Department of Biochemistry, Manipal Tata Medical College,
Jamshedpur
SGT for lipid metabolism.
23-25 January 2024
1. Essential fatty acids
2. Consumption of PUFA reduces the plasma cholesterol level.
3. Explain the significance of unsaturated, saturated, trans and cis fatty acids with examples.
(4 marks)
4. Explain the process of digestion of dietary lipids.
5. Fecal fat/steatorrhea: > 6gms/day
6. Phospholipids are amphipathic in nature.
7. Indicate the biochemical defect in to flowing disorders:
IEM Enzyme deficient Substance Prominent feature
accumulated
Refsum’s disease
Niemann Pick
disease
Gaucher’s disease
Tay Sach’s disease
Tangier’s disease
8. Write the reactions of beta- oxidation of palmitic acid.
9. Describe the reactions of beta oxidation of palmitov1 CoA in mitochondria. Calculate the
energetics.
10. Define beta oxidation. Name the three stages of this process. Describe the role of
camitine in the oxidation of fatty acids. Write the energetics
11. Write briefly on prostaglandins
12. Prostaglandins may be used in termination of pregnancy.
13. MOA of Aspirin.
Examples of NSAIDs: Aspirin, Indomethacine, Ibuprofen, Paracetamol.
Prepared by: Dr Kavita, Dr Sunita, Dr Elvis
Department of Biochemistry, Manipal Tata Medical College,
Jamshedpur
SGT for lipid metabolism.
23-25 January 2024
14. An 18-year-old boy was brought to casualty with hyperventilation. On examination, he
was dehydrated. His random blood glucose was 400mg/dL, and urine tested positive for
ketone bodies.
a) what is your probable diagnosis?
b) Name the ketone bodies.
c) How are the ketone bodies utilized?
15. Fates of acetyl Co-A
Sources of acetyl CoA Fates of acetyl Co-A Substances synthesized
1
2
3
4
5
16. A 45 year old man who is obese and has a sedentary job got his yearly health
checkup done. His serum lipid profile was as follows: -
Total Cholesterol: 280 mg/dL, HDL-C: 40mg/dL, TG: 190 mg/dl
Calculate the LDL-cholesterol level using Friedewald's formula.
Write the recommended reference range of the above parameters and comment on
the results
1B) Discuss in detail the normal metabolism of the lipoprotein that is increased in this
patient.
1C) Explain the mechanism of most common clinical complication of
hypercholesterolemia.
Prepared by: Dr Kavita, Dr Sunita, Dr Elvis
