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Record deal size. Crashing deal volume. Rising M&A. New deal structures. Quick rundown on the digital health landscape ahead of my HLTH USA panel with Frederique Dame (GV (Google Ventures)), Brenton Fargnoli, M.D. (Lightspeed), and Lenard Marcus (Edison Partners). 📈 Record median deal size at $6M, and an almost record-tying average deal size (2021 record) 📉 Q3'25 saw the lowest quarterly deal volume in over 5 years 📈 Highest M&A activity since Q1'23, steadily increasing since Q1'24 low 📉 Falling early-stage deal share 📈 Growing global deal share 📈 Increasing "Other" deal types across corporate minorities, partnerships, and joint ventures For those at #HLTHUSA, join us at the Plutus Stage at 3:10pm PST today (10/21) to dive into The New Healthcare Deal!

AI isn’t waiting for symptoms. It’s spotting illness before you’re even sick. Yesterday at HLTH Inc., Ellen Knapp sat down with leaders from Aidoc (Elad Walach), Northwell Health (Jill Kalman, M.D.), the American Heart Association (Jennifer Hall), and Health Data Analytics Institute (HDAI) (Nassib Chamoun) to talk about how predictive analytics is changing the game in healthcare. 💡 The idea: stop waiting for symptoms to show up. AI is now spotting risks before they turn into ER visits, sometimes before you even realize you’re sick. It’s ingesting patient data streams faster than any human ever could, surfacing patterns we’d never see, and building risk profiles that feel almost psychic. After the panel, Ellen unveiled this year’s Digital Health 50, and the conversation carried straight through. The companies leading healthcare forward are building exactly what we’d just been discussing: 🔮 Tools that shift care from reactive to preventive with earlier detection and remote access. ⚙️ Automation that frees clinicians to actually act on predictions. 🔐 Infrastructure that helps AI scale responsibly in a regulated space. 🗣️ Voice agents that make proactive care accessible from the first patient interaction. The future of medicine isn’t about predicting the next crisis. It’s about making sure it never happens in the first place. → Download the full Digital Health 50 report here: https://lnkd.in/e_tTgu8Z

We're at HLTH USA to provide predictive intelligence on the partnerships, investments, acquisitions, and strategic developments driving innovation in healthcare and life sciences. Visit us at Booth 2401 and make sure to catch Jason and Ellen Knapp's panels!

HLTH USA starts Sunday! Excited to be moderating a panel on The New Healthcare Deal as a part of CB Insights' partnership with the conference to bring predictive intelligence on the future of health to the center of the conference experience. The panel with Frederique Dame (GV (Google Ventures)), Brenton Fargnoli, M.D. (Lightspeed), and Lenard Marcus (Edison Partners) will help us examine the current healthcare deal landscape and how AI has accelerated deal timelines, inflated valuations, and shifted health tech companies from selling software to selling workloads, and how investors are approaching value creation and exit timelines. The rest of the conference week will be filled with two more awesome sessions from Ellen Knapp, including the launch of the Digital Health 50 and probably more spontaneous meetings at the hotel gym than any other conference I've been to (this is a health conference after all...) If you'll be at HLTH and want to meet up to talk about the latest insights on the future of health, drop me a comment or a DM. P.S. If anyone knows someone who is working on anti-aging for digital bobbleheads, I'll invest immediately.

More than 130 people packed the room with Christopher Sekerak at InsureTech Connect to see the reveal of the 2025 Insurtech 50, CB Insights’ definitive list of the world’s most promising insurtech startups. These 50 companies sit in the top 3% of private companies globally by success probability, with a median Mosaic score of 734/1,000. Together, they include 27 insurers and intermediaries and 23 tech vendors, who have raised a combined $3.6B in funding. 3 key trends shaping this year’s list: 1. Small and mid-sized businesses fuel growth opportunities for most insurers and intermediaries. 2. Many tech vendors build products for insurers seeking to deploy AI agents. 3. Personal lines P&C trails commercial among the winners. Post-reveal, Chris was joined on stage by Jane Tran (Sixfold), Mark Miller (Insurevision.ai), Hanna Wu (Amplify Life Insurance), and Kevin Stein (Delos Insurance Solutions) for a fireside chat. → Download the full Insurtech 50 report here: https://lnkd.in/duy6v3cP

The floor is noisy. Predictive intelligence cuts through it. Stop by the CB Insights Discovery Desk (Booth #411) at InsureTech Connect — open October 15–16. Meet with Christopher Sekerak, Jason Saltzman, and our team of strategists to get tailored insights on markets, competitors, and the 400+ companies on the expo floor. Spend less time wandering and more time winning.

