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Immunization against a Saccharide Epitope Accelerates Clearance of Experimental Gonococcal Infection

Figure 2

Survival of FA1090wt inoculated into mice passively immunized with mAb 2C7.

mAb 2C7 (dashed lines in A. and B.) vs. control IgG3λ mAb (solid lines) treated animals followed by challenge with FA1090wt. Two separate experiments were performed; Group 1 and Group 2 (n = number of infected mice in each group) as indicated. A. Kaplan Meier analysis of time to clearance of FA1090wt showing differences in clearance of mAb 2C7 vs. control IgG3λ mAb treated animals. B. Colonization of FA1090wt (Log₁₀ CFU) measured daily in mAb 2C7 vs. control IgG3λ mAb treated animals. C. Bacterial burdens consolidated over time (Area Under the Curve [log ₁₀ CFU] analysis) of mAb 2C7 vs. control IgG3λ mAb treated animals.

doi: https://doi.org/10.1371/journal.ppat.1003559.g002