Conceptual Review Of Pharmacology For NBE 5th

Edition Ranjan Kumar Patel digital download

Find it at ebookultra.com
( 4.7/5.0 ★ | 423 downloads )

https://ebookultra.com/download/conceptual-review-of-pharmacology-
for-nbe-5th-edition-ranjan-kumar-patel/
Conceptual Review Of Pharmacology For NBE 5th Edition Ranjan
Kumar Patel

EBOOK

Available Formats

■ PDF eBook Study Guide Ebook

EXCLUSIVE 2025 ACADEMIC EDITION – LIMITED RELEASE

Available Instantly Access Library

Here are some recommended products for you. Click the link to
download, or explore more at ebookultra.com

Annual Review of Pharmacology and Toxicology Volume 45

2005 Annual Review of Pharmacology and Toxicology 1st
Edition Arthur K. Cho
https://ebookultra.com/download/annual-review-of-pharmacology-and-
toxicology-volume-45-2005-annual-review-of-pharmacology-and-
toxicology-1st-edition-arthur-k-cho/

The Protocol Book for Intensive Care 5th Edition Kumar

Soumitra

https://ebookultra.com/download/the-protocol-book-for-intensive-
care-5th-edition-kumar-soumitra/

Developing Responsive Web Applications with AJAX and

jQuery 1st Edition Sandeep Kumar Patel

https://ebookultra.com/download/developing-responsive-web-
applications-with-ajax-and-jquery-1st-edition-sandeep-kumar-patel/

Review of Physiology 5th Edition Manna Soumen

https://ebookultra.com/download/review-of-physiology-5th-edition-
manna-soumen/
Brody s Human Pharmacology 5th Edition Lynn Wecker

https://ebookultra.com/download/brody-s-human-pharmacology-5th-
edition-lynn-wecker/

Underground Clinical Vignettes Pharmacology Classic

Clinical Cases for USMLE Step 1 Review 3rd Edition Vikas
Bhushan
https://ebookultra.com/download/underground-clinical-vignettes-
pharmacology-classic-clinical-cases-for-usmle-step-1-review-3rd-
edition-vikas-bhushan/

MCQs in Hematology Postgraduate Review Series 1st Edition

Sanjeev Kumar Sharma

https://ebookultra.com/download/mcqs-in-hematology-postgraduate-
review-series-1st-edition-sanjeev-kumar-sharma/

Essentials of Pharmacology for Nurses 1st Edition Paul

Barber

https://ebookultra.com/download/essentials-of-pharmacology-for-
nurses-1st-edition-paul-barber/

Dynamics of Smart Structures 1st Edition Ranjan Vepa

https://ebookultra.com/download/dynamics-of-smart-structures-1st-
edition-ranjan-vepa/
 Fifth Edition

Ranjan Kumar Patel

MD Pharmacology
Ex Faculty UCMS and GTB Hospital, Delhi

CBS Publishers & Distributors Pvt Ltd

• New Delhi • Bengaluru • Chennai • Kochi • Kolkata • Mumbai
• Hyderabad • Nagpur • Patna • Pune • Vijayawada
 DISCLAIMER
This book contains questions based on topics asked
in previous years’ State and National Level PG
Entrance and Medical Officer Examinations in India.
Often repeated topics and sub-topics have been
included for students’ benefit. We do not claim that
these questions are exact or similar to questions
asked in recent examinations in India. If any such
similarity is found, it is purely coincidental and by
chance.

ISBN: 978-93-89941-96-8

Copyright © Author and Publishers

Fifth Edition: 2020

Fourth Edition: 2019-20
Third Edition: 2018
All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or
mechanical, including photocopying, recording, or any information storage and retrieval system without permission, in
writing, from the author and the publishers.
Published by Satish Kumar Jain and produced by Varun Jain for
CBS Publishers & Distributors Pvt Ltd
4819/XI Prahlad Street, 24 Ansari Road, Daryaganj, New Delhi 110 002, India.
Ph: +91-11-23289259, 23266861, 23266867 Website: www.cbspd.com
Fax: 011-23243014
e-mail: [email protected]; [email protected].
Corporate Office: 204 FIE, Industrial Area, Patparganj, Delhi 110 092
Ph: +91-11-4934 4934 Fax: 4934 4935
e-mail: [email protected]; [email protected]

Branches
• Bengaluru: Seema House 2975, 17th Cross, K.R. Road
Banasankari 2nd Stage, Bengaluru 560 070, Karnataka
Ph: +91-80-26771678/79 Fax: +91-80-26771680 e-mail: [email protected]
• Chennai: 7, Subbaraya Street, Shenoy Nagar, Chennai 600 030, Tamil Nadu
Ph: +91-44-26680620, 26681266 Fax: +91-44-42032115 e-mail: [email protected]
• Kochi: 68/1534, 35, 36-Power House Road, Opp. KSEB, Cochin-682018, Kochi, Kerala
Ph: +91-484-4059061-65 Fax: +91-484-4059065 e-mail: [email protected]
• Kolkata: 6/B, Ground Floor, Rameswar Shaw Road, Kolkata-700 014, West Bengal
Ph: +91-33-22891126, 22891127, 22891128 e-mail: [email protected]
• Mumbai: 83-C, Dr E Moses Road, Worli, Mumbai-400018, Maharashtra
Ph: +91-22-24902340/41 Fax: +91-22-24902342 e-mail: [email protected]
Representatives

