Weimin Guo | Profiles RNS

Weimin Guo, MD, PhD

Research Assistant Professor (previously held)

Boston University Chobanian & Avedisian School of Medicine

Pathology & Laboratory Medicine

PhD, Shanghai Jiao Tong University
MMS/MMSc, Henan Medical University
BM/BMus, Henan Medical University

Pronouns: he/him/his

Websites

	ResearchGate
	Google Scholar

ORCID : 0000-0003-4318-7154

Dr. Weimin Guo is a Research Assistant Professor of Pathology & Laboratory Medicine at Boston University Chobanian & Avedisian School of Medicine. His research focuses on how dietary and nutritional interventions influence lifespan and healthspan, with particular emphasis on the mechanisms underlying colon cancer, immune regulation, obesity, and age-related metabolic dysfunction. Recent studies in his lab explore the effects of Mediterranean and plant-rich diets, zinc supplementation, and gut microbiota on tumor development, systemic inflammation, and healthy aging using preclinical models.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Guo W; Shukitt-Hale B; Wu D; Li L; Meydani SN. Dietary fruits and vegetables mitigate cognitive impairment in mice with high-fat diet-induced obesity: a pilot study. Nutr Neurosci. 2025. View Publication

Guo W, Crossland N, Crott JW. Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice. Exp Mol Pathol. 2025 Mar; 141:104953.View Related Profiles.

Crott, Jimmy
Crossland, Nicholas
Guo, Weimin

PMID: 39919552; PMCID: PMC11934114; DOI: 10.1016/j.yexmp.2025.104953;

Guo W, Wu D, Li L, Lewis ED, Meydani SN. Increased Fruit and Vegetable Consumption Prevents Dysregulated Immune and Inflammatory Responses in High-Fat Diet-Induced Obese Mice. J Nutr. 2024 Oct; 154(10):3144-3150. PMID: 39154866; DOI: 10.1016/j.tjnut.2024.08.009;

Ortega EF, Wu D, Guo W, Meydani SN, Panda A. Study protocol for a zinc intervention in the elderly for prevention of pneumonia, a randomized, placebo-controlled, double-blind clinical pilot trial. Front Nutr. 2024; 11:1356594. PMID: 38450236; PMCID: PMC10916881; DOI: 10.3389/fnut.2024.1356594;

Guo W, Ortega EF, Wu D, Li L, Bronson RT, Boehm SK, Meydani SN. Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice. Front Nutr. 2023; 10:1286792. PMID: 38125727; PMCID: PMC10731956; DOI: 10.3389/fnut.2023.1286792;

Crossland NA, Beck S, Tan WY, Lo M, Mason JB, Zhang C, Guo W, Crott JW. Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice. Gut Microbes. 2023 Dec; 15(2):2288187.View Related Profiles.

Crott, Jimmy
Lo, Ming
Crossland, Nicholas
Beck, Samuel
Guo, Weimin

PMID: 38031252; PMCID: PMC10730208; DOI: 10.1080/19490976.2023.2288187;

Lewis ED, Ortega EF, Dao MC, Barger K, Mason JB, Leong JM, Osburne MS, Magoun L, Nepveux V FJ, Chishti AH, Schwake C, Quynh A, Gilhooly CH, Petty G, Guo W, Matuszek G, Pereira D, Reddy M, Wang J, Wu D, Meydani SN, Combs GF. Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial - the safe iron study. Front Nutr. 2023; 10:1230061. PMID: 37899826; PMCID: PMC10603204; DOI: 10.3389/fnut.2023.1230061;

Guo W, Wu D, Li L, Ding S, Meydani SN. Obesity, rather than high fat diet, exacerbates the outcome of influenza virus infection in influenza-sensitized mice. Front Nutr. 2022; 9:1018831. PMID: 36337627; PMCID: PMC9631825; DOI: 10.3389/fnut.2022.1018831;

Guo W, Kim SH, Wu D, Li L, Ortega EF, Thomas M, Meydani SN, Meydani M. Dietary Fruit and Vegetable Supplementation Suppresses Diet-Induced Atherosclerosis in LDL Receptor Knockout Mice. J Nutr. 2021 Apr 08; 151(4):902-910. PMID: 33561256; DOI: 10.1093/jn/nxaa410;

Nimitphong H, Guo W, Holick MF, Fried SK, Lee MJ. Vitamin D Inhibits Adipokine Production and Inflammatory Signaling Through the Vitamin D Receptor in Human Adipocytes. Obesity (Silver Spring). 2021 03; 29(3):562-568.View Related Profiles.

