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 Detection Using Principle Component Analysis And Case...
Splice site detection using principle component analysis and case based reasoning with support
vector machine

Srabanti Maji*1 and Haripada Bhunia2

1 Computer Science Department

2 Department of Chemical Engineering

*Address Correspondence to this author at

E mail address: [email protected], [email protected]

ABSTRACT

Identification of coding region from genomic DNA sequence is the foremost step ... Show more
content on Helpwriting.net ...
feature selection; and the final stage, in which a support vector machine (SVM) with Polynomial
kernel is used for final classification. In comparison with other methods, the proposed SpliceCombo
model outperforms other prediction models as the prediction accuracies are 97.25% sensitivity,
97.46% Specificity for donor splice site and 96.51% Sensitivity, 94.48% Specificity for acceptor
splice site prediction.

Keywords: Gene Identification, Splicing Site, Principal Component Analysis (PCA); Cased Based
Reasoning (CBR); Support Vector Machine(SVM)
*Correspondence to Srabanti Maji,
E mail address: [email protected], [email protected]
Tel: +91 9356006454
Splice site detection using principle component analysis and case based reasoning with support
vector machine

1.INTRODUCTION

Research in the genome sequencing technology have been creating an enormous amount of genomic
sequencing data as its main objective is gene identification. In the eukaryotes, the prediction of a
coding region depends upon the exon intron structures recognition. Whereas its very challenging to
predict exon intron structure in sequence due to its complexity of structure and vast length. Research
analysis on the human genome have nearly 20,000 25,000 protein coding genes [1]. Still, there are
nearly 100,000 genes in human genome. Which indicates a huge number of genes are still
unidentified [2,3]. Most of the computational techniques
 Reflection Paper About Stress
For this week s essay I had the ability to learn about stress and the different categories that people
can fall into. People who experience stress more are categorized as type A people why people who
are less prone to these stresses are categorized as type B people. After talking the quiz I learned that I
scored a 267. This places me in the low type A range. This was little bit of a surprise to me because I
don t consider myself to be an over stressed person. I then thought about what causes me stressand
possible ways of being able to change my life style to help lessen the stress I experience. In this
essay I am going to share about what some of my major stresses are, how I reduce stress and finally
I will share a time when I was more of a type A person than a type B person.

When it comes to what stresses me in life it is the normal things at many college students
experience. I often find myself worrying about my grades and if I am doing well in school. One
major thing that I often find myself stressing over is if I am on track to graduate in a decent
amount of time. I understand that college is not something that can be finished over night but I
always want to make sure that I am moving at a decent pace to ensure that I wont be here for ever.
To help reduce this stress I often check my degree audit report to ensure I am on track. Another
way I cope with this concern is by making sure I talk with my advisors when it comes time to make
my schedule for the next semester. I
 In Opposition of Eugenics and Human Embryo Research
In Opposition of Eugenics and Human Embryo Research

There are a variety of views of eugenics and all that it entails. The definition of eugenics is the
science of improving the physical and mental qualities of human beings through control of the
factors influencing heredity, ( Funk and Wagnall s, 1984). Others think eugenics is the social control
of human genetic evolution, an ideology of racism and genocide, thought to improve society and halt
disease while others think only of the Nazi Regime (Saetz, 1985 and McGee, 1997). Eugenics has a
long and tumultous past but with the mapping of the human genome and research on human
embryos, where will eugenics lead the wolrd in the near future?

There are two main practices of ... Show more content on Helpwriting.net ...
The purpose of eugencis is to interefere with human reproduction, take out those people who are
biologically undesirable and multiply those who are desirable. In my opinion, from the past history
of eugenics, I feel the practice of eugenics is completely discriminatory and in the practice to rid
disease from our genes in the near future, only the rich will benefit, and those with money will find
ways of enhancing their children in any way they want to be taller, thinner, with blonde hair...the
possibilities are endless!

In 1932, the US had approved compulsory sterilization laws in 26 32 states (Davis, 1981). Those
sterilized were people in mental institutions, criminals, the feeble minded, and many women of
color who went into hospitals for, say, a heart surgery and woke up to find that they could no
longer have children (Davis, 1981). This is obviously discrimination and I am afraid of the direction
the human race will take with the advanced knowledge of the human genome and how to mainpulate
it. With reserach on human embryos and the mapping of the human genome, I realize the benefits
many people may have by ridding disease from their unborn children, curing infertility and many
other things, but what kind of regulation would there be especially if all the research would be
privately funded, due to the government not allowing this research? Parents could make the perfect
child, pick the sex of their children; the choices are
 Disney Princess Drawing Research Paper
I always knew I wanted to be artist ever since I was that little girl with an overactive imagination. If
my Grandma only knew, that one Disney princess drawing book would influence me so much. I still
remember feeling those crisps papers and staring at those colorful drawings for hours.The detailed
directions of creating these beautiful princess open something inside of me. My Grandma buying
that drawingbook that day, inspired me to draw. The coloring book wasn t enough to satisfy this
urge of creativity. Soon the world become my model as began to realize the tiny details that were
hidden that other kids seem unable to draw. All I wanted to do after that simple magical moment
was draw for a career and do something with this talent. That s
 Jack The Ripper Research Paper Outline
Paragraph 1:
Hook: all careful teachers have first to show the student how to recognize accurately the case. The
recognition depends in great measure on the accurate and rapid appreciation of small points in which
the diseased differs from the healthy state. In fact, the student must be taught to observe..... (Bell,
The Chronicles of Sir Arthur Conan Doyle. )
Background: Jack the Ripper is a notorious serial killer whose identity was never revealed. His
murders took place in between the years 1888 1891 in a city called Whitechapel near London where
he killed at least five people. Jack the Ripper was known for killing people in so many different
gruesome ways.
Thesis: We believe that Jack the Ripper was either an anti Semitic German, a doctor ... Show more
content on Helpwriting.net ...
Evidence: During his last murder Jack the Ripper wrote, The Juwes are not the men to be blamed for
nothing (BBC historic figures).
Explanation: This means that Jack the Ripper had something against the Jews.
Evidence: During the time of the murders there was a huge German population immigrating to
England at the time and anti Semitism was growing in Germany. During the 19th century, European
migrants came to the United Kingdom for a variety of reasons (BBC British History).
Explanation: Jack the Ripper could have come from Germany with an anti Semitic belief.
Wrap up: For these reasons we suspect Jack the Ripper was an anti Semitic German. Paragraph 3:
Topic sentence: Jack the Ripper was a doctor gone crazy.
Evidence: ...the mutilations that occurred, which showed a knowledge of human anatomy... (BBC
historic figures).
Explanation: This shows that he was trained to know how to kill people or how the body worked
which would make him a doctor.
Evidence: He always killed in unusual ways. All the woman that were murdered were...horribly
mutilated (BBC historic figures).
Explanation: This also goes to show that he was a crazy man to kill them in strange
 Advantages And Disadvantages Of A Single Leaf Swing Door...
Door plays an important area for the building as it allow access and egress from buildings and
between rooms, compartments and corridors. The two examples can be found in block 34 which is
the single hung single leaf swing door and the automatic sliding door at the library, refer to figure
7.1 and 7.2 of the picture in appendices respectively.

