SAMPLE REPORT

SAMPLE REPORT
INTRODUCTION

PAGE 2

Dear SAMPLE,

This report will present you with your personalized metabolism, diet, nutrition and exercise report. This
report is based on a DNA test and the lifestyle information that you recently submitted. It is well-
documented that genetics accounts for 40 to 70% of a person's predisposition to obesity1. If you are
thinking about starting a weight loss program or just maintaining a healthy diet, the goal of this test is
to give you information about yourself that may help you modify your behavior.

In this report we have tested over 75 genetic markers to provide you with the latest, most
comprehensive, and scientifically-advanced recommendations on diet, nutrition, exercise, addictive
behaviors and weight-related health conditions. This report provides personalized information, based
on your genetics and lifestyle, to help you meet the following goals:

• Understand your metabolism and behavior traits

• Reach and maintain a healthy weight
• Get the most benefit from physical activity and exercise
• Optimize the nutritional balance of your diet

PAGE 2 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE IMPORTANT
ACC #: F7715014 INFORMATION
DATE: NOV 12, 2015 PAGE 3

Personal Details
Name: SAMPLE PATIENT
DOB: Jan 1, 19XX
Gender: Female
Ethnicity: Caucasian
Report Date: Nov 12, 2015
Received Date: Nov 2, 2015

Test Performed / Method

Genotyping by array-based evaluation of
multiple molecular probes

SCIENTIFIC STRENGTH RATING SYSTEM

The genetic markers and studies selected for this report represent the
best and most recent genetic research in diet, nutrition, exercise and
weight-related health conditions. Some research can be described as
stronger than others based on the size of the population studied and
whether the outcome has been replicated. Due to the current state of
scientific research on the genetics of diet, exercise and nutrition, most
of the studies referenced in your report are based on individuals of
Caucasian ethnicity. While we all have the same genes, there are
genetic and non-genetic factors in different ethnicities that might yield
different outcomes for non-Caucasian populations. Your report includes
a star system, described below, to rate the strength of the research
evidence for the genetic marker and the associated result.

Results derived from a large study of approximately 2,000 or

★★★★ more people, with at least one additional study showing the
same results (replication study).

Results derived from a moderately-sized study of at least

★★★★ 400 people, with or without a replication study.

Small study of less than 400 people in some cases, with

★★★★ other small replicated studies. Results in this category are
preliminary, but pass our criteria for statistical significance.

Results in this category should be considered extremely

★★★★ preliminary.

PAGE 3 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE RECOMMENDATIONS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 4

DIET 71 Genetic Markers Tested

Eat a diet low in carbohydrates, particularly refined carbohydrates, instead of a low fat,
Mediterranean or other diet.

As someone who has enhanced bitter taste perception, you may not like the taste of certain
healthy vegetables, such as broccoli or leafy greens. Try recipes that mask the bitter flavors
without adding too many calories.

You may tend to feel hungry throughout the day more than other people do. You should keep
healthy snacks available to satisfy your hunger, and be sure to eat slowly in order to allow time
for your body to sense satisfaction from eating.

You are less likely to be lactose intolerant, which means you may consume dairy products and
not have gastrointestinal side effects. Choose dairy products that are lower in calories, fat and
added sugar.

You have a higher than average genetic risk for elevated LDL (bad) cholesterol. You should
limit your saturated fat intake and avoid foods containing trans or hydrogenated fats to help
reduce this risk.

NUTRITIONAL NEEDS 9 Genetic Markers Tested

You have a genetic variant associated with lower levels of folic acid. Good sources of folate
include vegetables, fruits, whole grains, legumes, as well as fortified foods and vitamin
supplements.

You have a genetic variant associated with lower vitamin B6 levels. Be sure your diet includes
foods rich in vitamin B6, such as dark green leafy vegetables, whole grains, legumes, poultry,
fish and eggs.

You have a genetic variant associated with lower vitamin B12 levels. Be sure your diet
includes foods rich in vitamin B12, such as meat, fish, poultry and milk products. You can also
obtain B12 from fortified foods and vitamin supplements.

PAGE 4 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE RECOMMENDATIONS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 5

EXERCISE 12 Genetic Markers Tested

Your genetics are associated with enhanced health benefits from endurance exercises, such
as mid-long distance walking, jogging and bicycling. Weight resistance exercises may be less
beneficial.

You have a genetic variant associated with being overweight. You can lower your chances by
leading a physically active lifestyle.

You have a genetic variant associated with elevated blood pressure if you are not physically
active. Exercise may help you manage your blood pressure.

You have a genetic variant some call the "sprinter gene" that most elite power athletes also
have. Thus, you may have an increased ability for sports or exercise that require fast bursts of
muscle power, such as sprinting or weightlifting.

METABOLIC HEALTH 53 Genetic Markers Tested

You have a higher than average genetic likelihood for elevated LDL cholesterol levels. Regular
monitoring of your cholesterol by your physician is recommended.

Your genetic profile shows a higher than average likelihood for decreased HDL (good)
cholesterol. HDL levels can sometimes be improved through aerobic exercise and a healthy
diet.

You have a higher than average genetic likelihood for elevated triglyceride levels. Therefore,
regular monitoring by your physician is recommended. You can help manage triglyceride
levels by maintaining a healthy weight, reducing saturated fat and sugar intake, and increasing
your consumption of omega-3 fatty acids (fish or seafood).

PAGE 5 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE SUMMARY
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 6

YOUR MATCHING DIET EXERCISE

Matching Diet Type p. 8 LOW CARB DIET Endurance Training p. 30 ENHANCED BENEFIT
Response To Monounsaturated
Strength Training p. 31 LESS BENEFICIAL
Fats p. 11 NEUTRAL
Aerobic Capacity (VO2max) p.
Response To Polyunsaturated
31 TYPICAL
Fats p. 11 INCREASED BENEFIT
ENHANCED MUSCLE
Omega-6 And Omega-3 Levels
Muscle Power p. 32 POWER
p. 12 TYPICAL
Achilles Tendinopathy p. 32 TYPICAL
EATING BEHAVIOR TRAITS Weight Loss Response To EXERCISE STRONGLY
Exercise p. 33 RECOMMENDED
Snacking p. 14 TYPICAL
Blood Pressure Response To EXERCISE STRONGLY
Hunger p. 14 INCREASED Exercise p. 33 RECOMMENDED
HDL (Good) Cholesterol
Satiety - Feeling Full p. 14 TYPICAL Response To Exercise p. 34 NORMAL BENEFIT
Eating Disinhibition p. 15 LESS LIKELY Loss Of Body Fat Response To
Exercise p. 34 NORMAL BENEFIT
Food Desire p. 15 TYPICAL Insulin Sensitivity Response To
Exercise p. 34 ENHANCED BENEFIT
Sweet Tooth p. 16 TYPICAL

YOUR BODY AND WEIGHT

FOOD REACTIONS
Obesity p. 37 AVERAGE
Caffeine Metabolism p. 18 FAST METABOLIZER
MORE LIKELY TO GAIN
Bitter Taste p. 18 TASTER Weight Loss-regain p. 37 WEIGHT BACK

Sweet Taste p. 19 TYPICAL Metabolism p. 38 NORMAL

Lactose Intolerance p. 19 LESS LIKELY Adiponectin Levels p. 38 POSSIBLY LOW

Alcohol Flush p. 20 LESS LIKELY METABOLIC HEALTH FACTORS

NUTRITIONAL NEEDS Elevated LDL Cholesterol p. 40 ABOVE AVERAGE
Decreased HDL Cholesterol p.
Vitamin B2 p. 22 STAY BALANCED 41 ABOVE AVERAGE
Vitamin B6 p. 23 OPTIMIZE INTAKE Elevated Triglycerides p. 42 ABOVE AVERAGE
Vitamin B12 p. 23 OPTIMIZE INTAKE Elevated Blood Sugar p. 43 AVERAGE
Folate - Folic Acid p. 24 OPTIMIZE INTAKE

Vitamin A p. 25 OPTIMIZE INTAKE

Vitamin C p. 26 STAY BALANCED

Vitamin D p. 26 STAY BALANCED

Vitamin E p. 27 STAY BALANCED

PAGE 6 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE DIET
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 7

PERSONALIZE YOUR DIET WITH

GENETICS
The way we eat, how our bodies process foods, and our overall
health are impacted by our genetics. Scientific studies have
shown that genetics can also be important for diet
effectiveness. Your results have been calculated to determine
the best diet likely to help you optimize your metabolism, lose
weight and improve your health.

YOUR RESULTS
MATCHING DIET TYPE page:8 LOW CARB DIET

RESPONSE TO
MONOUNSATURATED FATS page:11 NEUTRAL

RESPONSE TO
POLYUNSATURATED FATS page:11 INCREASED BENEFIT

OMEGA-6 AND OMEGA-3 LEVELS page:12 TYPICAL

PAGE 7 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE DIET
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 8

DIET
YOUR RESULT
MATCHING DIET TYPE
Your diet has been selected by looking at many genetic variants associated with LOW CARB DIET
how people respond to the different macronutrients (proteins, fats and Your genotype is associated with
carbohydrates) in their food2,3,4,5,6,7. Your genetic risk profiles for metabolic health weight loss or other health benefits
factors were also evaluated to determine your recommended diet8,9. Together, your from a diet lower in carbohydrates.
genetic results suggest which one of the following diets may be best for you: "Low
Fat," "Low Carb," "Mediterranean" or a "Balanced Diet." It is highly recommended to
discuss any change in your diet plan with your health care provider. YOUR RELATED GENES
Your Scientific
Gene Tested
Genotype Strength

YOUR DIET RECOMMENDATIONS ADIPOQ-rs17300539 G/G ★★★★

✓ Eat a diet low in carbohydrates, particularly refined carbohydrates, instead of a APOA2-rs5082 T/T ★★★★
low fat, Mediterranean or other diet.
FTO-rs9939609 T/A ★★★★
✓ As someone who has enhanced bitter taste perception, you may not like the
taste of certain healthy vegetables, such as broccoli or leafy greens. Try recipes KCTD10-rs10850219 G/G ★★★★
that mask the bitter flavors without adding too many calories.
LIPC-rs1800588 C/C ★★★★
✓ You may tend to feel hungry throughout the day more than other people do. You
should keep healthy snacks available to satisfy your hunger, and be sure to eat MMAB-rs2241201 C/C ★★★★
slowly in order to allow time for your body to sense satisfaction from eating. PPARG-rs1801282 C/C ★★★★
✓ You are less likely to be lactose intolerant, which means you may consume dairy
AND MORE...
products and not have gastrointestinal side effects. Choose dairy products that
are lower in calories, fat and added sugar.
✓ You have a higher than average genetic risk for elevated LDL (bad) cholesterol.
You should limit your saturated fat intake and avoid foods containing trans or
hydrogenated fats to help reduce this risk.

