on the
instrument

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Field Comments
No Field Type Max
No. cobas Type
(5) 5 Universal Test ID CM 12 Indicates order. Repeats up to 100. Setting is as follows:
^^^<ApplicationCode>^<Dilution>\…
Repeat \ (delimiter) for multiple test selection.

<ApplicationCode> Type: NM Max: 5

indicates cobas c 311 analyzer Host Test No.
<Dilution> Type: ST or MN Max: 3
indicates automatic dilution factor.
None: not diluted.
(attach ‘^’ after User Test No. like ‘^^^10^’)
‘clr’, ‘Dec’, “Inc”, ‘3’, ‘5’, ‘10’, ‘20’, ‘50’

NOTE:
Dilution ‘3’, and ‘5’ cannot be selected for HbA1c full blood
because of the limitation of the sample volume.
(6) 6 Priority ST 1 Indicates priority of patient samples.
Not used for control samples.
‘R’: routine sample.
‘S’: stat sample.
7 Requested/Ordered Field does not contain data.
Date and Time
(7) 8 Specimen Collection TS 14 Indicates reception date and time of request. Setting is as follows.
Date and Time Deletable.
YYYYMMDDHHMMSS
9 Collection End Time Field does not contain data.
10 Collection Volume Field does not contain data.
11 Collector ID Field does not contain data.
(8) 12 Action Code ST 1 Indicates type of information to be reported.
‘N’: communication of patient sample result from analyzer. (Upload)
‘Q’: communication of control sample result from analyzer (Upload)
‘A’: test order form HOST. (Download)
‘C’: Transmit by the host, to cancel an order
13 Danger Code Field does not contain data.
14 Relevant Clinical Field does not contain data.
Information
15 Date/Time Specimen Field does not contain data.
Received
(9) 16 Specimen Descriptor NM 1 This field indicates the type of sample
Field Value Description
1 Serum/Plasma
2 Urine
3 CSF
4 Suprnt
5 Others
17 Ordering Physician Field does not contain data.
18 Physician's Telephone Field does not contain data.
Number
19 User Field No.1 Field does not contain data.
20 Users Field No.2 Field does not contain data.
21 Laboratory Field No.1 Field does not contain data.
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Field Comments
No Field Type Max
No. cobas Type
22 Laboratory Field No.2 Field does not contain data.
(10) 23 Date/Time Results TS 14 Indicates date and time when the measuring schedule for the sample
Reported or Last is decided internally.
Modified Setting from HOST is not applicable. Setting is as follows:
YYYYMMDDHHMMSS
24 Instrument Charge to Field does not contain data.
Computer System
25 Instrument Section ID Field does not contain data.
(11) 26 Report Types ST 1 Indicates type of communication.
‘O’: test order. (Download)
‘F’: communication of result. (Upload)
27 Reserved Field Field does not contain data.
28 Location or Ward of Field does not contain data.
Specimen Collection
29 Nosocomial Infection Field does not contain data.
Flag
30 Specimen Service Field does not contain data.
31 Specimen Institution Field does not contain data.
Table 12: Test Order Record

Note Specimen Descriptor of Instrument Specimen ID for cobas type prior to Sample
Type when they are mismatched.

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Comment Record, that follows the order record

(used for patient demographic data)

cobas type (Upload, Download)

C|1 |I |······························^HSP1·····················^····················^···············^··········|G [CR]

(1)(2)(3) (4) (5)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘C’ fixed.
(2) 2 Sequence Number NM 6 Indicates sequence No. Normally it is ‘1’
Record in the current layer. Since this record is in the layer following
the Test Request Record, it is reset to ‘1’ each time a new Test
Request Record is presented and then numbered consecutively; 1, 2,
etc
(3) 3 Comment Source ST 1 If comment is sent from Host, "L" is displayed. If comment is send
from analyzer, "I" is displayed.
(4) 4 Comment Text CM 104
Indicates comment for sample. It is possible to display it on the screen and edit it.
If there is no comment, ‘^^^^’ is needed to send using with no comment mode.
<Comment1>^<Comment2>^<Comment3>^Comment4>^<Comment5>
Element Max Length Format
Comment1 30 ST
Comment2 25 ST
Comment3 20 ST
Comment4 15 ST
Comment5 10 ST
Note: In the case of analyzer to host, each comment is a fixed length
string. If the length of the comment is less than the specified number,
the string must be right-filled with an adequate number of spaces.
Note :Only ASCII characters are allowed for Comment Text. Refer
to Apendix B ASCII Table.

(5) 5 Comment Type ST 1 “G” fixed.

Table 13: Comment Record (after order record)

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Result Record

cobas type (Upload)

R|1|^^^2/|8.60|nmol/L||N||F||BMSERV|20050912165312||P1[CR]
(1)(2) (3 (4) (5) (6) (7) (8) (9) (10)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘R’ fixed.
(2) 2 Sequence Number NM 6 Indicates sequence No.
Record in the current layer. Since this record is the layer that follows
the Test Request Record, it resets to 1 for each occurrence of a new
Test Request Record. It is numbered consecutively; 1, 2, etc., for
each occurrence of this record.
(3) 3 Universal Test ID CM 24 Indicates order.
^^^<ApplicationCode>/<Dilution>/<pre-dilution>/…

<ApplicationCode> Type: NM Max: 5

indicates cobas c 311 analyzer Host Test No.
The analyzer identifies the test with 3-digit numbers. Specify these
3-digit numbers.
The range of application code is expanded to 5-digit.
Photometrics: 1-910, ISEs: Na=989, K=990, Cl=991
Serum Index: L=992, H=993, I=994, Calculated Tests: 961-968
<Dilution> Type: ST Max: 3
Indicates automatic dilution factor when ordering.
Inc, Dec,3,5,10,20,50
When not specified, pipetting and testing is done using the standard
analysis parameters
(4) 4 Data or CM 13
Measurement Value Quantitative:
<measurement value>

Qualitative:
<qualitative value> ^< measurement value> or <qualitative value>
It depends on the setting in Host Communication Setting/Text
Setting screen.