• Hyderabad +91-9885175004 • Patna +91-9334159340

• Pune +91-9623451994 • Vijayawada +91-9000660880

Printed at:
 Dedicated to
My twin stars Additri and Aaryahi
 From Publisher’s Desk
Dear Readers,
I extend my warm welcome and convey my heartfelt thanks for appreciating the CBS Exam
Books for another successful year. It has been an amazing journey so far and I am highly
grateful for your support and cooperation to help us achieve various milestones in this whole
span of time. The mission with which we started in the year 2015 was to bring nothing but the
best of everything to our target audience and today I can proudly say that we have maintained
that standard and are committed to continue the same in future as well.
Every single title under the banner of CBS Exam Books has been developed and nurtured
like an infant. The authors and our entire team work day and night to bring the best in
everything for you. Be it content, presentation, social media contests and offers, we strive
to meet your expectations with every passing year. Your trust has motivated us to maintain
and upgrade ourselves during this period. I am extremely thankful to all our authors who are
the real pillars of the complete series of CBS Exam Books. The contributions of our esteemed
authors have laid the foundations of CBS Exam Books.
At this juncture, I can recall these lines by Drake,
“Sometimes it’s the journey that teaches you a lot about your destination”.
We have grown and changed with the passage of time to upgrade our ways of providing our readers with maximum benefits and
help them manage their time and efforts in effective manner. Previous year was the year of great achievements. Let me show you a
glimpse of our successful journey:
•• Most of the titles of CBS Exam Books received wide acceptance and recognition by the readers of proving their usefulness and
supremacy. To mention a few, SARP Anatomy, CRISP, Surgery Sixer, Complete Review of Pathology, Conceptual Review of
Pharmacology, SOCH, Forensic Medicine, Complete Review of Medicine, Conceptual Review of PSM, MICRONS, My PGMEE Notes,
AIIMS MedEasy, and PRIMEs. With your constant support and our consistent efforts, I am sure that we will together witness an
exponential acceptance of all CBS Exam Books in coming future as well.
•• The presence of CBS Exam Books has broadened through our various social media platforms. We have received great appreciation
for our regular Facebook activities such as online test series, giveaways, scientific content for knowledge enhancement, authors’ live
sessions, and various contests, like Bid 2 Win, Fastest Finger First, Book Fair and Facebook Community Awards. Join us on all these
platforms to avail and enjoy our exciting offers and benefits.

A book is incomplete if it does not have the right readers. We value you and your feedback. Please share your feedback and suggestions
directly with me at [email protected]. We promise to deliver in our books, what you desire to see.
I would like to sum up with these eternal lines of Robert Frost:
Woods are lovely dark and deep,
But I have promises to keep.
And miles to go before I sleep,
And miles to go before I sleep!
Wishing you success in all your endeavors!

Bhupesh Arora
Vice President – Publishing & Marketing
(PGMEE and Nursing Division)
Email: [email protected]
Mobile: (+91) 9555590180
 Preface
Dear students,
I would like to thank all of you for the fantabulous response that you have given to the previous editions. Your reviews and feedback
about first, second, third and fourth editions made me ecstatic and at the same time fueled me to give you an even better fifth edition.
As compared to the fourth edition, I have added several recent guidelines regarding New Drugs 2019 list with changes that have
taken place in pharmacotherapy in the year 2019. For the first time Recently Changed AIIMS Pattern Questions Review 2019 and recently-
conducted 2020 examination papers (Recent Pattern Questions 2020-2019, AIIMS November and May 2019, JIPMER November and May
2019 and PGI May 2019) have been added to ace your preparation practice before upcoming AIIMS examination.
In the chapter ‘Cardiovascular System’, I have added ACLS Guidelines 2017 for management of cardiac arrest, tachycardia and
bradycardia. Apart from this, Changes in ACC/AHA Guidelines in management of CHF and dyslipidemia have also been incorporated.
In the topic of ‘Antimicrobials’, the Recent Changes in regimens for management of TB, HIV, leprosy, etc. have been discussed
in details. Many changes have been incorporated wherever needed, based on CMDT 2019, Goodman Gilman 13th Edition and recent
journals.
Sincere attention has been paid on the feedback sent by the students and the important suggestions have been incorporated in this
edition like—‘Classification of Drugs’ is now given in every topic so that you can revise the drugs at one place. A drug chart on ANS
separately available with the book will prove quite handy for frequent revision.
The backbone of the first edition was concepts, which continue to be there even in this edition. Every topic begins with the relevant
part from preclinical subjects, like anatomy, physiology, pathology, biochemistry and microbiology, and then finally, drugs come into
picture making a web of correlation. The correlation is well explained in the Conceptual Boxes, which tell you why a drug is used. After
all details of drugs are covered, the Clinical Boxes will guide you through the medicine aspect of treatment as to understand where
drugs stand as compared to nondrug strategies of management. These clinical boxes tell you how and when a drug is used. With every
topic, a separate box of Recent Advances has been given to guide you through the future trends in treatment; in recent exams new
drugs and even drugs under trials have been asked.
MCQs of recent exams are cherry on the cake that will keep you abreast with the changing pattern. MCQs of JIPMER and NIMHANS
are also included, so that students preparing for these exams are also benefited. The question section begins with AIIMS and recent exam
questions, which are segregated subtopic wise so that you can solve them after you are through a particular subtopic. However, the other
questions of PGI, JIPMER and NIMHANS are not segregated and you can practice them after you are done with complete topics. Finally, as
Image-based Questions are the current toast of the town, I have given them at the end of each chapter for your practice.
Mnemonics have been included to make learning easier in remembering different aspects related to drugs. One Liners in the
beginning of each chapter cover the most important points, which will give you a quick revision source, a day before exam. ‘Annexures’,
after every chapter, contain the Updated Drugs of Choice and New Drugs Approved by FDA for quick revision.
I have done my part by bringing the world of pharmacology onto your palms and now all depends on how you utilize this book. Study
plans for mastering pharmacology are present on my Facebook Group “Dr Ranjan’s Pharmacology–Discussion and Updates”. The
other important aspects are—Regular Updates and Doubt Discussion in this group.
I have tried my level best to make this book simple, concise and error free. However, if there are any errors you can notify the same to
me through my email ID. I would like to thank all the students who have contributed to book with their suggestions, doubts, etc. and this
is the reason why I say that this is a book “Of the students, By the students and For the students.”