YOUR RESULT
LOW CARB LOW FAT BALANCED MEDITERRANEAN

Non‐starchy vegetables, Lean proteins, fiber-rich Balance of healthy fats, Fish, monounsaturated fats,
high-quality proteins and vegetables, grains and carbohydrates and proteins and low glycemic, high fiber
healthy fats fruits, and healthy fats vegetables, fruits, grains
and legumes

PAGE 8 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE DIET
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 9

DIET
Low Carb Diet: Key Aspects
LOW CARB DIET
Fruits and Vegetables
A carbohydrate-controlled diet limits the amount of carbohydrates you consume.
➤ Bright colors, bold flavor.
Foods rich in carbohydrates include breads, cereals, grains, rice, starchy
➤ Consume a variety of colors.
vegetables, fruit, as well as milk and yogurt. More importantly, a carbohydrate-
➤ Try to eat 9 servings of fruits and
controlled diet plan focuses on non-starchy vegetables, healthy fats, as well as
vegetables per day.
high-quality protein foods. Although this diet plan limits carbohydrates, it does
➤ Leafy green veggies are optimal.
not completely exclude them. Refined and processed foods should be avoided
➤ Limit store-bought fruit juice to 1/2 cup per
in order for healthier, nutrient-dense carbohydrates to fit into your daily intake.
day (no sugar or sweetener).
Concentrate on strongly colored fruits and vegetables with bold flavors. For your
➤ Limit starchy vegetables.
protein intake, incorporate legumes, fish (and other seafood), lean chicken, and
limit your red meat consumption to about 3 ounces or less, 2 to 3 times per Grains and Starchy Vegetables
week. Regarding fats and oils, it’s best to choose vegetable fats and to minimize ➤ Avoid all refined grains.

your intake of animal fats. Processed and highly refined foods, trans fats, as ➤ Use satisfying alternatives to grain, such

well as added sugars, should be avoided. Most popular low-carbohydrate diets as sweet potato, squash, mushrooms, and
consist of a weight loss phase, which is very low in carbohydrates and is eggplant in moderation.
➤ Try quinoa.
followed by a maintenance phase that manages carbohydrates.
Protein Foods
➤ Eat at least a 1/4 to 1/2 cup of legumes per
day.
➤ Limit red meats.

➤ Eat fish or other seafood at least 2 to 3

times per week.
➤ Remove all visible fat and skin from meat,
fish and poultry.
➤ Prepare meat by baking, broiling, steaming
or poaching.
➤ Avoid frying meat.

Milk Products
➤ Plain Greek-style yogurt is optimal.
➤ Avoid milk products with added sugar.

➤ Limit cheese.

Fats and Oils

➤ Avoid hydrogenated and trans fats.
➤ Limit saturated fats.

General
➤Minimize or avoid added sugars and foods
with added sugar. This is especially
important if you are trying to lose weight or
control your blood sugar levels, or if your
triglyceride levels are elevated.

PAGE 9 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE DIET
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 10

DIET
TYPES OF FAT IN YOUR DIET
Acting as an important part of any diet and a source of energy, fat provides flavor to your diet, but more importantly, it is a vital
element in the absorption of fat-soluble vitamins such as vitamins A, D, E and K. The two major types of fat include saturated and
unsaturated (polyunsaturated and monounsaturated) fats. In order for your body to function normally, you need to maintain a
consistent and balanced supply of saturated and unsaturated fats. A third type of fats consists of hydrogenated fats, which are
processed fats that are not found naturally, such as in margarine and fried fast foods. Hydrogenated fats may also contain trans
fatty acids and are generally unhealthy and should be avoided.

SATURATED FAT UNSATURATED FAT HYDROGENATED FAT

➤ Beef ➤ Veal Polyunsaturated Monounsaturated ➤ Margarine ➤ Shortening
➤ Lamb ➤ Pork ➤ Cold water fish ➤ Avocados (stick) ➤ Foods
➤ Lard ➤ Butter (e.g., salmon, ➤ Nuts ➤ Most fast foods containing trans
➤ Milk ➤ Cheeses herring, halibut, ➤ Olives ➤ Fried foods fats
➤ Cream ➤ Coconut oil sardines, ➤ Extra virgin ➤ Highly
➤ Poultry (dark mackerel) olive oil processed
meat) ➤ Walnuts foods
➤ Almonds
➤ Flaxseed
➤ Chia seed
➤ Pumpkin Seed
➤ Evening
primrose oil
➤ Borage seed oil
➤ Nuts and seeds
➤ Poultry and
eggs

PAGE 10 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE DIET
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 11

DIET
YOUR RESULT
RESPONSE TO MONOUNSATURATED FATS
Fat is an important part of any diet, and not all fats are bad. Monounsaturated fat is NEUTRAL
considered a healthy dietary fat found in avocados, olives, and some nuts, as well For people with your genotype, the
as oils, such as olive oil. The two possible outcomes for this test are "Increased amount of dietary
Benefit" or "Neutral." Having an "Increased Benefit" from monounsaturated fat monounsaturated fat you eat is not
suggests you could benefit from eating foods containing monounsaturated fats. In likely to affect your body weight.
general, it is best to avoid trans fats and limit saturated fat intake. However, avoiding trans fats and
substituting some saturated fats
Genetic variants in two genes, ADIPOQ and PPARG, have been associated with a with monounsaturated fats is still
lower body weight in individuals when more than 13% of their calories come from recommended, as it has several
monounsaturated fats6,7. This would be equivalent to a person on an 1,800-calorie health benefits.
diet consuming about 1 to 2 tablespoons of olive oil and a quarter cup of nuts each
day as part of their total caloric intake. While the ADIPOQ study was done in a
population of both men and women, the PPARG study was done only in women. YOUR RELATED GENES
There is not enough scientific evidence to support if the PPARG association is also
Your Scientific
true in men. Gene Tested
Genotype Strength

ADIPOQ-rs17300539 G/G ★★★★

PPARG-rs1801282 C/C ★★★★

DIET
YOUR RESULT
RESPONSE TO POLYUNSATURATED FATS
Polyunsaturated fat is considered a healthy fat and is important for heart and brain INCREASED BENEFIT
function, as well as growth and development. Two types of polyunsaturated fats are People with your genotype who
omega-6 and omega-3 fats. Good sources of omega-6 fats include evening have a diet that includes more
primrose and borage oils, as well as olives, nuts and poultry. Additionally, good polyunsaturated fats, rather than
sources of omega-3 fats include fish and seafood, as well as flaxseed, walnuts, saturated fats, tend to have a
hemp seeds, and dark green leafy vegetables. lower body weight, compared to
those who do not.
The two possible outcomes in this report are "Increased Benefit" or "Neutral."
Having an "Increased Benefit" from polyunsaturated fat means you should try to eat
foods containing polyunsaturated fats. In general, it is best to avoid trans fats and YOUR RELATED GENES
minimize saturated fats. One study in women has shown that those with a certain
Your Scientific
genetic variant in the PPARG gene tend to have a lower body weight when they Gene Tested
Genotype Strength
consume more polyunsaturated fats than saturated fats7. This association has not
been studied in men.
PPARG-rs1801282 C/C ★★★★

PAGE 11 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE DIET
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 12

DIET
YOUR RESULT
OMEGA-6 AND OMEGA-3 LEVELS
Polyunsaturated fats (PUFAs) in our diet are composed of omega-3 and omega-6 TYPICAL
fatty acids, both of which are recommended by the American Heart Association People with your genotype were
(AHA) for good heart health. Long-chain PUFAs are provided by our diet, but can found to have typical blood levels
also be synthesized in our bodies starting from the precursor essential fatty acids, of an important omega-6 fat and
linoleic acid (LA, omega-6) and alpha-linolenic acid (ALA, omega-3). Both omega-3 an important omega-3 fat.
and omega-6 fats are processed in the body by the same enzyme complex10. The
major dietary sources of omega-3 fatty acids include foods, such as flaxseed and
walnuts, as well as fish oils and fish such as salmon. Processed foods often contain YOUR RELATED GENES
high levels of omega-6, while healthy sources of omega-6 include evening primrose
Your Scientific
and borage oils, as well as olives, nuts and poultry. Historically, the ratio of omega-6 Gene Tested
Genotype Strength
to omega-3 fats in the diet was maintained close to a healthy 1:1, while in the
FADS1-rs174547 T/T ★★★★
current Western diet it is estimated to be about 15:111.

In recent genome-wide association studies that included over 10,000 people, it was
found that those with the C/C or C/T genotypes at a variant in the FADS1 gene,
which codes for one of the enzymes involved in processing omega-3 and omega-6
fats, had "Decreased" blood levels of arachidonic acid (AA), a long-chain omega-6
fat, as well as eicosapentaenoic acid (EPA), a long-chain omega-3 fat. On the other
hand, those with a T/T genotype had "Typical" levels of these two omega-fats12,13.
Since both AA and EPA are precursors of biologically important metabolites, those
with a "Decreased" outcome should increase their dietary intake of both omega-3
and omega-6 fatty acids. However, considering the current skewed ratio of
omega-6:omega-3 fats, it is recommended that people monitor the intake of
omega-6 fats from processed foods, while increasing their intake of omega-3 fats.

PAGE 12 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EATING BEHAVIOR
ACC #: F7715014 TRAITS
DATE: NOV 12, 2015 PAGE 13

EATING BEHAVIORS CAN BE

INFLUENCED BY GENES
There are certain genes that have the potential to impact how
we perceive and desire particular foods, and influence our
eating behaviors, such as excessive snacking and difficulty
feeling full. For example, variants in the ANKK1 and DRD2
genes, which result in a reduced density of dopamine receptors
in your brain, have been associated with eating and addictive
behaviors14,15,16. This type of information, generated from
testing genetic markers in a number of genes, is included in
your report, and can be used to understand how to modify your
lifestyle and behaviors for optimum wellness.

