CSBio

Quality control and efficiency in your Solid Phase Peptide Synthesis (#SPPS) workflow can be a real challenge. Process Analytical Technologies (PATs) are the key to streamlining your process and ensuring product purity. These tools provide essential, real-time data on reaction completeness, allowing you to optimize steps📈, reduce waste♻️, and cut down on synthesis time⏱️. Our latest resource introduces the fundamentals of implementing PATs in SPPS, covering: 🔺 What PATs are and how they boost quality assurance. 🔺UV-vis spectroscopy, Refractive Index, and Raman spectroscopy and how they may be used to monitor deprotection, coupling, and washing steps. Take a look to learn more: 🔗 https://lnkd.in/gb33Ud5u #PeptideSynthesis #SPPS #ProcessAnalyticalTechnologies #PAT #QualityControl #Biotech

The peptide science landscape is constantly shifting, and 2025 is proving to be a landmark year for innovation. Don't miss the major breakthroughs and trends from the past quarter. 📆 We've compiled the biggest happenings from Q3 2025 into one essential blog roundup. Read the full update here 👇 🔗 https://lnkd.in/grTd6bGH #PeptideScience #DrugDiscovery #Biotech #LifeScience #Q3Review #Innovation

A quick reminder that our graduate research grant is open. 🔓 We are accepting applications through October 31. Check out the application guidelines below. 👇

At CSBio, we're committed to supporting the next generation of peptide researchers on their journey of discovery. That’s why we created the CSBio Graduate Research Grant for graduate students and post-docs working in peptide science. We're currently reviewing applications  until October 31, 2025. Don’t miss this opportunity to fund your research! 🥼 🧪 🔬 Learn more and apply via the link below. 👇 🔗 https://lnkd.in/gfQ5JN5m *Applications for this grant are eligible for up to one year following submission. #Peptides #Discovery #PeptideScience #Research #GraduateSchool

Protein-protein interactions (PPIs) are notoriously difficult to target with therapeutics, but a new peptide-gold nanoplatform may be a game-changer. Bcl9@TP is a novel peptide-based nanoprodrug. Designed as a self-assembling gold nanoplatform, this therapeutic safely and effectively delivers a peptide to competitively disrupt the β-catenin/BCL9 interaction, destabilizing the transcriptional complex that drives the Wnt/β-catenin signaling pathway in colorectal cancer models. The preclinical results are compelling: 📌 Downstream oncogenic targets were downregulated. 📌Tumor burden was significantly reduced, and tumor growth was inhibited. ‼️ The biggest breakthrough: Combination therapy of the Bcl9@TP nanoprodrug with traditional immunotherapy (specifically, an anti-PD-1 checkpoint inhibitor) produced a profoundly greater anti-tumor effect than either monotherapy alone. 📌Importantly, Bcl9@TP showed favorable safety and systemic biocompatibility—a vital step toward clinical use. The routine, repetitive chemistry of manual peptide synthesis consumes valuable research hours. Automated synthesizers, such as those offered by CSBio, eliminate this bottleneck, enabling scientists to dedicate their time and intellectual energy to high-level discovery and optimization rather than being bogged down by the labor-intensive work of peptide production. Innovations like this novel therapy come to life with support from automated synthesis. #DrugDiscovery #CancerResearch #Immunotherapy #PeptideTherapeutics #Nanotechnology #ColorectalCancer 🔗 https://lnkd.in/gk5s7C3q 🔗

Antimicrobial Resistance (AMR) and persistent fungal infections are among the most urgent global health threats. The need for innovative treatments is critical, and peptides are demonstrating their utility as a new class of therapeutics in this fight. 👊 Recent research showcases the incredible versatility and power of Antimicrobial Peptides (AMPs): 🔺 Targeting Fungi: We're seeing major breakthroughs with AMPs like SA-XV—a 15-amino acid fragment—which protects against fungal infections by specifically disrupting mitochondrial function. 🔗 https://lnkd.in/g4Ytm8bn Similarly, insect-derived peptides Act-6 and Act 8-20 are demonstrating potent antifungal activity, effectively tackling tough pathogens like Candida and Cryptococcus and inhibiting problematic biofilm formation. 🔗 https://lnkd.in/gskciVsZ 🔺Battling Biofilms: Beyond fungi, an engineered, leucine-substituted rice peptide named N3L is proving highly effective against hard-to-treat dental pathogens (P. gingivalis). It works by physically disrupting the bacterial membrane and downregulating virulence genes, offering a novel approach to treating conditions like periodontitis. 🔗 https://lnkd.in/guNCRbjc 🔺Smart Delivery Systems: Perhaps the most exciting development is the creation of Peptide-Drug Conjugates (PDCs). These conjugates use a positively charged AMP to actively guide an antibiotic payload to the bacterial membrane. One new design utilizes a β-lactamase cleavable linker, ensuring the drug is only released when it encounters the resistance enzyme, providing superior potency against resistant strains and potentially lowering systemic toxicity. 🔗 https://lnkd.in/gJBr43xZ Peptides are truly becoming the "smart bombs" of medicine—highly specific, versatile, and essential tools in building the next generation of anti-infectives. This is a field to watch! 👀 #AntimicrobialResistance #PeptideTherapeutics #DrugDiscovery #Biotechnology #InfectiousDisease #Innovation

