In vivo studies indicate that synaptic activity promotes dendritic arbor elaboration at early
stages of brain development. At later stages of development, synaptic activity stabilizes …

Plasticity, activity-dependent competition, and Hebbian synapes are terms frequently
associated with a set of cellular interactions that causally link early neural activity to the final …

The retinotectal system of lower vertebrates has provided considerable insight into the
cellular mechanisms underlying the development and maintenance of orderly visual …

Whole-cell recordings from optic tectal neurons in Xenopus tadpoles were used to study the
maturation of a glutamatergic synapse. The first glutamatergic transmission is mediated only …

The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the
N-methyl-D-aspartate (NMDA) receptor antagonist aminophosphonovaleric acid (APV), or to …

Previous studies suggest that neuronal activity may guide the development of synaptic
connections in the central nervous system through mechanisms involving glutamate …

We report an electroporation technique for targeting gene transfer to individual cells in intact
tissue. Electrical stimulation through a micropipette filled with DNA or other macromolecules …

Insulin receptor signaling has been postulated to play a role in synaptic plasticity; however,
the function of the insulin receptor in CNS is not clear. To test whether insulin receptor …

Calcium-calmodulin–dependent protein kinase II (CaMKII) promotes the maturation of
retinotectal glutamatergic synapses in Xenopus. Whether CaMKII activity also controls …

Summary Arc/Arg3. 1 is an immediate-early gene whose expression levels are increased by
strong synaptic activation, including synapse-strengthening activity patterns. Arc/Arg3. 1 …