YOUR RESULTS
SNACKING page:14 TYPICAL

HUNGER page:14 INCREASED

SATIETY - FEELING FULL page:14 TYPICAL

EATING DISINHIBITION page:15 LESS LIKELY

FOOD DESIRE page:15 TYPICAL

SWEET TOOTH page:16 TYPICAL

PAGE 13 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EATING BEHAVIOR
ACC #: F7715014 TRAITS
DATE: NOV 12, 2015 PAGE 14

EATING BEHAVIOR TRAITS

YOUR RESULT
SNACKING
Snacking can be a healthy or unhealthy behavior. Snacking on balanced foods, TYPICAL
containing healthy fats, lean protein, fiber and low glycemic index carbohydrates, in Your genotype is not associated
small portions, throughout the day can help control hunger cravings and reduce with extreme snacking behavior.
total caloric intake, while snacking on junk food can have negative health effects.
Genetic markers associated with snacking behavior include variants in the receptor
for leptin, an essential hormone for the regulation of food intake. The possible YOUR RELATED GENES
results in this report are "Typical" and "Increased." If you receive the "Increased"
Your Scientific
result, you may want to curtail the negative effects of snacking by choosing healthy Gene Tested
Genotype Strength
snacks, eating slowly and reducing the size or calories of snacks. People with the
G/G genotype in a leptin receptor (LEPR) genetic marker were more likely to show
LEPR-rs2025804 A/G ★★★★
"Increased" snacking behavior17. "Typical" genotypes were not associated with
"Increased" snacking behavior in the same study. This association has not been
studied in men.

EATING BEHAVIOR TRAITS

YOUR RESULT
HUNGER
While most of us know the feeling of hunger, some INCREASED
people feel hunger more intensely and more often People with your genotype are
than others. Susceptibility to hunger can now be more likely to exhibit high levels of
partially explained by genetics. A variation in the susceptibility to hunger.
NMB gene has been associated with increased
feelings of hunger18. When asked about their own
eating behaviors on a questionnaire, people with a YOUR RELATED GENES
T/T genotype were more likely to report an
Your Scientific
"Increased" susceptibility to hunger, while others Gene Tested
Genotype Strength
were likely to have a "Typical" hunger response. This
NMB-rs1051168 T/T ★★★★
preliminary information is based on a study rated
with one star of scientific strength.

EATING BEHAVIOR TRAITS

YOUR RESULT
SATIETY - FEELING FULL
Satiety can be described as the feeling of fullness after you eat. The FTO (fat mass TYPICAL
and obesity-associated) gene is known to be an important factor that predisposes a People with your genotype tend to
person to a healthy or unhealthy level of body weight19. The two possible outcomes feel full after a meal.
in this report are "Difficulty in Feeling Full" and "Typical." People who experience
"Difficulty in Feeling Full" tend to eat more without feeling satisfied. To help manage
this outcome, you could increase the amount of fiber in your diet and balance meals YOUR RELATED GENES
and snacks throughout the day. Examples of foods high in fiber include whole
Your Scientific
wheat bread, oatmeal, barley, lentils, black beans, artichokes, raspberries, and Gene Tested
Genotype Strength
peas. In a 2008 study, the A/A genotype at rs9939609 in the FTO gene was
FTO-rs9939609 A/T ★★★★
associated with "Difficulty in Feeling Full"20. Although this study was done in
children, there is preliminary data to support that the association also holds true in
adults21.

PAGE 14 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EATING BEHAVIOR
ACC #: F7715014 TRAITS
DATE: NOV 12, 2015 PAGE 15

EATING BEHAVIOR TRAITS

YOUR RESULT
EATING DISINHIBITION
Eating disinhibition describes the tendency to eat LESS LIKELY
more than normal in response to a stimulus, such as Your genotype is not associated
a tasty food or in situations that trigger overeating with an increase in susceptibility
(e.g., emotional stress or specific social situations). for eating disinhibition.
In a 2010 study, the T allele of rs1726866 was "More
Likely" to be associated with eating disinhibition in
women22. The C/C genotype at the same marker YOUR RELATED GENES
was "Less Likely" to be associated with eating
Your Scientific
disinhibition. There is not enough scientific evidence Gene Tested
Genotype Strength
yet to determine if this association also holds for
TAS2R38-rs1726866 C/C ★★★★
men.

EATING BEHAVIOR TRAITS

YOUR RESULT
FOOD DESIRE
Although there is no objective method to quantify someone’s feeling of hunger or TYPICAL
liking for a particular type of food, behavioral scientists have devised techniques to Your genotype is not associated
measure an individual’s motivation to consume food and compare it with that of with an increased desire or
others. This measurement, called the reinforcing value of food23, describes how willingness to put forth additional
much effort an individual is willing to put forth to get access to food. The reinforcing effort to obtain your favorite foods.
value can be determined through a series of tests in a laboratory setting. In each of
those tests, the individual being tested is asked to complete a task in exchange for
a small portion of his or her favorite foods. The task of the initial test is easy, so the YOUR RELATED GENES
food is not difficult to win. As the tests continue, the task gets more and more
Your Scientific
difficult until, at some point, the participant feels that the food is no longer worth the Gene Tested
Genotype Strength
effort and decides to quit. This experiment tells us that early quitters, when ANKK1/
compared with late quitters, are low in food reinforcement. Using this technique, a DRD2-rs1800497
C/C ★★★★
2007 study14 identified a genetic component in food reinforcement. Among people
who were considered obese, those who had a specific variant (T allele) of the
genetic marker rs1800497 had an "Increased" likelihood to make more effort to
obtain their favorite foods and eat more of them. In contrast, the C/C genotype was
associated with "Typical" levels of food reinforcement.

PAGE 15 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EATING BEHAVIOR
ACC #: F7715014 TRAITS
DATE: NOV 12, 2015 PAGE 16

EATING BEHAVIOR TRAITS

YOUR RESULT
SWEET TOOTH
Craving sweet foods is sometimes described as having a "sweet tooth." The TYPICAL
possible outcomes in this report are "Increased" or "Typical." If your genotype People with your genotype tend to
shows an "Increased" likelihood to eat lots of sweets, try choosing fruit as a healthy eat an average amount of sugary
sweet alternative to sugary foods or soda. Be sure to follow your diet as some diet foods.
plans, such as the low carbohydrate diets, significantly limit the amount of sugar
you can eat. Sweet foods can include healthy foods, such as fruits, or unhealthy
foods like candy and sweetened beverages. People with the C/T and T/T genotypes YOUR RELATED GENES
showed an "Increased" likelihood to eat more sweets and sugary foods, while
Your Scientific
people with the C/C genotype were more likely to have a "Typical" intake of sugary Gene Tested
Genotype Strength
foods24.
SLC2A2-rs5400 C/C ★★★★

PAGE 16 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE FOOD REACTIONS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 17

YOUR GENETICS MAY IMPACT HOW

YOU RESPOND TO SOME FOODS
Genetic studies have been reported on some types of food
reactions. Our tests draw on the current genetic data for
responses to caffeine, bitter foods, sweet foods, milk products
and alcohol. A summary of your results is provided below.

YOUR RESULTS
CAFFEINE METABOLISM page:18 FAST METABOLIZER

BITTER TASTE page:18 TASTER

SWEET TASTE page:19 TYPICAL

LACTOSE INTOLERANCE page:19 LESS LIKELY

ALCOHOL FLUSH page:20 LESS LIKELY

PAGE 17 of 50
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NAME/ID: SAMPLE PATIENT
SEX: FEMALE FOOD REACTIONS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 18

FOOD REACTIONS
YOUR RESULT
CAFFEINE METABOLISM
Caffeine is one of the most widely consumed FAST METABOLIZER
stimulants in the world, and it is found in the leaves You are likely to rapidly metabolize
and seeds of many plants. It is also produced caffeine.
artificially and added to some foods. Caffeine is
found in tea, coffee, chocolate, many soft drinks and
energy drinks, as well as in some pain relievers and YOUR RELATED GENES
other over-the-counter medications. Caffeine is
Your Scientific
metabolized by a liver enzyme, which is encoded by Gene Tested
Genotype Strength
the CYP1A2 gene. Variation at a marker in the
CYP1A2 gene results in different levels of enzyme
CYP1A2-rs762551 A/A ★★★★
activity, and thus, different metabolism rates for
caffeine25,26,27. Therefore, the two possible genetic
results in this report are “Fast Metabolizer” and “Slow
Metabolizer." If you are a "Slow Metabolizer," then
caffeine may have longer lasting stimulant effects for
you. In addition to genetics, your body’s ability to
metabolize caffeine also depends on other lifestyle
factors28,29. For example, how much coffee you drink,
whether you smoke or whether you take hormonal
birth control, may also affect your ability to
metabolize caffeine. Because these and other
lifestyle factors may both increase or decrease your
caffeine metabolism, the most sensible advice is to
make lifestyle choices that have the maximum
benefit for your overall health.

FOOD REACTIONS
YOUR RESULT
BITTER TASTE
People taste things differently. Variations in the TASTER
TAS2R38 gene are associated with different levels of You are likely to have a high
sensitivity to a chemical called PTC 30,31, which sensitivity to bitter taste.
produces a strong bitter taste. The possible results
for bitter taste are "Taster," "Non-Taster," or
"Inconclusive." A person described as a "Taster" may YOUR RELATED GENES
be more sensitive to bitter flavors found in foods,
Your Scientific
such as grapefruit, coffee, dark chocolate and Gene Tested
Genotype Strength
cruciferous vegetables, such as Brussels sprouts,
TAS2R38-rs713598 C/C ★★★★
cabbage and kale. Being a "Taster" does not mean
you do not enjoy these foods, but you may sense a TAS2R38-rs1726866 C/C ★★★★
stronger bitter taste compared to a "Non-Taster." In
addition, tasters may need to watch their salt intake,
because they may have an increased preference for
salty foods, which mask the bitterness32. A genetic
result of "Inconclusive" means that there is not
enough scientific evidence for how your genotype is
associated with bitter taste sensitivity.