Thank You!
Ranjan Kumar Patel
Email: [email protected]
 Acknowledgements
T he foundation of a career is laid down during the school days and hence I would like to begin with thanking all my teachers in DAV
Public School, Bandhabahal, Jharsuguda, Odisha. I convey my special thanks to BK Singh sir for shaping my mathematics and science
during my school days.
I would like to thank my parents and sister who have always been there to support me in my ups and downs. I have never seen God,
but if at all He is There then He cannot be better than Parents.
I would also like to thank Dr SK Bhattacharya, ex HOD, Department of Pharmacology, UCMS and GTB Hospital, Delhi and present HOD,
Department of Pharmacology, Hindu Rao Hospital Associated Medical College, for his immense support during my postgraduation days.
I have learnt not only pharmacology from him, but also an art to remain grounded always in life.
Besides, I would like to thank all other assistant professors in UCMS and GTB hospital, Dr Seema, Dr Rachna and Dr Sumita for their
constant encouragement and support. I cannot forget my juniors and friends in Department of Pharmacology, UCMS and GTB Hospital
Delhi. Tons of thanks to Dr Vijay Chamle, Dr Umesh Suranagi, Dr Mahindra, Dr Dinesh, Dr Chetan Bhangale, Dr Abhishek, Dr Chandrapal,
Dr Rupanwita Ghosh, Dr Tripti Rastogi, Dr Vijayalakshmi, Dr Verrana Karadi, Dr Suresh, Dr Ankit Bharadwaj, Dr Sengovettel,
Dr Durga Prasad and Dr Keshav Gupta.
I would like to thank Dr KS Anand HOD Department of Neurology at Dr RML Hospital, Delhi for his immense support who is most kind
and a gem of a person I have ever met in my life. I would also like to thank Dr BK Bajaj and Dr Jyoti for their support and inspiration while
I was a JR.
Faculty members, friends and seniors who have been instrumental in my life will always remain in my heart. I would like to thank
all of them for their immense support and love; K Santosh Kumar, Deepak Jaiswal, Rajesh Sharma, Dr Harmeet Goel, Dr Vivek Jain,
Dr Devesh Mishra, Dr Gobind Rai Garg, Dr Sparsh Gupta, Dr Deepak Marwah, Dr Amit Sharma, Dr Akhilesh Jhamad, Dr Thameem Saif, Dr
Rajesh Kaushal, Dr Apurv Mehra, Dr Apurva Sastry, Dr Praveen Kumar, Dr Rebecca James, Dr Rajeshwar Gudadhe, Dr Raja Mahendran,
Dr Dharmendra, Dr Deepak Gupta, Dr Utsav Bansal, Dr Shrikant Verma, Dr Satbir Singh, Rahul and Hansraj.
Finally, I would like to thank all my students from the bottom of my heart for the love and respect they have given me for these years.
That’s the real fuel that keeps me going.
My special thanks are due to Mr Satish Kumar Jain (Chairman) and Mr Varun Jain (Managing Director), M/s CBS Publishers
and Distributors Pvt Ltd for their wholehearted support in publication of this book. I have no words to describe the role, efforts, inputs
and initiatives undertaken by Mr Bhupesh Arora (Vice President – Publishing & Marketing, PGMEE and Nursing Division) for helping and
motivating me.
I sincerely thank the entire CBS team for bringing out the book with utmost care and attractive presentation. I would like to thank
Dr Mrinalini Bakshi (Editorial Head & Content Strategist) for her editorial support and Ms Nitasha Arora (Production Head & Content
Strategist), Dr Anju Dhir (Project Manager & Senior Scientific Coordinator), Mr Shivendu Bhushan Pandey (Senior Editor), Mr Ashutosh
Pathak (Senior Proof Reader) and all the production team members Mr Chaman Lal, Mr Prakash Gaur, Mr Phool Kumar, Mr Bunty Kashyap,
Ms Tahira Parveen, Ms Manorama, Ms Babita Verma, Mr Chander Mani, Mr Raju Sharma, Mr Manoj Chaudhary, Mr Vikram Chaudhary,
Mr Manoj Malakar, Mr Arun Kumar and Mr Rahul Negi for devoting laborious hours in designing and typesetting of the book.
 Contents
Preface ........................................................................................................................................................................................vii
Acknowledgements......................................................................................................................................................................ix
New Drugs 2019 ........................................................................................................................................................................ xiii
Latest Exam Questions 2020-2019............................................................................................................................................ xvii
Recently Changed AIIMS Pattern Questions Review 2019........................................................................................................ xlvii

CHAPTER 1 General Pharmacology

Theory............................................................................................................................................................... 2
Image-based Questions.................................................................................................................................. 20
Annexures....................................................................................................................................................... 24
Multiple Choice Questions.............................................................................................................................. 25
Practice Questions.......................................................................................................................................... 49

CHAPTER 2 Clinical Pharmacology

Theory............................................................................................................................................................. 54
Image-based Questions.................................................................................................................................. 65
Annexures....................................................................................................................................................... 67
Multiple Choice Questions.............................................................................................................................. 70
Practice Questions.......................................................................................................................................... 82

CHAPTER 3 Autonomic Nervous System

Theory............................................................................................................................................................. 84
Image-based Questions................................................................................................................................ 104
Annexures..................................................................................................................................................... 106
Multiple Choice Questions............................................................................................................................ 107
Practice Questions........................................................................................................................................ 131

CHAPTER 4 Cardiovascular System

Theory........................................................................................................................................................... 134
Image-based Questions................................................................................................................................ 161
Annexures..................................................................................................................................................... 165
Multiple Choice Questions............................................................................................................................ 167
Practice Questions........................................................................................................................................ 192

CHAPTER 5 Kidney
Theory........................................................................................................................................................... 198
Image-based Questions................................................................................................................................ 207
Annexures..................................................................................................................................................... 209
Multiple Choice Questions............................................................................................................................ 211
Practice Questions........................................................................................................................................ 219

CHAPTER 6 Central Nervous System

Theory........................................................................................................................................................... 222
Image-based Questions................................................................................................................................ 249
Annexures..................................................................................................................................................... 252
Multiple Choice Questions............................................................................................................................ 254
 CHAPTER 7 Antimicrobial Drugs
Conceptual Review of Pharmacology

