Dr Imad SFEIR

📄 Out now – the ERS & EULAR - European Alliance of Associations for Rheumatology clinical practice guideline on connective tissue diseases with ILD involvement has now been published in the European Respiratory Journal. Access the new guideline online: https://lnkd.in/epV8XHrX

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Exploring Deep Regeneration of the GI Tract Without an Incision This preclinical pathology report, 3 hours after endoscopic pulsed electric field (PEF) application to the lower esophageal sphincter, offers a glimpse into what might be possible with non-thermal, depth-agnostic, regenerative energy delivered endoscopically. In this animal pre-clinical model, we observed diffuse degeneration of the muscularis propria without inflammation or loss of esophageal structural integrity. These findings suggest a selective tissue response, raising the possibility of regeneration even within deep muscle and nerve layers of the GI tract. An important part of the future of interventional GI may lie at the intersection of precise navigation (robotics), targeted guidance (AI), and novel energy platforms. What was once thought out of reach, non-invasive access to and regeneration of deep GI tissue layers, may now be within sight. It’s early, and we’re not there yet, but it is exciting to imagine a future where we can perform incisionless selective myotomy for conditions like achalasia or gastroparesis, or even achieve deep-layer ablation of luminal GI malignancies and inflammatory conditions such as Crohn's disease without resection. These are unpublished preclinical observations shared to invite discussion, not to imply clinical readiness or effectiveness, but dialogue to stimulate thinking is how we move the needle forward in medicine. #InterventionalEndoscopy #IBD #RegenerativeGI #PulsedElectricField #Achalasia #Gastroparesis #PreclinicalResearch #Gastroenterology #InnovationInGI

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💬"As a post-grad, we were already doing immediate implants without fully understanding the biology - and we learned from our mistakes." In this new Straumann® ProTalk episode, Prof. Dr. France Lambert reflects on the defining moments, projects, and people that shaped her journey into becoming one of Europe’s most recognized clinical educators and researchers. 🎧 Listen now on https://brnw.ch/21wWlb9 #Straumann #dentist #dentistry #implantology #dentalimplants #ProTalk #podcast #dentalpodcast #FranceLambert

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#AgenticAI is coming to healthcare ✨ Not in the future, but in 1-2 years, according to Prof. Stéphanie Allassonniere, Vice-President for Valorization at the Université Paris Cité. AI agents will optimize care pathways, track patient progress, manage surgical operations, help individuals in self-care, and organize life around their health goals. I'm so delighted to publish my interview with Prof. Allassonniere. We discuss the implications of this new supervisor of all AI and human agents for medicine and its potential implementation in hospitals and clinics. The interview is out now on ICT&health Global 👉 https://lnkd.in/e7nCQJtW

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Highlighting integrins from extracellular vesicles as key players in the tumor microenvironment and metastasis: in this review article, Corina Ciobanasu at Alexandru Ioan Cuza University and Christophe Le Clainche at Institut de Biologie Intégrative de la Cellule - I2BC - discussed recent advances on the role of extracellular vesicle integrins in tumor initiation, proliferation, migration, and invasion. Integrins, a diverse family of cell adhesion molecules, were shown to regulate essential processes such as tumor differentiation, migration, growth, and neovascularization. Tumor-derived exosomes, a subtype of EVs, were found to be enriched in integrins reflective of their parent cells 🔗 https://lnkd.in/eurzD8wT These exosomal integrins promoted extracellular matrix remodeling, immune evasion, and vascular changes, and were strongly associated with tumor progression and organ-specific metastasis. Beyond their mechanistic role, exosomal integrins demonstrated potential as diagnostic and prognostic biomarkers due to their tissue-specific expression profiles. They also emerged as attractive therapeutic targets for disrupting tumor–stroma interactions and limiting metastatic dissemination. Overall, this study highlighted exosomal integrins as critical mediators of cancer biology and promising tools for advancing diagnosis and treatment. #extracellularvesicles #exosomes #integrins #cellmigration #Vesiculab

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🎉We’re thrilled to announce that last week, Dr. Francesco Traverso of CDC Habilita – I Cedri performed the first Arvis™ surgery in Europe🎉 Dr. Traverso successfully carried out a total knee arthroplasty, implanting a Physica LMC with the support of Arvis™ Augmented Reality Surgical Guidance. “I really enjoyed using Arvis™ for the surgery. From the start, I found it easy to use and cost efficient Technologie which can be especially helpful for less experienced surgeons or those performing a high volume of procedures.” Stated Dr. Traverso, “Our scrub nurses also appreciated how quickly it integrates with standard instrumentation, without the need for bulky equipment.” Arvis™, Enovis’ wearable and self-contained system, provides real-time, zero footprint surgical guidance. It received CE mark approval for hip and knee earlier this summer, with shoulder expected soon. 🥇This surgery marks a major milestone for Enovis, underscoring our commitment to advancing orthopedic innovation and empowering surgeons worldwide with smart, enabling technologies that enhance precision without adding complexity. Special thanks to Dr. Traverso and his team for pioneering this technology in Europe, and to our colleagues in Italy for their invaluable contribution to this success. 👉 If you’re an orthopedic surgeon and would like to learn more about Arvis™, visit our website. https://hubs.la/Q03KXlpf0 #Enovis #medtech #CreatingBetterTogether #Arvis™ #Innovation #AugmentedReality #Orthopaedics Habilita Robotics Healthcare

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