PAGE 18 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE FOOD REACTIONS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 19

FOOD REACTIONS
YOUR RESULT
SWEET TASTE
Sweet is one of the most basic tastes we can TYPICAL
experience, and is usually found in sugar and sugary You are likely to have typical
foods. The sensation of sweet taste is triggered to sensitivity to the sweet taste of
the brain from the taste buds. There are receptors on sugar.
your tongue that are programmed by your genes to
determine how you taste sweetness. A 2009 study
showed that genetic variants found in the sweet taste YOUR RELATED GENES
receptors can result in "Typical" or "Decreased"
Your Scientific
sensitivity to the sweet taste of sugar33. People with Gene Tested
Genotype Strength
"Decreased" sensitivity may prefer foods with more
TAS1R3-rs35744813 G/G ★★★★
sugar since they are less likely to taste sweetness in
foods that are low sugar.

FOOD REACTIONS
YOUR RESULT
LACTOSE INTOLERANCE
Lactose intolerance is the inability to digest lactose, LESS LIKELY
the sugar found in milk and milk products. This People with your genotype are
condition is caused by the lack of an enzyme called less likely to be lactose intolerant.
lactase. The rs4988235 variant lies close to the
lactase (LCT) gene, in the MCM6 gene, and has
been shown to regulate lactase levels34,35,36. If you YOUR RELATED GENES
are lactose intolerant you should make sure that you
Your Scientific
are getting enough calcium from non-dairy or Gene Tested
Genotype Strength
lactose-free sources. On the other hand, if you are
MCM6-rs4988235 T/C ★★★★
not lactose intolerant, be aware that dairy products
can be high in calories, fat, or both. You need to
watch your intake accordingly or select low fat dairy
products. People with a C/C genotype at rs4988235
are "More Likely" to be lactose intolerant, while
people with other genotypes are "Less Likely"37. This
variant has been found to be associated with lactose
intolerance in Caucasians, while other variants might
play an important role in other ethnicities, including
Africans and Asians.

PAGE 19 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE FOOD REACTIONS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 20

FOOD REACTIONS
YOUR RESULT
ALCOHOL FLUSH
Drinking alcoholic beverages is a relaxing or social activity for many, but for some it LESS LIKELY
is exceedingly unpleasant due to their body's adverse reaction to alcohol. One such People with your genotype are
reaction is called alcohol flush, in which drinking even small amounts of alcohol less likely to experience alcohol
causes a person's face to flush red and in some cases feel warm and itchy. People flush.
who flush may also experience other unpleasant symptoms, such as rapid
heartbeat, nausea, or dizziness in response to alcohol. Alcohol flush is largely
attributed to genetic variation in the ALDH2 gene, which encodes an enzyme critical YOUR RELATED GENES
for proper alcohol metabolism. Those who carry the inactive version of this gene
Your Scientific
are much "More Likely" to flush and experience other negative responses to Gene Tested
Genotype Strength
alcohol38,39, while people with other genotypes are "Less Likely" to flush. Perhaps
ALDH2-rs671 G/G ★★★★
not surprisingly, this variant is also associated with overall reduced consumption of
alcohol40. In most cases, avoiding alcohol is the best remedy for those who
experience alcohol flush.

PAGE 20 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE NUTRITIONAL NEEDS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 21

VITAMINS AND NUTRIENTS ARE AN

IMPORTANT PART OF OUR HEALTH
There are genetic markers associated with being predisposed
to lower levels of certain nutrients, which means you may want
to make certain your diet has enough of the foods that contain
these nutrients. Ensuring you consume the right amount of
vitamins and nutrients from your diet is an important part of
your health plan. The recommended daily allowances (RDA) for
vitamins and nutrients in this section are based on guidance
from the Institute of Medicine of the National Academies (IOM).
For more information regarding RDAs, visit www.iom.edu.

YOUR RESULTS
VITAMIN B2 page:22 STAY BALANCED

VITAMIN B6 page:23 OPTIMIZE INTAKE

VITAMIN B12 page:23 OPTIMIZE INTAKE

FOLATE - FOLIC ACID page:24 OPTIMIZE INTAKE

VITAMIN A page:25 OPTIMIZE INTAKE

VITAMIN C page:26 STAY BALANCED

VITAMIN D page:26 STAY BALANCED

VITAMIN E page:27 STAY BALANCED

PAGE 21 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE NUTRITIONAL NEEDS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 22

YOUR NUTRITION RECOMMENDATIONS

✓ You have a genetic variant associated with lower levels of folic acid. Good
sources of folate include vegetables, fruits, whole grains, legumes, as well as
fortified foods and vitamin supplements.
✓ You have a genetic variant associated with lower vitamin B6 levels. Be sure your
diet includes foods rich in vitamin B6, such as dark green leafy vegetables, whole
grains, legumes, poultry, fish and eggs.
✓ You have a genetic variant associated with lower vitamin B12 levels. Be sure
your diet includes foods rich in vitamin B12, such as meat, fish, poultry and milk
products. You can also obtain B12 from fortified foods and vitamin supplements.

NUTRITIONAL NEEDS
YOUR RESULT
VITAMIN B2
Vitamin B2, or riboflavin, is a central component of flavin mononucleotide (FMN) STAY BALANCED
and flavin adenine dinucleotide (FAD), both of which serve as cofactors of several In people with your genotype,
critical enzymes involved in the electron transport chain, as well as in the riboflavin levels have a relatively
metabolism of carbohydrates, fats and proteins41. Vitamin B2 is found in a variety of small impact on levels of
foods including milk, cheese, green leafy vegetables, legumes, beans, lean meats homocysteine. Elevated levels of
and fortified grains. Individuals with the T/T genotype at a variant in the MTHFR homocysteine are a risk factor for
gene are likely to have increased levels of homocysteine, which are a risk factor for heart disease. You should
cardiovascular disease and stroke42,43,44. Levels of homocysteine were highest in maintain a healthy diet.
T/T individuals with low riboflavin or vitamin B2 levels, and further, riboflavin
supplementation was found to reduce homocysteine levels in these individuals45,46.
Thus, individuals with the T/T genotype should "Optimize Intake" of vitamin B2 by YOUR RELATED GENES
eating foods rich in vitamin B2. On the other hand, vitamin B2 levels are likely to Your Scientific
Gene Tested
have a relatively small impact on homocysteine levels in people with the C/T or C/C Genotype Strength

genotypes, and hence, they should "Stay Balanced" and maintain a healthy diet. MTHFR-rs1801133 C/T ★★★★

PAGE 22 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE NUTRITIONAL NEEDS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 23

NUTRITIONAL NEEDS
YOUR RESULT
VITAMIN B6
Vitamin B6, also called pyridoxine, helps your body's neurological system to OPTIMIZE INTAKE
function properly, promotes red blood cell health, and is involved in sugar People with your genotype are
metabolism ("http://ods.od.nih.gov/factsheets/vitaminb6/"). Vitamin B6 is found more likely to have lower blood
naturally in many foods, including beans, whole grains, meat, eggs and fish. Most levels of vitamin B6. You may
people receive sufficient amounts of vitamin B6 from a healthy diet, and B6 optimize your intake of vitamin B6
deficiency is rare in the United States. by paying attention to your diet
and eating foods rich in vitamin
The genetic marker rs4654748 in the NBPF3 gene (near the ALPL gene) has been B6.
found in multiple studies to be associated with reduced levels of vitamin B6,
possibly due to faster than normal clearance of this vitamin from the
bloodstream47,48. Individuals with a C/C or C/T genotype had lower levels of B6 YOUR RELATED GENES
than those with the T/T genotype. Therefore, if your genotype is C/C or C/T, you will
Your Scientific
get a result of "Optimize Intake." If your genotype is T/T, it is suggested that you Gene Tested
Genotype Strength
"Stay Balanced" and maintain a healthy diet. The studies we report observed
associations between vitamin levels and particular genotypes; however, that does
NBPF3-rs4654748 C/C ★★★★
not mean that your levels are out of balance. You should ensure that you are eating
a healthy diet and discuss this result with your physician. The recommended intake
of vitamin B6 for most adults is 1.3 to 1.7 milligrams per day.

NUTRITIONAL NEEDS
YOUR RESULT
VITAMIN B12
Vitamin B12 plays an important role in how your brain and nervous system function. OPTIMIZE INTAKE
It helps to keep red blood cells healthy and is a critical component for synthesis and People with your genotype are
regulation of your DNA49. Vitamin B12 is found naturally in foods of animal origin more likely to have lower blood
including meat, fish, poultry, eggs and milk products. A healthy diet will typically levels of vitamin B12. You may
provide sufficient B12, although vegetarians, vegans, older people, and those with optimize your intake of vitamin B12
problems absorbing B12 due to digestive system disorders may be deficient. by paying attention to your diet
Symptoms of vitamin B12 deficiency can vary, but may include fatigue, weakness, and eating foods rich in vitamin
bloating, or numbness and tingling in the hands and feet. The recommended intake B12.
for adults is 2.4 micrograms per day.

Multiple genetic studies have identified a marker in the gene FUT2 as being YOUR RELATED GENES
associated with lower levels of B12 in the blood48,50,47. This effect may be due to
Your Scientific
reduced absorption of B12 in the gut48. People with G/G or A/G genotypes are Gene Tested
Genotype Strength
recommended to "Optimize Intake" because they may have lower levels of B12.
FUT2-rs602662 G/G ★★★★
Eating foods rich in vitamin B12 can promote healthy levels of B12, especially for
those over the age of 50. People with the A/A genotype should "Stay Balanced" and
maintain a healthy diet. The studies we report observed associations between
vitamin B12 levels and particular genotypes; however, that does not mean that your
levels are out of balance. You should ensure that you are eating a healthy diet and
discuss this result with your physician.

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 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE NUTRITIONAL NEEDS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 24

NUTRITIONAL NEEDS
YOUR RESULT
FOLATE - FOLIC ACID
Folate is found in many foods, such as green leafy vegetables like chard or kale, as OPTIMIZE INTAKE
well as beans, lentils, fruits and fortified grains. This nutrient plays a role in protein People with your genotype are
metabolism, as well as DNA repair51. Folate can lower the blood level of more likely to have lower blood
homocysteine, a substance linked to cardiovascular disease at high levels52. Diets levels of folate and higher blood
rich in folate have been associated with reduced risk of cardiovascular disease53. levels of homocysteine. Foods rich
Folate is particularly important early in pregnancy for preventing some birth in folic acid are recommended for
defects51. For this reason, pregnant women or women intending to become you.
pregnant are advised an elevated recommended daily intake of 600 micrograms of
folate. The recommended intake of folate for most adults is 400 micrograms per
day. YOUR RELATED GENES
Your Scientific
Gene Tested
A relatively common variant in the MTHFR gene, known as C677T (rs1801133), Genotype Strength
has been associated with lowered folate and elevated homocysteine levels in the MTHFR-rs1801133 C/T ★★★★
blood52. Hence, people with a T/T or C/T genotype should "Optimize Intake" of
folate. People with the C/C genotype should "Stay Balanced" and maintain a
healthy diet. The studies we report observed associations between vitamin levels
and particular genotypes; however, that does not mean that your levels are out of
balance. You should ensure that you are eating a healthy diet and discuss this
result with your physician.