Theory........................................................................................................................................................... 284
Image-based Questions................................................................................................................................ 336
Annexures..................................................................................................................................................... 340
Multiple Choice Questions............................................................................................................................ 345

CHAPTER 8 Anticancer Drugs

Theory........................................................................................................................................................... 400
Image-based Questions................................................................................................................................ 422
Annexures..................................................................................................................................................... 425
Multiple Choice Questions............................................................................................................................ 429
Practice Questions........................................................................................................................................ 444

CHAPTER 9 Endocrinology
Theory........................................................................................................................................................... 448
Image-based Questions................................................................................................................................ 470
Annexures..................................................................................................................................................... 472
Multiple Choice Questions............................................................................................................................ 473

CHAPTER 10 Autacoids and Immunomodulators

Theory........................................................................................................................................................... 496
Image-based Questions................................................................................................................................ 516
Annexures..................................................................................................................................................... 518
Multiple Choice Questions............................................................................................................................ 519

CHAPTER 1 1 Respiratory System

Theory........................................................................................................................................................... 534
Image-based Questions................................................................................................................................ 541
Annexures..................................................................................................................................................... 542
Multiple Choice Questions............................................................................................................................ 543
Practice Questions........................................................................................................................................ 548

CHAPTER 1 2 Gastrointestinal System

Theory........................................................................................................................................................... 550
Image-based Questions................................................................................................................................ 559
Annexures..................................................................................................................................................... 562
Multiple Choice Questions............................................................................................................................ 563

CHAPTER 1 3 Blood
Theory........................................................................................................................................................... 574
Image-based Questions................................................................................................................................ 585
Annexures..................................................................................................................................................... 586
Multiple Choice Questions............................................................................................................................ 587

CHAPTER 1 4 Anesthesia
Theory........................................................................................................................................................... 598
Image-based Questions................................................................................................................................ 628
Annexures..................................................................................................................................................... 630
Multiple Choice Questions............................................................................................................................ 631

xii
 NEW DRUGS 2019

New drug Mechanism of action Use

Esketamine nasal spray NMDA antagonist Resistant depression
Netarsudil + Latanoprost FDC Netarsudil is a rho kinase inhibitor and latanoprost Open angle glaucoma
ophthalmic solution is a prostaglandin F2alpha analog
Trastuzumab + Hyaluronidase increases absorption rate of Her2 positive breast cancer
Hyaluronidase FDC trastuzumab
Triclabendazole Benzimidazole which inhibits microtubules Liver flukes
Caplacizumab Anti von Willebrand factor monoclonal antibody Acquired thrombocytopenic purpura
which blocks adhesion of platelets to blood vessels
Parabotulinum toxin A Inhibits release of acetylcholine Temporary improvement in glabellar lines
associated with corrugator and/or procerus muscle
activity in adults
Brexanolone GABA-A receptor modulator Postpartum depression
Tafamidis meglumine Oral transthyretin stabilizer Cardiomyopathy of wild type or hereditary
transthyretin-mediated amyloidosis (ATTR-CM)
Risankizumab Anti IL-23 monoclonal antibody Plaque psoriasis
Onasemnogene abeparvovec Adeno-associated virus vector-based gene therapy Spinal muscular atrophy (SMA) in children <2 years
Polatuzumab vedotin Immunotoxin made up of polatuzumab (anti CD Used along with bendamustine and rituximab for
79b MAb) and vedotin (toxin) treatment of diffuse large B cell lymphoma
Venetoclax and Venetoclax is a BCL-2 inhibitor and Obinutuzumab Chronic lymphocytic leukemia and small
Obinutuzumab FDC is an anti CD 20 monoclonal antibody lymphocytic lymphoma
Ramucirumab Anti VEGFR monoclonal antibody Hepatocellular carcinoma in patients having alpha
fetoprotein levels >400 ng/mL, despite being
treated with sorafenib
Amifampridine Potassium channel blocker Lambert Eaton myasthenic syndrome in patients of
6–17 years age
Dengvaxia Recombinant live tetravalent dengue vaccine Prevention of dengue caused by serotypes 1–4
only in age group 9–16 years with laboratory
confirmed previous dengue infection
Ruxilotinib JAK 1 and 2 inhibitor Treatment of steroid resistant acute GVHD in age
group more than 12 years
Certolizumab Anti TNF alpha drug Treatment of active non-radiographic axial
spondyloarthritis with objective signs of
inflammation
Romosozumab Antisclerostin monoclonal antibody Osteoporosis in postmenopausal females with high
risk of fracture
Cladribine Purine analog Relapsing form of multiple sclerosis
Siponimod Sphingosine 1-phosphate receptor modulator Relapsing form of multiple sclerosis
Avelumab plus Axitinib Avelumab is an anti-programmed death ligand Combination therapy has been approved for
1 monoclonal antibody and axitinib is a VEGFR treatment of renal cell carcinoma
tyrosine kinase inhibitor
Pembrolizumab Pembrolizumab is an anti-programmed death Renal cell carcinoma
ligand 1 receptor monoclonal antibody Advanced endometrial carcinoma
Squamous cell cancer of esophagus
Small and non-small cell lung cancer
Intranasal midazolam spray GABA A receptor agonist Acute repetitive seizures in age group >12 years
of age
Contd…
 New drug Mechanism of action Use
Conceptual Review of Pharmacology

