There is a deluge of data across scientific disciplines. Future scientific breakthroughs will rely on algorithms to explore these massive data. Our group develops machine learning algorithms to automatically generate scientific discoveries from population-level datasets with brain MRI, behavioral, genetic and other physiological measures.
We are particularly interested in mapping brain networks in individuals and using brain network features to predict individual-level behavioral traits, mental disorder symptoms and disease progression. Insights from population-level studies are in turn used to develop N-of-1 mental disorder treatment in individuals.
10/2024: Welcome Zijie to the lab
7/2024: Welcome Xin Li to the lab
5/2024: Congrats to Mervyn for winning the NMRC Research Training Fellowship, allowing him to spend part of his PhD candidature at NIH
5/2024: Our clinical trials on Personalized TMS for Treatment-Resistant Depression are featured in the Singapore Business Review
4/2024: Our clinical trials on Personalized TMS for Treatment-Resistant Depression are featured in the The Straits Times, Lianhe Zaobo, The Star, Today Online, 8world,
3/2024: Thomas gave a virtual talk at the Sharif University Neuroscience Symposium
2/2024: Thomas gave a talk at the Noosa Workshop in Australia
9/2023: Thomas gave a talk at the Computational Psychiatry Course at Zurich
9/2023: We welcome Hongwei to the lab
8/2023: We welcome Shreya and Tian Fang to the lab
7/2023: Csaba organized a symposium at OHBM
7/2023: Shaoshi gave an educational talk at OHBM
7/2023: Shaoshi gave an invited talk at the Gradients Workshop in Montreal
7/2023: Csaba gave a talk at the University of Zurich
7/2023: New Imaging Neuroscience journal launched with MIT Press. The entire editorial team comprises past editors from NeuroImage and NeuroImage: Reports, who resigned due to high publication fees. Thomas remains as senior editor, while Ruby joins the editorial board of Imaging Neuroscience
7/2023: Thomas gave a talk at the 5th Chinese Computational & Cognitive Neuroscience Conference
7/2023: Jianzhong's & Leon's paper on the relationship between prediction accuracy and feature importance reliabliity is out in NeuroImage. This will be our lab's last paper in Neuroimage
7/2023: Welcome Sina to the lab
6/2023: Xiaoxuan's homotopic parcellation paper is out in NeuroImage
6/2023: Ruby's paper comparing gradients and parcellations for functional connectivity prediction of behavior is out in NeuroImage
3/2023: Thomas gave a talk at the CNS meeting in San Francisco
3/2023: Thomas gave a talk at the Mormino lab at Stanford
2/2023: Ruby & Thomas gave talks at the Whistler workshop
12/2022: Congrats to Aihuiping for defending her thesis
11/2022: ex-CBIG member (Raphaël Liégeois) is selected to be an astronaut for the ESA!
11/2022: Leon's paper comparing the predictive utility of anatomical T1, diffusion and functional connectivity is out in NeuroImage
11/2022: Lijun's paper on goal constrained harmonization is out in NeuroImage
9/2022: Tim Laumann (Wash U) visited our lab
8/2022: Casey Paquola (Juelich) gave a talk at our center
8/2022: We welcome Yapei, Yanquan and Tianchu to the lab!
7/2022: James Cole (UCL) gave a talk at our center
7/2022: Sofie Valk (Max Planck) gave a talk at our center
6/2022: Leon, Xiaoxuan, Ruby, Shaoshi, Csaba, Lijun and Thomas presented their work at OHBM
6/2022: Thomas gave a talk at the Brain Connectivity Workshop
5/2022: Our study on translating predictive models from big to small data is out in Nature Neuroscience [pdf] [commentary]
4/2022: Our study about brain network features predicting behavior is out in Nature Communications [free download]
4/2022: Our study about brain charts across the lifespan is out in Nature [free download]
3/2022: Thomas gave a talk at the Innovators in Cognitive Neuroscience Seminar Series organized by Dartmouth College
3/2022: Thomas gave a talk at the DGKN Congress
3/2022: Our study on racial biases in MRI-based behavioral prediction is out in Science Advances [free download]
3/2022: Our study about BWAS sample sizes is out in Nature [pdf]
3/2022: Congrats to Xiaolu for defending his thesis
1/2022: Thomas gave a talk at the Collaborative Research Center 1451 on Motor Control
1/2022: Thomas is now Senior Editor at NeuroImage
12/2021: Congrats to Jianzhong for defending his thesis.
11/2021: Our paper on biophysical brain models is out in Nature Communications [free download]
11/2021: Thomas is listed as a Clarivate highly cited researcher for the third consecutive year
11/2021: Yan Chao-Gan (CAS) gave a talk to our center
11/2021: Welcome Heidi to our group!
10/2021: Mac Shine (U Sydney) gave a talk to our center
8/2021: Welcome Zhang Chen, Trevor and Siqi to our group!