<measurement value> Type:NM Max:6

6-digit measurement value or 6 spaces if no result (or data has
overflowed)

<qualitative value>
-2, -1, 0, 1, 2, 3 or 6 spaces if no result
In case that qualitative value is 0 and concentration is 8.60, example
is as follows.
Example : 0^8.60

See Table 15: Qualitative Analysis Transmission Data below for

qualitative
(5) 5 Units ST 6 Indicates unit name of measurement results.
6 Reference Ranges CM Field does not contain data.

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Field Comments
No Field Type Max
No. cobas Type
(6) 7 Result Abnormal ST 2 Indicates normal/abnormal of measurement results.
Flags ‘L’: less than normal range.
‘H’: more than normal range.
‘LL’: less than Technical Limit range.
‘HH’: more than Technical Limit range.
‘N’: Normal.
‘A’: Abnormal.
8 Nature of Field does not contain data.
Abnormality Testing
(7) 9 Result Status ST 1 Indicates the number of the test conducted for the analytical data.

‘F’: initial result.

‘C’: rerun result.
10 Date of Change in Field does not contain data.
Instrument
Normative Values
Units

(8) 11 Operator ST 6 Indicates operator ID who conducted measurement. HOST is not

Identification allowed to do setting.
(9) 12 Data/Time Test TS 14 Date and time corresponding the test was pipetted is designated by
Started YYYYMMDDHHMMSS.
This data is sent to the host only when an option of “Send Time
stamp of pipetting of Sample” is selected.
13 Date/Time Test TS 14 Field does not contain data.
Completed
(10) 14 Instrument ST 4 Indicates the ID of the analytical unit (module) that performed the
Identification analysis.
Module Description
P1 cobas c 311 analyzer Module
ISE1 ISE Test
Non Calculate Test or Not measured test
Table 14: Result Record

Note cobas Type transmits calculated tests.

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Qualitative result format for cobas c 311 analyzer tests can be activated
on the Utility/Application/Range screen.
Analytical Result Range Transmission Data
Analytical Result =< Qualitative Analysis Concentration 1 -2
Qualitative Analysis Concentration 1 < Analytical Result =< Qualitative Analysis Concentration 2 -1
Qualitative Analysis Concentration 2 < Analytical Result =< Qualitative Analysis Concentration 3 0
Qualitative Analysis Concentration 3 < Analytical Result =< Qualitative Analysis Concentration 4 1
Qualitative Analysis Concentration 4 < Analytical Result =< Qualitative Analysis Concentration 5 2
Qualitative Analysis Concentration 5 < Analytical Result 3
Table 15: Qualitative Analysis Transmission Data

Figure 10: Sent to Host screen

Note Communication of batch results is based on option of “with Review by Exception

Results” on [Send to Host] window shown below.
On: tests specified by Exception Alarm are communicated.
Off: tests specified by Exception Alarm are not communicated.

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Comment Record, that follows the result record (result data flag)

cobas type (Upload)

C|1|I|16|l[CR]
(1)(2)(3)(4)(5)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘C’ fixed.
(2) 2 Sequence Number NM 6 Indicates sequence No. Normally it is ‘1’
(3) 3 Comment Source ST 1 Comment is send from analyzer. "I" is displayed.
(4) 4 Comment Text NM 3
(5) 5 Comment Type ST 1 ‘I’ fixed.
Table 16: Comment Record (after result record)

Note Skip this record when no data alarm for measured value.
See Table 20: for data alarm No. and alarm message..

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Photometric Calibration Result Record

cobas type (Upload)

An example in case that Chemistry Test Calibration Results Detail mode is disabled.

M|1|PCR|BMSERV|^^^714|P1|||2782^2805^2839^2860^^\6119^6577^6134^6592^^|[CR ]
(1)(2)(3) (4) (5) (6) (7) (8) (9)

An example in case that Chemistry Test Calibration Results Detail mode

is enabled.
M|1|PCR|BMSERV|^^^714|P1|||2782^2805^2839^2860^^\6119^6577^6134^6592^^\
(1)(2)(3) (4) (5) (6) (7) (8) (9)
^^^^^\^^^^^\^^^^^\^^^^^|649252^^649252^|24615^^10363^|1|
(10) (11) (12)
18689700^16627800^^^^|20051016144610|[CR ]
(13) (14)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 ‘M’ fixed.
(2) 2 Sequence Number NM 6 This record appears as the next layer of the Message Header Record.
For one record, the field value is ‘1’; for specifying several, sequence
numbers starting from 1 are assigned
(3) 3 Record Type Sub ID ST 3 Use ‘PCR’.
(4) 4 Operator ID ST 6 ID of the operator who performed the calibration at the analyzer
(5) 5 Test Code CM 8 Format ^^^<Application Code>
Element Max Length Format
Application Code 5 NM
(6) 6 Module ID ST 4 Indicates the ID of the analytical unit (module) that performed the
analysis.
Module Description
P1 cobas c 311 analyzer Module
Non Calculate Test or Not measured test
(7) 7 Calibration Alarm NM 3 Calibration alarm.
(8) 8 SD Data Field NM 6 SD value data.