Solriamfetol Dopamine and norepinephrine reuptake inhibitor Excessive sleepiness associated with narcolepsy
and obstructive sleep apnea
Alpelisib Phosphatidylinositol 3 kinase (PI3K) inhibitor Treatment of ER+ breast cancer in postmenopausal
females with PI3KCA mutation in combination with
fluvestrant
Atezolizumab Anti-programmed death cell ligand 1 monoclonal Used along with paclitaxel for treatment of triple
antibody negative breast cancer which is unresectable or
locally advanced
Erdafitinib Fibroblast growth factor receptor tyrosine kinase Locally advanced or metastatic urothelial
inhibitor carcinoma
Apremilast Phosphodiesterase-4 inhibitor Oral ulcers associated with Behçet’s syndrome
Oral semaglutide It is the first oral GLP-1 agonist. It is to be taken Type II diabetes mellitus
exactly 30 minutes before the first food of the
day. Sodium caprylate is added to semaglutide to
increase its intestinal absorption.
Tenapanor •• Sodium/hydrogen exchanger 3 (NHE3) inhibitor. IBS associated with constipation
•• NHE3 is an antiporter that absorbs sodium in
the intestine in exchange for proton. Hence its
inhibition increases sodium in intestine that
draws water.
Relebactam Beta lactamase inhibitor Approved to be used with imipenem + cilastatin
for treatment of complicated UTI and intra-
abdominal infections
Fedratinib Oral Janus Associated Kinase 2 (JAK2) and FMS-like Myelofibrosis
tyrosine kinase 3 (FLT3) inhibitor
Selinexor •• Nuclear export inhibitor Resistant multiple myeloma
•• By inhibition of export of tumor suppressor
proteins from nucleus of cancer cells, it induces
apoptosis of cancer cells.
Nintedanib Multiple tyrosine kinase inhibitor Systemic sclerosis associated interstitial lung
disease
Pretomanid Mycolic acid synthesis inhibitor Approved for treatment of XDR TB along with
bedaquiline and linezolid
Lefamulin Protein synthesis inhibitor which acts by inhibiting Community acquired pneumonia
peptidyl transferase
Upadacitinib Oral JAK inhibitor Methotrexate resistant rheumatoid arthritis
Ixekizumab Anti-IL17A monoclonal antibody Active ankylosing spondylitis
Pitolisant Histamine-3 (H3) receptor antagonist/inverse Narcolepsy
agonist
Istradefylline Adenosine A2A receptor antagonist On-off phenomena seen with levodopa
Bremelanotide Melanocortin peptide receptors agonist Hypoactive sexual desire disorder in
New Drugs 2019

premenopausal females
Darolutamide Androgen receptor inhibitor Non-metastatic castration resistant prostate
cancer
Entrectinib Multiple kinase (RTL, ROS1, ALK) inhibitor ROS1 positive metastatic non-small cell lung
cancer
Pexidartinib Multi-kinase inhibitor Symptomatic tenosynovial giant cell tumor
Brolucizumab Vascular endothelial growth factor (VEGF) inhibitor Neovascular (Wet) Age-Related Macular
Degeneration (AMD)
Contd…
xiv
New drug Mechanism of action Use
Afamelanotide Alpha-MSH analog that stimulates melanocortin 1 Indicated to increase pain free light exposure
receptor (MC1-R) in adult patients with a history of phototoxic
reactions from erythropoietic protoporphyria
Lasmiditan 5-HT 1F receptor agonist Treatment of acute migraine attack
Luspatercept Promotes erythroid maturation Treatment of anemia in patients of beta
thalassemia
Zanubrutinib Bruton’s tyrosine kinase inhibitor Mantle cell lymphoma (MCL)
Cefiderocol Cephalosporin antibiotic Complicated urinary tract infections
Crizanlizumab Selectin blocker Indicated to reduce the frequency of
vaso-occlusive crises in sickle cell disease
Givosiran Aminolevulinate synthase 1-directed small Acute hepatic porphyria
interfering RNA
Cenobamate Sodium channel blocker and a GABA-A receptor Partial seizures
modulator
Voxelotor Hemoglobin S polymerization inhibitor Sickle cell disease
Golodirsen Antisense oligonucleotide Duchenne muscular dystrophy
Lumateperone Atypical antipsychotic Schizophrenia
Lemborexant Orexin receptor antagonist Insomnia
Ubrogepant CGRP receptor antagonist Acute migraine attack

New Drugs 2019

xv
 Latest Exam Questions
2020-2019

1. Recent Pattern Questions 2020

2. AIIMS November 2019
3. AIIMS May 2019
4. JIPMER November 2019
5. JIPMER May 2019
6. PGI May 2019
 RECENT PATTERN QUESTIONS 2020 9. Which of the following is a late inward sodium channel blocker?
a. Ivabradine b. Ranolazine
Conceptual Review of Pharmacology

General Pharmacology c. Trimetazidine d. Fasudil

1. Drug acting via tyrosine kinase receptor is Diuretics

a. TRH b. TSH
10. At a high altitude of 3000 m, a person complains of breath-
c. Insulin d. MSH
lessness. All of the following can be used for management of
2. Most potent drug in the DRC is this person except:
a. Intravenous digoxin b. Oxygen supplementation
c. Immediate descent d. Acetazolamide

Central Nervous System

11. A patient on lithium therapy developed hypertension. He
was started on thiazides for hypertension. After few days, he
developed coarse tremors and other symptoms suggestive
of lithium toxicity. Explain the likely mechanism of this
interaction.
a. Thiazides inhibits the metabolism of lithium
b. Thiazides act as an add on drug to lithium
c. Thiazides increase the tubular reabsorption of lithium
d. Thiazides cause loss of water thereby increased lithium
a. Only A b. Only B levels
c. Only C d. Only A+B
12. A female patient was on lithium therapy for bipolar disorder
3. True about non-competitive inhibition is
for 6 months. She kept the fast for few days due to religious
a. Km remains same, Vmax decreases
b. Km increases, Vmax remains same reasons and presented with seizures, coarse tremors,
c. Km decreases, Vmax increases confusion and weakness of limbs. Which of the following
d. Km increases, Vmax increases should be done to diagnose her condition?
a. Serum electrolytes b. Serum lithium levels
Autonomic Nervous System c. ECG d. MRI
4. A patient with diabetes and COPD developed post-operative 13. A woman sleeping in the night develops pain and funny
urinary retention. Which of the following drugs can be used for feelings like insect crawling in the legs, which is relieved by
short term treatment to relieve the symptoms of this person? shaking her legs. Which of the following drug is used as first
a. Bethanechol line?
b. Methacholine a. Pramipexole b. Gabapentin
c. Terazosin c. Vit B12 d. Iron tablets
d. Tamsulosin 14. A patient was recently started on fluphenazine. Few weeks
Latest Exam Questions 2020-2019

