Biosynth

The success of modern therapeutics now relies on bioconjugation, on how precisely linked the drug to a targeting agent or carrier is. Probably, the most critical component in this system is the linker, which is far more than a simple bridge. Its design directly controls the drug's circulation time, stability and, ultimate, the therapeutic success. Optimized bioconjugates incorporate advanced carriers. Molecules like PEG enhance solubility and extend the half-life; targeting ligands such as GalNAc clusters (triGalNAc) ensure highly efficient, tissue-specific delivery, especially for oligonucleotide drugs targeting the liver. This modular approach integrating the payload, linker, and carrier is the essential chemical blueprint for achieving high-precision medicine and is key to the next generation of pharmaceuticals. Find out more in our blog, discover how all these components are connected, and explore our selection of products busing our interactive bioconjugation tool for the individual components that forms a conjugate: https://lnkd.in/gmrFDR2D #Bioconjugation #TargetedDrugDelivery #Linkers #PEG #GalNAc #DrugDevelopment

Are you looking to change your reducing agent in your protein research or sample handling? In drug discovery, every step counts. Using traditional reducing agents like DTT may be costing you time, stability and compatibility with your downstream applications. TCEP (tris(carboxyethyl)phosphine) has many advantages over other reducing agents, including:  • Odorless and water-soluble  • Crystalline solid, stable in the presence of oxygen  • Can be used at a broad pH range  • No sulfhydryl groups so no need for removal prior to subsequent reactions To find out more about this gold-standard reducing agent, read our white paper: https://lnkd.in/eX8S8cxh At Biosynth, we secure life science supply chains from R&D to GMP. We offer a comprehensive portfolio of disulfide reducing agents and can help you choose the best one for your needs. Whether you need a supply of high-purity TCEP for your lab assays, or custom manufacturing of key reagents or chemicals, we are your trusted partner in providing the products and expertise for your next breakthrough. #ReducingAgents #ProteinChemistry #ComplexChemistry #Biosynth

Today is the final day of CPHI Frankfurt. It has been a privilege to be "at the heart of pharma" and connect with our customers and partners to understand their needs from practical to pioneering. Biosynth provides the products, expertise, and commitment to support therapeutics, vaccines, and diagnostics projects at every stage; from raw materials and reagents to peptide synthesis, custom chemistry, and biologics services. Unlock new opportunities and overcome complex challenges with our integrated solutions for small molecules, bioconjugates, and peptides from R&D to GMP, backed by over 60 years of scientific expertise. There is still time to stop by Booth 6.0C57 and tell us about your project before the doors close! https://lnkd.in/eVx5-cHk #CPHI2025 #FromPracticalToPioneering #LifeScienceSolutions #CPHIFrankfurt #CPHIWorldwide #pharma #lifesciences

For peptide therapeutics, the molecule is only as good as its stability and ability to reach the target. Poor bioavailability, short half-life, and delivery challenges are the silent killers of promising drug candidates. At Biosynth, our expertise isn't just in synthesis—it's in the specialized chemistry required to transform a promising hit into a viable clinical drug. We've compiled a collection of our most popular blogs detailing the science, techniques, and strategies to overcome these hurdles: https://lnkd.in/ePvFpFBg This deep knowledge is the foundation of our comprehensive specialized services: The Expertise to Execute: We don't just read about complex chemistry; we perform it. Our decades of experience ensure high-yield, high-purity execution of the most difficult modifications.  • Enhanced Stability: Implementation of cyclization, stapling, and advanced modifications proven to increase proteolytic stability and prolong half-life.  • Targeted Delivery: Expertise in peptide-based bioconjugation (PDCs) and incorporating delivery-enhancing moieties (like PEGylation) to improve pharmacokinetics.  • Proprietary Advantage: Leverage our patented CLIPS™ Technology to lock peptides into biologically relevant, stable conformations that maximize target engagement.  • Seamless Scale-Up: Services and expertise from discovery through to GMP production for your clinical-phase material.  • Specialized Focus: Reliable, high-quality manufacturing of specialized candidates, including Neoantigen Peptides and highly modified sequences. Stop letting stability roadblocks derail your program. Partner with the experts who can both advise on the science and reliably execute the chemistry. https://lnkd.in/e8bfrbuC #PeptideOptimization #Bioavailability #PeptideChemistry #CDMO #LifeSciences #DrugDevelopment #Biosynth

So day one of CPHI Frankfurt was fantastic and our team were busy hearing about some of the roadblocks being faced in the industry. Stop by Booth 6.0C57 and tell us about your project and the challenges you are facing that we can solve. From raw materials and reagents to peptide synthesis, custom chemistry, and biologics services, Biosynth provides the products, expertise, and commitment to support therapeutics, vaccines, and diagnostics projects from the practical to the pioneering. Come see us at Booth 6.0C57 to tell us about your project or get in touch for a discussion. https://lnkd.in/eVx5-cHk Great video courtesy of The Medicine Maker #CPHI2025 #FromPracticalToPioneering #LifeScienceSolutions #CPHIFrankfurt #CPHIWorldwide #pharma #lifesciences

