Target DPP Test Contact Number: 9667591930 / 8527521718

1. Match each item in Column I with one item 5. The change in the reading frame will
in Column II and chose your answer from the depend on
codes given below:
(1)no of bases deleted
Column I Column II
(2)no of bases added
(nRNA codons) (Amino Acid)
I. GUG 1. Tryptophan
(3)no of bases deleted or added
II. UGG 2. Valine (4)always change the reading frame
III. UAC 3. Glutamic acid either bases are deleted or added
IV. GAG 4. Tyrosine
6. Choose the correct statements:
I. Binding of mRNA to the ribosome is loose and
Codes reversible.
I II III IV II. The ribosome, which is composed of tRNA
(1) 1 2 3 4 and proteins, consists of a small and large
(2) 2 1 4 3 subunit.
(3) 2 1 3 4 III. Each of the 20 amino acids has a minimum
(4) 1 2 4 3 of one specific tRNA molecule.
IV. tRNAMET binds to the first codon (AUG) -
this is called the START codon.
V. The second tRNA binds to the second codon
2. A codon consists of three nitrogenous bases so that their attached monosaccharides are
and there are four kind of bases in nucleic acid next to each other
altogether. How many codons will be there? VI. The newly formed polypeptide may undergo
(1)60 post-transcriptional modification.
(2)4 3 (1) I, III and IV
(3)34 (2) II, IV, VI
(4)46 (3) II, V and VI
(4) I, V, VI
3. Which of the following is not true for RNA
Polymerase? 7. Experiments by Avery, Macleod, and McCarty
1. It binds to promoter for initiation of supported DNA as the genetic material by
transcription showing that:
2. template dependent mode of action (1) Both protein and DNA samples provided the
3. It follows the rule of complementarity transforming factor
4. It uses nucleotide triphosphate as substrate (2) DNA was not complex enough to be the
genetic material
4. which of the following is true for (3) Only samples with DNA provided
bacterial transcription? transforming activity
(4) Even though DNA was molecularly simple, it
(1)RNA processing is required in it
provided adequate variation to act as the
(2)Transcription takes place in nucleus genetic material
(3)Transcription and translation takes
place in same compartment
(4)all of the above

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8. During DNA packaging in eukaryotic cells, 13. Identify the incorrect statement.
Non Histone Chromosomal proteins: (1) The repressor of the lac operon is
synthesized
1. Are not required constitutively.
2. Are required from the beginning to the end (2) Regulation of lac operon by repressor is
of packaging referred
3. Are required only for earlier stages of to as negative regulation.
packaging (3) Regulation of lac operon is a regulation of
4. Are required for higher level of packaging enzyme
synthesis by its substrate.
(4) In the presence of lactose or allolactose, the
repres-
9. Expressed Sequence Tags (ESTs) refers to: sor is activated and it binds to the operator.
Novel DNA Genes expressed as
1. 2.
sequence RNA 14. Select the incorrect statements from the
Polypeptide following
3. 4. DNA polymorphism
expression There are the evidence that DNA was the
(a)
first genetic material in the history of life.
(b) No RNA acts as catalyst
10. A nucleoside differs from a nucleotide. It
DNA replication is said to be
lacks the:
(c) semiconservative as it has two strands of
1. base
polynucleotide chain.
2. sugar
3. phosphate group A nitrogenous base is linked to the pentose
(d)
4. hydroxyl group sugar through N-glycosidic linkage.

1. (a), (b) and (c)

11. While analysing the DNA of an organism a
2. (b) and (c) only
total number of 5386 nucleotides were found
3. (c) and (d)
out of which the proportion of different bases
4. (b) and (d)
were: Adenine = 29%, Guanine = 17%, Cytosine
= 32%, Thymine = 17%. Considering Chargaff’s
rule it can be concluded that:
1. it is a double-stranded circular DNA 15. In split genes, the coding sequences are
2. It is single-stranded DNA called
3. It is a double-stranded linear DNA 1. Exons
4. No conclusion can be drawn 2. Cistrons
3. introns
4. Operons
12. The central dogma of molecular biology was
proposed by: 16. Haploid content of human DNA contains
1. Francis Crick 2. James Watson 1. 4.6 x 106 bp
8
3. Rosalind Franklin 4. Erwin Chargaff 2. 3.3 x 10 bp
3. 6.6 x 109 bp
9
4. 3.3 x 10 bp