The single hung single leaf swing door that is located at block 34 of Ngee Ann Polytechnic are
supported on hinges as side hung and on track as folding doors. The single hung single leaf swing
door is the most commonly used between rooms and corridors. The advantages of having a single
swing door is that they are very strong and stable, making it easier for maintenance. In addition
they have weather proof qualities which allows it to possess an anti rust quality. However, the
short back of having a single hung single leaf swing wall are it is inflexible as compared to a
double swing door, as it can only be open from one way. It also cause inconvenient to the users as
they have to open the door manually. Although it is weather resistance, they are prone to water stain
due to its material used. Furthermore, they took up larger amount of space as compared to other
door options.

The next example is the automatic door that can be found at ... Show more content on
Helpwriting.net ...
The window have a lower emissivity, causing it to allow lesser sunlight to pass through the room.
Similarly, the non see through window also have double glazed and a protective layers around it,
causing it to have the same advantages of a see through window. Apart from this, it provides people
with the privacy that they need as from the outside view, the people are unable to view the activities
that is happening in the room. With air gap in between the two glass, it prevent too much heat from
penetrating into the building which helps to reduce any energy wastage that is needed for air
condition to
 Analysis Of Santiago Calatrava s Concerning The...
Rebecca McKenney
Introduction to Humanities
Mr. Mansur
10 November 2016
Santiago Calatrava
Santiago Calatrava is a Spanish neofuturistic architect. Calatrava was born in the Benimamet
neighborhood of Valencia, Spain on July 28th, 1951. After becoming a qualified architect and civil
engineer, he earned his doctorate degree in technical science from the Eidgenössische Technische
Hochschule (Swiss Federal Institute of Technology) Department of Architecture for his thesis titled
Concerning the Foldability of Space Frames in 1981. It was also during this time that Calatrava
opened his first practice of architecture and engineering in Zurich, Switzerland. Throughout his
career, Calatrava has received numerous honorary doctorate degrees ranging from technical science
to philosophy. He has also claims membership to various organizations from the Schweizerische
Ingenieur und Architektenverein (Swiss Association of Engineers and Architects) to Real Academia
de Bellas Artes de San Carlos (Royal Academy of Fine Arts of San Carlos).
Calatrava is best known for his work with bridges and various building types. His first major project
was the Stadelhofen Railway Station in Zürich in 1983 which was completed in 1990. Some of
Calatrava s most notable works include; the Montjuic Communications Tower, the Lyon Saint
Exupéry Airport Railway Station, the Milwaukee Art Museum, Bridge of Strings, and the Bodegas
Ysios Winery.
As well as being an architect, Calatrava is also an artist.
 Getting to Yes Analysis Essay
Whether or not we are aware of it, each of us is faced with an abundance of conflict each and
every day. From the division of chores within a household, to asking one s boss for a raise, we ve
all learned the basic skills of negotiation. A national bestseller, Getting to Yes, introduces the method
of principled negotiation, a form of alternative dispute resolutions as opposed to the common method
of positional bargaining. Within the book, four basic elements of principled negotiation are stressed;
separate the people from the problem, focus on interests instead of positions, invest options for
mutual gain, and insist on using objective criteria. Following this section of the book are suggestions
for problems that may occur and finally a... Show more content on Helpwriting.net ...
Again, I found these guidelines to be oversimplified and completely void of the fact that human s are
inapt to simply putting their feelings aside. Also, following the suggestions such as using symbolic
gestures, an example being to [deliver] a small present for a grandchild seem to me as a pathetic
way of sucking up, and could even result in a power shift, as the other party could see the acts as
a way of asking for pity. Either way, aside from such conflicts where feelings are the cause, the
method of separating the people from the problem is a very intelligent one. Also, it makes way for
a better relationship at the end of the negotiations, as both parties feel respected by the other. The
second part of the method focuses on interests instead of positions. Interests refer to the result
needed, while positions refer to that wanted. Again, this is a very intellectual concept to ideal
conflict and negotiation. However, in a world where people always want more than enough, and
where positions can be advantageous, this concept is seems to be unnecessary and even
unfavourable. In the case of a victim in conflict, one can usually bargain more than they need for
their damages. In the case of positions and power, an employee not acknowledging a CEO his/her
power would not make a difference in the status of the two individuals and the potential outcome of
the