Recent cloning of a family of genes encoding inwardly rectifying K+ channels has provided
the opportunity to explain some venerable problems in membrane biology. An expanding …

New hypotheses and predictions have arisen from recent work revealing atomic-scale or
near-atomic-scale structures of receptors in the 'Cys-loop'superfamily. How general is the …

This summary article presents an overview of the molecular relationships among the voltage-
gated potassium channels and a standard nomenclature for them, which is derived from the …

A complementary DNA clone (designated GAT-1) encoding a transporter for the
neurotransmitter γ-aminobutyric acid (GABA) has been isolated from rat brain, and its …

The identity of nicotinic receptor subtypes sufficient to elicit both the acute and chronic
effects of nicotine dependence is unknown. We engineered mutant mice with α4 nicotinic …

The nicotinic acetylcholine receptor is the prototype ligand-gated ion channel. A number of
aromatic amino acids have been identified as contributing to the agonist binding site …

The inwardly rectifying potassium channel Kir4. 1 has been suggested to underlie the
principal K+ conductance of mammalian Müller cells and to participate in the generation of …

Hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor
superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an …

Nicotine addiction begins with high-affinity binding of nicotine to acetylcholine (ACh)
receptors in the brain. The end result is over 4,000,000 smoking-related deaths annually …

Fast synaptic transmission depends on the selective ionic permeability of transmitter-gated
ion channels. Here we show changes in the ion selectivity of neuronal P2X transmitter-gated …