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17. The similarity between DNA and RNA is that 21. Assertion(A): If the sequence of bases in one
both: strand is known then the sequence in another
1. are polymers of nucleotides strand can be predicted.
2. have a similar pyrimidine Reason(R): These strands run antiparallel to
3. have similar sugars each other.
4. genetic material 1. Both (A) and (R) are true and (R) is the
correct explanation of (A).
18. In the human genome: 2. Both (A) and (R) are true, but (R) is not the
correct explanation of (A).
1. the total number of genes are about 60000 3. (A) is true, but (R) is false.
less than 2 percent of genome does not code 4. (A) is false, but (R) is true.
2.
for proteins
22. What percent of the human DNA actually
3. repeated sequences are rarely found
codes for proteins?
4. SNPa occur at about 1.4 million locations 1. Less than 2%
2. Around 20%
3. Between 35% and 40%
19. If a DNA molecule is shortened by 25 base 4. More than 98%
pairs, how many helical turns will be reduced
from its structure? 23. Given below are two statements:
1. 1 In prokaryotes, the positively
2. 3 charged DNA is held with some
3. 2.5 Statement I:
negatively charged proteins in a
4. 2 region called nucleoid.
In eukaryotes, the negatively
20. Given below are two statements : one is
charged DNA is wrapped around
labelled as Assertion (A) and the other is Statement II:
the positively charged histone
labelled as Reason (R).
octamer to form nucleosome.
S-strain of Streptococcus
Assertion (A): In the light of the above statements, choose the
pneumoniae is virulent.
correct answer from the options given below:
Heat-killed S-strain 1. Statement I is incorrect but Statement II is
Streptococcus pneumoniae correct.
Reason (R): injected into mice did not cause 2. Both Statement I and Statement II are
pneumonia and did not kill correct.
them. 3. Both Statement I and Statement II are
In the light of the above statements, choose the incorrect.
most appropriate answer from the options 4. Statement I is correct but Statement II is
given below : incorrect.
Both (A) and (R) are True and (R) is the
1.
correct explanation of (A).
2. (A) is True but (R) is False.
Both (A) and (R) are True but (R) is not the
3.
correct explanation of (A).
4. Both (A) and (R) are False.

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 Target DPP Test Contact Number: 9667591930 / 8527521718

24. Consider the given two statements: 27. Which of the following statements will be
For sequencing, the total DNA from true regarding the effect of mutations in the
Assertion a cell is isolated and converted into components of the lac operon of E. coli [assume
(A): random fragments of relatively mutations will lead to loss of function in the
smaller sizes. affected gene]?
DNA is a very long polymer, and A mutation in the i gene will lead to a
I:
Reason there are technical limitations in stoppage of transcription of the operon.
(R): sequencing very long pieces of A mutation in the z gene will lead to an
DNA. II: inability in E .coli to hydrolyze the
disaccharide, lactose.
Both (A) and (R) are True but (R) does not A mutation in the y gene will lead to an
1.
correctly explain (A). III: inability in E. coli to pick up lactose from its
2. (A) is False but (R) is True. surroundings.
3. (A) is True but (R) is False.
1. Only I and II are correct
Both (A) and (R) are True and (R) correctly
4. 2. Only I and III are correct
explains (A).
3. Only II and III are correct
4. I, II and III are correct
25. Consider the given two statements:
28. DNA fingerprinting involves identifying
If each strand from a dsDNA acts as differences in some specific regions in DNA
a template for synthesis of a new sequence called as:
Assertion: strand, the two daughter DNA thus 1. repetitive DNA
produced, would be identical to the 2. satellite DNA
parental DNA molecule. 3. genomic DNA
The base pairing in a dsDNA 4. complementary DNA
Reason: molecule is complementary to each
other. 29. Consider the given two statements:
The probability of variation [due to
Both Assertion and Reason are True but mutation] to be observed in non-
1. Reason does not correctly explain the Assertion: coding DNA sequence would be
Assertion. higher than in coding DNA
2. Assertion is True but Reason is False. sequence.
3. Assertion is False but Reason is True. Mutations in non-coding DNA
Both Assertion and Reason are True and sequences may not have any
4. Reason:
Reason correctly explains the Assertion. immediate effect/impact in an
individual’s reproductive ability.

26. In 1953, James Watson and Francis Crick, Both Assertion and Reason are true but
proposed a very simple but famous Double 1. Reason does not correctly explain the
Helix model for the structure of DNA, based on Assertion.
the X-ray diffraction data produced by: 2. Assertion is true but Reason is False.
1. Maurice Wilkins and Rosalind Franklin 3. Assertion is false but Reason is True.
2. Beadle and Tatum Both Assertion and Reason are true and
4.
3. Temin and Baltimore Reason correctly explains the Assertion.
4. Avery–MacLeod–McCarty

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 Target DPP Test Contact Number: 9667591930 / 8527521718

30. How many of the given statements

regarding ribosomes are correct?
Ribosomes are the cellular factory
I:
responsible for synthesising proteins.
The ribosome consists of structural RNAs
II:
and about 800 different proteins.
In its inactive state, it exists as two
III: subunits; a large subunit and a small
subunit.
When the small subunit encounters an
IV: mRNA, the process of translation of the
mRNA to protein begins.
1. 1
2. 2
3. 3
4. 4

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