Tablet Granulation Interview Questions

In this post,we will try to discuss all the possible questions from the granulation process
which can be asked during various interviews, viva exams, or tests.
So if you are looking for production job interview questions or want to complete
preparation for various examinations or currently you are working in the pharmaceutical
industry and want to improve your knowledge then do read the complete article because
it will be helpful to improve your technical knowledge & skills.
If you have any query related to the granulation process do mention it in the comment
box & I will try to resolve your query.

What Is Granulation?
Granulation is the process which is used for manufacturing tablets, capsules, or dry
powder suspensions & is defined as follows,
The process of converting fine powders into large agglomerates or granules by using
solvent, binder solution, or by the application of pressure is known as granulation.

What are the Types Of Granulation?

There are two main types of granulation which are given below,

 Wet Granulation
 Dry granulation

How Many Methods Are Used For Tablet Manufacturing?

The following three methods are used for manufacturing tablets in pharmaceutical
industries,

 Wet Granulation
 Dry Granulation
 Direct Compression

Define Wet Granulation

Wet granulation is the process in which fine powders are converted into large
agglomerates or granules by using a solvent or binder solution.

Define Dry Granulation

Dry granulation is the process in which fine powders are converted into granules by
using pressure.

What Is the Direct Compression Method?

The direct compression method is the process that is used for those materials which
have good flow and high compaction properties.
Read Details
Direct Compression Method

What are The Steps Of Wet Granulation?

Following are the steps which are used during the wet granulation method of tablet
manufacturing in pharma,

 Weighing
 Sieving
 Pre-Mixing
 Wetting/Kneading/Binder addition
 Sieving Of Wet Mass
 Drying Of Wet Mass
 Sieving Of Dried Mass
 Final Mixing/Final Blending

What Are The Steps Of Dry Granulation?

Following are the steps which are used for the dry granulation method of tablet
manufacturing,

 Weighing
 Sieving
 Pre-Mixing
 Slugging/Roller Compaction
 Screening
 Final Mixing/Final Blending

What Are The Steps Of Direct Compression?

The following steps are used for the Direct Compression Method

 Weighing
 Sieving
 Mixing
 Compression
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


Why Do We Use 03 Different Methods For Tablet Manufacturing?

All products can not be manufactured by using a single method because each method
has some limitations so we use any of the three methods depending on the product's
nature.
For Which Products Do We Use the Wet Granulation Process?
A wet granulation process is used for those products which are not degraded by
moisture or heat.

For Which Products Do We Use the Dry Granulation Process?

The dry granulation method is used for heat-sensitive & moisture-sensitive products or
in simple words for thermolabile products.

For Which Products Do We Use Direct Compression Method?

The direct compression method is used for those materials which have the following
characteristics,

 Good Flow Properties

 Good Compaction
 Low Dose Products

What Is Kneading?
Kneading is the step of wet granulation in which we add solvent or binder solution to the
pre-mixed fine powders to form a wet mass.

How Granules Are Formed In Wet Granulation?

In wet granulation fine powders are converted into wet mass during the kneading
process & then this wet mass is sieved & dried. After drying the dried mass is again
sieved to get uniform-sized granules.

How Granules Are Formed In Dry Granulation?

As we know, the dry granulation method is used for thermolabile products so we can not
use solvent or binder solution means kneading is not done during the dry granulation
process, so a common question comes to mind which is,

"How do we convert powders into granules by the process of dry granulation"?

When I ask this question to various professionals who have no experience with
granulation, about 90% of people say it is done by the sieving process.
Then I ask if we sieve powders, they are not converted into granules, only particle size
is reduced.
The correct answer is by application of pressure we convert powders into slugs or
powder sheets and later by screening slugs or powder sheets we get granules.

Why Do We Perform Pre-Sieving Step In Granulation?

Sieving before mixing is done in wet & dry granulation because of the following,

 To break large lumps.

 To get uniform particle size.
 To remove any foreign particles.
 To Remove any foreign Material.

Why Do We Perform Wet Sieving In Wet Granulation Method?

Wet sieving in the wet granulation method is performed to break large lumps of wet
mass & to increase surface area. This increase in surface area facilitates the drying
process.

Why Do We Manufacture Granules?

Powders are converted into granules because of the following main reasons,

 To Improve Flow
 To increase compaction
 To prevent segregation.
 To get better content uniformity & assay.
 To prevent line loss due to a dusty environment
 Powders are elastic & tend to laminate or cap but granules are plastic.

Write Down Defects Of Granulation?

The following main defects can be observed during the granulation process.

 Over Wetting
 Under Wetting
 Over Drying
 Under Drying
 Excessive Fine
 Segregation
 Assay Issue

What Is the Sieve Selection Criteria?

The selection of sieve for oscillating granulator or dry mill depends on the following,

 Required Granules Size

 Weight Of Tablet
 Disintegration Time
 Dissolution Profile
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What Are The Factors Affecting Kneading?

The following factors may affect the kneading process,
 Solvent/Binder Solution Quantity
 Binder Addition Time
 Kneading Time
 Speed Of Impeller Blades
 Speed Of Chopper Blades

Name Of Equipment Used For Kneading?

 RMG
 Spiral Mixer
 Plough Mixer
 Diosna Mixer

What Is RMG?
RMG stands for Rapid Mixing Granulator and is the equipment that is used for the wet
granulation process.
It belongs to the class of mixers known as High Shear Mixers.

What Are the Components Of RMG?

Following are the main components or parts of the rapid mixing granulator or RMG,

 Mixing Bowl
 Impeller Blades
 Chopper Blades
 Binder Addition Hopper
 Breathing Filter
 View Port
 Discharging Port
 Pneumatic Sealed Lid
 HMI

A Wet mill is also attached with RMG for wet sieving of wet mass.

How RMG Works?

Powders to be mixed are added into a mixing bowl of RMG & are mixed with the solvent
with the help of impeller blades. The chopper Breaks down large lumps & later this wet
mass is passed through the wet mill to get a wet sieved mass.

Read
Details Of RMG

What Is a Spiral Mixer?

A spiral mixer is also used for kneading purposes during wet granulation & it belongs to
the class of mixers known as low shear Mixers.
A spiral mixer is also known as ribbon mixer.
Which Equipment is Used For the Drying Process?
Products manufactured by wet granulation processes in pharmaceutical industries are
dried by using one of the following.

 Tray Dryers
 Fluid Bed Dryers (FBD)

What Is the Working Principle Of FBD?

FBD works on the principle of fluidization in which the settling velocity of particles is less
than the air-carrying capacity of granules.

What Is Candle Filter?

The candle filter is the cloth filter used in FBD during the drying process. It has finger-
like or candle-like large hollow pockets so known as finger filters or candle filters.

What Are The Factors Affecting the Drying Process?

The following are the main factors that may affect the drying process of wet granulated
products using FBD

 Drying Temperature
 Drying Time
 Product Trolley Load
 Fan Motor Speed

Which Inprocess Test Is Performed During Wet Granulation?

LOD or loss on drying.

Read About FBD

Fluid Bed Dryer Working

Other Names Of Dry Granulation?

The other names used for dry granulation method are,

 Compression Granulation
 Double Compression Method
 Slugging Method
 Roller Compaction Method

What is a Roller Compactor?

A Roller compactor is used to form paper sheets during dry granulation. As the name
indicates it consists of two rolls that rotate and apply pressure over powder & form
paper sheets. These powder sheets are then broken down by the dry mill & screened to
get granules.

What is Chilsonator?
The roller compactor is also known as a chilsonator.

What Is Slugging?
Slugging is the step of dry granulation in which powders are compressed into large-size
tablets by using large flat-face punches.

What Is Slug?
A slug is a large tablet 2 inches in diameter.

Example Of Direct Compression?

Powders having crystalline form & good compaction properties are compressed using
the direct compression method.

Example

 Aspirin

Excipient Classes Used For Granulation?

The following main classes of excipients are used for manufacturing OSD depending on
the nature of the formulation.

 Diluents
 Binders
 Disintegrants
 Lubricants
 Glidents
 Colorants
 Flavourants

Read About
Classification Of Excipients

What Is OSD?
OSD represents the Oral Solid Dosage Form.

Stages Of Granules Growth?

Following are 4 stages of Granules growth during the kneading process,

 Pendular
 Funicular
 Capillary
 Droplet

Equipment For Wet Granulation?

