Ultrasound of Extracranial Cerebral Vessels
Ultrasound of Extracranial Cerebral Vessels
A Primer
Parker Freels, MD, Sherif Elsherif, MD, Dheeraj Gopireddy, MD, Chandana
Lall, MD, Sindhu Kumar, MD, Smita Sharma, MD, Joanna Kee-Sampson, MD
Author Affiliations:
University of Florida College of Medicine - Jacksonville
Department of Radiology
655 West 8th Street, C90
2nd Floor, Clinical Center
Jacksonville, FL 32209
Address correspondence to:
Parker Freels, MD
pdfreels@[Link]
S.E. received a travel stipend from RSNA to attend the ITAR meeting in 2021. All other authors have disclosed no relevant relationships.
Originally presented as an educational exhibit (VAEE-13) at the 2021 RSNA annual meeting.
Background and Purpose
• Cerebrovascular disease and stroke remain leading causes of death
in the United States, with someone having a stroke every 40
seconds.
• Stroke management is also a significant financial burden, and related
costs reached upwards of $46 billion U.S. dollars in 2014–2015.
• US is a vital tool in the evaluation of a patient with suspected stroke
and other atherosclerotic disease of the extracranial
cerebrovasculature (American College of Radiology appropriateness
criteria = 8).
Background and Purpose
• US is often performed by technologists, and radiologists may lack
experience in the acquisition of images, which limits examination
interpretation and troubleshooting.
• This presentation should be used as an educational tool and reference
when the radiologist needs to evaluate US findings of the extracranial
cerebral vessels.
• We aim to demonstrate imaging findings related to:
• Normal anatomy • Dysrhythmia
• Atherosclerotic disease • Internalization of the external carotid
artery (ECA)
• Stenosis
• Subclavian steal syndrome
• Plaque stability
• Trauma
• Postprocedural findings
• Tumor
Learning Objectives
• Discuss the proper technique for acquiring US images of vasculature
using the concepts of position, probe, and protocol.
• Appreciate the fundamentals of US physics as they apply to
extracranial cerebral vasculature.
• Recognize the major components of a vascular US examination with
description of pearls and pitfalls of acquisition.
• Detail how US can help assess hemodynamics, anatomy, and
pathologic features related to the extracranial carotid and vertebral
vasculature.
• Discuss how US can be used in the workup and management of a
patient.
US is a highly effective tool in the diagnosis of extracranial cerebrovascular disease.
It is mobile, widely available, inexpensive, noninvasive, and low risk without the use of ionizing radiation.
However, adequate image acquisition is highly dependent on the operator and patient.
c
The probe both transmits and receives sound waves… 𝛌= f
𝛌 = wavelength
c = speed of the ultrasound wave (1540 m/sec)
f = frequency
� wavelength (𝛌).
𝝅𝚫P
n=viscosity Q = v1 x A1
(
( constan
L=length of the vessel v=velocity
Q=
8nL
(r )
4
𝚫P=pressure difference variable
t and A=area (𝝅r2)
r=radius
Q1 = Q 2 = Q 3
Same column of
The system
blood must move
through a smaller Q1 Q2 Q3 compensates with
an ↑ velocity to
area (region of
maintain flow.
stenosis).
Power
Calipers
Zoom
Depth
PEAK SYSTOLIC
VELOCITY (PSV) END DIASTOLE waveform above baseline
Waveform varies VELOCITY (EDV)
with cardiac cycle =
TOWARD the probe
NOTE: Most of these protocol settings are the standard convention but can be altered by the sonographer.
Protocol
Important imaging parameters to optimize in order to avoid certain artifacts:
Gain Color Gain Spectral Doppler Scale
Color blooming artifact
Too
High
x
x
Aliasing: scale is too
Too narrow so data wrap around
Low the set parameters
(arrows).
✓
Aliasing is improved by
Just increasing the velocity
Right scale or pulse repetition
frequency.
Protocol
Important imaging parameters to optimize in order to avoid certain artifacts:
Doppler Angle Spectral Doppler Waveform
Too
High
x θ = 90°
signal barely detectable
Too
Low x θ = -60° with opposite
waveform direction (below
the baseline)
✓
Just
Right θ ≤ 60°
Protocol
Important imaging parameters to optimize:
Caliper Placement
Especially within tortuous anatomy, placing the caliper in the center of the vessel parallel to blood flow can be
challenging. When the caliper is inappropriately placed, Doppler readings can be falsely elevated, and artifact
x
may result.
✓
VS !