PAGE 24 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE NUTRITIONAL NEEDS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 25

NUTRITIONAL NEEDS
YOUR RESULT
VITAMIN A
Vitamin A is a nutrient that describes a number of OPTIMIZE INTAKE
related compounds, including retinol, retinal, and People with your genotype are
retinoic acid. Vitamin A is critical for numerous likely to have a reduced efficiency
functions in the body, including healthy vision, in converting beta-carotene into
immune system action, bone growth, reproduction, vitamin A. Therefore, you may
and the proper regulation of gene have a reduced level of vitamin A
expression54,55,56,57. The recommended intake of in your blood.
vitamin A for most adults is 700 to 900 micrograms
per day.
YOUR RELATED GENES
Much of the vitamin A found in your body is derived
Your Scientific
from beta-carotene, a nutrient found in some plants Gene Tested
Genotype Strength
and foods, such as pumpkin, carrots, sweet potatoes
and spinach. A genetic study has found that vitamin
BCMO1-rs7501331 T/T ★★★★
A conversion from beta-carotene is impaired in BCMO1-rs12934922 A/T ★★★★
women carrying variants of the BCMO1 gene58. This
association has not been studied in men.

Those with a result of "Optimize Intake" may bypass

this effect by consuming adequate amounts of
preformed vitamin A, which can be found in fortified
milk and breakfast cereals, as well as in
multivitamins containing retinyl palmitate or retinyl
acetate59,60. People who receive a "Stay Balanced"
outcome should maintain a healthy diet. An
additional outcome in this report is "Inconclusive,"
which means that there was not enough scientific
evidence to determine how your genotype relates to
the efficiency of converting beta-carotene to vitamin
A. The study we report observed associations
between vitamin A levels and particular genotypes.
However, that does not mean that your levels are out
of balance. You should eat a healthy diet and speak
with your physician before making specific changes
to your dietary regimen.

PAGE 25 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE NUTRITIONAL NEEDS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 26

NUTRITIONAL NEEDS
YOUR RESULT
VITAMIN C
Vitamin C, or L-ascorbic acid, must be acquired from dietary sources, as humans STAY BALANCED
are unable to synthesize it. Some dietary sources of vitamin C include lemons, Your genotype is not associated
oranges, red peppers, watermelons, strawberries and citrus juices or juices fortified with lower blood levels of vitamin
with vitamin C. While a severe deficiency of vitamin C ultimately leads to scurvy, C. You should maintain a healthy
variations in vitamin C levels have also been associated with a wide range of diet.
chronic complex diseases, such as atherosclerosis, type 2 diabetes and cancer61.
These associations are thought to result from a contribution of vitamin C as an
antioxidant, as well as its role in the synthesis of collagen and various hormones. YOUR RELATED GENES
After ingestion, the vitamin C in one's diet gets transported across the cell
Your Scientific
membrane via transport proteins, one of which is SLC23A1. A recent study of over Gene Tested
Genotype Strength
15,000 people found that the A allele of a variant in SLC23A1 was associated with
SLC23A1-rs33972313 G/G ★★★★
decreased levels of circulating vitamin C62. Therefore, if your genotype is A/A or
A/G, you will get a result of "Optimize Intake." People with a G/G genotype should
"Stay Balanced" and maintain a healthy diet.

NUTRITIONAL NEEDS
YOUR RESULT
VITAMIN D
Vitamin D is important for the absorption and utilization of calcium, which is STAY BALANCED
beneficial for maintaining good bone health63. Exposure to sunlight is an important Your genotype is not associated
determinant of a person's vitamin D level, since there are few natural dietary with lower levels of vitamin D
sources of vitamin D. While sunscreen use blocks skin production of vitamin D, (plasma 25-hydroxyvitamin D
excessive sun exposure is a risk factor for skin cancer and related conditions, and levels). However, other factors,
is not recommended. Dietary sources of vitamin D include some fatty fish, fish liver such as diet and exposure to
oils, and milk or cereals fortified with vitamin D. The recommended intake of vitamin sunlight, play an important role in
D for most adults is 600 IUs per day. About 115 IUs of vitamin D is found in one cup regulating levels of vitamin D in
of vitamin D-fortified, non-fat, fluid milk. blood.

Multiple genetic studies have identified a variant in the GC gene that codes for the
vitamin D-binding protein that is associated with decreased blood levels of YOUR RELATED GENES
25-hydroxyvitamin D, which is the major circulating form of vitamin D64,65. People
Your Scientific
with the G/G or G/T genotype at this genetic marker may be susceptible to lower Gene Tested
Genotype Strength
blood vitamin D levels due to reduced ability to transport vitamin D in the body.
GC-rs2282679 T/T ★★★★
Therefore, these people may need to "Optimize Intake" of vitamin D. People with a
T/T genotype are advised to "Stay Balanced" and maintain a healthy diet. The
studies we report observed associations between vitamin D levels and certain
genotypes; however, that does not mean that your levels are out of balance. You
should eat a healthy diet and speak with your physician before making specific
changes to your dietary regimen.

PAGE 26 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE NUTRITIONAL NEEDS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 27

NUTRITIONAL NEEDS
YOUR RESULT
VITAMIN E
Vitamin E is a group of eight antioxidant molecules, of which alpha-tocopherol is the STAY BALANCED
most abundant in the body. Vitamin E functions to promote a strong immune system Your genotype is associated with
and regulates other metabolic processes66,67. The recommended intake of vitamin increased alpha-tocopherol levels,
E for most adults is 15 milligrams per day. Note that synthetic varieties of vitamin E which is one compound that
found in some fortified foods and supplements are less biologically active. Sources makes up vitamin E. You should
of naturally-occurring vitamin E in foods are vegetable oils, green leafy vegetables, maintain a healthy diet to stay
eggs and nuts. balanced.

One study of 3,891 individuals found that people with the A/A or A/C genotypes at
an intergenic marker, rs12272004, near the APOA5 gene, had increased plasma YOUR RELATED GENES
levels of alpha-tocopherol68. Therefore, they should "Stay Balanced" and maintain a
Your Scientific
healthy diet. This is good news since increased vitamin E levels are associated with Gene Tested
Genotype Strength
decreased frailty and disability in old age69. People with the C/C genotype were not INTERGENIC-
associated with increased levels of alpha-tocopherol, and hence they would need to rs12272004
A/C ★★★★
"Optimize Intake" of vitamin E through the increased intake of foods rich in vitamin
E. Keep in mind, however, that most adults normally do not take in adequate
amounts of vitamin E on a daily basis70, so keeping an eye on your vitamin E intake
is good advice for anyone. The studies we report observed associations between
vitamin E levels and certain genotypes; however, that does not mean that your
levels are out of balance. You should eat a healthy diet and speak with your
physician before making specific changes to your dietary regimen.

PAGE 27 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE NUTRITIONAL NEEDS
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 28

NUTRIENTS, WEIGHT
MANAGEMENT AND
GENETICS
New studies continue to emerge that
demonstrate links between nutrients and
genetics that show benefits in health and
weight loss. Some of the benefits that
scientists observe in relation to genes are
listed below.
Important: The genes and associated benefits listed below are not
part of your genetic test. The content on this page is informational.

POTENTIAL HEALTH & WEIGHT

NUTRIENT/FOOD ASSOCIATED GENE(S)
LOSS BENEFITS

Resveratrol Weight Loss, Decrease Weight Gain SIRT1, PPARA, PPARG, ER

Polyphenols (tea) Decrease Weight Gain PPARG

Conjugated Linoleic Acid (CLA) Fat Burning, Weight Loss PPARA, PPARG

Ispoprenols (farnesol) Weight Loss PPARA, PPARG

Abietic Acid Weight Loss PPARG

Capsaicin (Hot Pepper) Weight Loss, Anti-inflammatory PPARG

Phytol (Chlorophyll) Weight Loss PPARA

Auraptene (Citrus) Weight Loss PPARA, PPARG

Isohumulone (Hops) Weight Loss PPARA, PPARG

Guggulsterone (Gugle) Weight Loss Farnesoid X Receptor

Steroid Receptors: Estrogen,

Soy/Genistein Weight Loss
Androgen, Progesterone

Diosgenin Weight Loss Steroid Receptors: Progesterone

Ginseng Weight Loss Steroid Receptors: Estrogen

Hyperforin Weight Loss Pregnane X Receptor

Alpha-lipoic Acid Reduction of Overeating AMPK Inhibitor

Anthocyanins (Pigment) Overall Health Benefit Adiponectin

Licorice LFO (Polyphenols) Overall Health Benefit FA synthase

Pomegranate Extract (Lenolenic Acid) Overall Health Benefit b-oxidation/PPARA

PAGE 28 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EXERCISE
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 29

EXERCISE HAS LONG BEEN SHOWN TO PROVIDE MANY

HEALTH BENEFITS
Studies have shown a link between genetics and exercise, and how people respond to
exercise for weight loss and other health benefits. A few examples of this link include the
ACE and ACTN3 genes and the association with elite athlete status, as well as the LPL gene
and its connection to the loss of body fat in response to exercise. A summary of your results
is listed below.