The following equipment may be used for manufacturing of granules by wet granulation
method

 Sifter/Sieves
 RMG/Spiral Mixer
 Wet Mill
 FBD/Tray Dryer
 Oscillating Granulator
 Dry Mill/Multi Mill
 Double Cone Blender/Bin Blender

Read Details
Equipment Used For Wet Granulation

Equipment For Dry Granulation?

The following equipment may be used for manufacturing of granules by wet granulation
method

 Sifter/Sieves
 Double Cone Blender/Bin Blender/Spiral Mixer
 Roller Compactor/Compression Machine
 Oscillating Granulator
 Dry Mill/Multi Mill/Fitz Mill

Equipment For Direct compression?

The following equipment may be used for Direct Compression

 Sifter/Sieves
 Double Cone Blender/Bin Blender/Spiral Mixer






Advanced Granulation Techniques?

Following are the advanced granulation techniques which are also used for
manufacturing OSD products in Pharmaceutical industries,

 Hot Granulation Technique

 Foam Binder Granulation
 Steam Granulation
 Reverse Wet Granulation
 Freeze Granulation
 Moisture Activated Dry Granulation
 Pneumatic Dry Granulation

Read Details
Advance Granulation Techniques

What To Check During Line Clearance?

The production pharmacist must check the following during line clearance,

 The area is properly cleaned & labeled.

 Equipment Cleaning & labeling
 No leftover of previous product
 Temperature & Humidity level
 Differential pressure
 Balance verification
 Signed BMR & Manufacturing Order is available.
 Verification of lots & weight of every material

Read Details
Line Clearance In Pharmaceutical Industries

What Will be The Drawback Of Over-wetting?

A common question is asked: what will happen if our product is over-wet during the
kneading step?
The possible effects may be as given below,

 Wet Mill Sieve Clogging

 Hard Granules Will be produced After Drying
 Difficulty in Dry Sieving
 Sieve damage during dry sieving due to hard granules
 Production Of Less Fine Which may promote capping or lamination.
 Prolong D.T
 Retarded Dissolution Profile
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
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
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What Will be The Drawback Of Under-Wetting?

 Weak Granules
 Production Of More Fine During Drying.
 Increased Line Loss During Drying.
 Dusty Environment During Dry Sieving.
 Segregation During Final Blending.
 Capping Or lamination Due to more fine.
 Flow Problems during Compression.
 Weight Variation

What Will Be The Drawback Of Over Drying?

 Excessive Fine May Produce

 Fragile Granules
 Capping
 Lamination
 Weight Variation

What Will Be The Drawback Of Under-Drying?

 High Moisture Content

 Sticking
 Picking
 Rathole
 Weight Variation

What Is Double Disintegration?

When a disintegrant or super disintegrant is used during both intragranular & extra
granular stages it is known as the Double Disintegration Phenomenon.

What Is Binder Activation?

Binder activation is a general term used during the wet granulation method in which we
do not prepare binder solution rather we mix our binder in dry form during the pre-
mixing stage & then in the kneading step we only add water or organic solvent to give a
binding effect.
As the binder in dry form is activated later on by solvent, this process is known as a
Binder Activation Method.

What Is Case Hardening?

Localized over-wetting may produce large lumps and binder may entrap if these large
lumps are not properly broken down. During drying, if a high temperature is applied at
the start it may dry the granules from the outside but inside, the binder remains wet.
This phenomenon is known as case hardening.
Case Hardening may result in sticking or picking during the compression process.

Read Details
Reasons For Tablet Sticking And Picking

Binder Quantity VS Dissolution?

If the amount of binder in wet granulation is very high it will result in strong bounding of
granules so drug release will be very slow & dissolution profile will be low.
If a very less quantity of binder is used during wet granulation it will result in weak
bounding & will result in capping or low hardness friable tablets.

What Is the Optimum Blending Time Of Granules With Lubricants?

Granules should be mixed with lubricants for 3 to 5 minutes. The mixing time with
lubricants should not exceed 5 minutes.

Drawbacks Of Lubricants Over-Mixing?

If lubricants are used in excessive amounts or blending time with lubricants is increased
it may result in the following defects,

 Increased Disintegration Time

 Low Dissolution Profile
 Low Hardness
 Tablet Capping
 Tablet Lamination

Pharmaceutical Questions and answer for

interview
What is Production?

All the activities involved in the manufacturing of a pharmaceutical product starting from
receipt of raw materials to the completion of a finished product means, from Raw material
Receipt to Finished product dispatch.

It contains the handling of manpower and recording of the manufacturing and the packing
activity.

What is Batch Manufacturing Record(BMR)

BMR is a Document that provides a history of a batch mean how a product is manufactured
step by step following written procedures.

It contains signs of qualified persons and operators involved in manufacturing.

What is Batch packaging Record (BPR)

Batch packaging record or BPR is the document that provides a history of batch packaging
and in-process checks of Packaging.
Also Read
Interview Question Why Should We Hire You

Define Tablet

Tablet is a solid dosage form prepared by a combination of API and Excipients by application
of pressure.

What is API

API stands for Active pharmaceutical ingredient.

API is a substance that gives pharmacological effects.

What is Excipient

Inert materials which do not give any pharmacological effect.

Classification of Excipients for Solid Dosage form

 Diluents
 Binders
 Disintegrants
 Glidents
 Lubricants
 Colourants
 Flavours

Tests for Tablet

 Weight variation
 Thickness
 Hardness
 Friability
 Disintegration
 Dissolution
 Assay
 Content uniformity
Also Read
Cleaning Validation In Pharmaceutical Industry

what are Defects of Tablet

 Capping
 Lamination
 Sticking
 Picking
 Weight Variation

What is Disintegration

The time needed for tablet or capsule to break down into particles which pass through # 10
mesh and no solid mass is left.

What is Disintegration Time of Capsules

30 Min.
What is Disintegration Time of uncoated tablet

Not more than 15 minutes.

What is Disintegration Time of Film-coated tabs?

Not more than 30 minutes.

What is Disintegration Time sugar-coated tablets?

Not more than 60 minutes.

What is Disintegration Time of Enteric-coated table?

Tablets which have Enteric-coating should not disintegrate for 2 hours in acidic media and
then these tablets when placed in basic media should disintegrate within 1 hour.

What is the limit of friability

Not more than 1%

Also Read
Why is a Separate Manufacturing Facility Required For Penicillin And Non Penicillin
Products

Defects of Coating
 sticking
 Colour variation
 Orange peel effect
 logo filling
 chipping
 Film cracking
Types of coating
1. Film Coating
2. Enteric Coating
3. Sugar Coating

What is HVAC?

Heating Ventilation and Air conditioning

Functions Of HVAC

 Prevent cross-contamination
 Maintain Temperature
 Maintain Humidity
 Create Differential Pressure
 Maintain Air Changes

Types of capsules

 Hard Gelatin Capsule

 Soft Gelatin Capsule

Revolution of Friability

25 rpm per minute and run-time is 4 minutes.

Name of 3 Natural binders

 Starch
 Cellulose
 Gelatin
Name OF Synthetic Binder

PVP k 30 or kollidon, povidone.

Why do we manufacture granules?

Granules are prepared for tablet compression because of the following main reasons.

 To enhance flow because powders flow is poor.

 To prevent weight variation.
 To reduce dusty environment because powders are dustier.
 To prevent segregation.
 To improve content uniformity.
 To improve compaction.
 Powders are elastic so tend to cap but granules are plastic so prevent tablet capping.
Also Read
Tips To Find Good Job

What is a rat hole?

Rathole is a powder flow defect in which powder adheres to the walls of compression
machine hopper or blender walls and stops the flow against walls creating a hole in the
middle. It results in weight variation and fragile tablets during compression.
Quality Assurance Interview Questions
What Is GMP?
GMP stands for Good Manufacturing Practices & it contains guidelines which are given
by US-FDA defined as,
GMP is the set of procedures & documentation which ensures that all the products are
manufactured according to the quality standards, are free from contamination, and are
fit for human use.

What Is cGMP?
cGMP refers to the Current Good Manufacturing Practices & is defined as,
cGMP is the use of current standards & systems to provide high-quality products.
cGMP gives a system that ensures proper design, control & monitoring of the
manufacturing process & facilities.

Read Details
Good Manufacturing Practice | GMP VS cGMP

Define Validation
Validation is the documented evidence that gives a high level of assurance that a
specific process or method will consistently produce the required level of results with
predefined specifications & quality.