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Field Comments
No Field Type Max
No. cobas Type
(9) 9 STD Data CM 38 Repeat Field.
Repeated from STD1 to STD6 for as many as there are.
Format<Absorbance Data for the first time>^<First time for the first
one or the final absorbance data>^<Absorbance Data of the second
time>^<Second time for the first one or the final absorbance
data>^<Data Alarm>^<Prozone Value>
Detail specification is shown below;
Element Max Length Format
<Absorbance Data for the 6 NM
first time>
<First time for the first one 6 NM
or the final absorbance data>
<Absorbance Data of the 6 NM
second time>
<Second time for the first one 6 NM
or the final absorbance data>
<Data Alarm> 3 NM
(See Table 20: .)
<Prozone Value> 6 NM
.
(10) 10 Reagent lot number NM 8 R1 Reagent bottle sequence number
1 to 99999999
This data is sent to the host only when an option of “Chemistry Test
Calibration Results Detail” is selected.
(11) 11 Reagent bottle NM 5 R1 Reagent bottle sequence number
number 1 to 199999
This data is sent to the host only when an option of “Chemistry Test
Calibration Results Detail” is selected.
(12) 12 Expired Flag NM 1 Expired Flag
0:Calibration performed with “Not Expired Bottle”
1:Calibration performed with “Expired Bottle”
This data is sent to the host only when an option of “Chemistry Test
Calibration Result Detail” is selected.
(13) 13 Calibrator lot NM 8 1 to 99999999
number This data is sent to the host only when an option of “Chemistry Test
Calibration Result Detail” is selected.
(14) 14 Pipetting Date and ST 14 Date and time corresponded the calibrator was scheduled measuring
Time is designated by YYYYMMDDHHMMSS.
This data is sent to the host only when an option of “Chemistry Test
Calibration Result Detail” is selected.
le 17: Photometric Calibration Result Record

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ISE Calibration Result Record

cobas type (Upload)

M|1|ICR|adm···|ISE11||||^^^^^^^|^^^^^^^|^^^^^^^|-32.4^-35.1^-28.1
(1)(2)(3) (4) (5)(6)(7)(8)(9) (10) (11) (12)
^-32.2^56.0^134.2^135.2^-0. 7|-34.9^-46.3^-25.8^-33.7^55.7^4.8^5
(13)
.04^-0.06|121.4^125.8^118.4^121.9^-42.0^102.0^99.5^-3.7[ C R ]
(14)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 Use ‘M’.
(2) 2 Sequence Number NM 6 This record appears as the next layer of the Message Header Record.
The field value is ‘1’ for one record. To specify several records, a
sequence number starting from 1 is assigned.
(3) 3 Record Type Sub ID ST 3 Use ‘ICR’.
(4) 4 Operator ID ST 6 ID of the operator that performed the calibration at the analyzer.
(5) 5 Module ID ST 5 ISExy
x : Module Number (1 only)
y : Calibration Type
‘1’ : Type A , ‘2’ : Type B
(6) 6 Na Calibration NM 3 Na test calibration alarm.
Alarm
(7) 7 K Calibration Alarm NM 3 K test calibration alarm.
(8) 8 Cl Calibration NM 3 Cl test calibration alarm.
Alarm
(9) 9 Na Data Alarm CM 31 Na test data alarm.
<Internal standard solution electromotive force data alarm>^<Low
solution electromotive force data alarm>^<High solution
electromotive force data alarm>^<Calibrator solution electromotive
force data alarm>^<Slope for display data alarm>^<Internal standard
solution concentration data alarm>^<Calibrator solution
concentration data alarm>^<Numbers for compensation data alarm>
Detail specification is shown below:
Element Max Len Format
<Internal standard solution 3 NM
electromotive force data alarm>
<Low solution electromotive 3 NM
force data alarm>
<High solution electromotive 3 NM
force data alarm>
<Calibrator solution electromotive 3 NM
force data alarm>
<Slope for display data alarm> 3 NM
<Internal standard solution 3 NM
concentration data alarm>
<Calibrator solution concentration 3 NM
data alarm>
<Numbers for compensation data 3 NM
alarm>
(10) 10 K Data Alarm CM 31 K test data alarm. Refer to Na data alarm.

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Field Comments
No Field Type Max
No. cobas Type
(11) 11 Cl Data Alarm CM 31 CI test data alarm. Refer to Na data alarm.

(12) 12 Na Data CM 55 Na test calibration analytical data.

(All Elements: Max Length = 6, Type =NM)
<Internal standard solution electromotive force data>^<Low solution
electromotive force data>^<High solution electromotive force
data>^<Calibrator solution electromotive force data>^<Slope for
display data>^<Internal standard solution concentration
data>^<Calibrator solution concentration data>^<Numbers for
compensations data>
(13) 13 K Data CM 55 K test calibration analytical data. Refer to Na data.
(14) 14 Cl Data CM 55 Cl test calibration analytical data. Refer to Na data.
Table 18: ISE Calibration Result Record

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Photometric Absorbance Data Record

cobas type (Upload)

M|1|ABS|P1|1||10|50|0\1497\1499\1499|13140\12828\12760\12699
(1)(2) )(3)(4) (5) (6) (7) (8)
\12646\12605\12571\12545\12526\12504\12495\12481\12474\12472\124
65\12463\12459\12454\12453\12449\12448\12442\12594\12986\12993
\12992\12987\12987\12980\12982\12975\12973\12974\12970\12972\129
70\12969\12969\12965\12970\12966\12970\12971\12974\12972\12977\1
2976\12982[ C R ]
(9)

Field Comments
No Field Type Max
No. cobas Type
(1) 1 Record Type ID ST 1 Use ‘M’.
(2) 2 Sequence Number NM 6 This record appears as the next layer of the Message Header Record.
The field value is ‘1’ for one record. To specify several records,
sequence numbers starting from 1 are assigned.
(3) 3 Record Type Sub ID ST 3 Use ‘ABS’.
(4) 4 Module ID ST 4 ID of the analytical unit (module) the test belongs to. The ID gives
the first character of the module that performed the analysis.
Module Description
P1 cobas c 311 analyzer Module
ISE1 ISE Test
Non Calculate Test or Not measured test
(5) 5 Cell No NM 3 Number of the Reaction Cell.
Input value: 1-66
6 In Out Information NM 1 Field does not contain data.
(6) 7 Reaction Time NM 2 Reaction time (Unit: minutes). Input values 3 to 10.
(7) 8 Point Num NM 2 Reaction point number. Input values 1 to 57.
(8) 9 Cell Blank Data NM 6 Repeat field.
Cell blank absorbance. The difference between the main wavelength
and sub-wavelength absorbance data [(main wavelength absorbance
data) - (sub-wavelength absorbance data)] can be repeated up to
4 points.1st data is ‘0’ fixed.
(9) 10 Delta ABS Data NM 6 Repeat field.
The difference between the main wavelength and the sub-wavelength
absorbance data [(main wavelength absorbance data) - (sub-
wavelength absorbance data)] repeated up to the value indicated by
Point Num.
Table 19: Photometric Absorbance Data Record