YOUR RESULTS
ENDURANCE TRAINING page:30 ENHANCED BENEFIT

STRENGTH TRAINING page:31 LESS BENEFICIAL

AEROBIC CAPACITY (VO2MAX) page:31 TYPICAL

MUSCLE POWER page:32 ENHANCED MUSCLE POWER

ACHILLES TENDINOPATHY page:32 TYPICAL

WEIGHT LOSS RESPONSE TO EXERCISE STRONGLY

EXERCISE page:33 RECOMMENDED

BLOOD PRESSURE RESPONSE EXERCISE STRONGLY

TO EXERCISE page:33 RECOMMENDED

HDL (GOOD) CHOLESTEROL

RESPONSE TO EXERCISE page:34 NORMAL BENEFIT

LOSS OF BODY FAT RESPONSE

TO EXERCISE page:34 NORMAL BENEFIT

INSULIN SENSITIVITY RESPONSE

TO EXERCISE page:34 ENHANCED BENEFIT

PAGE 29 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EXERCISE
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 30

YOUR EXERCISE RECOMMENDATIONS

✓ Your genetics are associated with enhanced health benefits from endurance
exercises, such as mid-long distance walking, jogging and bicycling. Weight
resistance exercises may be less beneficial.
✓ You have a genetic variant associated with being overweight. You can lower your
chances by leading a physically active lifestyle.
✓ You have a genetic variant associated with elevated blood pressure if you are not
physically active. Exercise may help you manage your blood pressure.
✓ You have a genetic variant some call the "sprinter gene" that most elite power
athletes also have. Thus, you may have an increased ability for sports or
exercise that require fast bursts of muscle power, such as sprinting or
weightlifting.

EXERCISE
YOUR RESULT
ENDURANCE TRAINING
Endurance training is generally used to describe exercise that is done for a longer ENHANCED BENEFIT
duration with moderate intensity. Most people can benefit from a combination of Endurance training may provide
endurance, high intensity and resistance exercises. Some people have genetic enhanced health benefits to
markers that are associated with "Enhanced Benefit" from endurance training, while people with your genotype.
others will gain "Normal Benefit." The studies that were used to calculate your result
tested responses to a 20-week endurance training program71,72,73. This result can
be used to help tailor your exercise routine. Always consult your physician or health YOUR RELATED GENES
care provider before beginning any exercise program.
Your Scientific
Gene Tested
Genotype Strength

LIPC-rs1800588 C/C ★★★★

LPL-rs328 C/C ★★★★
PPARD-rs2016520 A/A ★★★★

PAGE 30 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EXERCISE
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 31

EXERCISE
YOUR RESULT
STRENGTH TRAINING
Strength training can be described as exercises that incorporate the use of LESS BENEFICIAL
opposing forces to build muscle. The possible outcomes in this report are Strength training may be less
"Beneficial" and "Less Beneficial." In a small study of young adult men, those with beneficial to people with your
the C/G or C/C genotypes at rs7566605 were more likely to experience increased genotype, as there is a chance for
fat volume after participating in 12 weeks of resistance training, and thus strength a small gain in fat volume.
training was "Less Beneficial"74. This association has not been identified in women. Moderate strength training is still
recommended for overall health
benefits.

YOUR RELATED GENES

Your Scientific
Gene Tested
Genotype Strength

INSIG2-rs7566605 C/G ★★★★

EXERCISE
YOUR RESULT
AEROBIC CAPACITY (VO2MAX)
Maximal oxygen uptake (VO2max) is widely used as the best measure of an TYPICAL
individual's cardiorespiratory fitness. VO2max is defined as the maximum volume of Your genotype is associated with
oxygen per unit time that an individual uses at maximum exertion. The baseline typical aerobic capacity.
VO2max level can vary depending on age, gender, past medical history, current
health and level of physical activity. However, anyone can increase their fitness and
VO2max by endurance training. Elite athletes in endurance sports, such as cross- YOUR RELATED GENES
country skiing and long-distance running, have a higher VO2max than elite athletes
Your Scientific
in power sports, such as wrestling and weightlifting75. The rs8192678 SNP in the Gene Tested
Genotype Strength
PPARGC1A gene, which is a key regulator of energy metabolism, was associated
PPARGC1A-rs8192678 G/A ★★★★
with baseline VO2max (L/min) in a study of 303 Spanish and British men76. The
G/G and G/A genotypes of rs8192678 were associated with "Typical" VO2max,
whereas the A/A genotype was associated with a "Decreased" VO2max. This
association has not been studied in women. Please remember that you can always
increase your VO2max and fitness by endurance training, even if you start with a
decreased aerobic capacity.

PAGE 31 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EXERCISE
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 32

EXERCISE
YOUR RESULT
MUSCLE POWER
Do you have a genetic variant that is found in nearly ENHANCED MUSCLE
all sprinters qualified for top-level competitions like POWER
the Olympic Games? The so-called "sprinter gene" Your body is producing functional
refers to the functional version of the ACTN3 gene, ACTN3 protein, which is
which contains information for making a protein associated with enhanced
found in fast-twitch muscle fibers77. The protein and performance in sprinting and other
the fast-twitch muscle fibers are important in power sports.
generating explosive bursts of force. This is why the
functional version of ACTN3 is also seen with high
frequencies in other elite power-oriented athletes, YOUR RELATED GENES
such as weightlifters78. About 80% of people have at
Your Scientific
least one functional copy of the ACTN3 gene, which Gene Tested
Genotype Strength
can lead to enhanced muscle power. However,
ACTN3-rs1815739 C/T ★★★★
having functional ACTN3 is only one of a myriad of
genetic and non-genetic factors that contribute to the
success of elite athletes. The remaining 20% of
people, who do not have a functional copy of
ACTN3, may have less muscle power and are less
likely to be world-class sprinters or weightlifters, but
their chance to excel may not be affected in sports
that require other types of body performance, such
as endurance and nimbleness.

EXERCISE
YOUR RESULT
ACHILLES TENDINOPATHY
The Achilles tendon connects your calf muscles to TYPICAL
your heel bone. Tendinopathy describes either the Your genotype is associated with a
inflammation or tiny tears to the tendon. People who typical likelihood of Achilles
play sports and runners who place stress on the tendinopathy.
Achilles tendon have the greatest likelihood of
tendinopathy. If you have a G/G genotype you may
be more "Injury-Prone," while other genotypes have YOUR RELATED GENES
a "Typical" likelihood of developing Achilles
Your Scientific
tendinopathy. In a small study, people with the G/G Gene Tested
Genotype Strength
genotype at rs679620 (MMP3) had 2.5 times more
chance of developing Achilles tendinopathy
MMP3-rs679620 A/G ★★★★
compared to other genotypes79.

PAGE 32 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EXERCISE
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 33

EXERCISE
YOUR RESULT
WEIGHT LOSS RESPONSE TO EXERCISE
Exercise is a large part of many weight loss plans, as EXERCISE STRONGLY
it is a crucial tool for weight control for everyone. The RECOMMENDED
possible outcomes in this report are "Exercise You have a genetic variant that is
Strongly Recommended" and "Exercise associated with being overweight
Recommended." If your report shows "Exercise or obese. Regular exercise and an
Strongly Recommended," your genotype has been active lifestyle are strongly
shown to be associated with a tendency to be recommended.
overweight, and exercise is strongly recommended
for you. If your report shows "Exercise
Recommended," you have one less risk factor for YOUR RELATED GENES
being overweight. However, this should not be taken
Your Scientific
as one less reason to exercise, because being Gene Tested
Genotype Strength
physically active is beneficial to all people,
regardless of genetic makeup. People with the FTO-rs1121980 C/T ★★★★
“Exercise Strongly Recommended” outcome contain
a specific variant (T allele) in the genetic marker
rs1121890 of the FTO gene, which has been shown
to be associated with increased body mass index
(BMI) and waistline80,81. However, a large study
showed that people who have this variant could
reduce their propensity to increased BMI by being
physically active81.

EXERCISE
YOUR RESULT
BLOOD PRESSURE RESPONSE TO EXERCISE
High blood pressure, also known as hypertension, is a common health issue. It has EXERCISE STRONGLY
been estimated that a majority of people will have hypertension at some time in RECOMMENDED
their lives. A genetic variant in the EDN1 gene has been shown to increase the Your genotype is associated with
likelihood of hypertension in people who were low in cardiorespiratory fitness, which an increased likelihood of elevated
refers to the ability of the heart and lungs to provide muscles with oxygen for blood pressure, if you have low
physical activity82. This genetic variant did not show an effect in people who were fitness levels. Exercise may help
high in cardiorespiratory fitness. If you have this variant, your result is "Exercise you manage your blood pressure.
Strongly Recommended," since you may need to exercise to reduce your chances
of hypertension. If you do not have the variant, your result is "Exercise
Recommended," since exercise is still the right decision to manage other risk YOUR RELATED GENES
factors for high blood pressure you may have.
Your Scientific
Gene Tested
Genotype Strength

EDN1-rs5370 G/T ★★★★

PAGE 33 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE EXERCISE
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 34

EXERCISE
YOUR RESULT
HDL (GOOD) CHOLESTEROL RESPONSE TO EXERCISE
One of the health benefits of exercise can be the improvement of your cholesterol. NORMAL BENEFIT
HDL cholesterol is known as the good cholesterol, and having more HDL is Your genotype is associated with a
beneficial. Most people can improve their HDL levels by exercising. In the Heritage typical increase in HDL (good)
Family Study, people with the A/G and G/G genotypes were more likely to have an cholesterol in response to a
"Enhanced Benefit" in their HDL levels by exercising73. People with "Normal 20-week endurance training
Benefit" may also increase their HDL levels by exercising, but may not experience program.
an enhanced effect.

YOUR RELATED GENES

Your Scientific
Gene Tested
Genotype Strength

PPARD-rs2016520 A/A ★★★★

EXERCISE
YOUR RESULT
LOSS OF BODY FAT RESPONSE TO EXERCISE
Many people exercise to lose body fat. If you have a NORMAL BENEFIT
specific genotype in the gene LPL, you may have an Your genotype is associated with a
"Enhanced Benefit" from exercise to lose body fat71. typical reduction in body fat mass
If you have the "Normal Benefit" genotype, you will and percent of body fat in
still experience fat reduction if you exercise, but it response to exercise.
might take more effort. The study was based on
women who participated in a 20-week endurance
training program. This association has not been YOUR RELATED GENES
identified in men.
Your Scientific
Gene Tested
Genotype Strength

LPL-rs328 C/C ★★★★

EXERCISE
YOUR RESULT
INSULIN SENSITIVITY RESPONSE TO EXERCISE
Insulin sensitivity is a good thing. Insulin in your body helps control your response ENHANCED BENEFIT
to glucose, commonly known as sugar. Having an increased insulin sensitivity Your genotype is associated with
means that the body has a better ability to process sugar. The opposite of insulin enhanced insulin sensitivity in
sensitivity is called insulin resistance, which is linked to obesity and type 2 diabetes. response to exercise.
Most people have a beneficial response to exercise, resulting in increased insulin
sensitivity. According to a study, people with C/C or C/T genotypes, at a marker in
the LIPC gene, showed an "Enhanced Benefit," compared to those with a T/T YOUR RELATED GENES
genotype72. Although people with T/T genotypes are likely to gain "Less Benefit" in
Your Scientific
insulin sensitivity from exercise training, exercise remains important in many other Gene Tested
Genotype Strength
aspects of their health.
LIPC-rs1800588 C/C ★★★★

PAGE 34 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE YOUR BODY AND
ACC #: F7715014 WEIGHT
DATE: NOV 12, 2015 PAGE 35

YOUR WEIGHT CAN BE INFLUENCED

BY MANY GENES
Your report includes how your genes may relate to your
metabolism, if you are likely to maintain weight loss, as well as
your predisposition for obesity. A summary of your results is
provided below.