PITFALL
ICA
Normal Vessel Analysis
CCA
ECA
Normal Vessel Analysis
CCA
Intima
• Largest-caliber vessel, which Media
bifurcates into ICA and ECA Adventitia
• Mix of ICA and ECA waveforms
• Moderate diastolic flow but not as
much as ICA
Normal Vessel Analysis
ECA
Vertebral Artery
Plaque is most often eccentric, so multiple projections are needed until the best image plane is selected.
x ✓
• For plaque characterization, the artery should be imaged in both gray scale and color Doppler.
• Color Doppler imaging may obscure plaque because of bleeding artifact.
• By evaluating the sonographic three S’s when assessing extracranial vasculature, one can
determine the plaque’s characteristics and predict risk of neurologic events. *Anechoic.
Plaque Characterization: Calcified Plaques
The Three S’s:
Sonolucency, Surface, Stability
(A) Gray-scale and (B) color Doppler US images show predominantly anechoic plaque within the mid left ICA
(arrows). (C) Spectral Doppler US image shows significantly elevated PSV.
• Hypoechoic or anechoic (soft) plaque correlates with recent hemorrhage or thrombus
versus lipid core.
• Color Doppler US improves detection with separation between the color-filled lumen
and the vessel wall.
• Noncalcified plaque = instability → increased risk of embolism and neurologic events.
Plaque Characterization: Soft Plaques
The Three S’s:
Sonolucency, Surface, Stability
A. B.
Heterogeneous plaque (arrows) in the left CCA in another patient with focal depression
on the (A) gray-scale US image and confirmed on the (B) color Doppler US image.
• Surface irregularity is a negative predictor for plaque stability when evaluating
atherosclerotic disease.
• Characterization of plaque surface is improved with color flow analysis (above).
• Although US has poor sensitivity for ulceration detection, it can still be used to
evaluate plaque surface characteristics.
Criteria for Diagnosis of ICA Stenosis
Underestimate
CO
Patients with ↓ CO will have falsely ↓ PSV for the degree of stenosis.
Measuring
PSV within the CCA is more accurately measured at its distal aspect, 2–4 cm proximal
the proximal
CCA PSV to the bifurcation.
Overestimate
Contralateral
stenosis the major supplier of collateral flow.
Vessel The ICA PSV may be overestimated in tortuous vessels secondary to ↑ PSV and
tortuosity difficulty in setting a correct Doppler angle.
Therefore, both the gray-scale and color Doppler appearance of the carotid vessels, including evaluation
of the plaque burden and degree of luminal narrowing, are critical for assessment of suspected stenosis.
Updated Criteria by the Intersocietal Accreditation Commission (IAC)
(A) Gray-scale and (B) color Doppler US images with marked narrowing of the left proximal ICA by anechoic noncalcified
atherosclerotic plaque (arrows). (C) Elevated PSV and spectral broadening, suggesting hemodynamically flow limiting stenosis
and downstream turbulent flow.
• A filling in of the spectral window due to an increased range of velocities, related to turbulent flow in
poststenotic vessels
• Heterogeneous sampling from turbulent reflective red blood cells, contributing to more variable and wider
range in velocity data at Doppler US evaluation
• It may be related to technical factors including: Minimize artifactual spectral broadening by:
• Tortuous vessels
• ↑ Gain settings • ↓ Gain settings.
• Procedural changes
• ↑ Vessel wall motion • ↓ Size of the Doppler US sample volume.
• ↑ Velocities contralateral to a
severely diseased or occluded ICA
What is the role of US in the management of
extracranial cerebrovascular disease?
=
>70%
stenosis
Mixed atherosclerotic plaque with luminal narrowing of Elevated PSV with spectral broadening
the left ICA (arrows)
Before intervention: critical stenosis of the Following stent placement: increased diameter of
proximal left ICA (arrow) diminishing flow the left ICA (arrow) with markedly improved overall
distally on conventional angiograms. distal perfusion on conventional angiograms.
Restenosis most commonly develops from neointimal hyperplasia. Postprocedural results can be
monitored with follow-up US examinations.
Stent
PSV = 55.5 cm/sec
EDV = 19.1 cm/sec
ICA/CCA ratio =
<2.0
Follow-up US images in a patient with a left ICA stent (arrow). Hemodynamics returned to normal.
Carotid Doppler US after Intervention
(A) Patent vessels show scattered atherosclerotic disease throughout the carotid vasculature. (B) Spectral
Doppler US image of the ICA shows irregular heart rate, suggestive of dysrhythmia (double-sided arrows).
Irregularities in the morphology or frequency of the carotid artery Doppler waveform can detect
alterations in cardiac function and suggest dysrhythmia.
Low CO, aortic valvular disease, or cardiovascular devices may also alter the carotid Doppler waveforms.
