Cambridge A Level Biology Mid-Semester Project
Applying Biological Principles to Solve Real-World Challenges
Project Overview
This mid-semester project requires you to research and propose solutions to real-world
problems using your knowledge from AS and A2 Biology topics. Your work must connect
biological principles to challenges relevant to your career pathway.
AS Students (Medicine Pathway): Investigate challenges related to human health, diseases,
or medical advancements.
A2 Students (Forensic Science Pathway): Apply A2 biology knowledge (biotechnology,
genetics, homeostasis, ecology) to forensic and investigative science.
Each term paper should be a minimum of 10 pages (excluding references) and show clear
biological reasoning, data interpretation, and reference to current scientific research.
Objectives
To connect A Level biology theory to real-life medical and forensic contexts.
To demonstrate independent research and critical application of biological concepts.
To improve scientific writing, analysis, and referencing skills.
To develop creativity and innovation in biological problem-solving.
AS Medicine Pathway Topics (from AS syllabus)
Focus on cell biology, enzymes, transport, immunity, and physiology.
The role of mitosis and uncontrolled cell division in cancer.
Enzyme inhibitors as therapeutic agents in medicine.
The immune response and vaccine development for viral infections.
The impact of sickle-cell anaemia on oxygen transport and survival.
The role of lipids and diet in cardiovascular disease.
Cell membrane transport in medical treatments (e.g., dialysis, drug uptake).
Use of microscopy in early disease diagnosis.
Gas exchange and respiratory diseases (e.g., asthma, emphysema).
Application of biological molecules in diagnostic testing (e.g., glucose biosensors).
Stem cell research and its potential in regenerative medicine.
A2 Forensic Science Pathway Topics (from A2 syllabus)
Focus on biotechnology, inheritance, homeostasis, ecology, and the nervous system —
applied to forensic biology.
Use of DNA profiling and PCR in forensic identification.
Application of gel electrophoresis in crime scene investigation.
Genetic variation and inheritance in determining biological relationships.
Role of enzymes and biochemical tests in forensic toxicology.
Forensic applications of gene technology (cloning, genetic markers, GMOs).
Analysis of physiological responses (e.g., stress, reflexes) in lie detection.
Homeostasis and body temperature in estimating time of death.
Role of microorganisms and decomposition in forensic ecology.
Effect of environmental factors on biological evidence degradation.
The nervous system and behaviour in forensic neurobiology.
Suggested Headings for the Term Paper
1. Title Page – Include your name, candidate number, class, project title, and submission
date.
2. Abstract – 200–300 words summarizing your project.
3. Introduction – Background, relevance, and research question.
4. Literature Review – Summary of scientific findings related to your topic.
5. Biological Principles Involved – Link your chosen topic to A Level Biology content.
6. Proposed Solution / Analysis – Your model, method, or approach to the challenge.
7. Expected Outcomes and Benefits – Biological and societal implications.
8. Limitations and Ethical Issues – Challenges, risks, or moral considerations.
9. Conclusion – Key takeaways and recommendations.
10. References / Bibliography – At least 5 credible academic sources (APA/Harvard/MLA
format).
Submission Guidelines
Length: Minimum 10 pages (excluding references)
Font: Times New Roman, size 12, 1.5 line spacing
Format: Typed, well-organized, and paginated
Due Date: (Insert date)
Submission Mode: Printed or PDF version (via Google Classroom or email)
Assessment Criteria
Criteria Marks
Depth of biological understanding 20
Application of biological concepts 20
Research and analysis 20
Organization and clarity 15
Creativity and originality 15
Use of references 10
Total 100