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List of Result Data Flags ( Data Alarm List )

Alarm Alarm Result Photo- ISE Printer Screen Host

code Data * metry
no alarm 0
1 ADC abnormal X X ADC.E ADC.E 1
2 Cell blank abnormal X >Cuvet >Cuvet 2
3 Sample short SPACE* X X Samp.S Samp.S 3
4 Reagent short SPACE* X X Reag.S Reag.S 4
5 ABS over X >Abs >Abs 5
6 Prozone error X >Proz >Proz 6
7 Reaction limit over(all photometry points) X >React >React 7
8 Reaction limit over(second and subsequent photometry X >React >React 8
points)
9 Reaction limit over(third and fourth and subsequent X >React >React 9
photometry points)
10 Linearity abnormal(nine or more) X >Lin >Lin 10
11 Linearity abnormal(eight or less) X >Lin >Lin 11
12 Standard Solution 1 Absorbance Abnormal X S1A.E S1A.E 12
13 Duplicate Error X Dup.E Dup.E 13
14 STD Error X X Std.E Std.E 14
15 Sensitivity Error X Sens.E Sens.E 15
16 Calibration Error X X Cal.E Cal.E 16
17 Convergence Error X SD.E SD.E 17
18 Noise error X ISE.N ISE.N 18
19 Level error X ISE.E ISE.E 19
20 Slope Error X Slop.E Slop.E 20
21 ISE Slope Marginal X Prep.E Prep.E 21
22 Internal Concentration Abnormal X Istd.E IStd.E 22
23 Sample range over X <>Test <>Test 23
24 Data error in Compensate test X X CmpT.E CmpT.E 24
25 Unable to calculate compensate test SPACE X X CmpT.? CmpT.? 25
26 PANIC value over (upper) X X >Test >Test 26
27 PANIC value over (lower) X X <Test <Test 27
28 Random Error [R-4s] X X R4SD R4SD 28
29 System Error 1 [2-2sA] X X S2-2Sa S2-2Sa 29
30 System Error 2 [2-2sW] X X S2-2Sw S2-2Sw 30
31 System Error 3 [4-1sA] X X S4-1Sa S4-1Sa 31
32 System Error 4 [4-1sW] X X S4-1Sw S4-1Sw 32
33 System Error 5 [10xA] X X S10Xa S10Xa 33
34 System Error 6 [10xW] X X S10Xw S10Xw 34
35 QC Error 1 X X Q3SD Q3SD 35
36 QC Error 2 X X Q2.5SD Q2.5SD 36
37 Calculated test error X X ClcT.E ClcT.E 37
38 Overflow SPACE X X Over.E Over.E 38

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Alarm Alarm Result Photo- ISE Printer Screen Host

code Data * metry
39 Calculation not possible SPACE X X Calc.? Calc.? 39
40 Outside of expected value(upper) X X H n.a.
41 Outside of expected value(lower) X X L n.a.
42 Edited test X X Edited Edited 42
43 Calibration result abnormal SPACE* X X Cal.E Cal.E 43
44 Repeat limit over(upper) X X >Rept >Rept 44
45 Repeat limit over(lower) X X <Rept <Rept 45
46 ABS maximum over SPACE X Samp.? Samp.? 46
51 Response Error 1 X Rsp1.E Rsp1.E 51
52 Response Error 2 X Rsp2.E Rsp2.E 52
53 Conditioning Error X Cond.E Cond.E 53
55 ISE Range over X >ISE >ISE 55
56 Kinetic unstable (Prozone error 2) X >Kin >Kin 56
57 Serum index 1 interference X X >Index >Index 57
58 Serum index multiple interference X X >Index >Index 58
59 Mixing abnormal X X Mix.E Mix.E 59
60 Drop in ultrasonic output X X <Mix <Mix 60
71 Detergent short X Det.S Det.S 71
72 Sample Clot SPACE X Samp.C Samp.C 72
101 Expired reagent X ReagEx ReagEx 101
Table 20: List of Result Data Flags

*Result Data In case a column of “Result Data” is blank, result is output as value.
In case a column of “Result Data” is “SPACE”, result is output as space.
In case a column of “Result Data” is “SPACE*”, it is dependent on a case whether a result
is output as a value or it is output as a space.

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Communication trace 5

21. Test Selection Information in Real Time................................................................ 54

22. Real Time Test Results .................................................................................................. 55

23. Batch Test Selection Information ............................................................................. 56

Roche/Hitachi cobas c 311 analyzer

Test Selection Information in Real Time

The following trace is shown without:

• Start ([STX][FN]),
• End ([CR][EXT][CS1[CS2][CR][LF]],
• and response from each receiver ([ENQ][ACK][EOT]).

HOST is required to send Sequence No, Rack ID, and Position asked by
cobas c 311 analyzer.
Sequence No communicated from cobas c 311 analyzer may not be sequential number
depending on cobas c 311 analyzer status. As they are different from on-line sample
No. (work sheet operation), Sequence No is not allowed to be on-lined for key
information.

cobas c 311 analyzer sends inquiry for sample ID=000002, sequence

No.=3 and Position=2.
Rack ID is with Position and Sample Type.