Nimitphong, Hataikarn
Holick, Michael
Fried, Susan
Guo, Weimin

PMID: 33624437

Showing 10 of 43 results. Show More

Guo W, Wu D, Dao MC, Li L, Lewis ED, Ortega EF, Eom H, Thomas M, Nikolova-Karakashian M, Meydani M, Meydani SN. A Novel Combination of Fruits and Vegetables Prevents Diet-Induced Hepatic Steatosis and Metabolic Dysfunction in Mice. J Nutr. 2020 Nov 19; 150(11):2950-2960. PMID: 32939550; PMCID: PMC7919336; DOI: 10.1093/jn/nxaa259;

Thomas M, Kim S, Guo W, Collins FW, Wise ML, Meydani M. High Levels of Avenanthramides in Oat-Based Diet Further Suppress High Fat Diet-Induced Atherosclerosis in Ldlr-/- Mice. J Agric Food Chem. 2018 Jan 17; 66(2):498-504. PMID: 29298067; DOI: 10.1021/acs.jafc.7b04860;

Guo W, Xu T, Lee JJ, Murphy GF, Lian CG. Epigenetic markers in melanoma. Melanoma Manag. 2015 Nov; 2(4):367-382. PMID: 30190864; PMCID: PMC6094672; DOI: 10.2217/mmt.15.30;

Lian CG, Xu S, Guo W, Yan J, Frank MY, Liu R, Liu C, Chen Y, Murphy GF, Chen T. Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid. Mol Carcinog. 2015 Nov; 54(11):1503-7. PMID: 25154389; DOI: 10.1002/mc.22201;

Lee JJ, Granter SR, Laga AC, Saavedra AP, Zhan Q, Guo W, Xu S, Murphy GF, Lian CG. 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies. Mod Pathol. 2015 Feb; 28(2):218-29. PMID: 25081754; PMCID: PMC4312506; DOI: 10.1038/modpathol.2014.99;

Divoux A, Karastergiou K, Xie H, Guo W, Perera RJ, Fried SK, Smith SR. Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation. Obesity (Silver Spring). 2014 Aug; 22(8):1781-5.View Related Profiles.

Karastergiou, Kalypso
Fried, Susan
Guo, Weimin

PMID: 24862299; PMCID: PMC4228784; DOI: 10.1002/oby.20793;

Meydani M, Kwan P, Band M, Knight A, Guo W, Goutis J, Ordovas J. Long-term vitamin E supplementation reduces atherosclerosis and mortality in Ldlr-/- mice, but not when fed Western style diet. Atherosclerosis. 2014 Mar; 233(1):196-205. PMID: 24529144; PMCID: PMC4028145; DOI: 10.1016/j.atherosclerosis.2013.12.006;

Earnest CP, Kupper JS, Thompson AM, Guo W, Church T. Complementary effects of multivitamin and omega-3 fatty acid supplementation on indices of cardiovascular health in individuals with elevated homocysteine. Int J Vitam Nutr Res. 2012 Feb; 82(1):41-52. PMID: 22811376; DOI: 10.1024/0300-9831/a000093;

Guo W, Nie L, Wu D, Wise ML, Collins FW, Meydani SN, Meydani M. Avenanthramides inhibit proliferation of human colon cancer cell lines in vitro. Nutr Cancer. 2010; 62(8):1007-16. PMID: 21058188; DOI: 10.1080/01635581.2010.492090;

Wu D, Guo Z, Ren Z, Guo W, Meydani SN. Green tea EGCG suppresses T cell proliferation through impairment of IL-2/IL-2 receptor signaling. Free Radic Biol Med. 2009 Sep 01; 47(5):636-43. PMID: 19501156; DOI: 10.1016/j.freeradbiomed.2009.06.001;

Guo W, Kong E, Meydani M. Dietary polyphenols, inflammation, and cancer. Nutr Cancer. 2009; 61(6):807-10. PMID: 20155620; DOI: 10.1080/01635580903285098;

Guo W, Wise ML, Collins FW, Meydani M. Avenanthramides, polyphenols from oats, inhibit IL-1beta-induced NF-kappaB activation in endothelial cells. Free Radic Biol Med. 2008 Feb 01; 44(3):415-29. PMID: 18062932; DOI: 10.1016/j.freeradbiomed.2007.10.036;

Wu D, Ren Z, Pae M, Guo W, Cui X, Merrill AH, Meydani SN. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J Immunol. 2007 Oct 01; 179(7):4829-39. PMID: 17878382; DOI: 10.4049/jimmunol.179.7.4829;

Guo W, Zingg JM, Meydani M, Azzi A. Alpha-Tocopherol counteracts ritonavir-induced proinflammatory cytokines expression in differentiated THP-1 cells. Biofactors. 2007; 31(3-4):171-9. PMID: 18997280; DOI: 10.1002/biof.5520310304;

Fernandes AF, Guo W, Zhang X, Gallagher M, Ivan M, Taylor A, Pereira P, Shang F. Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells. Exp Eye Res. 2006 Dec; 83(6):1472-81. PMID: 17027001; PMCID: PMC2039698; DOI: 10.1016/j.exer.2006.07.024;

Guo W, Shang F, Liu Q, Urim L, Zhang M, Taylor A. Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2569-75. PMID: 16723472; DOI: 10.1167/iovs.05-0261;

Rodriguez SK, Guo W, Liu L, Band MA, Paulson EK, Meydani M. Green tea catechin, epigallocatechin-3-gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex. Int J Cancer. 2006 Apr 01; 118(7):1635-44. PMID: 16217757; DOI: 10.1002/ijc.21545;