YOUR RESULTS
OBESITY page:37 AVERAGE

MORE LIKELY TO GAIN WEIGHT

WEIGHT LOSS-REGAIN page:37 BACK

METABOLISM page:38 NORMAL

ADIPONECTIN LEVELS page:38 POSSIBLY LOW

PAGE 35 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE YOUR BODY AND
ACC #: F7715014 WEIGHT
DATE: NOV 12, 2015 PAGE 36

YOUR BODY AND WEIGHT

YOUR ACTUAL WEIGHT (BMI)

Body mass index (BMI) is a measure of body fat based on height and weight that
Actual Weight applies to adult men and women. BMI is usually represented in kg/m2. Your BMI
was calculated using your survey responses for weight and height. If your BMI is
Weight: 140 lbs Height: 5' 6" not listed here, you may not have completed those responses in the survey.

Your actual weight is a result of a combination of factors including lifestyle,

Normal environment and genetics. Your Obesity Index result is a measure of your
likelihood, based on genetics, to have a BMI over 35 (clinically or extremely
obese). Since your weight is affected by many factors, it is possible for your
YOUR Obesity Index result to be very different than your actual weight. The important

BMI
body mass index
22.6 point is that the genetics of obesity do not lead to an inevitable outcome. Many
people have a choice of managing lifestyle to counteract genetics. For example,
some people that are of normal weight BMI can have an Obesity Index of above
Category BMI range - kg/m2
average or high. This example is commonly seen in someone who is controlling
Underweight Less than 18.5 diet, nutrition, eating behaviors and/or exercise to manage their body weight. The
Normal from 18.5 to 24.9 opposite can also be true. Some people who have an actual BMI in the obese
categories can have an Obesity Index of average, below average or low. This
Overweight from 25 to 29.9
case can sometimes be explained by lifestyle choices, environment or other
Obese from 30 to 34.9 health factors that have led a person to become obese without having the
Clinically Obese from 35 to 39.9
genetics associated to obesity.

Extremely Obese 40 or greater

PAGE 36 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE YOUR BODY AND
ACC #: F7715014 WEIGHT
DATE: NOV 12, 2015 PAGE 37

YOUR BODY AND WEIGHT

YOUR RESULT
OBESITY
Obesity is influenced by both genetic and environmental factors. Approximately 40 AVERAGE
to 70% of an individual’s susceptibility to obesity is inherited1. When someone Your genetic profile indicates an
reaches a body mass index (BMI) of 30 to 35 (clinically obese) or above 40 average predisposition for being
(morbidly obese), genetic factors with strong effects are likely to be involved. There overweight.
are 2 possible outcomes of this test: “Average” and “Above Average”. An “Above
Average” outcome does not mean that you are obese, it only means that you have
a higher than average genetic likelihood for a high BMI. YOUR RELATED GENES
Your Scientific
Your genetic predisposition to obesity is determined from your genotypes at variants Gene Tested
Genotype Strength
in the FTO (fat mass and obesity associated) and MC4R (melanocortin-4 receptor)
genes. The association of these genes to obesity is well-established. The MC4R
FTO-rs9939609 A/T ★★★★
gene is expressed in the brain’s hunger center and is involved in regulating energy MC4R-rs17782313 T/T ★★★★
balance83. Rare mutations in the MC4R gene have been shown to cause a rare,
inherited form of obesity. FTO is less well-understood, but is also believed to be
important for controlling feeding behavior and energy balance84. Your test result
includes common variants that have been confirmed in many large genetic studies
(including multiple studies of over 38000 individuals) to be associated with a
predisposition for high BMI and/or obesity19,85,86,87,88. However, as lifestyle also has
a considerable impact on obesity, you can mitigate your risks by eating a proper
diet, exercising and reducing stress89,90.

YOUR BODY AND WEIGHT

YOUR RESULT
WEIGHT LOSS-REGAIN
There are genes associated with the tendency to MORE LIKELY TO
gain weight back after a person loses weight, and GAIN WEIGHT BACK
there are genes that protect a person from weight You may have difficulty keeping
regain. In one study, people with the G/G genotype weight off after losing weight.
at a marker in the ADIPOQ gene were "More Likely
to Gain Weight Back," while people with other
genotypes were more likely to show "Weight Loss YOUR RELATED GENES
Maintained"91. It is best after losing weight to
Your Scientific
maintain a healthy diet, exercise and nutrition plan to Gene Tested
Genotype Strength
keep the extra pounds off and support long-term
health.
ADIPOQ-rs17300539 G/G ★★★★

PAGE 37 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE YOUR BODY AND
ACC #: F7715014 WEIGHT
DATE: NOV 12, 2015 PAGE 38

YOUR BODY AND WEIGHT

YOUR RESULT
METABOLISM
Metabolism describes the way your body burns energy (calories) and tends to have NORMAL
a strong correlation to managing your weight. Resting metabolism is how your body Your genotype is associated with a
burns energy while at rest. People with a "Fast" metabolism can sometimes eat normal resting metabolic rate.
more food with little exercise and not gain weight. People with a "Normal"
metabolism tend to require average amounts of food intake and average amounts
of exercise to maintain weight. A genetic marker in the leptin receptor (LEPR) is YOUR RELATED GENES
associated with interactions in your brain that trigger how and when you burn
Your Scientific
energy. People with a C/C genotype tend to have an increased resting metabolic Gene Tested
Genotype Strength
rate, or "Fast" metabolism, while people with C/G or G/G genotypes are not
associated with an increased resting metabolic rate; therefore, they have a
LEPR-rs8179183 G/G ★★★★
"Normal" metabolism92. However, having this genetic variant is only one of many
other genetic and non-genetic factors that contribute towards your metabolism.
Exercise is a common method of increasing your metabolism.

YOUR BODY AND WEIGHT

YOUR RESULT
ADIPONECTIN LEVELS
Adiponectin is a hormone that is produced by fat cells and functions in the body to POSSIBLY LOW
trigger your liver and muscles to get energy from fat93. Higher levels of adiponectin Your genotype is associated with
are considered good for weight loss and health94. Your health care provider can test lower adiponectin levels.
your adiponectin levels. If you have low levels, losing weight may be a good way to
increase your adiponectin levels93. A variant in the adiponectin gene (ADIPOQ) is
associated with adiponectin levels. People with A/A or A/G genotypes were YOUR RELATED GENES
associated with "Possibly Low" levels of adiponectin, while those with the G/G Your Scientific
Gene Tested
genotype had "Typical" levels95. Genotype Strength

ADIPOQ-rs17366568 A/G ★★★★

PAGE 38 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE METABOLIC HEALTH
ACC #: F7715014 FACTORS
DATE: NOV 12, 2015 PAGE 39

YOUR METABOLIC HEALTH CAN BE

INFLUENCED BY MANY GENES
Your report includes genetic variants that measure your
likelihood for having decreased HDL cholesterol levels, as well
as elevated LDL cholesterol, blood sugar and triglyceride
levels. All of these are indicators of adverse metabolic health,
which are precursors to various health conditions, including
coronary artery disease, stroke and type 2 diabetes. Your
genetic results for these metabolic health factors are
summarized below.

YOUR PROBABILITIES
ELEVATED LDL CHOLESTEROL page:40 ABOVE AVERAGE

DECREASED HDL CHOLESTEROL page:41 ABOVE AVERAGE

ELEVATED TRIGLYCERIDES page:42 ABOVE AVERAGE

ELEVATED BLOOD SUGAR page:43 AVERAGE

PAGE 39 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE METABOLIC HEALTH
ACC #: F7715014 FACTORS
DATE: NOV 12, 2015 PAGE 40

YOUR HEALTH RECOMMENDATIONS

✓ You have a higher than average genetic likelihood for elevated LDL cholesterol
levels. Regular monitoring of your cholesterol by your physician is recommended.
✓ Your genetic profile shows a higher than average likelihood for decreased HDL
(good) cholesterol. HDL levels can sometimes be improved through aerobic
exercise and a healthy diet.
✓ You have a higher than average genetic likelihood for elevated triglyceride levels.
Therefore, regular monitoring by your physician is recommended. You can help
manage triglyceride levels by maintaining a healthy weight, reducing saturated
fat and sugar intake, and increasing your consumption of omega-3 fatty acids
(fish or seafood).