Write down Types Of validation.

There are four types of validation given below,
 Prospective Validation
 Concurrent Validation
 Retrospective Validation
 Revalidation

Read Details
Validation | Process Validation

What Is RCA?
RCA is the Root Cause Analysis and it is the technique used to find out the main reason
for a specific problem.
In RCA we use an investigation & data-driven approach to find out the reason for the
problem & provide or find out its solution.

Which Tools Are Used For Root Cause Analysis?

The following are commonly used tools for problem-solving.

 5 Whys
 Ishikawa Fishbone Diagram (IFD)
 Failure Mode and Effects Analysis (FMEA)
 Fault Tree Analysis (FTA)
 Pareto Chart
 Scatter Diagram

What Is Line Clearance?

Line clearance is the activity or process which ensures that the area, line, or equipment
is free from residues, and labels of previous products and is ready for
dispensing,manufacturing,printing or packaging activity.

What We Check During Line Clearance?

During line clearance, QA officers check that all the area and equipment are properly
cleaned/washed and there is no leftover of the previous product.
The following main points are checked,

 Area/equipment Identification
 Calibration Record
 Temperature
 Humidity
 Differential Pressure
 Log Books Record

Read Details
Line Clearance in Pharmaceutical Industries

What Is Documentation?
All types of written material used in pharmaceutical industries including procedures,
SOPs, work instructions, etc are known as documentation.

What Is Good Documentation Practice GDP?

Good documentation practice or GDP is the collection of standards or internationally
accepted guidelines that are used for creating documents & record keeping and it helps
for data integrity.

What Is ALCOA?
ALCOA is used for good documentation practices and stands for,
 Attributable
 Legible
 Contemporaneous
 Original
 Accurate

What Is SOP?
SOP is the standard operating procedure and it is written instruction about how a task or
activity will be performed.

Read Details
How To Write a SOP?
What Is SCP?
SCP is a standard cleaning procedure & is a written document that contains all the
instructions regarding the cleaning procedure of equipment, utility, or facility.

What are The Types Of Cleaning?

There are 3 types of cleaning in the pharmaceutical industry which are given as below

 Major Cleaning
 Minor Cleaning
 Shift End Cleaning

What Is Change Control?

Change control is a documented system in pharmaceutical industries to control &
regulate any changes in the existing system.

Is Change Control Required For New Area Or Equipment?

Most people in the pharmaceutical industry think that change control is only generated
when we change any old procedure or equipment but the reality is that it is also
generated whenever we want to add any new equipment or facility.

Types Of Changes
Changes May be of two types
 Planned Changes
 Unplanned Changes

What Are Inprocess Checks?

In-process checks are the tests/activities which are performed during the period when a
specific activity i.e manufacturing, filling, printing,labeling or packaging is running and is
not finished.
These checks are performed to ensure that all the required standards are met during a
specific operation.

Examples Of Inprocess Checks?

Following are some examples of in-process checking for various operations.

For Granulation
LOD
Granule size

For Compression
Hardness
Weight Variation

For Coating
Weight Gain
Color uniformity
For Filling
Volume Checking
Clarity Checking

For Printing
Embossing Pattern

For Blistering
Sealing
Mfg & Expiry

Oral Solid Dosage Forms Are Manufactured In Which ISO Class?

OSD like tablets & capsules are manufactured in an area that maintains ISO class 8 or
grade D at rest & during working it is non-classified.

Oral Liquid Dosage Forms Are Manufactured In Which ISO Class?

Oral liquid dosage forms like syrups & suspensions are manufactured in an area that
maintains ISO class 7 or grade C at rest & during working it is ISO class 8 or grade D.

Filling & Sealing Of Sterile Products Take Place in Which ISO Class?
Filling & Sealing Of sterile products take Place In ISO class 5 or grade A.

In Pharmaceutical Industries How We Can Prevent Cross Contamination?

Cross-contamination in various manufacturing areas is prevented by creating a
pressure difference using airlock systems.

Write Down Types Of Airlocks?

There are three types of airlocks which are given below,
 Sink Airlock
 Bubble Airlock
 Cascade Airlock

Write Down the Name Of Official Tests or Pharmacopoeial Tests Performed For
Tablets.
Official Tests Performed for tablets are given,

 Assay
 Content Uniformity
 Weight Variation
 Disintegration Test
 Dissolution Test

Write the Down Name Of Non-Official Tests or Non-Pharmacopoeial Tests For

Tablets.
Non Official Tests Performed for tablets are given,
 Hardness Test
 Friability Test
 Thickness Test

Name Of Dissolution Apparatus?

According to USP 07 types of dissolution apparatus are used which are given below,

 Basket Apparatus
 Paddle Apparatus
 Reciprocating Cylinder
 Flow Through Cell
 Paddle Over Disc
 Rotating Cylinder
 Reciprocating Disc

Which Equipment Is Used For Disintegration Tests?

The equipment which is used for checking Disintegration time is known as Basket Rack
Assembly.

How Many Tablets Are Used For Disintegration Tests?

First, we take 6 tablets for the disintegration test & if one or two tablets fail to
disintegrate we repeat the test with 12 more tablets. The test is considered pass if 16
out of 18 tablets disintegrate in a specified time.

Define Friability?
Percentage weight loss is known as friability.

Which Equipment Is Used For Friability Tests?

Roche friabilator is used for checking the friability of tablets.

For Which Types Of Tablets Do We Perform Friability Tests?

Friability test is performed for core or uncoated tablets.
It is not performed for coated tablets because polymers in coting formulations give
strength to the tablets.

At Which Height Tablets Fall during Friability Test?

Tablets fall at a height of 6 inches during the friability test.

What Is The Acceptance Criteria for Friability Test?

Not more than 1%

What Is The Formula To Calculate Tablet Friability?

Tablet friability is calculated by using the following formula,

Initial Weight(W1) - Final Weight(W2)÷ Initial Weight(W1) × 100

Which Quality Control Tests Are Performed For Suppositories?

Following quality control tests are performed for the suppositories,

 Assay
 Weight Uniformity
 Disintegration
 Dissolution
 Melting Range Test
 Softening Time Test
 Breaking Test

Which Quality Control Tests Are Performed For Sterile Parenterls?

Following tests are performed for injectables,

 Assay
 pH Checking
 Volume Checking
 Leak Test
 Clarity Test
 Pyrogen Test
 Sterility Test

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


Write Inprocess Test For Liquid Dosage Form?

Following in-process Tests are performed for the non-sterile liquid dosage forms.

 pH
 Volume
 Viscosity
 Density
 Clarity Test
 Leakage Test

Which Quality Tests Are Performed For Hard Gelatin Capsules?

 Size & Shape Checking

 Color Verification
 Weight Variation
 Assay
 Disintegration

Which Quality Control Tests Are Performed For Creams & Ointments?
Following quality control tests are performed for creams and ointments.

 Physical Appearance
 Particle Size Determination
 Assay
 Weight Variation Checking
 Solubility Test
 Viscosity Test
 Microbial Growth Test
 Metal Particles Test For Ointments

Pharmaceutical test preparation

Q:1
Dry granulation is also called___________
a) Direct Compression
b) Milling
c)Roller Compaction
d)Sieving

The correct answer is (c)

Roller Compaction is a process of dry granulation in which, roller compactor is used to convert
granules into powder sheets by application of pressure. These paper sheets are then screened
to form granules.

Q:2
Aerosil is also known as ___________
a) Cab-o-sil
b) Fumed silica
c) Colloidal silicon dioxide
d) All of the above

The Correct answer is (d)

Aerosil is a brand name cab-o-sil is also a brand name and both contain silica or colloidal
silicon dioxide.it is mostly used as a glident in tablet formulation.

Q:3
Croscarmellose sodium in Tablets is used as ___________
a) Glident
b)Disintegrant
c) Binder
d) All of the above
The Correct answer is (b)
Disintegrants break the tablets into small fragments which can pass through the basket rack
assembly leaving behind no solid mass.

Q:4
Kollidon is also known as ___________
a) Povidone
b) PVP
c) Polyvinylpyrrolidone
d) All of the above
e) b & c

The Correct answer is (d)

Kollidone is a brand name povidone is also a brand name and both contain PVP or
Polyvinylpyrrolidone

Q:5
Kollidon in tablet manufacturing is used as ___________
a) Suspending agent
b) Binding agent
c) Lubricant
d) All of the for answer

The Correct answer is ( b)

It is used as a binder.