H|\^&|||cobas c 311^1|||||host|TSREQ^REAL|P|1[CR]
Q|1|^^ 000002^3^50002^002^^S1^SC||ALL||||||||O[CR]
L|1|N[CR]
HOST replies test selection information of sample ID=000002.
H|\^&|||host^1|||||cobas c 311|TSDWN^REPLY|P|1[CR]
P| 1 [ C R ]
O |1| 00 00 0 2|3^ 5 000 2^0 02^ ^S1 ^S C| ^^^ 10^ |R
||||| |A || ||1| |||| ||| ||O [ C R ]
L|1|N[CR]
cobas c 311 analyzer sends inquiry for sequence No.=3, Position=2, and
no sample ID.
H|\^&|||cobas c 311^1|||||host|TSREQ^REAL|P|1[CR]
Q |1|^ ^ ^3^50 0 02 ^002 ^^ S1^ S C||A LL |||| |||| O [ C R ]
L|1|N[CR]

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Real Time Test Results

(1) When the result value is cobas c 311 analyzer sends test result of sample ID=000004, sequence No.=40, and
within normal range. Position=5.
H|\^&|||cobas c 311^1|||||host|RSUPL^REAL|P|1[CR]
P|1 [ C R ]
O |1| 0 00 00 4 |4 0^5 00 05 ^00 5^^ S1^ S C|^ ^^10 ^\^^^ 30^3 \^^^4 0^|
R |||| || N ||| |1| |||| ||20 0512 20095 504| ||F [ C R ]

C|1 |I | ^
^ ^ ^ |G [ C R ]
R |1|^ ^^1 0/ |1. 25| ul U/ m l|| N||F || ad m in ||| P1 [ C R ]
C|1 |I |0 | I [ C R ]
R |2|^ ^^3 0/ 2|0 .0 91 |u g/ dL| |N| |F || ad m i n||| P 1 [ C R ]
C|1 |I |0 | I [ C R ]
R |3|^ ^^4 0/ in c| 1.1 7|n g / mL || N||F || ad m in| || P1 [ C R ]
C|1 |I |0 | I [ C R ]
L|1|N[CR]

(2) When the result value is less cobas c 311 analyzer sends a test result of sample ID=000002, sequence No.=3, and
than normal range. Position=2.
H|\^&|||cobas c 311^1|||||host|RSUPL^REAL|P|1[CR]
P|1 [ C R ]
O |1| 000 002 |3^50 002 ^002 ^^ S1^ S C| ^^^ 10^| R ||| ||| N|| ||1 || |||||
20051 22 01 0 44 1 8|||F [ C R ]
R |1|^ ^^1 0/ |0. 163| m l U/ m l|| L||F || ad m in| || P1 [ CR ]
C|1 |I |45| I[ C R ]
L|1|N[CR]

(3) When the result value is a cobas c 311 analyzer sends a test result of sample ID=000010, sequence No.=442, and
qualitative test. Position=1.
H|\^&|||cobas c 311^1|||||host|RSUPL^REAL|P|1[CR]
P|1 [ C R ]
O |1| 0 00 01 0 |4 42 ^ 5 0 00 1^0 01^ ^S1 ^S C| ^^^6 72^ |R || ||||
N||| |1| |||| ||
20051 22 01 0 44 1 8|||F [ C R ]
R |1|^ ^^4 00 /| -1 ^0 .3 0 3| u mo l / l|| N||F || ad m in ||| P 1 [ C R ]
C|1 |I |4 5| I [ CR ]
L|1|N[CR]

(4) When it is a control sample.

H|\^&|||cobas c 311^1|||||host|RSUPL^REAL|P|1[CR]
P|1 [ C R ]
O |1| 1 7222 2 00 |1 00 9 6^ 3008 5^08 5^ ^Q C ^S C |^^ ^672 ^|| |||| | Q |||| 1
||||| ||20 0512 2 01 0 44 1 8|| |F [ CR ] C |1| I|^ ^
^^|G [ CR ]R |1 |^^ ^10 /| 1.26| ul U / m L|| L||F || ad m i n||| P 1[ CR ]
C|1 |I |45 |I[CR]
L|1|N[CR]

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Batch Test Selection Information

Download test selection information of sample ID=000051 from HOST.

H|\^&|||host^1|||||cobas c 311|TSDWN^BATCH|P|1[CR]
P|1 [ C R ]
O |1| 00 0 05 1 |^^^ ^S 1^S C |^^ ^10 ^/ ^^^3 0^
3/^ ^^4 0^|R ||| |||A | ||| 1
||||| |||| |O [ C R ]
C|1 |I | ^
^ ^ ^ |G [ C R ]
L|1|N[CR]

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Appendix 6

24. Appendix A: Instrument Alarms................................................................................ 58

25. Appendix B: ASCII Table .............................................................................................. 70

Roche/Hitachi cobas c 311 analyzer

Appendix A: Instrument Alarms

Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
110 001 Abnormal Receiving Abnormal Text has been received from a. Check the host computer. Is it ON?
Text from Host Host. b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
111 002 Abnormal TS from No response for the inquiry within a set a. Check the host computer. Is it ON?
Host time in GUI: [Utility]-[System]-[Host b. Verify Host Communication on Start Conditions.
Communication].
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
Resume operation; if alarm recurs, call Technical Support.
111 003 Abnormal TS from No response for the inquiry within 10 a. Check the host computer. Is it ON?
Host minutes. b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
111 005 Abnormal TS from Application code requested by the host is a. Check the host computer. Is it ON?
Host not registered in the analyzer; or b. Verify Host Communication on Start Conditions.
received application code other than
Photometric test, ISE test or serum index c. Check cable connections between the analyzer and host computer.
test. d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
111 007 Abnormal TS from Received request for increased or a. Check the host computer. Is it ON?
Host decreased quantity for other than Sample b. Verify Host Communication on Start Conditions.
Type 2 (Urine) of ISE test.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
111 008 Abnormal TS from Received request for ISE test is wrong. a. Check the host computer. Is it ON?
Host b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
Resume operation; if alarm recurs, call Technical Support.
111 009 Abnormal TS from Received request for serum index test is a. Check the host computer. Is it ON?
Host wrong. b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
111 010 Abnormal TS from Received comment even though the a. Check the host computer. Is it ON?
Host mode was set for no transmission of b. Verify Host Communication on Start Conditions.
comments.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
112 002 Abnormal Automatic No response for the inquiry within a set a. Check the host computer. Is it ON?
Rerun TS from Host time in GUI: [Utility]-[System]-[Host b. Verify Host Communication on Start Conditions.
Communication].
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.

