SAFETY DATA SHEET Version 6.

7
Revision Date 08/06/2024
Print Date 08/07/2024

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Phenylacetic acid
Product Number : P16621
Brand : Aldrich
CAS-No. : 103-82-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Synthesis of substances

Uses advised against : The product is being supplied under the TSCA R&D Exemption
(40 CFR Section 720.36). It is the recipient’s responsibility to
comply with the requirements of the R&D exemption. The
product may not be used for a non-exempt commercial purpose
under TSCA unless appropriate consent is granted in writing by
MilliporeSigma.
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Inc.
3050 SPRUCE ST
ST. LOUIS MO 63103
UNITED STATES
Telephone : +1 314 771-5765
Fax : +1 800 325-5052
1.4 Emergency telephone
Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-
527-3887 CHEMTREC (International) 24
Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Eye irritation (Category 2A), H319
Short-term (acute) aquatic hazard (Category 3), H402
For the full text of the H-Statements mentioned in this Section, see Section 16.

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2.2 GHS Label elements, including precautionary statements
Pictogram

Signal Word Warning

Hazard Statements
H319 Causes serious eye irritation.
H402 Harmful to aquatic life.
Precautionary Statements
P264 Wash skin thoroughly after handling.
P273 Avoid release to the environment.
P280 Wear eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P501 Dispose of contents/ container to an approved waste disposal
plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS

Stench.

SECTION 3: Composition/information on ingredients

3.1 Substances
Synonyms : Benzeneacetic acid
α-Tolylic acid
PAA

Formula : C8H8O2
Molecular weight : 136.15 g/mol
CAS-No. : 103-82-2
EC-No. : 203-148-6
Component Classification Concentration
phenylacetic acid
Eye Irrit. 2A; Aquatic <= 100 %
Acute 3; H319, H402

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
No data available

Aldrich - P16621
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operates as MilliporeSigma in the US and Canada
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
No data available
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
5.3 Advice for firefighters
No data available
5.4 Further information
No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
For personal protection see section 8.
6.2 Environmental precautions
No data available
6.3 Methods and materials for containment and cleaning up
No data available
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
No data available
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

Aldrich - P16621
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SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
Personal protective equipment
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN 16523-1 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN 16523-1 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L

Control of environmental exposure

Prevent product from entering drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: crystalline
Color: beige
b) Odor Stench.
c) Odor Threshold No data available
d) pH No data available
e) Melting Melting point/ range: 76 - 78 °C (169 - 172 °F)
point/freezing point
f) Initial boiling point 265 °C 509 °F - lit.
and boiling range

Aldrich - P16621
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 g) Flash point 132 °C (270 °F) - closed cup - closed cup
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower No data available
flammability or
explosive limits
k) Vapor pressure 1 hPa at 97 °C (207 °F)
l) Vapor density No data available
m) Density 1.081 g/cm3 at 25 °C (77 °F) - lit.
Relative density No data available
n) Water solubility ca.15 g/l
o) Partition coefficient: log Pow: 1.37 - 1.43
n-octanol/water
p) Autoignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity No data available
s) Explosive properties Not classified as explosive.
t) Oxidizing properties none
9.2 Other safety information
Solubility in other Ethanol - soluble
solvents

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
No data available
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents
Strong bases
strong reducing agents

10.4 Conditions to avoid

No data available

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10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - > 5,000 mg/kg
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and
gastrointestinal tract.
Remarks: (IUCLID)
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of
respiratory tract
Inhalation: Irritating to respiratory system.
LD50 Dermal - Rabbit - > 5,000 mg/kg
Remarks: (RTECS)
Skin corrosion/irritation
Skin - Guinea pig
Result: No skin irritation - 24 h
Remarks: (ECHA)
Serious eye damage/eye irritation
Eyes - In vitro study
Result: Causes serious eye irritation. - 6 h
(OECD Test Guideline 492)
Eyes - Rabbit
Result: Moderate eye irritation - 24 h
(Draize Test)
Respiratory or skin sensitization
Open epicutaneous test - Guinea pig
Result: negative
Remarks: (ECHA)
Germ cell mutagenicity
No data available
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
NTP: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is
on OSHA’s list of regulated carcinogens.
Reproductive toxicity
No data available

Aldrich - P16621
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The life science business of Merck KGaA, Darmstadt, Germany

operates as MilliporeSigma in the US and Canada
 Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
RTECS: AJ2430000
Nausea, Dizziness, Headache, To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.

Handle in accordance with good industrial hygiene and safety practice.

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 52.5 mg/l - 48 h
and other aquatic (OECD Test Guideline 202)
invertebrates
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - 177
mg/l - 7 Days
Remarks: (ECHA)

Toxicity to bacteria static test EC50 - Pseudomonas putida - 223 mg/l - 16 h

Remarks: (ECHA)

12.2 Persistence and degradability

Biodegradability Result: 57.81 % - Inherently biodegradable.
(OECD Test Guideline 301D)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not
conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
Discharge into the environment must be avoided.

Aldrich - P16621
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The life science business of Merck KGaA, Darmstadt, Germany

operates as MilliporeSigma in the US and Canada
SECTION 13: Disposal considerations
13.1 Waste treatment methods
No data available

SECTION 14: Transport information

DOT (US)
Not dangerous goods

IMDG
Not dangerous goods

IATA
UN number: 3335 Class: 9 Packing group: III
Proper shipping name: Aviation regulated solid, n.o.s. (phenylacetic acid)

SECTION 15: Regulatory information

CERCLA Reportable Quantity
This material does not contain any components with a CERCLA RQ.
SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.
SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.
SARA 311/312 : Acute Health Hazard
Hazards

SARA 313 : This material does not contain any chemical

components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by
SARA Title III, Section 313.

US State Regulations
Massachusetts Right To Know
No components are subject to the Massachusetts Right to Know Act.
Maine Chemicals of High Concern
Product does not contain any listed chemicals
Vermont Chemicals of High Concern
Aldrich - P16621
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The life science business of Merck KGaA, Darmstadt, Germany

operates as MilliporeSigma in the US and Canada
 Product does not contain any listed chemicals
Washington Chemicals of High Concern
Product does not contain any listed chemicals
The ingredients of this product are reported in the following inventories:
TSCA : All substances listed as active on the TSCA inventory

TSCA list
No substances are subject to a Significant New Use Rule.

No substances are subject to TSCA 12(b) export notification requirements.

SECTION 16: Other information

The branding on the header and/or footer of this document may temporarily not visually
match the product purchased as we transition our branding. However, all of the
information in the document regarding the product remains unchanged and matches the
product ordered. For further information please contact [email protected].
Version: 6.7 Revision Date: 08/06/2024 Print Date: 08/07/2024

Aldrich - P16621
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The life science business of Merck KGaA, Darmstadt, Germany

operates as MilliporeSigma in the US and Canada