PAVAN PHARMA TUTORIAL

TEST PAPER - 3 Total Marks: 200

1. Preformulation is about ensuring?
a. Stability
b. Safety
c. Efficacy
d. All the above

2. Amorphous form shows?

a. Good solubility
b. Poor solubility
c. Long range order
d. None of the above

3. Coulter Counter can analyse?

a. Size distribution
b. Crystallinity & Solubility
c. Number of functional groups
d. Flow property

4. Most advanced particle size analysis technique is?

a. SEM
b. DLS
c. XRPD
d. Sieving

5. Less soluble salts are intentionally used for?

a. Increasing drug release
b. Masking taste
c. Protecting the parent drug from degradation
d. Both b & c

6. Which salt is used most widely in Pharma Industry?

a. Hydrochloride
b. Sodium
c. Potassium
d. Sulphate

7. The ability of a substance to exist as two or more crystalline phases with

different arrangements of molecules in crystal lattice is?
a. Cocrystal
b. Crystal
c. Polymorphism
d. None of the above

8. Solubility can be improved by?

a. Cyclodextrin Complexation
b. Salt formation
c. Solid dispersion
d. All the above

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 PAVAN PHARMA TUTORIAL
TEST PAPER - 3 Total Marks: 200
9. SEM can analyse?
a. Shape & Size
b. Crystallinity & Solubility
c. Complexation
d. Flow property

10. For good bioavailability what is needed is?

a. Good solubility
b. Good Permeability
c. Good solubility poor permeability
d. Good solubility, good permeability

11. Two or more molecules are hydrogen bonded to each other are called?
a. Crystals
b. Cocrystal
c. Polymorph
d. All the above

12. DSC is?

a. Differential scanning calorimetry
b. Differential scattering calorimetry
c. Digital scanning calorimetry
d. None of the above

13. Bragg’s law defines the?

a. Shape
b. Solubility
c. Diffraction
d. All the above

14. Micronization increases?

a. Size
b. Surface area
c. Bioactivity
d. Duration of action

15. The solubility of the pure form of API is determined by?

a. Partition coefficient
b. Phase Solubility Study
c. Permeability study
d. All the above

16. Polymorphs differ in?

a. Physical properties
b. Chemical Properties
c. Both a & b
d. None of the above

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 PAVAN PHARMA TUTORIAL
TEST PAPER - 3 Total Marks: 200
17. X ray diffraction pattern indicate?
a. Solubility
b. Crystallinity
c. Functional groups
d. Permeability

18. Water solubility of API is needed for?

a. Formulation development
b. Dissolution into GI fluid
c. Both a & b
d. None of the above

19. In _______________stability changes the physical appearance of solid dosage

forms?
a. Physical Stability
b. Chemical Stability
c. Solution Stability
d. Toxicological Stability

20. Which of the following solvent is most suitable for determining partition
coefficient?
a. Liquid paraffin
b. Butanol
c. Heptane
d. Octanol

21. The value of Carr’s index for excellent flow of powder is?
a. 15%
b. 18%
c. 25 %
d. 30 %

22. Drugs converted to suitable form are known as?

a. Excipient
b. Source of drug
c. Dosage form
d. API

23. Every dosage form is a combination of drug and different kind of non-drug
components called?
a. Additives
b. Non-Additives
c. New chemical entity
d. All the above
24. Powders are more stable than?
a. Syrup
b. Tablet
c. Capsule
d. Elixirs

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 PAVAN PHARMA TUTORIAL
TEST PAPER - 3 Total Marks: 200

25. The component present in solution in large quantity is known as?

a. Solvent
b. Solution
c. Solute
d. Liquid

26. Solutions are …….dosage form.

a. Monophasic
b. Biphasic
c. Triphasic
d. Solid

27. Buffering agent is also called as?

a. Sweetening agent
b. Thickening agent
c. pH modifiers
d. Wetting agent

28. The following chemical structure is present in Sulfamethiazole

a. 1, 3-diazine
b. 1, 4-aza thiazole
c. 3-methyl Thiadiazine
d. 3-methyl azoxazole