59
Roche/Hitachi cobas c 311 analyzer

Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
112 003 Abnormal Automatic No response for the inquiry within 10 a. Check the host computer. Is it ON?
Rerun TS from Host minutes. b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
112 005 Abnormal Automatic Application code requested by the host is a. Check the host computer. Is it ON?
Rerun TS from Host not registered in the analyzer; or b. Verify Host Communication on Start Conditions.
received application code other than
Photometric test, ISE test or serum index c. Check cable connections between the analyzer and host computer.
test. d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
112 007 Abnormal Automatic Received request for increased or a. Check the host computer. Is it ON?
Rerun TS from Host decreased quantity for other than Sample b. Verify Host Communication on Start Conditions.
Type 2 (Urine) of ISE test.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
112 008 Abnormal Automatic Received request for ISE test is wrong. a. Check the host computer. Is it ON?
Rerun TS from Host Received request for other than pair of b. Verify Host Communication on Start Conditions.
Na, K or Na, K, Cl for ISE test.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
112 009 Abnormal Automatic Received request for serum index test is a. Check the host computer. Is it ON?
Rerun TS from Host wrong. Received request for increased or b. Verify Host Communication on Start Conditions.
decreased quantity.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
112 010 Abnormal Automatic Received comment even though the a. Check the host computer. Is it ON?
Rerun TS from Host mode was set for no transmission of b. Verify Host Communication on Start Conditions.
comments.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 001 Host Communication The analyzer failed to open session. a. Check the host computer. Is it ON?
Error b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 004 Host Communication When analyzer has sent <ENQ> but Host a. Check the host computer. Is it ON?
Error sent <NAK>. Analyzer stop b. Verify Host Communication on Start Conditions.
transmission.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 005 Host Communication When analyzer has sent <ENQ>, but host a. Check the host computer. Is it ON?
Error did not send <ACK> nor <NAK>. (Link b. Verify Host Communication on Start Conditions.
Time Out)
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 006 Host Communication When analyzer has sent <STX> with text a. Check the host computer. Is it ON?
Error frame, but host sent <NAK>. Analyzer b. Verify Host Communication on Start Conditions.
sent again.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.

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Roche/Hitachi cobas c 311 analyzer

Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
126 007 Host Communication When analyzer has sent <STX> with text a. Check the host computer. Is it ON?
Error frame, but host did not send <ACK> or b. Verify Host Communication on Start Conditions.
<NAK>. (Receiving time out) 15
Seconds c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 008 Host Communication Re-transmission has gone over the limit a. Check the host computer. Is it ON?
Error (6 times). b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 009 Host Communication When analyzer has sent <ENQ> as a. Check the host computer. Is it ON?
Error transmission request, host sent <ENQ> b. Verify Host Communication on Start Conditions.
as transmission request (Link
Contention). c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
Resume operation; if alarm recurs, call Technical Support.
126 011 Host Communication When the analyzer has received <ACK> a. Check the host computer. Is it ON?
Error or <NAK> as a reception request from b. Verify Host Communication on Start Conditions.
the host and has become ready for
reception, but the host did not transmit c. Check cable connections between the analyzer and host computer.
<STX> nor <EOT> in 30 sec. d. Check the host computer transmit condition.
(Reception Timeout). e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 012 Host Communication Analyzer received reception request a. Check the host computer. Is it ON?
Error from host, but not in condition to b. Verify Host Communication on Start Conditions.
receive.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
126 016 Host Communication Buffer Over Flow a. Check the host computer. Is it ON?
Error Over Flow occurred in the receiving b. Verify Host Communication on Start Conditions.
buffer during message receiving. c. Check cable connections between the analyzer and host computer.
Communication stopped between d. Check the host computer transmit condition.
analyzer and host.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 017 Host Communication Retry Over in Error message receiving a. Check the host computer. Is it ON?
Error When the analyzer received incorrect b. Verify Host Communication on Start Conditions.
message and sent <NAK> to host. c. Check cable connections between the analyzer and host computer.
Analyzer retried this process more than
12 times (Upper Retry Limit). d. Check the host computer transmit condition.
Communication stopped between e. Ensure that the host and the analyzer are utilizing the same communication configuration.
analyzer and host. f. Resume operation; if alarm recurs, call Technical Support.
126 018 Host Communication Undefined Error is detected in MBSI a. Check the host computer. Is it ON?
Error b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 019 Host Communication Although ‘7 Bit’ format is selected in a. Check the host communication setting in Utility/System/Host Setting screen.
Error Utility/System/Host Setting screen, b. Verify the characters sent to the host.
transmitted data contain the character
that can only be represented in '8 bit' c. Resume operation; if alarm recurs, call Technical Support.
format. The character is converted into
‘#’ in 7 bit code.
126 020 Host Communication Automatic recovery of connection a. Check the host computer. Is it ON?
Error between host and the analyzer occurs 5 b. Verify Host Communication on Start Conditions.
times consecutively. Host
communication has stopped. c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
126 021 Host Communication No valid Record. a. Check the host computer. Is it ON?
Error b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 022 Host Communication First Record is not a Header Record. a. Check the host computer. Is it ON?
Error b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 023 Host Communication Undefined Record. a. Check the host computer. Is it ON?
Error b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 024 Host Communication Data other than specified. a. Check the host computer. Is it ON?
Error b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.
126 025 Host Communication Data other than specified. a. Check the host computer. Is it ON?
Error b. Verify Host Communication on Start Conditions.
c. Check cable connections between the analyzer and host computer.
d. Check the host computer transmit condition.
e. Ensure that the host and the analyzer are utilizing the same communication configuration.
f. Resume operation; if alarm recurs, call Technical Support.

