Seat No.: _____ Enrolment No.
_____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 8 EXAMINATION – SUMMER-2024
Subject Code:BP801TT Date: 29/04/2024
Subject Name: Biostatistics and Research Methodology
Time: 10.30 a.m. to 1.30 p.m. Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Explain correlation. Discuss different types of correlation in detail. 06
(b) For the following tablet weights: 100, 98, 101, 94, 104, 102, 108, 108, calculate (a) the 05
mean, (b) the median, (c) the mode
(c) Define the terms: Range, Median, Frequency distribution, Variance 05
Q.2 (a) Define Probability. Explain normal distribution giving example. 06
(b) Compare and contrast: (i) Type-I Error & Type-II Error (ii) Null & Alternative 05
hypothesis
(c) Write a note on sampling. 05
Q.3 (a) What are non-parametric tests? Explain Wilcoxon Rank Sum Test in detail. 06
(b) Discuss giving reasons the need for designing an experiment. 05
(c) Define plagiarism. Discuss different types of plagiarism giving examples. 05
Q.4 (a) Discuss step-wise Hypothesis testing procedure in Multiple regression models. What 06
do you understand by multiple regression?
(b) Write the significance of Blocking and confounding for variables in Two-level 05
factorials?
(c) Enlist different software used in biostatistics. Write a note on any one software with its 05
features and applications.
Q.5 (a) Write advantages of factorial experimental designs over traditional one factor at a time 06
experimental designs. State the differences between 2-level and 3-level experimental
design.
(b) Describe central composite design considering a formulation development of oral solid 05
dosage form.
(c) Discuss statistical optimization techniques for development of a pharmaceutical 05
product.
Q. 6 (a) Describe least square method for simple regression analysis. 06
(b) What is t-test with reference to hypothesis testing? Under which conditions we apply 05
Unpaired and Paired t-test?
(c) Explain ANOVA as hypothesis testing method. Write the difference between one-way 05
and two-way ANOVA.
Q.7 (a) Discuss “Shape” as distribution of data values with schematic illustrations (diagram) 06
of different shapes.
(b) How can we visualize data using different graphs/charts? Discuss different types of 05
graphs/charts for different types of data.
(c) Enlist different sections of a research report. Describe any three sections of a research 05
report giving suitable example of your practice school report.