A. B. A. B.
A. B. C. G.
D. E. F.
(A) Gray-scale and (B) color Doppler US images in a patient with suspected right ICA occlusion (arrows). (C) There are dampened spectral
Doppler waveforms upstream. (D) Gray-scale and (E) color Doppler US images of the right ECA show patent flow (arrows). (F) Altered ECA
spectral waveforms show broad systolic peaks (double-headed arrows), low resistance, and increased diastolic flow (arrows), resembling an ICA
waveform. (G) CT angiographic image confirms occlusion of the right ICA from atherosclerotic disease (arrow).
• In cases of ICA occlusion, low-resistance collateralization occurs between the ICA and ECA.
• Internalization of the ECA decreases vascular resistance and provides continuous diastolic flow to maximize
perfusion to the brain through the alternate collateral pathway.
False-Positive Diagnosis of ICA Occlusion
A. B. C.
Contributing Factors:
• Carotid artery is obscured by
calcified plaque
• Poor image quality
• Slow trickle flow from near- total
occlusion
• Low gain
(A) Plaque obscures evaluation of the left proximal ICA (arrows). (B) Axial CT angiographic image
of the neck shows heavy calcific atherosclerosis with vessel irregularity in the bilateral ICAs
(arrows). (C) Findings on sagittal CT angiographic image rule out occlusion and correlate with
approximately 60% stenosis (arrows).
PEARL
C.
(C) In another patient, the “bunny waveform”
results from a steep deceleration during systole
after a drop in pressure in the stenotic
subclavian artery and is seen in the early
phase of the subclavian steal phenomenon
prior to occlusion.
Follow-up CT angiography of the neck was performed for improved evaluation of the proximal cervical
vasculature and aortic arch.
Gray-scale and color Doppler images show an echogenic Pseudoaneurysm of the right ICA with yin-yang flow on color Doppler
dissection flap within the CCA (solid arrow) with filling of the images (arrows).
false lumen (dashed arrow).
US can also help evaluate other extracranial cerebral vascular pathologic conditions…
A. B. C. D.
TUMOR
(A) Gray-scale and (B) color Doppler images show a solid hypoechoic mass with internal vascularity (arrows) splaying the
carotid vessels at the bifurcation, consistent with a glomus body tumor. (C) Contrast-enhanced CT image shows a
heterogeneously enhancing mass centered within the left carotid space. (D) Axial contrast-enhanced T1-weighted MR
image shows similar findings (arrows), confirming the diagnosis.
Carotid body tumors are rare highly vascular glomus tumors of low malignant
potential seen at the level of the carotid bifurcation, classically splaying the vessels.
Summary
• In the era of advanced imaging, US remains an invaluable tool due
to its relative low risk and cost and significant diagnostic yield.
• However, it is highly dependent on the operator and patient.
• Awareness of the subtle sonographic nuances and parameters is
imperative for accurate interpretation by the radiologist.
• US remains an important modality in the diagnosis and
management of extracranial cerebral vasculature.
• The radiologist should use this presentation as a reference tool
when evaluating US examinations of extracranial vasculature.
• There is no substitute for practice, so radiologists should also take
every opportunity to image patients themselves!
References
1. Centers for Disease Control and Prevention. Underlying Cause of Death, 1999–2018. CDC WONDER Online Database. Atlanta, GA: Centers for Disease Control and Prevention; 2018.
2. Pellerito, J.S. ed., 2005. Introduction to vascular ultrasonography (pp. 19-89). Philadelphia: Elsevier Saunders.
3. Jahromi AS, Cina CS, Liu Y, Clase CM. Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis. J Vasc
Surg 2005;41:962-72.
4. Grant, E.G., Benson, C.B., Moneta, G.L., Alexandrov, A.V., Baker, J.D., Bluth, E.I., Carroll, B.A., Eliasziw, M., Gocke, J., Hertzberg, B.S. and Katanick, S., 2003. Carotid artery stenosis: gray-scale and
Doppler US diagnosis—Society of Radiologists in Ultrasound Consensus Conference. Radiology, 229(2), pp.340-346.
5. Bluth, E.I., Stavros, A.T., Marich, K.W., Wetzner, S.M., Aufrichtig, D. and Baker, J.D., 1988. Carotid duplex sonography: a multicenter recommendation for standardized imaging and Doppler
criteria. Radiographics, 8(3), pp.487-506.
6. Tahmasebpour, H.R., Buckley, A.R., Cooperberg, P.L. and Fix, C.H., 2005. Sonographic examination of the carotid arteries. Radiographics, 25(6), pp.1561-1575.