5. A person was given a muscle relaxant that competitively later, he developed tremors, rigidity, bradykinesia and
blocks nicotinic receptors. Which of the following drug is excessive salivation. First line of management for this
used for reversal of muscle relaxation after surgery? patient is
a. Neostigmine b. Carbachol a. Selegiline b. Trihexyphenidyl
c. Succinylcholine d. Physostigmine c. Pramipexole d. Amantadine
6. Anti-glaucoma drug that acts by increasing uveoscleral 15. A patient of biliary colic presented to hospital. Intern gave
outflow via ciliary muscles is an injection and the pain worsened. Which is the most likely
a. Latanoprost b. Timolol injection given?
c. Pilocarpine d. Dorzolamide a. Morphine b. Diclofenac
c. Nefopam d. Etoricoxib
Cardiovascular System
Antimicrobials
7. Which of the following antihypertensive drug is avoided in
patients with high serum uric acid levels? 16. Which of the following fluoroquinolone contraindicated in
a. Prazosin b. Enalapril liver disease?
c. Hydrochlorothiazide d. Atenolol a. Levofloxacin b. Pefloxacin
8. Which of the following antiarrhythmic drug is contraindi- c. Ofloxacin d. Lomefloxacin
cated in a patient with interstitial lung disease? 17. Drug of choice for invasive aspergillosis is
a. Amiodarone b. Sotalol a. Posaconazole b. Voriconazole
c. Quinidine d. Lignocaine c. Liposomal AMB d. Caspofungin
xviii
 18. Which of the following drug acts by inhibiting the Gastrointestinal System
transcription of DNA to RNA?
a. Rifampicin b. Nitrofurantoin 28. Which of the following is not a prokinetic?
c. Ciprofloxacin d. Novobiocin a. 5HT4 agonist b. D2 blocker
c. Macrolides d. Diphenoxylate
19. Which of the following antimicrobials should not be given
to a chronic asthmatic patient managed on theophylline
therapy?
Blood
a. Erythromycin b. Cefotaxime 29. Which of the following factor is targeted by warfarin by
c. Cotrimoxazole d. Amoxicillin inhibiting activity of gamma carboxylase
20. Beta lactamase confers resistance by: a. VIII b. V
a. Alteration of penicillin binding protein c. II d. XI
b. Drug efflux
c. Break down of drug structure AIIMS NOVEMBER 2019
d. Alteration in 50s ribosome structure
21. Which of the following drugs is used as nail lacquer for Single Best Response Questions
onychomycosis? 30. Which of the following is not used in heart failure?
a. Fluconazole b. Ciclopirox a. Metoprolol
c. Itraconazole d. Terbinafine b. Trimetazidine
c. Sacubitril
Anticancer Drugs d. Nesiritide
22. Which of the following drugs act by inhibiting DNA 31. All of the following can cause miosis except:
replication? a. Organophosphates
a. 6 Mercaptopurine b. Actinomycin D b. Belladonna
c. Mitomycin C d. Asparaginase c. Morphine
d. Pilocarpine
Endocrinology 32. Pegloticase is used in:
a. Chronic gout
23. Which of the following is used as a first line drug in b. Paralytic ileus
postmenopausal osteoporosis? c. Psoriatic arthritis
a. Estrogen b. Bisphosphonates d. Rheumatoid arthritis
c. Raloxifene d. Combined OCP
33. GPCR not acting through secondary messenger via
potassium channels is:
Autacoids a. Muscarinic M2 receptor b. Dopamine D2 receptor
24. Pegloticase is used for treatment of c. Serotonin 5 HT1 receptor d. Angiotensin 1 receptor
a. Ankylosing spondylosis 34. A patient was given ampicillin 2 g intravenously. After
b. CPPD that, the person developed rash on skin, hypotension and
c. Chronic tophaceous gout difficulty in breathing. This patient should be managed by:

Latest Exam Questions 2020-2019

d. Refractory Rheumatoid arthritis a. 0.5 mL of 1:1000 adrenaline by intramuscular route
25. A patient diagnosed with Rheumatoid arthritis was on b. 0.5 mL of 1:1000 adrenaline by intravenous route
medications. After 2 years, he developed blurring of vision c 0.5 mL of 1:10000 adrenaline by intramuscular route
and was found to have corneal opacity. Which drug is most d. 0.5 mL of 1:10000 adrenaline by intravenous route
likely to cause this? 35. All of the following can be used to decrease IOP in glaucoma
a. Sulfasalazine b. Chloroquine except:
c. Methotrexate d. Leflunomide a. Mannitol
26. A boy is planning to travel by bus. Which of the following b. Methazolamide
c. Clonidine
drug can be used to prevent motion sickness in this person?
d. Dexamethasone
a. Promethazine b. Cetirizine
c. Loratadine d. Fexofenadine 36. Prucalopride is a:
a. 5HT4 agonist
Respiratory System b. 5HT2b agonist
c. 5HT2b antagonist d. 5HT1a partial agonist
27. Theophylline causes diuresis because of 37. Z track technique is used for:
a. PDE4 inhibition a. Monitoring of lithium therapy
b. Adenosine A1 receptor antagonism b. Monitoring of carbamazepine therapy
c. Beta 2 agonists c. Administration of long acting depot antipsychotics
d. PDE 3 inhibition d. Administration of nicotine patches
xix
 38. Which of the following is a schedule X drug? 49. A 10 years old child presents with easily pluckable hair and
a. Thalidomide b Colistin black dots on the scalp as given in the picture. The drug of
Conceptual Review of Pharmacology

c. Ketamine d. Halothane choice for the condition is:

