FATIMA JINNAH DENTAL COLLEGE

PREPROFF PHARMACOLOGY 2019

1) A patient is brought to the emergency department due to the drug overdose which of the following
route of administration is the most desirable for administering the antidote for drug overdose
a) Intramuscular injection
b) Intravenous injection
c) Subcutaneous injection
d) Intradermal injection
2) Which of the following phase II metabolic reactions makes phase 1 metabolites readily excretable in
urine?
a) Oxidation
b) Reduction
c) Glucuronidation
d) Hydrolysis
3) A patient was recently diagnosed with infection involving methicillin resistant S.aureus. He receives
2000mg of vancomycin as an IV loading dose. A loading dose is

ANS:- A drug is administered to achieve the desired plasma level rapidly.

4) Which of the following terms best define a drug that binds to the alpha adrenergic receptor has no
intrinsic activity and cannot be displaced by epinephrine

ANS:- Irreversible antagonist

5) A woman is diagnosed with urinary tract infection started a therapy with trimethoprim and
sulfamethoxazole combination. Both trimethoprim and sulfamethoxazole are bacteriostatic drugs.
When given alone however a bactericidal effect is obtained. When two drugs are given in
combination which of the following term best define the drug interaction

ANS:- Potentiation

6) The drug receptor complex initiates alteration in biochemical or molecular activity of a cell by a
process called
a) Amplification
b) Transcription
c) Signal transduction
d) Translation
7) A 32 years old patient receives 50mg of atenolol. The plasma level of drug was 1.25mg/L. Calculate
the volume of distribution

ANS:- 40L

8) A 55 year old female is going to be treated with tetracycline through IV route. If the clearance of the
drug is 6.2ml/min and the desired steady state plasma concentration is 2.5mg/ml. Dose of drug
ANS:- 15.5

9) If the usual dose of penicillin is 1000mg for adults in treating the dental infections. What could be
the dose for 10 years old girl whose weight is 35 pounds

ANS:- 233.3

10) Which of the following characteristics is most likely to be associated with a high apparent volume of
distribution

ANS:- Penetration into tissue protein

11) The therapeutic dose range for candesartan is 4-32mg as compared to 75-300mg for irbesartan. The
therapeutic preparation of those drugs reflect their

ANS:- Potency

12) A child with severe asthma is being treated with high doses of corticosteroids. What type of receptor
of corticosteroids binds to

ANS:- Intracellular

13) A 60 year old female patient started on an antihypertensive medication terazosin. Terazosin is a
a) Competitive agonist at alpha-1 adrenoreceptors
b) Competitive antagonist at alpha-1 adrenoreceptors
c) Noncompetitive agonist at alpha-1 adrenoreceptors
d) Noncompetitive antagonist at alpha-1 adrenoreceptors

14) The volume of distribution of gentamicin a highly polar water soluble drug is 14L/70kg. This reflects
the distribution of gentamicin into

ANS:- Tissue fluid

15) Which of the following is systemic effect of muscarinic agonist

a) Decreased heart rate & cardiac output
b) Decrease bronchial secretion
c) Increase blood pressure
d) Mydriasis

16) Chronic long term therapy for myasthenia gravis is usually accomplished by
a) Edrophonium
b) Neostigmine
c) Echothiophate
d) Carbachol
17) During an ophthalamic surgery procedure, the surgeon wanted to dilate the pupil of a patient using
a mydraitic drug. Most likely which of the following drug he used?
a) Acetylcholine
b) Pilocarpine
c) Phentolamine
 d) Tropicamide
18) A patient was administered a neuromuscular blocker prior to surgical procedure to produce a
skeletal muscle paralysis. The effect of this drug was easily reversed with neostigmine. Which of the
following neuromuscular blockers was most likely administered to this patient?
a) Rocuronium
b) Succinylcholine
c) Diazepam
d) Tubocurarine
19) A patient is required a rapid endotracheal intubation during the induction of anesthesia. Which of
the following agent is the best choice for this patient