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
340 1 Host Receiving Text A field pause of L record is insufficient. Please check L record.
Error
340 2 Host Receiving Text There is no record end of L record. Please check whether '<CR>' (0x0d) is in the terminus of L record.
Error
340 3 Host Receiving Text Termination Code of L record is not Please check Termination Code of L record.
Error effective value.
340 4 Host Receiving Text There is no record end of P record. Please check whether '<CR>' (0x0d) is in the terminus of P record.
Error
340 7 Host Receiving Text A field pause of O record is insufficient. Please check O record.
Error
340 8 Host Receiving Text Sequence Number of O record is not Please check Sequence Number of O record.
Error effective value.
340 18 Host Receiving Text There is no record end of O record. Please check whether '<CR>' (0x0d) is in the terminus of O record.
Error
340 19 Host Receiving Text Report Type is not effective value. Please check Report Type.
Error
340 20 Host Receiving Text A field pause of Q record is insufficient. Please check Q record.
Error
340 21 Host Receiving Text Sequence Number of Q record is not Please check Sequence Number of Q record.
Error effective value.
340 22 Host Receiving Text Starting Range ID Number is not Please check Starting Range ID Number.
Error effective value.
340 23 Host Receiving Text There is no record end of Q record. Please check whether '<CR>' (0x0d) is in the terminus of Q record.
Error
340 24 Host Receiving Text Request Information Status Code is not Please check Request Information Status.
Error effective value.
340 25 Host Receiving Text Specimen ID is not effective value. Please check Specimen ID.
Error
340 26 Host Receiving Text Sample No. is not effective value. Please check Sample No.
Error
340 28 Host Receiving Text Sample Type is not effective value. Please check Sample Type.
Error

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
340 30 Host Receiving Text Rack Position No. is not effective value. Please check Rack Position No.
Error
340 31 Host Receiving Text A component pause of Universal Test ID Please check Universal Test ID.
Error is insufficient.
340 32 Host Receiving Text Action Code & Value is not effective Please check Action Code & Value.
Error value.
340 33 Host Receiving Text A component pause of User Field No. 2 Please check User Field No. 2.
Error is insufficient.
340 34 Host Receiving Text Instrument Specimen ID is not effective Please check Instrument Specimen ID.
Error value.
340 35 Host Receiving Text A component pause of Comment or Please check Comment or Special Instructions.
Error Special Instructions.
340 36 Host Receiving Text Comment or Special Instructions is not Please check Comment or Special Instructions.
Error effective value.
340 37 Host Receiving Text A field pause of H record is insufficient. Please check H record.
Error
340 38 Host Receiving Text Comment or Special Instructions is not Please check Comment or Special Instructions.
Error effective value.
340 39 Host Receiving Text There is no record end of H record. Please check whether '<CR>' (0x0d) is in the terminus of H record.
Error
340 40 Host Receiving Text A field pause of P record is insufficient. Please check P record.
Error
340 41 Host Receiving Text Sequence Number of P record is not Please check Sequence Number of P record.
Error effective value.
340 44 Host Receiving Text There is no record end of P record. Please check whether '<CR>' (0x0d) is in the terminus of P record.
Error
340 45 Host Receiving Text Application Code is not effective value. Please check Application Code.
Error
340 47 Host Receiving Text A field pause of O record is insufficient. Please check O record.
Error
340 48 Host Receiving Text Sequence Number of O record is not Please check Sequence Number of O record.
Error effective value.

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
340 50 Host Receiving Text Instrument Specimen ID is not effective Please check Instrument Specimen ID.
Error value.
340 57 Host Receiving Text There is no record end of O record. Please check whether '<CR>' (0x0d) is in the terminus of O record.
Error
340 59 Host Receiving Text Sample ID is not effective value. Please check Sample ID.
Error
340 60 Host Receiving Text Sample No. is not effective value. Please check Sample No.
Error
340 62 Host Receiving Text Rack Position is not effective value. Please check Rack Position.
Error
340 63 Host Receiving Text A field pause of Q record is insufficient. Please check Q record.
Error
340 64 Host Receiving Text Sequence Number of Q record is not Please check Sequence Number of Q record.
Error effective value.
340 65 Host Receiving Text Specimen ID is not effective value. Please check Specimen ID.
Error
340 67 Host Receiving Text There is no record end of Q record. Please check whether '<CR>' (0x0d) is in the terminus of Q record.
Error
340 68 Host Receiving Text A field pause of C record is insufficient. Please check C record.
Error
340 69 Host Receiving Text Sequence Number of C record is not Please check Sequence Number of C record.
Error effective value.
340 73 Host Receiving Text There is no record end of C record. Please check whether '<CR>' (0x0d) is in the terminus of C record.
Error
340 101 Host Receiving Text Sample No. is outside the range. Please check Sample No.
Error
340 102 Host Receiving Text Class is outside the range. Please check Class.
Error
340 104 Host Receiving Text Cup Position is outside the range. Please check Cup Position.
Error
340 105 Host Receiving Text First run/rerun is not specified. Please confirm whether to be the First run or rerun.
Error

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
340 106 Host Receiving Text Application Code is outside the range. Please check Application Code.
Error
340 107 Host Receiving Text Sample Volume is outside the range. Please check Sample Volume.
Error
340 108 Host Receiving Text Draw Time (Year) is outside the range. Please check Draw Time (Year).
Error
340 109 Host Receiving Text Draw Time (Month) is outside the range. Please check Draw Time (Month).
Error
340 110 Host Receiving Text Draw Time (Day) is outside the range. Please check Draw Time (Day).
Error
340 111 Host Receiving Text Draw Time (Hour) is outside the range. Please check Draw Time (Hour).
Error
340 112 Host Receiving Text Draw Time (Min) is outside the range. Please check Draw Time (Min).
Error
340 113 Host Receiving Text Draw Time (Second) is outside the Please check Draw Time (Second).
Error range.
340 114 Host Receiving Text Age is outside the range. Please check Age.
Error
340 115 Host Receiving Text Age Unit is outside the range. Please check Age Unit.
Error
340 116 Host Receiving Text Sex is outside the range. Please check Sex.
Error
340 117 Host Receiving Text Cup size is outside the range. Please check Cup size.
Error
340 118 Host Receiving Text Sample ID is outside the range. Please check Sample ID.
Error
340 120 Host Receiving Text The number of TS exceeds the number Please check number of TS.
Error of the regulations.
340 121 Host Receiving Text Sample ID is not effective value. Please check Sample ID.
Error
340 122 Host Receiving Text Dilution Rate is outside the range. Please check Dilution Rate.
Error