Join Ellen Knapp and Jason Saltzman for two executive panels at HLTH Inc. in Vegas. 🔮 Crystal Ball Medicine | October 20 @ 10:15 AM (Holos Stage) Moderated by Ellen Knapp Details → https://lnkd.in/e4R2DmTG What if care started before symptoms ever appeared? AI is shifting healthcare from reactive treatment to proactive prevention, predicting risks, flagging issues early, and helping clinicians step in before routine checkups turn into ER visits. But key questions remain: Are these tools biased? Do patients want this level of insight? And how should clinicians use the information? Panelists include: Elad Walach, Chief Executive Officer, Aidoc Dr. Jennifer Hall, PhD, Chief of Data Science and Analytics, American Heart Association Social Impact Jill Kalman, M.D., EVP, Chief Medical Officer, and Physician in Chief, Northwell Health Nassib Chamoun, MS, Founder and CEO, Health Data Analytics Institute (HDAI) 🤝 The New Healthcare Deal | October 21 @ 3:10 PM (Plutus Stage) Moderated by Jason Saltzman Details → https://lnkd.in/eaTJf4iv The investment landscape is moving beyond traditional venture capital. Strategic minority stakes, joint ventures, and hybrid public-private partnerships are giving healthcare leaders new ways to access innovation while managing risk. Hear from specialty funds leading this shift and learn how to find the right partners for sustainable growth. Panelists include: Brenton Fargnoli, M.D., Partner, Lightspeed Venture Partners Frederique Dame, General Partner, GV (Google Ventures) Lenard Marcus, General Partner, Edison Partners

Each year, Zurich Insurance brings together thousands of startups, entrepreneurs and pioneers through its Zurich Innovation Championship, to tackle real-world insurance challenges. The catch? Sorting through that many companies to find genuine innovators would normally take months. To manage the large volume of applicants, Zurich uses CB Insights’ predictive intelligence, which significantly streamlines the process and improves the quality of Selections. “When it comes to investments in the tech startup ecosystem, CB Insights is data you don’t get publicly – you can use their predictive signals to see where the money is flowing, who sits behind the companies, and how they stack up against the competition,” says Joel Agard, Head of Group Innovation at Zurich Insurance Group. A recent example: Sixfold, Commercial Insurance Category winner from the 2024 Zurich Innovation Championship, was identified with the support of CB Insights’ predictive signals. Sixfold has demonstrated impressive growth, received strategic investment, launched new products, and earned industry recognition. Zurich’s early identification of high-potential companies enables meaningful partnerships and supports transformative results for both Zurich and its partners. Want to see who’s next? Meet the winners of Zurich’s 2025 Agentic AI Hyper Challenge: Interloom, AgentricAI, WordLift, and Wangari Global. These companies, alongside others on CB Insights’ 2025 Insurtech 50, are shaping the future of insurance technology. The future of insurance is being shaped now by innovative companies. Zurich’s use of CB Insights ensures they stay ahead of industry trends. Learn more about how Zurich uses CB Insights to stay ahead: https://lnkd.in/g3NqAsRw

AI. Preventive medicine. Clinical automation. These are the forces reshaping healthcare according to this year’s Digital Health 50: CB Insights’ data-driven ranking of the world’s most promising private digital health companies, selected using proprietary scoring and market signals. See who’s winning the 🏁 innovation race 🏁 at HLTH Inc. Vegas, where Ellen Knapp will reveal the leaders shaping digital health and unpack the trends defining what’s next. Details here → https://lnkd.in/gaq6kFbf

📘Your ultimate pre-InsureTech Connect Vegas prep: The Book of Scouting Reports We looked at nearly 400 companies exhibiting at ITC Vegas 2025 and built a report to help you figure out who’s worth your time. 📊 Download the report to get company profiles, SWOT analyses, and market context before you land in Vegas. Download → https://lnkd.in/gib5nrgU 🔎 Already a CB Insights customer or on a trial? Access the Expert Collection to go deeper, follow companies over time, and find new ones that fit your goals. Access → https://lnkd.in/gHqRzYNx