Bicycle Therapeutics

Today marks World Mental Health Day 💚   To recognize the day, we were joined by Samaritans, a mental health charity that Bicycle supports, who led an engaging and thought-provoking discussion around mental health, listening, and creating supportive spaces.   The session was hosted by our Mental Health First Aider team and brought together the entire Bicycle team at Granta Park, with many colleagues joining remotely as well. Over a relaxed pizza lunch, we had an open conversation about how we can all play a part in fostering understanding, compassion, and safe spaces at work. A theme that strongly resonates for is how important a supportive workplace is to our wider wellbeing.   A big thank you to Samaritans team for the meaningful discussion, and to everyone who took part!    #TeamBicycle #WorldMentalHealthDay #MentalHealthAwareness #WellbeingAtWork #Samaritans #TeamCulture

#TeamBicycle works hard and plays hard, supporting great causes and building community in the process. In recent months, UK colleagues completed a charity bicycle ride in support of Mind, raising funds for mental health, and gathered for a fun-filled sports day. In the US, employees got together for an ice cream social and a community bike ride around Cambridge. What an incredible season of community and connection!

At the European Association of Nuclear Medicine (EANM) World Leading Meeting 2025, researchers from DKFZ German Cancer Research Center presented data from the first clinical experience with an early Bicycle® Imaging Agent (BIA) targeting MT1-MMP, a protein overexpressed in various solid tumors. They also presented preclinical data for BIAs optimized for pharmacokinetics to significantly enhance tumor targeting and minimize non-specific uptake. Check out the posters here: https://bit.ly/4ab2P9c. As we look to start our own Bicycle Therapeutics-sponsored #radiopharmaceutical clinical trials next year, we are encouraged by the data as they continue to validate the potential of MT1-MMP as a novel #cancer target and position our Bicycle technology for use as potential #radiopharm therapies.

We kicked off the Fall investor conference season with appearances at Cantor Fitzgerald, Morgan Stanley and Oppenheimer & Co. Inc. A big thanks to analysts Li Watsek, Maxwell Skor and Jeff Jones for hosting us. Missed our fireside chats? Visit https://bit.ly/45nF6S6 to listen to the replays.

A warm welcome to our newest Board members Roger Dansey and Herve Hoppenot! Together with Alessandro Riva, M.D. and Charles Swanton, who joined our Board earlier this year, their expertise in oncology research, drug development and commercialization will be invaluable as we execute on our strategy to develop next-generation targeted therapies with the potential to help patients live longer and live well. More here: https://bit.ly/467KGZ9. 

A new school year means a new student cohort at Bicycle! We’re pleased to welcome this group of next-generation scientists and drug developers to our Research & Innovation team. Over the next year, they will work on projects to support the advancement of our platform technology and our pre-clinical pipeline of #cancer therapies.

At two investor conferences in September, our management team will discuss our upcoming milestones and the progress we’ve made in leveraging our Bicycle® platform technology to develop innovative medicines for cancer. Tune in live to our fireside chats here: http://bit.ly/45nF6S6.

We are pleased to announce our new Research and Innovation Advisory Board (RAB)! Chaired by Bicycle Therapeutics Board member Jose-Carlos Gutiérrez-Ramos, our RAB inaugural members include Jason Lewis from Memorial Sloan Kettering Cancer Center, biopharma consultant and advisor Bob Lutz, and Michael Hofman from the Peter MacCallum Cancer Centre. The insights from these distinguished global #drugdiscovery and #oncology experts will be invaluable as we advance our #discoveryresearch programs. Learn more about them here: http://bit.ly/47tj1El.

Today we reported recent business progress and second quarter 2025 financial results, including a workforce reduction to extend our expected financial runway and a listing of anticipated milestones for the second half of the year. Read our press release here: http://bit.ly/45qIFXG.

We recently held our UK Science Fair, an annual event hosted by our Research & Innovation Team to showcase the research being conducted at Bicycle Therapeutics. Out of 27 posters highlighting the breadth and potential of our Bicycle® platform, congrats to Zoe Miller; Martin Wilkinson, Karen Lim and Ben Blakeman; Nicolas Guthertz, Lucy Gilmour and Philip Murray; and Dominika Krzyzanska and Ecem Kaya for being this year’s winners! And a big thank you to the organizing committee led by Mark Frigerio.