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Immunization against a Saccharide Epitope Accelerates Clearance of Experimental Gonococcal Infection

Figure 6

Survival of FA1090wt inoculated into mice actively immunized with MAP1-MPL.

Group 1: MAP1-MPL immunized mice (16 immunized, 14 infected) and MAP-control-MPL immunized mice (16 immunized, 15 infected) were challenged with FA1090wt (5.4×10⁵ CFU). Group 2: MAP1 immunized mice (10 immunized, 10 infected) and MAP-control immunized mice (7 immunized, 6 infected were challenged with FA1090wt (4×10⁵ CFU). A. Kaplan-Meier curves indicating time to clearance of challenged N. gonorrhoeae FA1090wt. B. Mean log₁₀ (CFU) isolation trends over time. Isolation of N. gonorrhoeae from MAP1 and MAP-control immunized mice are represented by dashed and solid lines, respectively. C. Mean area under the curve (AUC log₁₀ CFU) vs. time computed for each mouse to consolidate cumulative infection; AUC log₁₀ CFU was compared between groups.

doi: https://doi.org/10.1371/journal.ppat.1003559.g006