ROCHELLE CONFESOR
BSN2 BARNARD
DRUG TABULATION
DRUG NAME CONTENT CLASS AND INDICATION CONTRA SIDE EFFECT NURSING
MECHANISM OF INDICATION (Per System) CONSIDERATION
ACTION
BRAND NAME: Oxytocin Oxytocin plays a vital role in Administration of exogenous • Contraindicated in patients CNS: subarachnoid Alert: All patients receiving
Pitocin labour and delivery. The oxytocin is indicated in the hypersensitive to drug. hemorrhage, seizures, oxytocin
GENERIC NAME: hormone is produced in the antepartum period to initiate • Contraindicated when vaginal coma. CV: arrhythmias, IV must be under continuous
oxytocin hypothalamus and is secreted or improve uterine delivery isn't advised (placenta HTN, PVCs, observation by trained
CLASSIFICATION: from the paraventricular contractions for vaginal previa, vasa previa, invasive hypotension, personnel who have a thorough
Oxytocin is a nucleus to the posterior delivery in situations where cervical carcinoma, genital tachycardia. Gl: knowledge of the drug and are
recombinant hormone pituitary where it is stored. It is there is fetal or maternal herpes), when cephalopelvic nausea, vomiting. GU: qualified to identify
used to induce or then released in pulses during concern. For example, it may disproportion is present, or when abruptio placentae, complications.
strengthen uterine childbirth to induce uterine be used to induce labor in delivery requires conversion, as in tetanic uterine © Alert: Discontinue oxytocin
contractions in contractions. cases of Rh sensitization, transverse lie. contractions, infusion immediately if uterine
pregnant women to maternal diabetes, • Contraindicated in fetal distress postpartum hyperactivity or fetal distress
aid in labor and The concentration of oxytocin preeclampsia at or near term, when delivery isn't imminent, in hemorrhage, uterine occurs. Administer oxygen to
delivery or to control receptors on the myometrium and when delivery is prematurity, in other obstetric rupture, impaired the mother.
postpartum bleeding. increases significantly during indicated due to prematurely emergencies, and in patients with uterine blood flow, Mother and fetus must be
pregnancy and reaches a peak ruptured severe toxemia or hypertonic pelvic hematoma, evaluated by the responsible
DOSAGE : in early labor. membranes. Importantly, uterine patterns. increased uterine physician.
To induce or oxytocin is not approved or • Use cautiously, if at all, in motility. Hematologic: • Drug is used to induce or
stimulate labor Activation of oxytocin indicated for elective patients with invasive cervical afibrinogenemia, reinforce labor only when pelvis
Adults: Initially, 0.5 receptors on the myometrium induction of labor. Oxytocin cancer and in those with previous possibly related to is known to be adequate, when
to 1 milliunit/minute triggers a downstream cascade may be used to reinforce cervical or uterine surgery postpartum bleeding, vaginal delivery is indicated,
IV infusion that leads to increased labor in select cases of (including cesarean section), pelvic hematoma. when feal maturity is assured,
intracellular calcium in uterine uterine inertia and as grand multiparty, leine. sepsis, Ocher: anaphylaxis, and when fetal position is
To reduce myofibrils which strengthens adjunctive therapy in the traumatic delivery, or over death from oxytocin- favorable. Use drug only in
postpartum bleeding and increases the frequency of management of incomplete distends induced water hospital where critical care
after expulsion of uterine contractions. or inevitable abortion. In the uterus. intoxication, facilities and prescriber are
placenta postpartum period, oxytocin • Alert: May cause antidiuretic hypersensitivity immediately available.
In humans, most hormones are
Adults: 10 to 40 units regulated by negative may be used to induced effect and risk of severe water reactions. • Monitor fluid intake and
IV infused at rate feedback; however, oxytocin is contractions in the 3rd stage intoxication, seizures, a death, Fetal output. Antidiuretic effect may
needed to sustain one of the few that is regulated of labor and to control particularly with large doses or CNS infant brain lead to fluid overload, seizures,
uterine contraction by positive feedback. The head postpartum bleeding or when given by slow infusion over damage, seizures. and coma from water
and uterine atony. of the fetus pushing on the hemorrhage. 24 hours and it patient is CV: bradycardia, intoxication.
cervix signals the release of receiving fluids by mouth. arrhythmias, PVCs.
Incomplete, oxytocin from the posterior Dialyzable drug: Unknown. EENT: neonatal retinal Monitor and record uterine
inevitable, or elective pituitary of the mother. & Overdose S&S: Uterine hemorrhage. contractions, HR, BP,
abortion Adults: 10 Oxytocin then travels to the hypersensitivity, tumultuous Hepatic: neonatal intrauterine pressure, fetal HR,
units IV infusion at 10 uterus where it stimulates labor, uterine rupture, cervical jaundice. Other: low and character of blood loss at
to 20 milliunits (20 to uterine contractions. The and vaginal lacerations, Apgar scores at 5 least every 15 minutes.
40 drops)/minute. elicited uterine contractions postpartum hemorrhage, minutes, death.
will then stimulate the release uteroplacental hypoperfusion,
ROUTE: of increasing amounts of vanabe, deceleration of fetal HR,
IV INFUSION oxytocin. This positive fetal hypoxia, hypercapnia,
feedback loop will continue perinatal hepatic necrosis, water
until parturition. intoxication, seizures, death.
Since exogenously
administered and
endogenously secreted
oxytocin result in the same
effects on the female
reproductive system, synthetic
oxytocin may be used in
specific instances during the
antepartum and postpartum
period to induce or improve
uterine contractions.