8/2021: Andrew Zalesky (U Melbourne) gave a talk to our center
7/2021: Our paper on individual-specific areal-level parcellations is out [free download]
7/2021: Pierre Bellec (U Montreal) gave a talk to our center
7/2021: Christopher Chen (NUS) gave a talk to our center
6/2021: Emily Jacobs (UC Santa Barbara) gave a talk to our center
4/2021: Congrats to Valeria for being a finalist for the Somerfeld-Ziskind Research Award
3/2021: John Murray (Yale) gave a talk to our center
2/2021: Our paper on individual-level cerebellum organization is out [free download]
2/2021: Lucina Uddin (University of Miami) gave a talk to our center
1/2021: Welcome Naren and Yan Quan to our group!
11/2020: Congrats to Tong He for defending his PhD thesis
10/2020: Nico Dosenbach (Washington University at St. Louis) gave a talk to our center
9/2020: Jean Chen (U Toronto) gave a talk to our center
8/2020: Our paper on predicting Alzheimer's Disease progression is out in NeuroImage [free download] [code]
8/2020: Caterina Gratton (Northwestern) gave a talk to our center
8/2020: Welcome Pansheng, Terence, Frederick, Kang Wei, Nicholas Alexander and Xintong to our group!
6/2020: Our paper on reconciling dimensional and categorical models of autism heterogeneity is now out in Biological Psychiatry [free download]
5/2020: Simon Eickhoff (Heinrich-Heine University Düsseldorf) gave a talk to our center
4/2020: Avram Holmes (Yale) gave a talk to our center
4/2020: Justin Baker (Harvard Medical School) gave a talk to our center
2/2020: Our paper on global signal amplitude decreasing with time of day is out in PLoS Biology [free download] [science daily]
2/2020: Our paper on DNN and kernel regression achieving similar RSFC behavioral prediction performance is out in NeuroImage [free download] [code]
12/2019: Congrats to Nanbo for successfully defending his thesis!
11/2019: Congrats to Jingwei for successfully defending her thesis!
11/2019: Our papers on multimodal AD heterogeneity and single-hemisphere intrinsic FC are out respectively on NeuroImage [paper] [code] and Cell Reports [free download]
9/2019: Our paper showing that deep neural networks and kernel regression achieve comparable RSFC-based behavioral prediction is in press in NeuroImage [preprint] [code]
8/2019: Our paper on somatosensory-motor dysconnectivity spannning multiple transdiagnostic dimensions of psychopathology is now in press at Biological Psychiatry [pdf]
8/2019: Danilo Bzdok (Aachen) visited our group
8/2019: Good luck to Nanbo Sun, Qing Yang, Nicole Kuek and Minh Nguyen in their future endeavor!
8/2019: Welcome Leon and Xiaoxuan to our group!
7/2019: John Murray (Yale) visited our group
6/2019: Congrats to Minh and other team members for placing 5th overall (out of 53 entries) in the TADPOLE competition
6/2019: Thomas is the recipient of OHBM2019 Early Career Investigator Award
6/2019: Ruby, Valeria, Csaba, Xiaolu, Jingwei & Thomas are presenting their work at OHBM2019
5/2019: Our paper showing resting dynamics at different timescales is out in Nature Communications [free download]
4/2019: Our paper showing that global signal regression improves RSFC-behavior associations is out in NeuroImage [pdf]
4/2019: Congrats to Minh for acceptance to UC Davis PhD program
4/2019: Thomas presented Alex's, Ruby's and Peng's work at Washington University, St Louis
3/2019: Valeria, Ruby and Jingwei gave oral presentations of their work at the Noosa-Whistler workshop
2/2019: Peter Fox and Jack Lancaster (UT San Antonio) visited our group
1/2019: Simon Eickhoff (Heinrich-Heine University & Research Center Juelich) visited our group
1/2019: Our neural mass model paper is out at Science Advances [free paper download] [physics world] [asian scientist]
1/2019: Thomas is now an editor at eLife
1/2019: Welcome Lijun An to our group!
11/2018: Our paper on default network sub-specialization is out at PNAS [pdf]
10/2018: Review with Simon Eickhoff & Sarah Genon on Imaging-Based Brain Parcellations is out at Nature Reviews Neuroscience [pdf]
09/2018: Thomas presented Ruby's work on individual-specific cortical parcellations at RSBC
09/2018: Thomas received the Singapore Neuroscience Association Young Neuroscientist Award
09/2018: Welcome Angela to our group.
09/2018: Our paper on connector hubs tuning modularity and optimizing behavioral performance is out at Nature Human Behavior [pdf]
08/2018: Welcome Aihuiping to our group.
06/2018: Welcome Shaoshi to the group.
06/2018: Lucina Uddin (University of Miami), Nathan Spreng (McGill), Danilo Bzdok (RWTH Aachen) visited our group.