Q:6

Starch in wet granulation is used as

a)Binder
b)Diluent
c)Disintegrant
d)All of the above
The answer is (d)

Q:7
Mannitol in Tablets is used as ___________

a) Glident
b) Disintegrant
c) Binder
d) Diluent

The Correct answer is (d)

Q:8
Pregelatinized starch in Tablets is used as ___________
a) Glident
b) Disintegrant
c) Binder
d) b and c
The Correct answer is (d)

Q:9
HPMC in Tablet manufacturing is used as ___________
a) Glident
b) Disintegrant
c) Binder
d) All of the above

The Correct answer is (c)

Q:10
Sodium starch glycolate in Tablets is used as ___________
a) Glide
b) Disintegrant
c) Binder
d) All of the above

The Correct answer is b

It breaks the tablets into small fragments which pass through mesh no 10 in basket rack
assembly leaving behind no solid mass.

Read More:

Airlocks in pharmaceutical industries.

Clean rooms in pharmaceutical industries.

The potency of Active pharmaceutical Ingredients.

Q:11
Formation of biofilm is prevented by ___________
a) Laminar Flow
b) Turbulent
c) None of the above
d) All of the above

The Correct answer is (b)

Formation of biofilm is prevented by turbulent flow.

Q:12
Avicel is also called ___________
a) Microcrystalline Cellulose.
b) Croscarmellose sodium
c) Methyl Cellulose
d) Both a and c

The Correct answer is (a)

Avicel is a brand name and it contains microcrystalline cellulose also known as MCC.
Q:13
Lactose in tablet manufacturing is used as ___________
a) Diluent
b) Lubricant
c) Flavourant
d) All of the above

The Correct answer is (a)

Lactose in tablet manufacture g is used as diluent.
Q:14
At operation syrup manufacturing takes place________
a) Class A
b) Class B
c) Class C
d) Class D

The Correct answer is (d)

At operation Oral liquid manufacturing area classification is class D.

Q:15
Oral Liquid Manufacturing area at rest is__________
a) Class A
b) Class B
c) Class C
d) Class D

The Correct answer is (c)

Q:16
Filling and sealing of the ampules takes place in which clean room class___________
a) Class A
b) Class B
c) Class C
d) Class D

The Correct answer is (a)

Filling and sealing of the ampules takes place in class A

Q:17
Lactose in tablet manufacturing is used as_________

a) Binder
b) Diluent
c) Disintegrant
d) All of the above

The Correct answer is (b)

Lactose is used as a diluent in tablet manufacturing.
Q:18
One possible cause of Tablet capping may be_______
a) High compression machine speed
b) Low machine speed
c) High moisture content
d) All of the above
Ans: The Correct answer is (a)
High compression machine may cause capping.

Q:19
Mannitol in tablet manufacturing is used as______

a) Lubricant
b) Diluent
c) Sweetener
d) Flavouring
e) b & c

The answer is (e)

Mannitol is used as Diluent and sweetener.

Q:20
Talc in tablet manufacturing is used as______

a) Lubricant
b) Diluent
c) Sweetener
d) Flavouring

The answer is (a)

Read More:

Loop system for purified water.

Classification of Excipients.

Q:21
Starch in tablet manufacturing is used as______

a) Binder
b) Sweetener
d) Flavouring
e) All

The answer is (a)

Q:22
Starch in capsule manufacturing is used as______
a) Binder
b) Diluent
c) a&b
d) Flavouring

The answer is (c)

Q:23
Sodium stearyl fumarate in tablet manufacturing is used as______

a) Lubricant
b) Diluent
c) Sweetener
d) Flavouring

The answer is (a)

It is used as a Lubricant.

Q:24
Klucel used in tablet manufacturing is ______

a) HPMC
b) HPC
c) MC
d) All of the above

The answer is (b)

Klucel is HPC (hydroxypropyl cellulose)

Q:25
In tablet manufacturing klucel is used as______

a) Binder
b) Diluent
c) lubricant
d) None of the above

The answer is (a)

Klucel or HPC (hydroxypropyl cellulose)
is used as a binder in wet granulation for tablet manufacturing.

Q:26
In tablet compression,pre-compression is to______

a) Prevent capping
b) remove entrapped air
c) a&b
d) None of the above
The answer is (c)
Precompression prevents capping by removing entrapped air in granules.
Q:27
Commonly used tablet compression machine tooling are______

a) C Type
b) B Type
c) D Type
d) both b&c

The answer is (d)

B type and D type tooling are used.

Q:28
Remedies of tablet capping may include______

a) Pre-compression
b) Tapered dies
c) slow machine speed
d) a&b
e) All of the above

The answer is (e)

Capping can be prevented by using any of the above-mentioned options.

Q:29
Lamination of tablet is caused by______

a) Low moisture content

b) High moisture content
c) a&b
d) none
The answer is (a)
Lamination is caused by low moisture content.

Q:30
Dwell time in tablet compression is ___
a) The Time spent by a punch in the die
b) Time spent by upper punch under compression roller
c) a&b
d) Time spent by a punch in the tool room

The answer is (b)

The Time spent by a punch under a compression roller is called the dwell time.

Important Topics:

Tablet Granulation in pharmaceutical industries.

Reasons and of tablet capping.

Q:31
Tapered dies in tablet compression are used to prevent ___
a) Capping
b) Sticking
c) Picking
d) All

The answer is (a)

Tapered dies are used to prevent capping

Q:32
Simethicone in tablet coating suspension preparation is used as ___

a) Viscosity enhancer
b) suspending agent
c) Anti-foaming agent
d) All

The answer is (c)

Simethicone is used to prevent foam formation during coating suspension preparation.

Q:33
Rat-hole is a defect which may occur during ___

a) Flow of powder in the hopper of the compression machine.

b) flows through the vale of the blender.
c) Flow of powder the feeder of the compression machined)
d)Both A and b
The answer is (d)
Rathole is a powder flow defect that may occur during compression in the hopper or during
discharging of powder from a blender butterfly valve.

Q:34
To prevent Rat-hole which of following is used ___

a) Vibratory mechanism for hopper

b) Rotating rod for hopper
c) Modern valves for discharge
d) a&c
e) All

The answer is (e)

Rathole defect may occur in compression hoppers or during powder discharge from the blender,
so to prevent it force mechanisms like vibratory mechanism for hopper or rotating rods in hooper
are used. To prevent the rat hole in blender discharge, the latest valve design is used.

Q:35

BMS or building management system controls_____

 a)Temperature
b) Humidity
c) Differential pressure
e) All

The answer is (e)

BMS is a building management system which controls HVAC so regulates temperature,
humidity differential pressure etc online.

Q:36
Candle filter is used in_____

a)FBD
b) Tray dryer
c) Tunnel dryer
d) All

The answer is (a)

Candle filter of finger bag filter is used in fluid bed dryer(FBD)

Q:37
Types of FBD are _____

a)Vertical FBD
b) Horizontal FBD
c) a & b
d) Both a&b
The answer is (d)
There are two types of FBD horizontal and vertical.

Q:38

Macrogol in tablet manufacturing is used as _____

a)Binder
b) plasticizer
c) Lubricant
d) All

The answer to Question is (d)

In pharmaceutical industries, macrogol is used in tablet manufacturing as a binder in

granulation, lubricant in compression and a plasticizer in tablet coating.

Q:39

Mg stearate in tablet manufacturing s used as _____

a)Lubricant
b) Binder
c) Disintegrant
 d) All

The answer to Question is (a)

Mg Stearate is used as a lubricant.

Q:40

Triacetin is the manufacturing of tablets and cosmetics is used as _____

a)Solvent
b) Humectant
c) Plasticizer
d) All

The answer to Question is (d)

Triacetin is used as plasticizer, humectant and also as a solvent in tablets and cosmetic
manufacturing.

Q:41
Sodium stearyl fumarate in the manufacturing of tablets is used as _____

a) Binder
b) Lubricant
c) Plasticizer
d) All

The answer to Question is (b)

Sodium stearyl fumarate is used as a lubricant in tablet manufacturing. It is a hydrophilic

lubricant and is used in cases where the dissolution profile is affected by hydrophobic lubricant
like Mg-stearate.