ANS:- Succinycholine

20) Which of the following are long term β-agonist that are β-2 selective
a) Albuterol
b) Mirabegron
c) Salmeterol
d) Terabutaline

21) Which of the following sympathomimetic is used in therapy of bronchial asthma

a) Dobutamine
b) Formeterol
c) Methoxamine
d) Norepinephrine

22) A female patient in her third trimester of pregnancy visited to her gynaecologist for her regular
checkup. On examination her blood pressure was found 160/100mmHg. Which of the following drug
can be given to this patient
a) Prazosin
b) Labetolol
c) Atenolol
d) Propranolol
23) A female patient started on a new antihypertensive medications recently. Her blood pressure seems
to be under control. But she complains of fatigue, drowsiness and fainting when she gets up from
the bed(Orthostatic hypotension). Which of the following drug is she most likely taking?
a) Metoprolol
b) Propranolol
c) Prazosin
d) Clonidine
24) Which of the following non selective β-blocker is used to reduce intraocular pressure to treat open
angle glaucoma

ANS:- Timolol

25) Which of the following β-adrenergic receptor antagonist also block alpha receptors

ANS:- Carvedilol
26) Which of the following β-blockers has partial agonist activity

ANS:- Acebutolol

27) Which of the following antidepressant is least likely to be prescribed to a patient with prostatic
hypertrophy, glaucoma, coronary and cerebrovascular disease
a) Amitriptyline
b) Paroxetine
c) Buproprion
d) Fluoxetine
28) Which of the following antidepressant is selective serotonic receptor reuptake inhibitor
a) Amitriptyline
b) Fluoxitine
c) Maprotiline
d) Phenelzine

29) Which of the following antiparkinson’s drug has also been used to treat hyperprolactinemia

ANS:- Bromocriptine

30) Which of the following antiparkinson’s drug is an antiviral drug used in the prophylaxis of influenza
A-2 receptor
a) Selegiline
b) Sinemet
c) Pergolige
d) Amantadine
31) Which of the following antipsychotic drug is typical

ANS:- Thiothixene

32) Which of the following antipsychotic has been shown to be a partial agonist at a dopamine D-2
receptor
a) Aripiprazole
b) Clozapine
c) Haloperidol
d) Risperidone
33) Which of the following drug will be given in absence seizure
a) Ethosuximide
b) Carbamazepine
c) Diazepam
d) Carbamazepine plus primidone
34) Which of the following is a first line medication for generalized tonic clonic seizures?
a) Ethosuximide
b) Felbamate
c) Vigabatrin
d) Topiramte
35) Which of the following agent has a rapid anxiolytic effect and would be best for acute management
of anxiety
a) Buspirone
b) Venlafaxine
c) Lorazepam
d) Escitalopram
36) A patient visits his dentist for his wisdom tooth extraction. The oral surgeon uses an agent that has
good analgesic and sedative property but doesn’t cause skeletal muscle relaxation. Which agent has
these ideal property
a) Halothane
b) Isoflurane
c) Enflurane
d) Nitrousoxide
37) An old patient with asthma and low blood pressure require anesthesia for an emergency surgical
procedure. Which of the following agent would be most appropriate for inducing anesthesia in this
patient?
a) Desflurane
b) Ketamine
c) Propofol
d) Thiopental
38) A 20 year old patient seens an otolaryangologist with complains of recurrent sinusitis. The surgeon
decided to perform sinus surgery to depride the scarred sinus tissue. Which of the following agent
would surgeon like to use having good local anesthetic as well as vasoconstrictive properties
a) Cocaine
b) Procaine
c) Tetracaine
d) Lidocaine
39) Which of the following local anesthesia is more likely to cause allergic reactions
a) Bupivacaine
b) Lidocaine
c) Procaine
d) Rupivacaine

40) A 25 year old pregnant women who is near term decides to have a day delivery under the spinal
anesthesia. Past history of the patient include an anaphylactic reaction 3 years ago apparently due
to sun screen cream apparently due to para-amino benzoicacid. Which of the following local
anesthetic would be appropriate for this patient.

