Change value in Excel using Python Last Updated : 22 Jun, 2021 Comments Improve Suggest changes Like Article Like Report In this article, We are going to change the value in an Excel Spreadsheet using Python. Method 1: Using openxml: openpyxl is a Python library to read/write Excel xlsx/xlsm/xltx/xltm files. It was born from a lack of an existing library to read/write natively from Python the Office Open XML format. openpyxl is the library needed for the following task. You can install openpyxl module by using the following command in Python. pip install openpyxl Function used: load_workbook(): function used to read the excel spreadsheetworkbook.active: points towards the active sheet in the excel spreadsheetworkbook.save(): saves the workbook Approach: Import openpyxl libraryStart by opening the spreadsheet and selecting the main sheetWrite what you want into a specific cellSave the spreadsheet Excel File Used: Below is the implementation: Python3 from openpyxl import load_workbook #load excel file workbook = load_workbook(filename="csv/Email_sample.xlsx") #open workbook sheet = workbook.active #modify the desired cell sheet["A1"] = "Full Name" #save the file workbook.save(filename="csv/output.xlsx") Output: Method 1: Using xlwt/xlrd/xlutils. This package provides a collection of utilities for working with Excel files. Since these utilities may require either or both of the xlrd and xlwt packages, they are collected together here, separate from either package.You can install xlwt/xlrd/xlutils modules by using the following command in Python pip install xlwt pip install xlrd pip install xlutils Prerequisite: open_workbook(): function used to read the excel spreadsheetcopy(): copies the content of a workbookget_sheet(): points towards a specific sheet in excel workbookwrite(): writes data in the filesave(): saves the file Approach: Open Excel FileMake a writable copy of the opened Excel fileRead the first sheet to write within the writable copyModify value at the desired locationSave the workbookRun the program Excel File Used: Below is the implementation: Python3 import xlwt import xlrd from xlutils.copy import copy # load the excel file rb = xlrd.open_workbook('UserBook.xls') # copy the contents of excel file wb = copy(rb) # open the first sheet w_sheet = wb.get_sheet(0) # row number = 0 , column number = 1 w_sheet.write(0,1,'Modified !') # save the file wb.save('UserBook.xls') Output: After  Comment More infoAdvertise with us Next Article Change value in Excel using Python biswasarkadip Follow Improve Article Tags : Python Python-excel Practice Tags : python Similar Reads How to Change Values in a String in Python The task of changing values in a string in Python involves modifying specific parts of the string based on certain conditions. 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