Cell-penetrating peptides (CPPs) are critical tools for intracellular delivery of diverse therapeutic and diagnostics and have shown successful application in tumor suppression. In a recent article in European Biopharmaceutical Review (EBR), Laurent Caron and Faye Wood, PhD review the aspects that impact successful delivery, including physicochemical properties, target cell type and desired intracellular localization. This article also examines strategies for enhancing CPP utility. With services for peptide discovery and manufacture from R&D to GMP, alongside bioconjugate manufacturing, we would love to hear how we can help you in your intracellular delivery goals. European Biopharmaceutical Review, Autumn 2025, pages 45-48. © Samedan Ltd Read on our publications page > https://lnkd.in/eK3imT4j See our extensive catalog selection of CPPs > https://lnkd.in/eA9-eXXt #peptides #cellpenetratingpeptides #drugdevelopment #lifesciences

While native enzymes remain useful for research, recombinant enzymes are the smarter choice for modern diagnostics. Native enzymes can limit assay performance due to inconsistent supply, impurities, and batch-to-batch variability. Recombinant enzymes, produced via microbial fermentation, solve these challenges by offering: - Scalable, reliable supply - High purity & batch-to-batch consistency - Enhanced specificity, activity, and stability The result? More sensitive, reproducible, and reliable diagnostic assays. Biosynth are helping our partners transition to recombinant reagents, ensuring consistent, high-performing reagents for every assay. Contact our experts today to learn how recombinant enzymes can transform your diagnostic workflows https://lnkd.in/emXx4MQH For more on our enzyme capabilities, visit our enzyme webpage https://lnkd.in/eqcmJH52 See our full range of diagnostic reagents https://lnkd.in/d4f2Zx4P #Diagnostics #Assaydevelopment #RecombinantEnzymes #Enzymes #Recombinantproteins #Innovation #LifeSciences

In bioconjugation, a 𝗹𝗶𝗻𝗸𝗲𝗿 is more than a simple spacer. It governs how efficiently a biomolecule and a functional group react, and how the resulting conjugate behaves under physiological conditions. The choice of linker chemistry defines not only the success of the coupling reaction but also the conjugate’s stability, selectivity, and release characteristics.   This miniguide outlines the fundamental principles of linker chemistry, from cleavable and non-cleavable designs to key synthetic strategies and conjugation methods. It offers a concise overview of how thoughtful linker selection supports the development of stable and selective bioconjugates.   Explore our selection of linkers for bioconjugation here https://lnkd.in/eAgT2qx9, with a curated list of representative cleavable and non-cleavable linkers. If you do not see what you need, please contact us https://lnkd.in/eSaxYZdz to discuss custom solutions.   📘 Read the miniguide here: https://lnkd.in/eTw-TQaM   #Biosynth #LinkerChemistry #Bioconjugation #ADC #CustomSynthesis #MedicinalChemistry #ChemicalBiology #DrugDevelopment #Conjugates  

Bioconjugate With Success Bioconjugation is at the centre of innovative drug and vaccine development, unlocking new potential in existing therapeutics, aiding in drug delivery, and discovering next-generation treatments. Join Biosynth's expert team for an in-depth webinar, "Precision Matters: PEGylation and glycosylation as critical tools in bioconjugation for drug development." This session will delve into current strategies and overcoming challenges in this complex field. What you'll learn:  • PEGylation and conjugate vaccine strategies  • Reaction optimization and process development workflows  • Carbohydrate and peptide conjugation strategies and challenges Hosted by Dr Scott Miller, Senior Director of R&D, and bringing together the expertise of Dr Julia Wittmann, Dr Hansjörg Streicher, and Dr Laurent Caron, gain insights into bioconjugation chemistry techniques in drug development and pharmaceuticals. Register now and watch the webinar on demand: https://lnkd.in/dYHd6UDg #Bioconjugation #DrugDiscovery #Webinar #Biosynth #PEGylation #Glycosylation

Only a week to go now until CPHI Frankfurt, where we get the chance to be at the "heart of pharma" once again with our customers, suppliers and collaborators. Biosynth combines high-quality raw materials, reagents, antibodies, peptides, and enzymes with scientific expertise in chemistry, peptides, biologics and conjugates. Talk to our team about how we ensure projects progress efficiently, from early R&D through regulatory milestones. Set up a meeting or come see us at Booth 6.0C57. See more > https://lnkd.in/eVx5-cHk #CPHI2025 #FromPracticalToPioneering #LifeScienceSolutions #CPHIFrankfurt #CPHIWorldwide #pharma #lifesciences CPHI