29. Penetration of drug into tissues in Sulphonamides is limited by

a. Protein binding
b. Acetylation
c. Conjugation
d. Glomerular filtration

30. The following chemical formula is present in Sulfadoxine

a. N1 – (4, 5 dimethoxy – 3 – Pyrimidinyl. – fanasil
b. N1 – (5, 6 dimethoxy – 4 – Pyrimidinyl. - fanasil
c. N1 – (4, 5, 6 Trimethoxy – 3 – Pyrimidinyl. – fanasil
d. None of the above

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 PAVAN PHARMA TUTORIAL
TEST PAPER - 3 Total Marks: 200
31.
O X
H2N S Cl
O

What must be ‘X’ to get Sulphanilamide?

a. Methyl amine
b. Ammonia
c. 2-amino pyridine
d. 3-amino, 5-methyl isoxazole

32.
N
NO2 NH2
+
N

X Y Z

What is X?
a. HNO3
b. HNO3/H2SO4
c. HNO2
d. HNO2/H2SO4

33. Nalidixic acid is used to treat

a. Sexual transmitted diseases
b. Immuno suppressant diseases
c. Urinary tract infections
d. Cancer

34. The drug of choice in leprosy is

a. PAS
b. Dapsone
c. Ethambutol
d. INH

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 PAVAN PHARMA TUTORIAL
TEST PAPER - 3 Total Marks: 200
35. Mebendazole is effective against
a. E. histolytica
b. Leshmania donovani
c. Helminthic Tape and round worms.
d. Cancer

36. Mebendazole is an example of a broad spectrum

a. Anthelmintic
b. Antiameobic
c. Antibacterial
d. Bacteriostatic

37. An agent used to decrease the adverse effect of trimethoprim is

a. Nicotinic acid
b. Ascorbic acid
c. Folic Acid
d. Tocopherols

38. The sulphonamide that is rapidly absorbed and excreted is

a. Phthalyl sulphathiazole
b. Succinyl sulphathiazole
c. Sulphamethoxy pyridazine
d. Sulfisoxazole

39. Diethyl carbamazine is used in the treatment of

a. Caclexia
b. Bronchitis
c. Filariasis
d. Tapeworm infestation

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 PAVAN PHARMA TUTORIAL
TEST PAPER - 3 Total Marks: 200
40. The anthelmintic drug acting by producing flaccid paralysis of the worm is
a. Stibophen
b. Diethylcarbamazine
c. Pyrantel pamoate
d. Mebendazole

41. Thiabendazole is an anthelmintic drug used to treat infections caused by

a. Ascaris
b. Entamoeba histolytica
c. Vibrio cholera
d. Treponema pellidum

42. The main site for absorption of sulphonamides is present in

a. Large intestine
b. Small intestine
c. Duodenum
d. Ileum

43. Antileprotic action of Sulphones is due to inhibition of

a. DNA synthesis
b. Folic acid synthesis
c. Protein synthesis
d. Haemoglobin synthesis

44. Pathway in biotransformation of sulphonamide is

a. carboxylation
b. Acetylation
c. Nitration
d. sulfonation

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 PAVAN PHARMA TUTORIAL
TEST PAPER - 3 Total Marks: 200
45. The common side effect of diloxanide furoate is
a. Nausea
b. Flatulence
c. Pruritis
d. Headache
46. Drug of choice in Round worm infection is
a. Clotrimazole
b. Albendazole
c. Nystatin
d. Griseofulvin

47. Chemical kinetics is the study of the

a. rate of chemical reactions
b. particle size
c. rheological property
d. interfacial tension
48. The accelerated stability studies are primarily used to determine:
a. energy of the activation of the reaction
b. k value at elevated temperatures
c. k value at the room temperature
d. shelf life of the product

49. Usually, the rate of a chemical reaction may be enhanced by:

a. cooling the reaction mixture
b. increasing the rate of stirring
c. raising the temperature of the reaction mixture
d. using stoichiometric quantities of each reactant

50. On a product, the label states ‘protect from light’. What type of decomposition does
the product undergo?
a. carboxylation
b. decarboxylation
c. hydrolysis
d. oxidation