Q:42

Disintegration Time for uncoated tablets is _____

a) NMT 10 minutes
b) NMT 15 minutes
c) NMT 20 minutes
d) NMT 30 minutes

The answer to Question is (b)

Un-coated tablets should disintegrate within 15 minutes.

Q:43

Aspartame in pharmaceutical products is used as _____

a)Diluent
b) Plasticizer
 c) Film former
d) Sweetener

The answer to Question is (d)

Aspartame is used as a sweetening agent.

Q:44

Boric acid is used as ____

a)Suspending agent
b) Antimicrobial Preservative
c) Buffering agent
d) B&C
The answer to Question is (d)

it is used as an antimicrobial agent in eye drops, ointments and creams.

Boric acid is also used to adjust the pH of eye drop preparations.

Q:45

Tablet coating is used to______

a)Mask the taste

b)Protect the tablet
c) All

The answer is (c)

Q:46

Benzyl Alcohol in pharmaceutical preparations is used as ____

a)Solvent
b) Antimicrobial Preservative
c) Antiseptic
d) All

The answer to Question is (d)

it is utilised as an antimicrobial agent in cosmetic and pharmaceutical products. It is used in oral

and parenteral formulations.
It is also used as a solvent and antiseptic agent.
it causes some adverse fatal reactions in newborns so products preserved with benzyl alcohol
are not recommended for newborns.

Q:47
Benzethonium Chloride is utilized as ____

a)Suspending agent
b) Antimicrobial Preservative
 c) Plasticizer
d) B&C
The answer to Question is (b)
It is employed as an antimicrobial agent in otic preparations, injections and ophthalmic products.

Q:48

Benzoic Acid in pharmaceutical products are used as ____

a)Therapeutic
b) Antimicrobial Preservative
c) Binder
d) A&B
The answer to Question is (d)
Benzoic acid is used as an antimicrobial preservative in pharmaceutical products. It is also used
to treat fungal infection.

Q:49
Benzyl benzoate in pharmaceutical products is used as ____

a)Therapeutic
b) For treating Scabies
c) Plasticizer
d) All
The answer to Question is (d)
Benzyl Benzoate is used as a plasticizer in pharmaceutical products. It is used as a
therapeutic agent or the treatment of scabies.
Benzyl benzoate is also used as a therapeutic agent in veterinary medicines.

Q:50
The pore size of the ULPA filter is ____
a)0.1 micron
b) 0.3 micron
c) 0.5micron
d) None

The answer to Question is (a)

ULPA filter is the ultra-low particulate air filter and its pore size is 0.1 microns.

Important Topics:

Use of 70% IPA.

7 Steps to be a skilled pharmacist.

Q:51
HEPA filter has_____pore size

a)0.1 micron
b) 0.3 micron
 c) 0.35 micron
d) None

The answer to Question is (b)

The HEPA filter is High efficient particulate air filter and its pore size is 0.3 microns. The HEPA
filter is used in pharmaceutical industries for Clean rooms.

Q:52
Frequency of Basket rack assembly during disintegration test is _____
a)27-31 cycle/minute
b) 29-32 cycle/minute
c) 27-32 cycle/minute
d) 29-34 cycle/minute

The answer to Question is (b)

During the disintegration test, the basket rack assembly moves 29-32 times in fluid beaker in
one minute.

Q:53

Wire mesh of Basket rack assembly during disintegration test should descend _______
from the bottom of the fluid beaker.

a)NLT 15 mm
b) NLT 20 mm
c) NLT 25 mm
d) NLT 30 mm

The answer to Question is (c)

During disintegration test wire mesh of the basket rack assembly should descend NLT 25 mm
from beaker bottom on the downward stroke.

Q:54

Types of basket rack assembly apparatus are _______

a. Type A
b. Type B
c. Both a & b
d. None

The answer to Question is (c)

Basket rack assembly apparatus are of two types. Type A and Type B.

Q:55

During the disintegration test, the wire mesh of the basket rack assembly should remain
_______ below the fluid surface.
 a) 05 mm
b) 10 mm
c) 15 mm
d) 20 mm

The answer to Question is (c)

During disintegration test wire mesh of the basket rack assembly should remain 15 mm below
the fluid surface in the beaker on the upward stroke.

Q:56

Glass tubes in basket rack assembly are _______

a) 6
b) 12
c) 10
d) 8

The answer to Question is (a)

Basket rack assembly apparatus consists of 6 tubes.

Q:57

Disintegration Time for film coated tablets is _____

a) NMT 15 minutes
b) NMT 30 minutes
c) NMT 40 minutes
d) NMT 60 minutes

The answer is (b)

Film-coated tablets should disintegrate within 30 minutes.

Q:58

Which of the following filters are used in HVAC_____

a) Carbon filter
b) bag filters
c) Sand filter
d) None

The answer is (b)

In HVAC bag filters are used to filter the air.

Q:59

Bag filters of HVAC are also called_____

a) Coarse Filters
b) Fine Filters
c) Ultra pure filters
d) All

The answer is (b)

In HVAC bag filters are installed to filter the air. Bag filters are also known as fine filters.

Q:60

HEPA filters used in HVAC are also known as_____

a) Coarse Filters
b) Fine Filters
c) Aerosol filters
d) All

The answer is (c)

In HVAC HEPA filters are present to filter the air.HEPA filters are also known as Aerosol filters.

Read More:

Scope of a pharmacist.

Working of a tray dryer.

Use of fluid bed dryer.

Q:61
Lungs of HVAC is also known as_____

a) Dampers
b) Ducts
c) AHU
d) HEPA filters

The answer is (c)

AHU or air handling unit is also known as lungs of HVAC because it contains different type of
filters to purify the air.

Q:62
Size of Wire mesh attached to the bottom of basket rack assembly Is _______
 a) 1.8 mm - 2.2 mm
b) 1.5 mm - 2.0 mm
c) 08mm - 10 mm
d) 10.0 mm

The answer to Question is (a)

( Ref USP)

In disintegration test wire mesh is attached to the basket rack assembly and size of the hole in
wire mesh is 2.0 ± 2 mean
1.8 mm - 2.2 mm.

Q:63
PVP-k30 in tablet manufacturing is used as_____

a) Binder
b) lubricant
c) Glident
d) All of the above
e)Both a&c

The answer is (a)

PVP-k30 is used as a binder in tablet and capsules manufacturing.

Q:64

Length of glass tubes in basket rack assembly used for disintegration test is_______

a) 70 mm - 80 mm
b) 75 mm - 80mm
c) 65 mm - 70 mm
d) 85 mm - 90 mm

The answer to Question is (b)

( Ref USP)

75mm to 80 mm long glass tubes are attached to the basket rack assemBLY Several ched is6.
The unit is added inside the glass tubes to check the disintegration time.

Q:65

The capacity of glass beaker used in basket rack assembly is_______

a)1000 ml
b) 1500 ml
c) 900 ml
d) 1200 ml

The answer to Question is (a)

( Ref USP)

1 litre or 1000 ml capacity glass beaker is used in basket rack assembly filled with water or fluid.

Q:66

Height of glass beaker in basket rack assembly disintegration test is_______

a) 138 mm - 160 mm
b) 140mm - 150mm
c) 148 mm - 170 mm
d) 225 mm

The answer to Question is (a)

( Ref USP)

Height of the glass beaker in the basket rack assembly is 138 mm- 160 mm.

Q:67

Temperature of fluid in basket rack assembly used for disintegration test is_______

a) 34°C-39°C
b) 35°C-37°C
c) 35°C-39°C
d) 35°C-40°C

The answer to Question is (c)

( Ref USP)

37±2°C means 35°C to 39°C temperature.

Q:68
Which statement is true about Lake colours ______

a) Lake colours are water-soluble

b) Lake colours are water-insoluble
c) Lake colour is slightly soluble in warm water
d) None of the above

The answer to Question is (b)

Lake colour used for tablet coating water-insoluble.

Q:69

Mannitol may cause ______ when it is used in higher amounts.

a) High sugar level

b) Laxative effect
c) Increase blood pressure
d) All
Answer to Question is (b)

Mannitol is used as an excipient in tablet manufacturing. When higher quantities of mannitol

are used it may result in a laxative effect. Use of mannitol does not increase the blood sugar
level.

Q:70

Which statement is true about Dyes ______

a) Dyes are water-soluble

b) Dyes are water-insoluble
c) Dyes are slightly soluble in Moreno
d )None above

The answer to Question is (a)

Dyes used for tablet coating are water-soluble.