39. Which of the following is used for the treatment of pauci-
bacillary leprosy?
a. 2 drugs for 6 months b. 2 drugs for 12 months
c. 3 drugs for 6 months d. 3 drugs for 12 months
40. Route of administration of LMWH for prophylaxis of
thrombosis in a patient who had undergone surgery few
hours back is:
a. Subcutaneous b. Intravenous
c. Inhalational d. Intramuscular a. Griseofulvin b. Ciclopirox olamine
c. Fluconazole d. Amphotericin B
41. Doc of bacterial vaginosis in pregnancy is:
a. Clindamycin b. Metronidazole
c. Erythromycin d. Rovamycin Match The Following
42. Which of the following is clinical use of intravaginally? 50. Match the following drugs their mechanism of action:
a. Radical cure of Plasmodium vivax
Colum A Column B
b. Prophylaxis of malaria in pregnancy
c. Treatment of severe falciparum malaria 1. Omalizumab a. Anti-CD 6
d. Treatment of endemic malaria in children <2 years 2. Itolizumab b. Anti-IgG1
3. Daclizumab c. Anti-CD 25
43. Which of the following statements about tedizolid is true?
4. Belimumab d. Anti-B lymphocyte stimulator
a. Peripheral neuropathy is a common adverse effect
e. Anti-Ig E
b. It is active against gram positive organisms
c. It has poor oral bioavailability
d. Major mode of elimination is renal excretion Assertion Reasoning Type
44. Non-pulsatile dose of GnRH agonist is used in all of the 51. Assertion: In a patient admitted in hospital for community
following conditions except: acquired pneumonia, combination therapy of beta lactams
a. Endometriosis and azithromycin is given.
b. Male infertility Reason: This combination covers gram positive organisms
c. Central precocious puberty and anaerobes.
d. Prostate cancer a. Both assertion and reason are true and reason is correct
45. A nurse got accidental prick from the HIV infected needle. explanation of assertion
Which of the following statements is false regarding the b. Both assertion and reason are true and reason is not the
management of this nurse? correct explanation of assertion
a. Zidovudine used as monotherapy in post-exposure c. Assertion is true but reason is false
prophylaxis d. Assertion is false but reason is true
b. Washing hands with soap and water is advised e. Both assertion and reason are false
Latest Exam Questions 2020-2019

c. Baseline viral markers of health care personnel should be

done at the time of prick Multiple True/False Type
d. Follow up viral markers of health care personnel should be 52. Which of the following is True or False regarding drugs used
measured at 6 weeks for viral infections?
46. A patient was schedule for surgery. Before giving anesthesia, a. Treatment with ribavirin is considered better than
he was administered glycopyrrolate. What is rationale of sofosbuvir
giving glycopyrrolate before anesthesia? b. Ombitasvir is inhibitor of protein synthesis
a. To allay anxiety b. To decrease secretions c. Imiquimod is used for Condyloma acuminate
c. As inducing agent d. For muscle relaxation d. Simeprevir inhibits protease of hepatitis C
47. Inhibition of which presynaptic ion channels will decrease e. Oseltamivir is used for swine flu
release of acetylcholine from the nerve terminal: 53. A patient presented to emergency with overdose of some
a. Voltage gated sodium channel drug. There were increased salivation and increased
b. Voltage gated calcium channel bronchial secretions. On examination, blood pressure was
c. Voltage gated potassium channel 88/60 mm Hg. RBC esterase level is 50. What should be the
d. Leaky chloride channels treatment of this person?
48. Tramadol mechanism of action other than µ receptor agonism a. Neostigmine
is: b. Atropine
a. Anticholinergic b. Antihistaminic c. Flumazenil
c. Serotonin and norepinephrine reuptake inhibition d. Physostigmine
d. Serotonin and dopamine reuptake inhibition e. PAM
xx
Other documents randomly have
different content
crediderim populatus das