We recently had the pleasure of interviewing Phil Dawson, the 2025 Bruce Merrifield Award recipient. He shared with us fascinating insights on his pioneering work in Native Chemical Ligation, the evolution of Solid-Phase Peptide Synthesis (SPPS), and what he sees as the biggest growth areas for peptide science in the coming years. Check out the full conversation here: 👇 🔗 https://lnkd.in/g4EtHuhz 🔗 #PeptideScience #Chemistry #SPPS #AmericanPeptideSociety

Peptides: The Next Frontier in Diagnostics 💪 📈 New research is showcasing the power of peptides as a non-invasive, highly precise diagnostic tool. Two recent studies highlight how peptides are revolutionizing our ability to detect disease. Recent research demonstrates the use of charge-changing peptides (CCPs) to detect gastrointestinal (GI) cancers. These peptides act as smart probes, changing their charge and glowing when cleaved by specific proteases that are often elevated in cancer patients. This method accurately profiles protease activity, offering a new path for early, non-invasive cancer screening. 🔗 https://lnkd.in/gZq6nd3x In another study, "Twinkling Peptide Nanoemulsions" were used  for the precision detection of atherosclerotic plaques. These specialized peptides target and accumulate in plaque-ridden areas. When activated by ultrasound, they produce a unique "twinkling" effect, allowing clinicians to identify and visualize vulnerable plaques. 🔗 https://lnkd.in/gGKy3_aA Together, these studies show that designing peptides with specific functionalities can provide non-invasive, accurate, and scalable solutions for diagnosing complex diseases,  a potential game-changer for early detection and personalized medicine. #Peptides #Biotechnology #Diagnostics #MedTech #Innovation #CancerResearch #Cardiology

The world of medicine is undergoing a peptide revolution! ⚕️ While we often hear about antibodies and small molecules, current research in peptides is showcasing their versatility as a new class of therapeutics. From fighting infections to tackling complex diseases, peptides are at the forefront of innovation. Here's a look at four recent papers that illustrate this trend: ⏺️ A study in antimicrobial peptides derived from plants (Filipendula ulmaria) shows us a sustainable path to developing new biopesticides and antimicrobials for agriculture and medicine. 🔗 https://lnkd.in/gEqRZj4S ⏺️Another paper highlights how machine learning is accelerating the discovery of novel peptides. Researchers successfully developed Healitide-GP1 for treating infected wounds, demonstrating that computational design is a powerful tool for creating effective therapeutics. 🔗 https://lnkd.in/g7WknJXk ⏺️In ophthalmology, a short peptide called OBM1701 shows significant promise in treating neovascular age-related macular degeneration (nAMD) by targeting the disease's root causes. 🔗 https://lnkd.in/gfTFSe9b ⏺️Finally, a fascinating proteogenomic approach is paving the way for personalized medicine, identifying shared peptide epitopes for new therapeutic cancer vaccines against ovarian tumors. 🔗 https://lnkd.in/gxMVgg2Y Peptides are emerging as a powerful and highly specific tool in medicine, offering a diverse range of applications. This convergence of bioengineering, AI, and clinical research is rapidly expanding the frontiers of what's possible in treatment and prevention. #Peptides #Therapeutics #Biotech #Innovation #Research #Medicine

Peptide synthesis is revolutionizing scientific research 🔬 across multiple disciplines, with groundbreaking work being published in 📅2025. This research showcases the power of peptides in tackling some of the most challenging health issues today, with much of this work made possible using tools like peptide synthesizers from CSBio. Check out the summaries below for a closer look. 👀 🔍 In this study published in Cell Press, researchers developed a peptide-peptide conjugate vaccine candidate, TENDU, for prostate cancer. The vaccine uses long synthetic peptides with epitopes from prostate-specific antigen (PAP) and prostate-specific membrane antigen (PSMA)2. The vaccine also includes a tetanus toxin-derived B cell epitope (MTTE) to leverage pre-existing anti-tetanus toxin antibodies, which helps facilitate antigen delivery to and activation of dendritic cells. 🔗 https://lnkd.in/gdwTfvxp In this work published in American Chemical Society Chemical Biology, researchers used a peptide mimic of the N-heptad repeat (NHR) of the HIV-1 gp41 protein, called IQN17, to determine the crystal structure of an antibody bound to this peptide. This work also used protein language models and machine learning to create small libraries of antibody variants, which were then screened for improved neutralization potency against HIV. 🔗 https://lnkd.in/g7gjH9ED This article published in American Chemical Society Nano describes a supramolecular chiral peptide-based construct, called a "cancer corrector" (CCtor). The peptide construct is designed to be cleaved by lysosomal proteases in cancer cells, triggering the release of a therapeutic agent to normalize aberrant signaling pathways. 🔗 https://lnkd.in/gz7U-RNc Published in Science Magazine Advances, this study involved the chemical synthesis of receptor-biased and photocaged interleukin-4 (IL-4) variants. The synthesis and folding of the IL-4 protein were accomplished using alpha-ketoacid-hydroxylamine (KAHA) ligation to assemble three peptide segments. These chemically synthesized peptides were used to create variants that selectively interacted with specific receptors and were conditionally activatable with light to control inflammation. 🔗 https://lnkd.in/gSydfwTK