Read More:

Dust cups for compression machines.

Learn how to write SOP.

Q:71

For Chewable tablets, disintegration time is ______

a) Should disintegrate within 5 minutes.

b) Should disintegrate within 3 minutes.
c) Should disintegrate within 6 minutes.
d) Disintegration test is not applicable.

The answer to Question is (d)

For chewable tablets disintegration test is not applicable. So this test is not performed.

Q:72

For Dispersible tablets,disintegration time is ______

a) Should disintegrate in Not More Than 15 minutes.

b) Should disintegrate in Not More Than 5 minutes.
c) Should disintegrate in Not More than 3 minutes.
d) Disintegration test is not applicable.

The answer to Question is (c)

The correct answer is option c.

Dispersible tablets should disintegrate In Not More Than 3 minutes. For dispersible tablets
disintegration test is performed at 15°C to 25°C temperature.
For film-coated tablets in basket rack assembly, the disintegration test is performed at
temperature 37±2 °C.

Q:73

For Effervescent tablets,disintegration time is ______

a) Disintegration time should Not be More Than 5 minutes.

b) Disintegration time should Not be More Than 3 minutes.
c) Disintegration time should Not be More Than 15 minutes.
d) Disintegration time should Not be More Than 2 minutes.
e)Disintegration time test is not applicable for effervescent tablets.

The answer to Question is (a)

Effervescent tablets should disintegrate in not more than 5 minutes.
This test is performed at 15°C to 25°C temperature.

Q:74
HPMC in tablet manufacturing is used as_____

a) Binder
b) Film former
c) Matrix formation
d) All of the above
e)None of the above

The answer is (d)

 HPMC is an abbreviation and it is Hydroxypropyl Methylcellulose.

 It is derivative of cellulose and is a semi-synthetic type of excipient.
 It is also known as Methocel E5( brand name).
 Hydroxypropyl Methyl Cellulose is used in tablets as a binder.
 It is used in wet granulation as a For sustain release or extended-release it is used to
form a matrix.





 Matrix formation releases the drug slowly over time.
 Different grades are used for matrix formation like HPMC k100 etc.
 It is also used in tablet coatings as a film-forming polymer.

Q:75
HPMC in tablet manufacturing is used as_____

a) Binder
b) Film former
c) Matrix formation
d) All of the above
e)None of the above
The answer is (d)

Q:76
PVP-k30 in tablet manufacturing is_____

a)Natural Binder
b)Semi-synthetic binder
c) Synthetic binder
d) All of the above
e)Both a&b

The answer is (c)

PVP-k30 is employed as a binder in tablet and capsules manufacturing.

It is a synthetic binder.

Q:77
PVP-k30 is used in tablet manufacturing and is_____

a)water-soluble Binder
b water-insoluble binder
c) Partially water soluble
d) None of the above
e)Both a&c

The answer is (a)

PVP k30 is a water-soluble binder.

Q:78
To calculate the capacity of blender which parameters are required

a)Volume of blender
b kgs of blender
c) bulk density of the product
d) a&c
e)All
The answer is e.

Q:79

Methyl paraben sodium in liquid manufacturing is used as______

a)Preservative
b) Solubility enhancer
c) Sweetener
d) Flavouring

The answer is (a)

Q:80
Xanthan gum in tablet manufacturing is used as______
a) Binder
b) Diluent
c) Sweetener
d) Flavouring
e) b & c

The answer is (a)

Q:81
Xanthan gum in liquid manufacturing is used as______

a) Suspending agent
b) Antimicrobial
c) Sweetener
d) Flavouring
e) b & c

The answer is (a)

Q:82
Gum acacia in tablet manufacturing is used as______

a) Suspending agent
b) Antimicrobial
c) binder
d) Flavouring
e) b & c

The answer is ( c)

Q:83

Carnauba wax is used in______

a) Tablet compression
b) Tablet Coating
c) Slugging
d) All

The answer is (b)

Q:84

Carnauba wax is used in tablet coating as______

a) Film former
b) Polishing agent
c) colourant
d) All
The answer is (b)

Q:85

Types of tablet coating are______

a)Film coating
b)Sugarcoating
c) Enteric coating
d) All

The answer is (d)

Q:86

HVAC in pharmaceutical industries is used for______

a)Creating differential pressure

b)To prevent cross-contamination
c)To Maintain temperature
d) All

The answer is (d)

Q:87

Filters of HVAC in pharmaceutical industries are_____

a)HEPA Filters
b)Bag filters
c)Prefilters
d) All

The answer is (d)

Q:86

HVAC stands for______

a)Heating ventilation & air conditioning

b)Humidity ventilation & air conditioning
c)Heating ventilation & air controlling
d) None of the above

The answer is (a)

Q:87

Taste of ciprofloxacin is______

a. Bitter
b. sour
 c. Tasteless
d. None of the above
e.
f.
g.
h.
i.

The answer is (a)

Q:88
Dibasic calcium phosphate is in tablet manufacturing is used as_______
a. Binder
b. Disintegrant
c. Diluent
d. sweetener
The answer is (c)

Q:89
Friability of the tablet should not be more than______
a. 1%
b. 2%
c. 3%
d. 4%
e.
f.
g.
h.
i.
The answer is (a)

Q:90
Apparatus used for tablet friability is
a. Roche friabilator
b. Pfizer friabilator
c. GSK friabilator
d. OBS friabilator
e.
f.
g.
h.
i.
The answer is (a)

Q:91

For checking friability the rpm is

a. 25
b. 35
c. 15
d. 20
The answer is (a)

Q:92
For checking friability, the drum of friabilator revolves for_____
a. 2 Minutes
b.[a.] 3 Minutes
c.[b.] 4 Minutes
d.[c.] 5 Minutes
e.[d.]
f.[e.]
g.[f.]
h.[g.]
i.[h.]

The answer is (c)

Q:93

PVP k30 is soluble in_____

a)Water
b)IPA
c)Both
d)None
The answer is (c)

Q:94
Tween 80 is used as_____
a)Solubility enhancer
b)Binder
c)Lubricant
d)None
The answer is (a)

Q:95

Microcrystalline cellulose is also known as_____

a)Avicel
b)Kollidone
c)Klucel
d)None of the above
The answer is (a)

Q:96

Microcrystalline cellulose in tablet manufacturing is used as_____

a. Diluent
b. Dry binder
c. Disintegrant
d. All of the above
e.
 f.
g.
h.
i.

The answer is (d)

Q:97

Lamination of tablet is______

a. Removal of crown edges of the tablet.

b. Separation of the tablet into two layers.
c. Both a and b

The answer is (b)

Q:98
Lamination of tablet is caused by_____

a. Low moisture content

b. High moisture content
c. Poor powder flow
d.
e.
f.
g.
h.

The answer is (a)

Q:99

Tablet capping is_____

a. Removal of crown edges of the tablet.

b. Separation of the tablet into two layers.
c. Both a and b

The answer is (a)

Q:100
Tablet capping is caused by_____

a. Low moisture content

b. High moisture content
c. More fine powder
d. Both a and c
e.
f.
g.
 h.
i.