METABOLIC HEALTH FACTORS

YOUR PROBABILITY
ELEVATED LDL CHOLESTEROL
Low-density lipoprotein (LDL) is the type of cholesterol that can become dangerous ABOVE AVERAGE
if you have too much of it. Like gunk clogging up your kitchen drain, LDL cholesterol You share a similar genetic profile
can form plaque and build up in the walls of your arteries. This can make your with individuals who exhibit
arteries narrower and less flexible, putting you at risk for conditions like a heart borderline-high LDL cholesterol
attack or stroke. Optimally, LDL levels should be less than 100 mg/dl. Near-optimal levels. Therefore, you have a
levels range from 100 to 129 mg/dl and borderline high from 130 to 159 mg/dl. A higher than average likelihood for
score greater than 160 mg/dl is high and greater than 190 mg/dl is very high. Your elevated LDL (bad) cholesterol
physician can measure your cholesterol levels. levels.
A genetic result of "High" or "Above Average" does not mean you have elevated
LDL cholesterol levels, but tells you that you may have a genetic propensity for YOUR RELATED GENES
elevated LDL cholesterol levels. On the other hand, a result of "Low" or "Below
Your Scientific
Average," tells you that you have a lower than average genetic likelihood for Gene Tested
Genotype Strength
elevated LDL cholesterol levels. However, you could still develop problems with
your LDL levels as a result of your diet and other factors. This report is based on ABCG8-rs6544713 C/T ★★★★
genetic variants studied in over 19,000 individuals. A genetic result of "High" means APOB-rs515135 G/A ★★★★
that you share a similar genetic profile with individuals from the Framingham Heart
Study who had elevated LDL cholesterol levels measuring, on average, above 139 CELSR2-rs12740374 G/G ★★★★
mg/dl with approximately 25% of individuals measuring above 160 mg/dl8. A genetic HMGCR-rs3846663 C/T ★★★★
result of "Above Average" means that you share a similar genetic profile with
individuals measuring, on average, above 130 mg/dl LDL with approximately 17% HNF1A-rs2650000 A/C ★★★★
of individuals measuring above 160 mg/dl LDL cholesterol8. A genetic result of INTERGENIC-
G/G ★★★★
"Average" means that you share a similar genetic profile with individuals measuring, rs1501908

on average, near-optimal LDL cholesterol levels. Diet plays an important part in LDLR-rs6511720 G/G ★★★★
LDL levels. Processed foods and foods high in trans fat contribute to elevated LDL
levels. MAFB-rs6102059 C/T ★★★★
NCAN-rs10401969 T/T ★★★★
PCSK9-rs11206510 T/T ★★★★

PAGE 40 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE METABOLIC HEALTH
ACC #: F7715014 FACTORS
DATE: NOV 12, 2015 PAGE 41

METABOLIC HEALTH FACTORS

YOUR PROBABILITY
DECREASED HDL CHOLESTEROL
High-density lipoprotein (HDL) cholesterol is known as good cholesterol, because ABOVE AVERAGE
high levels of HDL cholesterol seem to protect against heart attack, while low levels You share a similar genetic profile
of HDL cholesterol (less than 40 mg/dL) increase the risk of heart disease96. While with individuals exhibiting
multiple mechanisms are known to account for this, the major one is thought to be decreased HDL cholesterol levels.
the role of HDL in transporting excess cholesterol away from the arteries and back Therefore, you have a higher than
to the liver, where it is passed from the body97. Your HDL cholesterol can be average likelihood for decreased
measured with a simple blood test. In men, typical HDL cholesterol levels range HDL cholesterol levels.
from 40 to 50 mg/dl. In women, female hormones cause typical HDL cholesterol
levels to range from 50 to 60 mg/dl; however, after menopause there is a tendency
for decreased HDL cholesterol levels. Foods containing trans fats can lower HDL YOUR RELATED GENES
cholesterol levels, which is unhealthy. Cholesterol levels should be monitored by Your Scientific
Gene Tested
your physician. Genotype Strength

ABCA1-rs1883025 G/G ★★★★

A genetic result of "High" or "Above Average" does not mean you have decreased
HDL cholesterol levels, but tells you that you may have a high propensity for ANGPTL4-rs2967605 G/G ★★★★
decreased HDL cholesterol levels. On the other hand, a result of "Low" or "Below
Average," tells you that you have a lower than average propensity for decreased CETP-rs247616 C/C ★★★★
HDL cholesterol levels. Our genetic testing is based on genetic variants studied in FADS1-rs174547 T/T ★★★★
over 19,000 individuals. A result of "High" means that you share a similar genetic
profile with individuals from the Framingham Heart Study who had decreased HDL GALNT2-rs4846914 A/G ★★★★
cholesterol levels measuring, on average, below 46 mg/dl with approximately 37% HNF4A-rs1800961 C/C ★★★★
of individuals measuring below 40 mg/dl8. On the other hand, a result of "Above
Average" means that you share a similar genetic profile with individuals measuring, KCTD10-rs2338104 C/C ★★★★
on average, below 50 mg/dl HDL cholesterol with approximately 30% of individuals LCAT-rs2271293 A/G ★★★★
measuring below 40 mg/dl HDL cholesterol8.
LIPC-rs10468017 C/C ★★★★
LIPG-rs4939883 T/T ★★★★
LPL-rs12678919 A/A ★★★★
PLTP-rs7679 C/T ★★★★
TTC39B-rs471364 A/A ★★★★
ZNF259-rs964184 C/G ★★★★

PAGE 41 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE METABOLIC HEALTH
ACC #: F7715014 FACTORS
DATE: NOV 12, 2015 PAGE 42

METABOLIC HEALTH FACTORS

YOUR PROBABILITY
ELEVATED TRIGLYCERIDES
Triglyceride is the chemical term for fat as it is stored ABOVE AVERAGE
in your body. People with elevated triglycerides are You share a similar genetic profile
at risk of conditions, such as coronary artery disease with individuals who exhibit
or type 2 diabetes. Having higher triglycerides is borderline-high triglyceride levels.
often associated with poor lifestyle choices, such as Therefore, you have a higher than
lack of exercise, excessive alcohol consumption, average likelihood for elevated
cigarette smoking, excessive refined carbohydrate triglyceride levels.
consumption and being overweight. A normal
triglyceride score is under 150 mg/dl. Triglyceride
levels in the range of 150 to 199 mg/dl are defined as YOUR RELATED GENES
borderline high, with over 200 mg/dl considered high
Your Scientific
and over 500 mg/dl very high. Your triglyceride levels Gene Tested
Genotype Strength
can be monitored by your physician.
ANGPTL3-rs10889353 A/C ★★★★
A result of "High" or "Above Average" does not mean APOB-rs7557067 A/A ★★★★
you have elevated triglyceride levels, but tells you
that you may have a propensity for elevated FADS1-rs174547 T/T ★★★★
triglycerides levels. On the other hand, a genetic test GCKR-rs1260326 C/T ★★★★
result of "Low" or "Below Average," tells you that you
have a lower than average likelihood for elevated LPL-rs12678919 A/A ★★★★
triglyceride levels. The genetic test is based on
MLXIPL-rs714052 T/T ★★★★
genetic variants studied in over 19,000 individuals. A
genetic result of "High" means that you share a NCAN-rs17216525 C/C ★★★★
similar genetic profile with individuals from the
Framingham Heart Study who had elevated
PLTP-rs7679 C/T ★★★★
triglyceride levels measuring on average above 150 TRIB1-rs2954029 A/A ★★★★
mg/dl with approximately 31% of individuals
measuring above 200 mg/dl8. XKR6-rs7819412 A/A ★★★★
ZNF259-rs964184 C/G ★★★★

PAGE 42 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE METABOLIC HEALTH
ACC #: F7715014 FACTORS
DATE: NOV 12, 2015 PAGE 43

METABOLIC HEALTH FACTORS

YOUR PROBABILITY
ELEVATED BLOOD SUGAR
Elevated blood sugar is a health condition that AVERAGE
results from higher than normal levels of the sugar Based on your genetic profile you
(glucose) in the blood plasma. High blood sugar have an average likelihood for
levels are measured as a reading greater than 140 elevated blood sugar levels.
mg/dl or a fasting plasma glucose level of greater
than 100 mg/dl. High blood sugar levels often
indicate a condition called insulin resistance and can YOUR RELATED GENES
lead to type 2 diabetes. Your physician can directly
Your Scientific
measure blood sugar or you can use a blood test at Gene Tested
Genotype Strength
home to check your blood sugar.
ADCY5-rs11708067 A/A ★★★★
A genetic result of "High" or "Above Average" does ADRA2A-rs10885122 G/G ★★★★
not mean you have elevated blood sugar levels, but
tells you that you may have a genetic propensity for CRY2-rs11605924 A/C ★★★★
elevated blood sugar levels. On the other hand, a FADS1-rs174550 T/T ★★★★
result of "Low" or "Below Average," tells you that you
have a lower than average genetic likelihood for G6PC2-rs560887 G/G ★★★★
elevated blood sugar levels. This report is based on
GCK-rs4607517 A/G ★★★★
genetic variants identified in a study of more than
100,000 individuals9,98. GCKR-rs780094 G/A ★★★★
GLIS3-rs7034200 A/C ★★★★
MADD-rs7944584 A/T ★★★★
MTNR1B-rs10830963 C/C ★★★★
PROX1-rs340874 C/C ★★★★
SLC2A2-rs11920090 T/T ★★★★
TCF7L2-rs7903146 C/C ★★★★

END OF REPORT

PAGE 43 of 50
 SAMPLE REPORT
NAME/ID: SAMPLE PATIENT
SEX: FEMALE APPENDIX
ACC #: F7715014
DATE: NOV 12, 2015 PAGE 44

The scientific studies referenced in this report are provided below and can be referenced at www.pubmed.gov. All of these
papers were published in peer-reviewed journals. PubMed is a service managed by the National Institutes of Health (NIH), a
part of the U.S. Department of Health and Human Services, and it tracks more than 19 million citations for biomedical articles
and scientific research.
1. O'Rahilly S et al. Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive To Environmental
Conditions. Diabetes 57, 2905-10 (2008).
2. Ordovas JM et al. Dietary Fat Intake Determines The Effect Of A Common Polymorphism In The Hepatic Lipase Gene
Promoter On High-density Lipoprotein Metabolism: Evidence Of A Strong Dose Effect In This Gene-nutrient Interaction
In The Framingham Study. Circulation 106, 2315-21 (2002).
3. Junyent M et al. Novel Variants At KCTD10, MVK, And MMAB Genes Interact With Dietary Carbohydrates To Modulate
HDL-cholesterol Concentrations In The Genetics Of Lipid Lowering Drugs And Diet Network Study. The American
Journal Of Clinical Nutrition 90, 686-94 (2009).
4. Sonestedt E et al. Fat And Carbohydrate Intake Modify The Association Between Genetic Variation In The FTO
Genotype And Obesity. The American Journal Of Clinical Nutrition 90, 1418-25 (2009).
5. Corella D et al. APOA2, Dietary Fat, And Body Mass Index: Replication Of A Gene-diet Interaction In 3 Independent
Populations. Archives Of Internal Medicine 169, 1897-906 (2009).
6. Warodomwichit D et al. ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, And Obesity Risk: The GOLDN Study.
Obesity (Silver Spring, Md.) 17, 510-7 (2009).
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