MYCOPLASMA
PNEUMONIA
By: Charles J. Seals
CAUSATIVE ORGANISM
Mycoplasma Pneumoniae
• Smallest known organism
• Lack cell wall
• Free living
• Require Cholesterol
(Cowan & Talaro, 2009)
MYCOPLASMA PNEUMONIAE
Morphology/Arrangement
Can appear in various shapes:
- cocci
- filamentous rods - spirals
- irregular in arrangement
Gram Stain
- no reaction
(as cited by Howard, 1999)
(Cowan & Talaro, 2009)
MYCOPLASMA PNEUMONIA
Transmission
•Aerosol droplets
•Contact with contaminated
surfaces
•Bacteria remaining airborne
(Gould, 2006)
LINES OF DEFENSE
• First line of defense
- nasal hairs
- cilia
- mucus
• Second line of defense
- tonsils
- secretory
immuniglobulin A (IgA)
•Third line of defense
- alveolar macrophages
(Cowan & Talaro, 2009)
VIRULENCE FACTORS
• Adherence to host cells-
possesses attachment organelle at
one end with membrane associated
P1 protein clustered at its tip
• Penetration of the mucus
membrane of respiratory tract
(as cited by Howard, 1999)
• Uses host cell to reproduce
(Winn, Allen, Janda, et al., 2006)
SIGNS/SYMPTOMS
• Dry cough
• Sore throat
• Fever
• Headache
(Bishop, 2009)
• Muscle aches
• Ear infection
(Cowan & Talaro, 2009)
DIAGNOSIS
• Physical exam
• Chest x-ray
• Sputum culture
• Blood test
• Lung biopsy (severe only)
(Cowan & Talaro, 2009; Gould, 2006)
TREATMENT
Minor cases: 3-10 days
• No Treatment
• OTC medications
Severe cases: 10 days – 6 weeks
• Erythromycin
• Tetracycline – warning!
(Gould, 2006; Winn, et al., 2006)
(Fortin, 1999)
STATISTICS/EPIDEMIOLOGY
• Infects anyone
• 2 Million annually
• 20% - 40% community acquired
• 1/5 asymptomatic
(Winn, et al., 2006)
PREVENTION
• No vaccine
• Hand washing
• Cover face when coughing/sneezing
• STAY HOME !
REFERENCES
• Bishop, K. (2009). Practical H1N1 prevention. Preparedness Pro. Retrieved on
April 20, 2010 from http://preparednesspro.wordpress.com/category/
disasters/swine-flu-disasters/ .
• Cowan, M.K., & Talaro, K.P. (2009). Infectious diseases affecting the respiratory
system.
Microbiology: A systems approach (2nd ed.) (pp. 649-685). New York, NY: McGraw-
Hill.
• Fortin, D.J.J. (1999). Porcelain veneers: A challenging case. Journal of the
Canadian Dental Association, 65,110-112.
• Gould, B. (2006). Respiratory disorders. Pathophysiology for the health professions
(pp. 362-421). Philadelphia, PA: Elsevier.
• Howard, K. (1999). Mycoplasma pneumoniae: The mystery bug. Retrieved from
s99.middlebury.edu/BI330Aprojects/Howard/Mpneumoniae.html.
• Winn, W., Allen, S, Janda, W., Koneman, E., Procop, G., Schreckenberger, P., Woods,
G.
(2006). Mycoplasmas and ureaplasmas. Koneman’s color atlas and textbook of
diagnostic microbiology (6th ed.) (pp.1022-1063). Baltimore, MD: Lippincott
Williams & Wilkins.