The answer is (d)

Pharmaceutical MCQs|Pharmaceutical Revision

Test|Pharma Interview Questions
Q:1

Which of the following gives a fast effect?

a)Solution.
b)Tablet.
c)Capsule.
d)Creams
Correct Answer is (a)

Q:2
Which pharmaceutical dosage form is more stable
a)OSD
b)Liquid
c)Both
Correct Answer is (a)

Q:3
Pharmaceutical solutions are
a)Homogeneous
b)Heterogeneous
c)Opaques
d)All of the above
Correct Answer is (a)

Q:4
Pharmaceutical mixtures maybe
a)Homogeneous
b)Heterogeneous
c) a & b
d)None
Correct Answer is (c)

Q:5
The pharmaceutical eye preparations are
a)Sterile
b) Non-Sterile
c)None
d)All of the above
Correct Answer is (a)
Q:6
Components of elixir are
a)Alcohol
b)water
c)Glycerin
d)All of the above
Correct Answer is (d)

Q:7
Types of elixir are
a)Medicated
b) Non-Medicated
c)Both
d)None
Correct Answer is (c)

Q:8
Non medicated elixirs are used as a
a)Vehicle
b)Flavour
c)Therapeutic agent
d)a&b
Correct Answer is (d)

Q:9
Linctuses are
a)solid preparations
b)Liquid preparations
c)Semi-solid preparations
Correct Answer is (b)

Q:10
Draught is
a)solid preparations
b)Liquid preparations
c)Semi-solid preparations
Correct Answer is (b)

Q:11
Throat paints are
a)solid preparations
b)Liquid preparations
c)Semi-solid preparations
Correct Answer is (b)

Q:12
_____ is used as a base in Throat paints.
a)Cellulose
b)Glycerine
c)IPA
Correct Answer is (b)
Q:13
Throat paints are
a)solid preparations
b)Liquid preparations
c)Semi-solid preparations
Correct Answer is (b)

Q:14
Enemas have_____ effect
a)Antiemetic
b)Antihistamine
c)Purgative
Correct Answer is (c)

Q:15
Douches are
a)solid preparations
b)Liquid preparations
c)Semi-solid preparations
Correct Answer is (b)

Q:16
Douches are
a)Apply on skin
b)Injected
c)Introduced in the body cavity
Correct Answer is (c)

Q:17
Liniments are
a)solid preparations
b)Liquid preparations
c)Semi-solid preparations
d)b&c
Correct Answer is (d)

Q:18
Liniments are
a)Applied on skin
b)Injected
c)Introduced in the body cavity
Correct Answer is (a)

Q:19
Rubefacients when applied to skin cause___
a)Congestion
b)Redness
c)Both
d)None
Correct Answer is (c)
Q:20
_____ act as Rubefacients.
a)Menthol
b)Camphor
c)Glycerine
d)None
Correct Answer is (b)

Q:21
Particle size in suspensions is usually____
a)0.5-5 micron
b)0.7-6 micron
c)0.7-7micron
d)0.1-1 micron
Correct Answer is (a)

Q:22
_____ are types of suspension
a)Flocculated
b)Non flocculated
c)Both
d)None
Correct Answer is (c)

Q:23
Which of the following is true about flocculated suspensions
a)Rate of sedimentation is high.
b)Rate of sedimentation is Low.
c)None of the above
Correct Answer is (a)

Q:24
Which of the following is true about non-flocculated suspensions
a)Rate of sedimentation is high
b)Rate of sedimentation is Low
c)None of the above
Correct Answer is (b)

Q:25
In which of the following suspension particles can easily be dispersed.
a)Flocculated
b)Non flocculated
c)Both
d)None
Correct Answer is (a)

Q:26
Suspending agents in suspension are used to
a)Increase the viscosity
b)Decrease the viscosity
c)Maintain pH
Correct Answer is (a)

Q:27
Commonly used Suspending agents are
a)MC
b)HPMC
c)CMC
d)All of the above
Correct Answer is (d)

Q:28
Clays are used as
a)Suspending agent
b)Binder
c)Diluent
d)Flavouring
Correct Answer is (a)

Q:29
To prevent microbial growth in suspension ____ are added
a)Binders
b)Colorants
c)Preservatives
d) None
Correct Answer is ©

Q:30
______ are used as preservatives
a)Methyl parabens
b)Propyl parabens
c)Sodium Benzoate
d)All
Correct Answer is (d)

Q:31
Caramel is used as a ___ in suspensions
a)Flavouring agent
b)Suspending agent
c)Preservative
Correct Answer is (a)

Q:32
Type of coating in which polymer changes the release of drug is known as
a. Sugar coating
b. Functional coating
c. Non Functional coating
d. Film Coating
e. All of the above
Correct Answer is (b)
Q:33
Minimum weight of tablet for easy compression should be
a. About 30 mg
b. About 40 mg
c. About 50 mg
d. About 80 mg
Correct Answer is (c)

Q:34
Recommended time for optical checking of ampoules against a white and black
background is
a) 10 seconds each
b) 05 seconds each
c) 15 seconds each
d) 7.5 seconds each
Correct Answer is (b)

Q:35
Airlocks for Clean rooms in pharmaceutical industries are of following types
a)Bubble airlock
b)Sink airlock
c)Cascade airlock
d)MAL airlock
e)PAL airlock
f)a,b&c
g)All of the above
Correct Answer is (f)
For Details Read
Types of airlocks in pharmaceutical industries.

Q:36
Stearic acid used as a lubricant in tablet manufacturing is obtained from
a)Minerals
b)Animal
c)Marine
d)All of the above
Correct Answer is (b)

Q:37
Manufacturing of sterile products which require terminal sterilization takes place in
a)Class A
b)Class B
c)Class C
d)Class D
Correct Answer is (C)

Q:38
lux level of direct sunlight is
a)10,000 lux
b) 50,000 lux
c) 100,000 lux
d)10,000,00 lux
Correct Answer is (d)
For Details Read
Lux level for Different areas in pharma.

Q:39
Which of the following step is not performed in Hot melt Granulation Method
a) Wet Sieving
b) Addition of solvent
c) Drying to remove the solvent
d) B&C
e) All of Above
Correct Answer is (e)

Q:40
First vaccination of coronavirus is approved in
a) UK
b) USA
c) UAE
d) None
Correct Answer is (a)

Q:41
If Spray gun to tablet bed distance is decreased which of the following defect may occur
a)Sticking
b)Picking
c)Twinning
d) a & c
e) All of the above
Correct Answer is (e)

Q:42
All the parts of pharmaceutical equipment which are in direct contact with the product
are made of
a)SS grade 304
b) SS grade 304L
c) SS grade 316
d) SS grade 316L
Correct Answer is (d)

Q:43
In the pharmaceutical industry, we have a double cone blender of 400 Liters. Product
bulk density is 0.8 g/ml.what will be the 75% mixing volume for this product in the
blender.
a) 300 kg
b)260 kg
c)240 kg
d)320 kg
Correct Answer is (c)
To learn above calculation read
Easy Steps to calculate Double cone blender capacity.

Q:44
Concentration of Croscarmellose sodium as disintegrant in tablets is
a) 0.5-4.0%
b) 0.5-5.0%
c) 0.5-6.0%
d 0.5-8.0%
Correct Answer is (b)

Q:45
Pregelatinized starch in tablet manufacturing is used as
a) Binder
b) Disintegrant
c) Diluent
d) A & B
e) All
Correct Answer is (e)

Q:46
During manufacturing, which type of cleaning is performed when we move from Higher
dose(strength) to a lower dose of the same product in pharmaceutical industries?
a) Type A cleaning
b) Type B cleaning
c) Type C cleaning
d) None of the above
Correct Answer is (b)

Q:47
If Mg Stearate is hydrophobic lubricant then which of the following is a hydrophilic
lubricant
a)Stearic Acid
b)Sodium stearyl fumarate
c)Calcium stearate
d)Iron oxide
Correct Answer is (b)

Q:48
During Operation,Tablet manufacturing area maintains
a)Class B
b)Class C
c)Class D
d)Non classified
Correct Answer is (d)

Q:49
Steps of wet granulation are
a)Slugging
b)Kneading
c)Compacting
d)None Of Above
Correct Answer is (b)

Q:50
Case hardening results in which of following tablet defect
a)Sticking
b)Capping
c)Weight variation
d)Prolong Disintegration time
Correct Answer is (a)
For More Details Read
Reasons and remedies of tablet sticking and picking.

Q:51
In bubble air-lock system,on door opening air moves from
a)Airlock to the primary area
b)Primary area to air-lock
c)Corridor to air-lock
d) None
Correct Answer is (a)

Q:52
Which of the following type of HVAC is more efficient
a)Dx type
b)Chilled water
c)SAD
d)RAD
Correct Answer is (a)

Q:53
The First compression machine manufactured by Stroke was
a) B type
b) D type
c) BB type
d) DB type
Correct Answer is (b)

Q:54
Dust cups are used during tablet compression to prevent
a)Black particles
b)Leakage of lubricants
c)Capping
d) a and b
e)All of the above
Correct Answer is (d)

Q:55
Height of partition between two packaging lines in pharmaceutical industries should
be____
a)1 meter
b)2 meter
c)1 feet
d 2 feet
Correct Answer is (b)

Q:56
In DOP test the scanning is performed at the distance of____ mm from HEPA filter face
a) 15 mm
b) 20 mm
c) 25 mm
d) 40 mm

Correct Answer is (c)

Q:57
Tablet capping may be caused by which of the following reasons.
a)Higher concentration of Lubricant.
b)Lower concentration of Lubricant.
c)Higher blending time with Lubricant
d)Lower blending time with Lubricant
e) a&c
f) b&d
Correct Answer is (e)

Q:58
As a Disinfectant which concentration of Isopropyl Alcohol (IPA) is more effective?
a) 60%
b) 70%
c) 80%
d) 90%
Correct Answer is (b)
Read Details
Why we Use only 70% IPA.