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Alarm Alarm Alarm Message Alarm Description Alarm Remedy

Type No
340 123 Host Receiving Text Sample Type is not Routine or Stat. Please check Sample Type.
Error
340 124 Host Receiving Text Sample ID is outside the range. Please check Sample ID.
Error
340 133 Host Receiving Text Application Code is not effective value. Please check Application Code.
Error
340 134 Host Receiving Text Dilution Rate is outside the range. Please check Dilution Rate.
Error
341 XX App. Code An application code is not convertible at Please check whether the application code for HOST is set up correctly.
Conversion Error. (To the time of HOST communication. *
HOST) Subcode ”XX” indicates the application
code in [Utility]-[Application] screen.
342 1 App. Code An application code is not convertible at Please check whether the application code for HOST is set up correctly.
Conversion Error. the time of HOST communication.
(From HOST)
Table 21: Instrument Alarms

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Roche/Hitachi cobas c 311 analyzer

Appendix B: ASCII Table

Control Characters

Binary Dec Hex Abbreviation Description

0000 0000 0 00 NUL Null character

0000 0001 1 01 SOH Start of Header
0000 0010 2 02 STX Start of Text
0000 0011 3 03 ETX End of Text
0000 0100 4 04 EOT End of Transmission
0000 0101 5 05 ENQ Enquiry
0000 0110 6 06 ACK Acknowledgment
0000 0111 7 07 BEL Bell
0000 1000 8 08 BS Backspace
0000 1001 9 09 HT Horizontal Tab
0000 1010 10 0A LF Line feed
0000 1011 11 0B VT Vertical Tab
0000 1100 12 0C FF Form feed
0000 1101 13 0D CR Carriage return
0000 1110 14 0E SO Shift Out
0000 1111 15 0F SI Shift In
0001 0000 16 10 DLE Data Link Escape
0001 0001 17 11 DC1 Device Control 1
0001 0010 18 12 DC2 Device Control 2
0001 0011 19 13 DC3 Device Control 3
0001 0100 20 14 DC4 Device Control 4
0001 0101 21 15 NAK Negative Acknowledgement
0001 0110 22 16 SYN Synchronous Idle
0001 0111 23 17 ETB End of Trans. Block
0001 1000 24 18 CAN Cancel
0001 1001 25 19 EM End of Medium
0001 1010 26 1A SUB Substitute
0001 1011 27 1B ESC Escape
0001 1100 28 1C FS File Separator
0001 1101 29 1D GS Group Separator
0001 1110 30 1E RS Record Separator
0001 1111 31 1F US Unit Separator
0111 1111 127 7F DEL Delete
Table 22: Control Characters

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Printable Characters
Binary Dec Hex Char Binary Dec Hex Char Binary Dec Hex Char
0010 0000 32 20 blank 0100 0000 64 40 @ 0110 0000 96 60 `
0010 0001 33 21 ! 0100 0001 65 41 A 0110 0001 97 61 a
0010 0010 34 22 " 0100 0010 66 42 B 0110 0010 98 62 b
0010 0011 35 23 # 0100 0011 67 43 C 0110 0011 99 63 c
0010 0100 36 24 $ 0100 0100 68 44 D 0110 0100 100 64 d
0010 0101 37 25 % 0100 0101 69 45 E 0110 0101 101 65 e
0010 0110 38 26 & 0100 0110 70 46 F 0110 0110 102 66 f
0010 0111 39 27 ' 0100 0111 71 47 G 0110 0111 103 67 g
0010 1000 40 28 ( 0100 1000 72 48 H 0110 1000 104 68 h
0010 1001 41 29 ) 0100 1001 73 49 I 0110 1001 105 69 i
0010 1010 42 2A * 0100 1010 74 4A J 0110 1010 106 6A j
0010 1011 43 2B + 0100 1011 75 4B K 0110 1011 107 6B k
0010 1100 44 2C , 0100 1100 76 4C L 0110 1100 108 6C l
0010 1101 45 2D - 0100 1101 77 4D M 0110 1101 109 6D m
0010 1110 46 2E . 0100 1110 78 4E N 0110 1110 110 6E n
0010 1111 47 2F / 0100 1111 79 4F O 0110 1111 111 6F o
0011 0000 48 30 0 0101 0000 80 50 P 0111 0000 112 70 p
0011 0001 49 31 1 0101 0001 81 51 Q 0111 0001 113 71 q
0011 0010 50 32 2 0101 0010 82 52 R 0111 0010 114 72 r
0011 0011 51 33 3 0101 0011 83 53 S 0111 0011 115 73 s
0011 0100 52 34 4 0101 0100 84 54 T 0111 0100 116 74 t
0011 0101 53 35 5 0101 0101 85 55 U 0111 0101 117 75 u
0011 0110 54 36 6 0101 0110 86 56 V 0111 0110 118 76 v
0011 0111 55 37 7 0101 0111 87 57 W 0111 0111 119 77 w
0011 1000 56 38 8 0101 1000 88 58 X 0111 1000 120 78 x
0011 1001 57 39 9 0101 1001 89 59 Y 0111 1001 121 79 y
0011 1010 58 3A : 0101 1010 90 5A Z 0111 1010 122 7A z
0011 1011 59 3B ; 0101 1011 91 5B [ 0111 1011 123 7B {
0011 1100 60 3C < 0101 1100 92 5C \ 0111 1100 124 7C |
0011 1101 61 3D = 0101 1101 93 5D ] 0111 1101 125 7D }
0011 1110 62 3E > 0101 1110 94 5E ^ 0111 1110 126 7E ~
0011 1111 63 3F ? 0101 1111 95 5F _
Table 23: Printable Characters

71