Liu Q, Shang F, Whitcomb E, Guo W, Li W, Taylor A. Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1302-9. PMID: 16565361; DOI: 10.1167/iovs.05-0935;

Marques C, Guo W, Pereira P, Taylor A, Patterson C, Evans PC, Shang F. The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. FASEB J. 2006 Apr; 20(6):741-3. PMID: 16469848; PMCID: PMC2100384; DOI: 10.1096/fj.05-5080fje;

Kim JD, Liu L, Guo W, Meydani M. Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion. J Nutr Biochem. 2006 Mar; 17(3):165-76. PMID: 16169200; DOI: 10.1016/j.jnutbio.2005.06.006;

Shang F, Deng G, Liu Q, Guo W, Haas AL, Crosas B, Finley D, Taylor A. Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem. 2005 May 27; 280(21):20365-74. PMID: 15790562; PMCID: PMC1382285; DOI: 10.1074/jbc.M414356200;

Guo W, Shang F, Liu Q, Urim L, West-Mays J, Taylor A. Differential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiation. Invest Ophthalmol Vis Sci. 2004 Apr; 45(4):1194-201. PMID: 15037588; PMCID: PMC1446108; DOI: 10.1167/iovs.03-0830;

Liu Q, Shang F, Guo W, Hobbs M, Valverde P, Reddy V, Taylor A. Regulation of the ubiquitin proteasome pathway in human lens epithelial cells during the cell cycle. Exp Eye Res. 2004 Feb; 78(2):197-205. PMID: 14729352; DOI: 10.1016/j.exer.2003.11.009;

Zhao W, Wang H, Wang X, Wu F, Guo W, Qu B, Shen Z, Wang Z. Effects of all-trans-retinoic acid and arsenic trioxide on the hemostatic disturbance associated with acute promyelocytic leukemia. Thromb Res. 2001 May 01; 102(3):197-204. PMID: 11369412; DOI: 10.1016/s0049-3848(01)00233-x;

Guo W, Wang H, Zhao W, Zhu J, Ju B, Wang X. Effect of all-trans retinoic acid and arsenic trioxide on tissue factor expression in acute promyelocytic leukemia cells. Chin Med J (Engl). 2001 Jan; 114(1):30-4. PMID: 11779431

Zhao W, Wang X, Guo W, Qu B, Wang H, Shen Z, Chen Z, Wang Z. Hemostatic abnormalities associated with acute promyelocytic leukemia and corrective effects of all-trans-retinoic acid or arsenic trioxide treatment. Chin Med J (Engl). 2000 Mar; 113(3):236-40. PMID: 11775254

Zhu J, Guo WM, Yao YY, Zhao WL, Pan L, Cai X, Ju B, Sun GL, Wang HL, Chen SJ, Chen GQ, Caen J, Chen Z, Wang ZY. Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. Leukemia. 1999 Jul; 13(7):1062-70. PMID: 10400422; DOI: 10.1038/sj.leu.2401448;

Cheng GX, Zhu XH, Men XQ, Wang L, Huang QH, Jin XL, Xiong SM, Zhu J, Guo WM, Chen JQ, Xu SF, So E, Chan LC, Waxman S, Zelent A, Chen GQ, Dong S, Liu JX, Chen SJ. Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6318-23. PMID: 10339585; PMCID: PMC26879; DOI: 10.1073/pnas.96.11.6318;

Viswanathan KR, Swamy MS, Prasad NN. Effect of increased level of CO2 exposure in a closed environment on calcium and phosphorus balance in rats. Indian J Exp Biol. 1989 Feb; 27(2):151-5. PMID: 2572546

Foster HH. Violence toward children: medicolegal aspects. Bull Am Acad Psychiatry Law. 1976; 4(4):336-40. PMID: 1028415

Veshohilova TP. [Effect of combined use of steroid preparations with pyrroxane on the gonadotropic function of the hypophysis]. Akush Ginekol (Mosk). 1975 Oct; (10):10-2.View Related Profiles.

Sullivan, Kimberly
Claudel, Sophie
Guo, Weimin

PMID: 2025

Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 1; 24(17):1639-41.View Related Profiles.

Havasi, Andrea
Neri, Caitlin
Ceballos Ochoa, Diana
Landesman, Esther
Sullivan, Kimberly
Laird, Lance
Berman, Marlene
Hoffman, Miriam
White, Roberta
Claudel, Sophie
Guo, Weimin

PMID: 10

Robinson JV, James AL. Some observations on the effects produced in white mice following the injection of certain suspensions of corroding bacilli. Br J Exp Pathol. 1975 Feb; 56(1):14-6. PMID: 1080; PMCID: PMC2072709

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 39 publications over 20 distinct years, with a maximum of 5 publications in 2006

Bar chart showing 39 publications over 20 distinct years, with a maximum of 5 publications in 2006

Year	Publications
1989	1
1999	2
2000	1
2001	2
2004	2
2005	2
2006	5
2007	3
2009	2
2010	1
2012	1
2014	4
2015	1
2018	1
2020	1
2021	2
2022	1
2023	3
2024	2
2025	2

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