Q:59
Lactose used as a diluent in tablet manufacturing is obtained from
a)Plants
b)Animal
c)Synthetic process
d)All of the above
Correct Answer is (b)

Q:60
In HVAC system, the mixing box is present in
a)Supply air duct
b)Return air duct
c)Air handling Unit
d)Damper
Correct Answer is (c)

Q:61
Pregelatinized starch is manufactured from native starch by
a) Cooling the native starch
b) Granulating the native starch
c) Compressing the native starch
d) Cooking the native starch
Correct Answer is (d)

Q:62
To calculate the capacity of blender which parameters are required
a)Volume of blender
b) kgs of blender
c) bulk density of the product
d) a&c
e)All
Correct Answer is (d)

Q:63
Dibasic Calcium phosphate used as diluent is incompatible with
a)Paracetamol
b)Aspirin
c)Metformin
d)Sitagliptin
Correct Answer is (b)

Q:64
Cros-carmellose sodium is used as______ in wet granulation.

a)Disintegrant
b)Diluent
c)Binder
d)Lubricant
Correct Answer is (a)

Q:65
Type C cleaning in pharmaceutical industries is also known as
a)Product changeover cleaning
b)Same product cleaning
c)Shift End cleaning
d)All of the above
Correct Answer is (c)
Read Details
Line Clearance in pharmaceuticals.

Q:66
Fill cams are used in
a)Advance Compression machines
b)Conventional compression machines
c)Single punch compression machines.
d)All of the above
Correct Answer is (a)
Q:67
Which is the synthetic binder used in wet granulation.
a)PVP k 30
b)HPMC
c)Starch
d)Klucel
Correct Answer is (a)

Q:68
Which of the following may cause the breakdown of the compression machine
a. under lubrication
b. Overloading
c. lose die bolts
d. Untrained operator
e. All of the above
Correct Answer is (e)

Q:69
Which grade of Avicel has the largest particle size
a. Avicel PH 102
b. Avicel PH 200
c. Avicel PH 301
d. Avicel PH 302
Correct Answer is (b)

Q:70
The particle size of Avicel 200 is
a)180 micron
a)200 micron
b)240 micron
c)300 micron
Correct Answer is (a)
Read Details.
Different Grades of Microcrystalline Cellulose or Avicel .

Q:71
During manufacturing,Oral liquid manufacturing area maintains which of the following
cleanroom class
a)Class A
b)Class B
c)Class C
d)Class D
Correct Answer is (d)

Q:72
Turbulent flow occurs at Reynold Number____?
a)More than 1000
b)More than 2000
c)More than 3000
d)More than 4000
The answer is (d)

Q:73
Croscarmellose sodium(Ac-di-sol) is not compatible with
a)Iron salt
b)Sodium salt
c)Calcium salt
d) Magnesium salt
Correct Answer is (a)

Q:74
Case hardening is the defect of
a)Coating
b)Granulation
c)Compression
d)Creams
Correct Answer is (b)

Q:75
A higher quantity of Mg Stearate lubricant may result in
a)Prolong Disintegration Time
b)Reduction of Disintegration Time
c)High tablet hardness
d)High tablet weight
Correct Answer is (a)

Q:76
The banana technique is used in
a)Ointment manufacturing
b)Syrup manufacturing
c)Tablet manufacturing
d)Preventive maintenance
Correct Answer is (c)

Q:77
Usually, Direct compression method is used for
a)High dose Of API
b)Low dose of API
c)Fine powders
d)All
Correct Answer is (b)
Read
Direct compression method for tablets.

Q:78
J hock is the defect of___
a) Punch head
b) Punch tip surface
c) Punch barrel
d) Die bore
Correct Answer is (b)

Q:79
Rota head is an advance compression machine tooling used for______
a)To Enhance speed
b)To prevent breakdown
c)To prevent Capping
d) To reduce change over time
Correct Answer is (c)

Q:80
Commonly used binder in hot granulation technique is
a)PVP k30
b)HPMC
c)Macrogol
d)Starch
Correct Answer is (c)

Q:81
Dead legs in water loop circulation system can be prevented by maintaining the velocity
of purified water at
a) 1.0-2.0 meter/sec
b) 2.0-3.0 meter/sec
c) 2.5-3.5 meter/sec
d) 0.5-1.0 meter/sec
Correct Answer is (a)
Read Details
Loop Circulation system for purified water.

Q:82
The particle size of Avicel PH 302 is
a) 100 micron
b) 200 micron
c) 75 micron
d) 150 micron
Correct Answer is (a)

Q:83
Maximum working capacity of a blender is___
a)90-96% of the final volume
b)80-90% of the final volume
c)70-80% of the final volume
d)55-70% of the final volume
Correct Answer is (c)

Q:84
Inspector fatigue occurs during
a)Granulation
b)Optical Checking
c)Compression
d)Dispensing
Correct Answer is (b)

Q:85
Moisture content in Avicel 101 is
a) ≤ 2.5%
b) ≤ 3.0%
c) ≤ 5.0%
d) ≤ 7%
Correct Answer is (c)

Q:86
DOP test for ISO class 8 or Class D should be carried out after
a)3 Months
b)6 Months
c)9 Months
d)12 Months
Correct Answer is (d)

Q:87
DOP test for ISO class 5 or Class A should be carried out after
a)3 Months
b)6 Months
c)9 Months
d)12 Months
Correct Answer is (b)

Q:88
The particle size of Avicel 101 is
a) 10 micron
b) 50 micron
c)100 micron
d)200 micron
Correct Answer is (b)

Q:89
Compression machine capacity calculation requires which of the following
a)rpm
b)no of punched
c)no of feeding system
d) All
Correct Answer is (d)

Q:90
Which lubricant is known as boundary wall lubricant
a)Mg-stearate
a)Sodium Stearyl Fumarate
b)Sodium Benzoate
c)SLS
Correct Answer is (a)

Q:91
Type cleaning is commonly known as
a)Minor Cleaning
b)Major Cleaning
c)Shift change cleaning
d)All of the above
Correct Answer is (a)

Q:92
Concentration of starch used as binder is______
a)3-8%
b)3-15%
c)3-20%
d5-22%
Correct Answer is (c)

Q:93
Dibasic calcium phosphate is incompatible with
a)Aspartame
b)Ampicillin
c)Erythromycin
d)All of the above
Correct Answer is (d)

Q:94
Class D cleanroom is also called
a) ISO class 5
b)ISO class 6
c)ISO class 7
d)ISO class 8
Correct Answer is (d)

Q:95
Lactose for inhalation is also known as
a)Respitose
b)Inhaltose
c)Lactulose
Correct Answer is (a)

Q:96
The inlet air for tablet coating must be processed by
a)Pre Filters
b)Bag filters
c)HEPA filters
d)All
Correct Answer is (d)

Q:97
Lined dies are used for ____?
a)Corrosive Materials.
b)Fine materials
c)Sticky Materials
d)Coloring Materials
Correct Answer is (a)

Q:98
The solid flow meter is installed in
a. Tray dryer
b. FBD
c. Granulator
d. Blender
e. All
f.
g.
h.
i.
j.
Correct Answer is (b)
Read Details
Working of fluid bed dryer.

Q:99
The solid flow meter is installed to
a)To detect filter leakage
b)To monitor drying time
c)To monitor LOD
d)All of the above
Correct Answer is (a)

Q:100
The solid flow meter is installed in
a)Product trolley of FBD
b)Inlet air duct
c)Return air duct
d)All of the above
Correct Answer is (c)

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Sajjad Ahmad
Sajjad Ahmad is a young Pakistani Pharmaceutical Blogger.He has spent more than a
decade in different Pharmaceutical Industries.Currently he is working as a Production
Manager in a well Reputed Pharmaceutical Industry.He is the founder & author of
Pharmainform.com an emerging Pharmaceutical Blog. Pharmainform is also on
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 Calculations (6)
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 Excipients (24)
 General-Topics(18)
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 HVAC (6)
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Questions (10)
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