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CAL Graphs

The document discusses the effects of various drugs on blood pressure (BP) and heart rate in anaesthetized dogs, identifying specific drugs such as ACh, atropine, adrenaline, noradrenaline, and isoprenaline. It highlights phenomena like tachyphylaxis and Dale's Vasomotor reversal, explaining the biphasic response of adrenaline and its interaction with receptors. Additionally, it mentions other drugs that can mimic the effects of ACh on BP, such as calcium channel blockers and beta blockers.

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amaangaur18
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207 views21 pages

CAL Graphs

The document discusses the effects of various drugs on blood pressure (BP) and heart rate in anaesthetized dogs, identifying specific drugs such as ACh, atropine, adrenaline, noradrenaline, and isoprenaline. It highlights phenomena like tachyphylaxis and Dale's Vasomotor reversal, explaining the biphasic response of adrenaline and its interaction with receptors. Additionally, it mentions other drugs that can mimic the effects of ACh on BP, such as calcium channel blockers and beta blockers.

Uploaded by

amaangaur18
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

Effect of drugs on BP (black line) and Heart rate (red line) on anaesthetized dog

1. Identify Drug A and B in the graph


2. Identify the specific response of “A” shown
• Drug A- ACh (Acetylcholine)
• Drug B- Atropine

The specific response of ‘A’ –


Nicotinic effect of ACh on
sympathetic ganglia and adrenal
medulla
Effect of drugs on BP (black line) and Heart rate (red line) on anaesthetized dog

Set

1. Identify Drug A and Drug B in the graph


2. State the other drugs which can have the same effect on BP as
Drug A
• Drug A- ACh (Acetylcholine)
• Drug B- Atropine

Other drugs which can have the same effect on BP as drug - A


Calcium channel blockers (diltiazem)
Beta blockers
Effect of drugs on BP (black line) and Heart rate (red line) on anaesthetized dog

Set

1. State the phenomenon showed in the graph


2. Name 2 drugs which show this phenomenon
• Drug - Tyramine
• Drug - Ephedrine

Phenomenon showed – Tachyphylaxis


Effect of drugs on BP (black line) and Heart rate (red line) on anaesthetized dog

1. Identify Drug A, B and C in the graph


2. What is meant by Mean BP?
3. Explain the response of Drug A with respect to receptors
• Drug A- Adrenaline
• Drug B- Noradrenaline
• Drug c- Isoprenaline
Mean BP = DBP+1/3 PP (pulse pressure)
PP = SBP - DBP
THE response of drug A with respect to receptor
A- Adrenaline (Biphasic)
All receptors- α1, α2, β1, β2
α- Vasoconstriction, β- Vasodilation
Effect of drugs on BP (black line) and Heart rate (red line) on anaesthetized dog

1. Identify Drug A and Drug B in the graph


2. Why is the response obtained initially on injecting Drug A
not obtained on subsequent application of Drug A?
3. What is the response showed in the graph called?
• Drug A- Adrenaline (Biphasic Response)
• Drug B- α Blocker
The response obtained initially on injecting Drug A is not
obtained on subsequent application of drug A after blocker
(Drug B), so receptor shows unopposed action- vasodilation.
Dale’s Vasomotor reversal phenomenon
.

BIPHASIC
RESPONSE

α1> β2

α blocker
β2
ADRENALINE

α1 β1 α2 β2 weak β3
.

BIPHASIC
RESPONSE

α1> β2

β2
NOR-ADRENALINE

α1 α2 β1 β3 NO β2
ISOPRENALINE

β1 β2 β3 NO α
,.
,
• • ' !..
’
De artment of Pharmacol Barei3
,
!- ,of unknown drug on pwfosed frag's
depicñng nature ood site ofoali,1x,
heart

*tz=
“

1. is tde nature of unknown


2. is the site of action of unknown
3. Explain ie effect of above unknown drug.
G¿tli p}i G a t iO f l S bel9ngs?
4. Wba( due wig G f th N c l a S S to Whi‹:habOVe unknown

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