06/2018: Congrats to He Tong for best paper award runner-up at PRNI
06/2018: Our paper on individual-specific cortical networks is out at Cerebral Cortex [free download]
06/2018: Thomas presented Alex's, Ruby's and Peng's work on brain parcellations and dynamics at PRNI
05/2018: Our paper on mapping between MNI152/Colin27 and fsaverage is now out in HBM [pdf]
05/2018: Welcome Yan Rui to our group
04/2018: Congrats to Siyi for admittance into Stanford EE PhD program
03/2018: Thomas presented Alex's and Ruby's work on brain parcellation at Whistler's workshop
02/2018: Thomas presented Xiuming's and Nanbo's work on Alzheimer's Disease subtypes at EUROPOND 2018
12/2017: Our paper on interpreting dynamic functional connectivity is out in NeuroImage [pdf]
12/2017: Michael Breakspear (QIMR Berghofer) visited our group
11/2017: Our paper on the diverse club is out in Nature Communications [pdf]
10/2017: CM Ting (Universiti Teknologi Malaysia) visited our group
08/2017: JB Poline (McGill) and Russ Poldrack (Stanford) visited our group
08/2017: Welcome Valeria, Jianzhong, Xiaolu, Qing Yang, Jeremy and Alisia to our group
08/2017: Thomas started his NRF fellowship on mental disorder subtypes
07/2017: Our new local-global cortical parcellation is out in Cerebral Cortex [pdf]
07/2017: Welcome Nicole Kuek to our group
04/2017: Thomas received the NUS Young Researcher Award
03/2017: Our commentary on multiscale neuroscience is out in Neuron [pdf]
03/2017: Welcome Siyi Tang to our group
03/2017: Lucina Uddin (University of Miami) visited our group
02/2017: Congrats to Gia for admittance into Cornell ECE PhD program
02/2017: Our commentary on best practices in data analysis and sharing in neuroimaging using MRI is out in Nature Neuroscience [pdf]
02/2017: Tom Nichols (Warwick) visited our group
11/2016: Congrats to Xilin for Rhodes Scholarship to Oxford
11/2016: Itamar Kahn (Technion) visited our group
10/2016: Our paper on latent atrophy factors in Alzheimer's Disease is out in PNAS [free download] [NUS press release] [MGH press release] [science daily] [upi]
08/2016: Our paper on the collapsed variation Bayes inference of the author-topic model is out in PRNI [pdf]
08/2016: Welcome Wenyan Hu, Tong He, Chu-Ming Chang and Csaba Orban to our team
07/2016: Daniel Rueckert (Imperial College) visited our group
07/2016: Commentary with Simon Eickhoff (Heinrich-Heine) is out in Nature [commentary pdf] [scientific american, huffington post, vice, popular science, geekwire]
07/2016: Welcome Minh Binh Nguyen and Ke Wang to our team
06/2016: Congrats to Ruby for OHBM merit abstract award
06/2016: Welcome Rajan Kashyap to our team
05/2016: Congrats to Ruby and Xiuming for the ISMRM educational awards
05/2016: Daniel Alexander (UCL), Jonathan Polimeni (HMS), Steve Smith (Oxford) and Anastasia Yendiki (HMS) visited our group
05/2016: Welcome Peng Wang and Muhammad Anwar to our team
04/2016: Simon Eickhoff (Heinrich-Heine) visited our group
03/2016: Suzanne Haber (University of Rochester) visited our group
02/2016: Welcome Dragana Pavlovic to our team
01/2016: Thomas is now editor of NeuroImage
01/2016: Rodolphe Sepulchre (Cambridge) visited our group
01/2016: Our paper on the genetic architecture of cortical networks is out in PNAS [pdf] [medicalxpress news]
11/2015: Our paper on the modular and integrative structure of the human brain is out in PNAS [pdf] [Berkeley press release]
11/2015: Welcome Raphael Liegeois to our team
10/2015: Commentary with Avram Holmes (Yale) is out in Nature Neuroscience [commentary pdf] [Steve's awesome paper]
08/2015: Welcome Jingwei Li, Nanbo Sun, Rensheng Liu to our team
05/2015: Daniel Margulies (Max Planck) visited our group
05/2015: Welcome Jianxiao Wu, Binbin Tang and Yuanhao Gong to our team
03/2015: Tom Nichols (Warwick) visited our group
03/2015: Congrats to Alex for being awarded the German DAAD Postdoctoral Fellowship
03/2015: Our paper on predicting sleep deprivation vulnerability with functional connectivity is out in Neuroimage [pdf]
02/2015: New MOE Tier 2 grant for estimating brain networks from resting-state fMRI and meta-analytic fMRI
02/2015: Congrats to Xiuming for admittance into MIT EECS PhD program
01/2015: Welcome Buu Vinh Tang to our team
10/2014: Our meta-analysis of 10,449 imaging experiments is out in Cerebral Cortex [pdf] [interactive ontology]
09/2014: New NUS Strategic Research Grant for studying memory networks in rodents and primates
08/2014: Polina Golland (MIT) visited our group
08/2014: Welcome Ruby Ru, Xiuming Zhang and Ngo Hoang Gia to our team
07/2014: Welcome Alex Schaefer to our team