ANS:- Lidocaine

41) Which opioid drug when combine with local anesthetics provide epidural analgesia for labor

ANS:- Fentanyl

42) Which of the following opioid analgesic is a partial (mu)µ-receptor agonist

ANS:- Buprenorphine
43) Which of the following is a short acting hypnotic and better for sleeping induction compared to
sleep maintainance

ANS:- Zoliplon

44) A 62 year old patient with a history of asthma and vasospastic angina states that he gets chest pain
both with exertion and at rest about 10 minutes and ten times per week. One sublingual
nitroglycerin tablet always releaves his symptoms. But this medications gives him an awful headache
everytime he takes it. Which is the best option for improving his angina
a) Change to sublingual nitroglycerin spray
b) Add amlodipine
c) Add propranolol
d) Replace nitroglycerin with ranolazine

45) A 60 year old women is prescribed to take nitrates each day for his condition. As a competent doctor
you know the result of nitrate administration
a) Decreased myocardial oxygen demand
b) Increased myocardial oxygen demand
c) Increased left ventricular end diastolic volume
d) Increased atrial pressure
46) Which of the following is class 1C antiarythmic drug
a) Flecainide
b) Lidocaine
c) Sotalol
d) Verapamil

47) A 74 year old female patient was admitted to hospital with shortness of breath and ankle edema.
She has no chest pain and has been stable for outpatient treatment. Which of the following is the
best recommendation for her

ANS:- Loop diuretic

48) A 54 year old women has a myocardial infarction. Which of the following would be the appropriate
prophylactic antiarythmic pharmacotherapy

ANS:- Metoprolol

49) A patient presents to the emergency department with an extreme headache. After a thorough
workup, the attending physician concludes that the pain is due to increased intracranial pressure.
Which diuretic would work best to reduce this pressure?
a) Azetazolamide
b) Furosemide
c) Hydrochlorothiazide
d) Mannitol
50) A 55 year old male with kidney stone has been placed on a diuretic to decrease calcium excretion.
However after few weeks he develops an attack of gout. Which diuretic was he taking?
a) Furosemide
 b) Hydrochlorothiazide
c) Spironolactone
d) Triamterene
e) Urea
51) Select the diuretic that can cause gynaecomastia, hirsuitism and menstrual disturbances with long
term use
a) Amiloride
b) Spironolactone
c) Metolazone
d) Acetazolamide
52) The therapeutic indication of dorzolamide is

ANS:- Open angle glaucoma

53) Choose the group of antihypertensive drugs which diminishes the metabolism of bradykinin
a) α-blocker
b) Angiotensin converting enzyme inhibitor
c) Diuretics
d) Ganglion blocker

54) Which of the following agent can precipitate a hypertensive crisis following abrupt cessation therapy
a) Clonidine
b) Diltiazem
c) Enalapril
d) Losartan
55) A 58 year old female reports that she recently stopped taking her blood pressure medications
because of swelling in her feet that began shortly after she started treatment. Which is most likely
to cause peripheral edema?
a) Atenolol
b) Clonidine
c) Felodipine
d) Hydralazine
56) A 56 year old female is discovered to have megaloblastic anemia. Her past medical history is
significant for alcoholism. Which of the following would be the best treatment option for this
patient?
a) Oral folate
b) Oral vitamin B12
c) Oral vitamin B12 with Oral folate
d) Parenteral vitamin B12

57) A 60 year old female presents to her primary care physician complaining of dizziness and fatigue.
Following laboratory testing, the patient is diagnosed with iron deficiency anemia, and oral iron
supplementation is needed. Which of the following would be the most appropriate dosing regimen
for the patient?
a) Ferrous fumarate 325mg once daily
 b) Ferrous gluconate 256mg once daily
c) Polysaccharide-iron complex 150mg two to three times daily
d) Ferrous sulfate 325mg two to three times daily