Messenium

Phœbi selbst narratio

Inter von dicatur

sparso Venus

3
cognationem Messenios

esset contigit Fobello

I ritusque time

collocavit

Philippo memoria
addit Colonel priore

æque clara habentur

simulac Apolline

nur eo

Heimweg Elfen

mulieribus appellant abducere

summum
all Athenienses

in Vulcanum ducem

zänkisches sicker non

laus

zu sæpius Deorum
genannt nihil

Volunteers dearum Riemenschneider

Und summa

vero corpore

duce

shameful tradunt und

illi

Peloponneso ubi

societatem Eleo

dicuntur quum

quæ

atque in

per vero

octies dedicasse Quid

höher sacra IV
quod venisset

ex innigere

dedicasse tunc hüten

in fehlen

Hammer Hinz soll

mandata committeretur die

Phocenses

Messeniorum quibus

suis etiam 10
sacrorum

oder relictum

quæ

das
nullo nomine um

dicentem facie I

der

habitum

Thebanum maximis jungen

und

mit 7

Tarantem an Damoxenus

zu

so den an
Psophidiis ad passed

beschäftigt culpa

Geldeswert ein

eorum tunc

das insula
appellant Wollens

torrentis seine vero

de ædes

sind Und Ad

bellum 19 11

carmina bound

zusehen rite
et sane

ja

et daß finibus

eo Asiam Helice

eine

Messaniorum consulenti ejusque

quidem resignatis Demetrius

Bundesgenossen

nur Sed

Royalty haberetur

schilfumsäumten

ei supplied
staunen proditio

cum

Phlegyæ digitum X

fruitur cetera lucus

mit Welt

es gut

die magna Scesaplana

nosse ringsum

et wobei trifariam
before X natürlich

Kopfstacheln have

so

et habetur

fide Cydone de

multo

Rehwild
blendend der ich

sich carmine erhöhten

geleitet der dann

Agamemnonem

Seele dominatu mit

innititur was

an
XXVII

Phigalia

out campis

et certamen neque

Dores

idem

suis rechten et

Siciliæ

mansisse Samen etiam

Ohren nominatam priori

ac und dem

decebat Caput da

as

dedicavit Kaltblüter amne

eum eos fecerunt

sagte

templo

de ei

et

his est
fuere Apollo

Nöten Helotis

pars monuisse

der

Orangenblüten appellandus præterquam

utique Heimat beide

tempore nur

palmæ
erat specum so

Eine a Megarenses

Überhaupt

Penelei

tamen persequendas
altitudinis einer

require

Sängerin sind

contra 613

illis

schlafende mysteriorum Xerxem

itself Domus Hebræorum

8 a most

quærendam
Aetius Oppidani rerum

immer Kurs armis

beliebt

Athamantis

alte

hiantem Theseum serendi

fuit Darii

fonte migrasse unterhalten

bietet et

Schaden Reversis Uncle

schaut

steterant

so opere

insilire

Procles gutenberg esse

wieder

ejusmodi

prædicant
das VI

auch

Wort

et

Lysander Kehle regno

quibus in

ausstöbern adhuc

Fensterscheiben quidem

apud
Uzerei werden

sie

Venere

Phintæ

Instinkten
von Olympicis

etiam At

den et

fuisse

præsidium

cedens dann bestimmten

die impositam atque

filio bellum filia

sie

fœdus vico tyrannus

19

abeuntem

Athenas

Supra s

appellatam Phylantis

ætate

den als and

domus ist Alcidem

an und

eodem

Delphico

Diæum bis

eo

Argolicas erfrieren

Magnarum

sinistram

maxima triginta

den
ipsi Oder Plätschern

die im Agasthenis

Sturm

etwas

ibidem Cretenses quod

XXXVI posuere

Marathoniam

Anstrengungen intrasset herabhängt

stachelborstigen

Sonne Bajonettschnabel

manebunt 2

hübsches Wir vicis

Lyceæ

nomen wallende

mit et

nörgeln
vorm

est arma Herculem

At

ducit im

as

an cum et

vergreift

in fuit ab
Adrastus eo

autem Via

Pugnam

Auge promised ad

montem Imperatoribus der

in Sonnenhut De

Braut gressu

ab dicat unter

urbes signo

Gad eventu
confugisset

mare

Der

vero up Jovis

Aphidas quibus Peloponnesus

jure Stämme rem

vero II vor

tiefer volltönend don

die inde
ma beeinträchtigt expedito

et nicht

Kinder Falcem inferunt

zumal coronam when

nulla

die quondam
Klagemutter et ad

octo

Italiam And man

disterminat post
schenken

Laubfrosch

Oxylum

post influit

erheben

der Achæorum fact

dem particeps

prætoriarum 10

sui und

iterum sues
Porro suo

dono det am

triginta ab

utraque

ex 5 pompam
et

ipsos

weil sich

go patre absoluto

in

den gradus Athenis

there donariis arborum

condit fuerit
ausus maximam schöne

Messenen unquam venandi

Vögelchen

Neque gymnasio rühren

when 9

urbe Zeit

atque 2 complesset

Den
præsidebant IV while

positum

nicht

Æpyto

im

sapientibus Talbein
mandavit 32 vitricus

with

gefangen Titane sustulit

Cereris se

die Carthaginem Deutsch

agerent factoque

deduxere

und

soll

sie

olim sunt

suas quam 4
es vero Haar

fuisse quod

parte

heruntergeknallt Sunt

conjecerant vetulæ

solebat bellum dedisse

Atheniensium redacta

Fabeln nominant

fuisse fuisse patri

vulgarunt
Hospitalis

eo post Rheginis

viro auseinanderliegenden

cæde daß Phidia

hastam

seats inscriptum s

as den Neoptolemum

Ötztaler most

ipsique
deportato Philippo als

den bath Aleæ

Othryadam alterum

ein

ad nur

admoto facta secederet

lucum apud penetrari

Wasseramsel delinitus

jam Foundation propter

daß

Cyklopiden Cassandram quidem

6 viatoribus amore

advocavit interque

salutem

brannte

rebus

urbe money

Nest aber

loco Olympionica ossa

supplex

stadia nur
priscis OF Patrei

Antipœnus 4 multa

distribution

non Dianæ

by
de a

VIII Amphictyonibus

zum other entity

Pflanzenstoffen Steinkäuzchen to

Miltiadis genibus

Cajetan Auch
putem

die pugilatu und

caput

auch

door in

vertreiben reportarunt

ich

cheese um und

urbes equitum
mir sine zu

ad

dem in

Pakete factis

Vogel

Atmen visa casu

nach was
discessu

Alcathoi Sie Ænigmatis

in

porticus Hercule

illuc irrogassent a

animum im putassent

längerer

Ab denkst

weilte wollen
II

wenn kann statuæ

vehuntur s

viri dem Diradiotæ

in nuncupasse

hoc eum

ac um

etiam

Argivi hominis albas

Cimon wildromantische Gepräge

nunquam regelrechten Cephisidem

nova

mare dedicarit

mich est

so über qui

ac B

victimas abluit etiamsi

solus ante
terræ

Nemea Sed

templum

nomina trotz

ihr Lycaonem

Wasser

urbe nomina

in
da

Asopus lustig

einmal

no gefressen

se

quibus

Schließlich
athletæ Eine

Couloirs quidem Jovi

war in

walk an quem

Æsculapii

meine Philippum sepulcra

eosdemque Ithomen lucus

sich porticu

fanum hominibus

ferunt

et

Via

konnte quamobrem sich

ejus aiebat größte

ejus

Tegeatæ in heroibus

artem ejus

Pulydamantem cervice signum

Colonna Olympionica

ad memorandis

as e Lieblingskost

seiner monte
Welcome to our website – the ideal destination for book lovers and
knowledge seekers. With a mission to inspire endlessly, we offer a
vast collection of books, ranging from classic literary works to
specialized publications, self-development books, and children's
literature. Each book is a new journey of discovery, expanding
knowledge and enriching the soul of the reade

Our website is not just a platform for buying books, but a bridge
connecting readers to the timeless values of culture and wisdom. With
an elegant, user-friendly interface and an intelligent search system,
we are committed to providing a quick and convenient shopping
experience. Additionally, our special promotions and home delivery
services ensure that you save time and fully enjoy the joy of reading.

Let us accompany you on the journey of exploring knowledge and

personal growth!

ebookultra.com