7. AbuRahma AF, Pollack JA, Robinson PA, Mullins D. The reliability of color duplex ultrasound in diagnosing total carotid artery occlusion. Am J Surg 1997;174:185–187.
8. Bushberg, J. T. (2002). The essential physics of medical imaging. Philadelphia: Lippincott Williams & Wilkins.
9. Abbott AL, Paraskevas KI, Kakkos SK, Golledge J, Eckstein HH, Diaz-Sandoval LJ, Cao L, Fu Q, Wijeratne T, Leung TW, Montero-Baker M, Lee BC, Pircher S, Bosch M, Dennekamp M, Ringleb P.
Systematic Review of Guidelines for the Management of Asymptomatic and Symptomatic Carotid Stenosis. Stroke. 2015 Nov;46(11):3288-301. doi: 10.1161/STROKEAHA.115.003390. Epub 2015 Oct 8.
PMID: 26451020.
10. AbuRahma AF, Avgerinos ED, Chang RW, Darling RC 3rd, Duncan AA, Forbes TL, Malas MB, Murad MH, Perler BA, Powell RJ, Rockman CB, Zhou W. Society for Vascular Surgery clinical practice
guidelines for management of extracranial cerebrovascular disease. J Vasc Surg. 2022 Jan;75(1S):4S-22S. doi: 10.1016/[Link].2021.04.073. Epub 2021 Jun 19. PMID: 34153348.
11. DP, Romero JM, Hannon KM, Dick J, Jaff MR. Detection of common carotid artery stenosis using duplex ultrasonography: a validation study with computed tomographic angiography. J Vasc Surg. 2010
Jan;51(1):65-70. doi: 10.1016/[Link].2009.08.002. Epub 2009 Oct 30. PMID: 19879097.
12. Lal BK, Hobson RW 2nd, Tofighi B, Kapadia I, Cuadra S, Jamil Z. Duplex ultrasound velocity criteria for the stented carotid artery. J Vasc Surg. 2008 Jan;47(1):63-73. doi: 10.1016/[Link].2007.09.038. PMID:
18178455.
13. AbuRahma AF, Abu-Halimah S, Bensenhaver J, Dean LS, Keiffer T, Emmett M, Flaherty S. Optimal carotid duplex velocity criteria for defining the severity of carotid in-stent restenosis. J Vasc Surg. 2008
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Suggested Readings
Abbott AL, Paraskevas KI, Kakkos SK, et al. Systematic Review of Guidelines for the Management of Asymptomatic and Symptomatic Carotid Stenosis. Stroke 2015;46(11):3288–3301.
AbuRahma AF, Pollack JA, Robinson PA, Mullins D. The reliability of color duplex ultrasound in diagnosing total carotid artery occlusion. Am J Surg 1997;174(2):185–187.
AbuRahma AF, Avgerinos ED, Chang RW, et al. Society for Vascular Surgery clinical practice guidelines for management of extracranial cerebrovascular disease. J Vasc Surg 2022;75(1S):4S–22S.
Bluth EI, Stavros AT, Marich KW, Wetzner SM, Aufrichtig D, Baker JD. Carotid duplex sonography: a multicenter recommendation for standardized imaging and Doppler criteria. RadioGraphics 1988;8(3):487–506.
Bushberg JT. The essential physics of medical imaging. Philadelphia, Pa: Lippincott Williams & Wilkins, 2002.
Centers for Disease Control and Prevention. Underlying Cause of Death, 1999–2018. CDC WONDER Online Database. Atlanta, Ga: Centers for Disease Control and Prevention, 2018.
Grant EG, Benson CB, Moneta GL, et al. Carotid artery stenosis: gray-scale and Doppler US diagnosis--Society of Radiologists in Ultrasound Consensus Conference. Radiology 2003;229(2):340–346.
Jahromi AS, Cinà CS, Liu Y, Clase CM. Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis. J Vasc Surg
2005;41(6):962–972.
Lal BK, Hobson RW 2nd, Tofighi B, Kapadia I, Cuadra S, Jamil Z. Duplex ultrasound velocity criteria for the stented carotid artery. J Vasc Surg 2008;47(1):63–73.
Pellerito JS, ed. Introduction to vascular ultrasonography. Philadelphia, Pa: Elsevier Saunders, 2005; 19–89.
Slovut DP, Romero JM, Hannon KM, Dick J, Jaff MR. Detection of common carotid artery stenosis using duplex ultrasonography: a validation study with computed tomographic angiography. J Vasc Surg
2010;51(1):65–70.
Tahmasebpour HR, Buckley AR, Cooperberg PL, Fix CH. Sonographic examination of the carotid arteries. RadioGraphics 2005;25(6):1561–1575.
A special thank you to…