58) Which must heparin bind to in order to exert its anticoagulant effect?
a) GP IIb/IIIa receptor
b) Thrombin
c) Antithrombin III
d) Von willebrand factor
59) Which of the following drug most likely to block ADP receptors and prevent platelet aggregation

ANS:- Clopidogrel

60) Which of the following drugs binds bile acids in the intestine, thus preventing their return to the
liver via the enterohepatic circulation?
a) Niacin
b) Fenofibrate
c) Cholestyramine
d) Fluvastatin
61) Which of the following drug is fibrinolytic

ANS:- Streptokinase

62) Highly selective cox-2 inhibitor or anti-inflammatory drugs with fewer side effects compared to non-
selective cox-inhibitor Aspirin. What other effects do Cox-2 inhibitor lack in contrast to aspirin

ANS:- Antiplatelet

63) Which of the following agent is an antidote for acetaminophen overdose

ANS:- N-acetylcysteine

64) A drug that has an analgesic and antipyretic effect but is not anti-inflammatory can cause potentially
fetal hepatotoxicity over a short period of time

ANS:- Acetaminophen

65) Which of the following is the most appropriate drug for the treatment of oropharyngeal candiadis

ANS:- Nystatin

66) Which of the following is the most appropriate drug for the treatment of onchomycoses of toe

ANS:- Terbinafine

67) A 35 year old black women has been on primary therapy for acute pulmonary tuberculosis for the
past two months, She complains of a pins and needle sensation in a feet. Which of the following
vitamin she might be deficient of?
a) Ascorbic acid
b) Niacin
c) Pyridoxine
 d) Folic acid
68) A routine mentoux test for a 23 year old male Pakistani citizen was found to be a strongly positive.
Further investigations were done and his sputum was found to contain acid fast bacilli and
mycobacterium tuberculosis subsequently cultured. A diagnosis of pulmonary tuberculosis was
made. What is the 1st line treatment for the patient
a) Amikacin, Kenamycin, Ciprofloxacin.
b) Ethionamide, Para-amino salicyclic acid, sephalocirine.
c) Isoniazid, Rifampicin, Ethambutol, Pyrazinamide.
d) Levofloxacin, Capreomicin, Rifabutin

69) Which of the following antituberculosis drug is discontinued to prevent liver toxicity after first 2
months of treatment because of its early occurring clinical benefits during the six month regimen

ANS:- Pyrazinamide

70) What is true regarding antiviral

a) Abacavir is a protease inhibitor
b) Nevirapine is nucleoside reverse transcriptase inhibitor
c) NRTI require intra cyclo plasmic activation to the triphosphate form
d) Zidovudine is a nonnucleoside reverse transcriptase inhibitor

71) Which drug reduces the chances of transmission of HIV to an unborn fetus during pregnancy
a) Didanosine
b) Interferon-α
c) Saquinavir
d) Zidovudine

72) Which of the following drug is used tropically for post genital herpes infection

ANS:- Acyclovir

73) Which of the following anticancer drug is a microtubular inhibitor

ANS:- Docetaxel

74) Which of the following drug produces anticancer effect during the S-phase of the cell cycle

ANS:- Methotrexate

75) A 25 year old female was complaining of persistent headache, fever, bodyache and fatigue since two
weeks. It was misdiagnosed as common flue. On examination swollen lymph nodes were noted.
Serologic test confirm toxoplasmosis. Which drug should be used to test this patient
a) Sulfadiazine + Pyrimethamine
b) Levofloxacin
c) Ampillicin + Sulbactam
d) Trimethoprim
76) The best CSF penetration of the β-lactam containing antibiotic is achieved by which of the following
drug
ANS:- Ceftriaxone

77) What is the drug of choice for community acquired pneumococcal pneumonia
a) Levofloxacin
b) Ciprofloxacin
c) Norfloxacin
d) Sulfonamides
78) A man is treated for typical pneumonia due to legionella pneumophila with erythromycin.
Administrations of large IV doses of this agent are typically associated with which adverse effect
a) Myalgia and arthralgia
b) Ototoxicity
c) Thrombocytopenia
d) Aplastic Anemia
79) A 25 year old male patient comes to dental clinic with severe pain and swelling on the right side of
the face. Radiographic examination show periapical abscess and pulpal involvement. For starting
root canal treatment which drug will be given as he is allergic to penicillin

ANS:- Doxycycline

80) Which of the following drug binds with 30s subunit and interfere with assembly of functional
ribosomal apparatus and cause the 30s subunit of completed ribosomes to misread the genetic code

ANS:- Gentamicin

81) Which of the following drug is used to treat rocky mountain spotted fever

ANS:- Tetracycline

82) Which of the following drug should be added along with estrogen therapy for reducing the post
menopausal endometrial carcinoma

ANS:- Progesterone

83) A 46 years old male presented to ER with complain of vertigo and increase urination on examination
his blood reports reveals blood glucose level 400mg/dl. Which of the following treatment will be
done to treat this emergency?
a) Regular insulin
b) NPH
c) Metformin
d) Insulin glargine
84) Which drug will be recommended for hyperthyroidism in 1st trimester of pregnancy to treat
hyperthyroidism

ANS:- PTU

85) Which of the following drug are effective in blunting the widespread sympathetic stimulation that
occurs in hyperthyroidism

ANS:- Propranolol
86) Which serum is associated with increase risk of deep vein thrombosis and retinal vein thrombosis

ANS:- Raloxifen

87) A 50 year old female visited her physician with complain of increase apetite and leg cramp. She had
fasting blood glucose value of 160mg/dl HPA1c reveals that she is suffering from diabetes. Which of
the following is most appropriate initial oral hypoglycemic agent for the treatment of type II
diabetes with no other comorbid condition
a) Glipizide
b) Insulin
c) Metformin
d) Pioglitazone
88) Which of the following drug is appropriate to be used for the treatment of emesis as well as
gastropherisis

ANS:- Metoclopramide

89) Which of the following antiemetic drugs selectively blocks the 5-HT3 receptor in the periphery and
in the brain

ANS:- Ondansetron

90) Extra pyramidal symptoms has been associated with which of the following drugs?
a) Metoclopramide
b) Alprazolam
c) Aprepitant
d) Loperamide
91) A 62 years old male with history of MI taking warfarin and calcium channel blockers for prophylaxis.
But from last few weeks he complains of heart burn. Which of the following drug should be avoided
to treat GERD?
a) Cimitidine
b) Methylsubsalicylate
c) Famotidine
d) Omeprazole
92) Which of the following antitussive drug has expectorant property
a) Benzonatate
b) Codeine
c) Dextromethoprim
d) Guanfenacin

93) Which of the following drug is a non-prescription opioid agonist and used to treat diarrhea

ANS:- Loperamide

94) A 37 years old man presented with complains of severe pain in abdomen with burning sensation.
Pain occurs when his stomach is empty and relief after food or antacid. Laboratory test shows
H.pylori. What is the most likely treatment combination for this patient
ANS:- PPI+Metronidazole+Penicillin+Tetracycline

95) Which of the following antacid lead to metabolic alkalosis if used in higher doses
a) Al(OH)3
b) CaCO3
c) Mg(OH)3
d) NaHCO3
96) Which of the following drug binds to Hydrogen/Potassium ATPase enzyme system and suppress the
secretion of gastric acid

ANS:- PPIs(Omeprazole)

97) A 12 year old girl had severe asthma attack thrice in two days for which she took SABA. She needed
a therapy which reduce the frequency of these severe attacks. Which of the following therapy is
most likely responsible for this benefit
a) Inhaled ipratropium
b) Inhaled fluticasone
c) Theophyline
d) Cromolyn
98) Which of the following drug will be appropriate to treat SSI induce bronchospasm

ANS:- Albuterol

99) Which of the following drug have narrow therapeutic window with both bronchodilator and anti-
inflammatory effect

ANS:- Theophyline