CSBio

Exciting week in Fukuoka — supporting the peptide community by sponsoring Solid Phase 2025 and exhibiting at the Japanese Peptide Symposium! Great to connect with researchers across Japan, spend time with our partner AS ONE Corporation, and see inspiring talks — especially from Prof. Fernando Albericio on greener SPPS chemistry 🌱 #peptides #SPPS #SolidPhase #Japan #CSBio #greenerchemistry #peptidesynthesis

New research in BMC Plant Biology reveals that the CLE14 peptide acts as a crucial regulator in delaying post-harvest senescence in broccoli. 🥦 The exogenous application of the CLE14 peptide significantly preserved broccoli quality by inhibiting chlorophyll degradation, which kept the vegetable greener for longer during storage. Peptide treatment helped maintain cellular health by preventing the accumulation of reactive oxygen species (ROS) through enhanced antioxidant activity. The application of CLE14 peptide may be a promising strategy for extending the shelf life of fresh produce and reducing food waste. ♻️ Read more here: 🔗 https://lnkd.in/gFwu8qUF

Quality control and efficiency in your Solid Phase Peptide Synthesis (#SPPS) workflow can be a real challenge. Process Analytical Technologies (PATs) are the key to streamlining your process and ensuring product purity. These tools provide essential, real-time data on reaction completeness, allowing you to optimize steps📈, reduce waste♻️, and cut down on synthesis time⏱️. Our latest resource introduces the fundamentals of implementing PATs in SPPS, covering: 🔺 What PATs are and how they boost quality assurance. 🔺UV-vis spectroscopy, Refractive Index, and Raman spectroscopy and how they may be used to monitor deprotection, coupling, and washing steps. Take a look to learn more: 🔗 https://lnkd.in/gb33Ud5u #PeptideSynthesis #SPPS #ProcessAnalyticalTechnologies #PAT #QualityControl #Biotech

The peptide science landscape is constantly shifting, and 2025 is proving to be a landmark year for innovation. Don't miss the major breakthroughs and trends from the past quarter. 📆 We've compiled the biggest happenings from Q3 2025 into one essential blog roundup. Read the full update here 👇 🔗 https://lnkd.in/grTd6bGH #PeptideScience #DrugDiscovery #Biotech #LifeScience #Q3Review #Innovation

A quick reminder that our graduate research grant is open. 🔓 We are accepting applications through October 31. Check out the application guidelines below. 👇

At CSBio, we're committed to supporting the next generation of peptide researchers on their journey of discovery. That’s why we created the CSBio Graduate Research Grant for graduate students and post-docs working in peptide science. We're currently reviewing applications  until October 31, 2025. Don’t miss this opportunity to fund your research! 🥼 🧪 🔬 Learn more and apply via the link below. 👇 🔗 https://lnkd.in/gfQ5JN5m *Applications for this grant are eligible for up to one year following submission. #Peptides #Discovery #PeptideScience #Research #GraduateSchool

Protein-protein interactions (PPIs) are notoriously difficult to target with therapeutics, but a new peptide-gold nanoplatform may be a game-changer. Bcl9@TP is a novel peptide-based nanoprodrug. Designed as a self-assembling gold nanoplatform, this therapeutic safely and effectively delivers a peptide to competitively disrupt the β-catenin/BCL9 interaction, destabilizing the transcriptional complex that drives the Wnt/β-catenin signaling pathway in colorectal cancer models. The preclinical results are compelling: 📌 Downstream oncogenic targets were downregulated. 📌Tumor burden was significantly reduced, and tumor growth was inhibited. ‼️ The biggest breakthrough: Combination therapy of the Bcl9@TP nanoprodrug with traditional immunotherapy (specifically, an anti-PD-1 checkpoint inhibitor) produced a profoundly greater anti-tumor effect than either monotherapy alone. 📌Importantly, Bcl9@TP showed favorable safety and systemic biocompatibility—a vital step toward clinical use. The routine, repetitive chemistry of manual peptide synthesis consumes valuable research hours. Automated synthesizers, such as those offered by CSBio, eliminate this bottleneck, enabling scientists to dedicate their time and intellectual energy to high-level discovery and optimization rather than being bogged down by the labor-intensive work of peptide production. Innovations like this novel therapy come to life with support from automated synthesis. #DrugDiscovery #CancerResearch #Immunotherapy #PeptideTherapeutics #Nanotechnology #ColorectalCancer 🔗 https://lnkd.in/gk5s7C3q 🔗

Antimicrobial Resistance (AMR) and persistent fungal infections are among the most urgent global health threats. The need for innovative treatments is critical, and peptides are demonstrating their utility as a new class of therapeutics in this fight. 👊 Recent research showcases the incredible versatility and power of Antimicrobial Peptides (AMPs): 🔺 Targeting Fungi: We're seeing major breakthroughs with AMPs like SA-XV—a 15-amino acid fragment—which protects against fungal infections by specifically disrupting mitochondrial function. 🔗 https://lnkd.in/g4Ytm8bn Similarly, insect-derived peptides Act-6 and Act 8-20 are demonstrating potent antifungal activity, effectively tackling tough pathogens like Candida and Cryptococcus and inhibiting problematic biofilm formation. 🔗 https://lnkd.in/gskciVsZ 🔺Battling Biofilms: Beyond fungi, an engineered, leucine-substituted rice peptide named N3L is proving highly effective against hard-to-treat dental pathogens (P. gingivalis). It works by physically disrupting the bacterial membrane and downregulating virulence genes, offering a novel approach to treating conditions like periodontitis. 🔗 https://lnkd.in/guNCRbjc 🔺Smart Delivery Systems: Perhaps the most exciting development is the creation of Peptide-Drug Conjugates (PDCs). These conjugates use a positively charged AMP to actively guide an antibiotic payload to the bacterial membrane. One new design utilizes a β-lactamase cleavable linker, ensuring the drug is only released when it encounters the resistance enzyme, providing superior potency against resistant strains and potentially lowering systemic toxicity. 🔗 https://lnkd.in/gJBr43xZ Peptides are truly becoming the "smart bombs" of medicine—highly specific, versatile, and essential tools in building the next generation of anti-infectives. This is a field to watch! 👀 #AntimicrobialResistance #PeptideTherapeutics #DrugDiscovery #Biotechnology #InfectiousDisease #Innovation

We recently had the pleasure of interviewing Phil Dawson, the 2025 Bruce Merrifield Award recipient. He shared with us fascinating insights on his pioneering work in Native Chemical Ligation, the evolution of Solid-Phase Peptide Synthesis (SPPS), and what he sees as the biggest growth areas for peptide science in the coming years. Check out the full conversation here: 👇 🔗 https://lnkd.in/g4EtHuhz 🔗 #PeptideScience #Chemistry #SPPS #AmericanPeptideSociety

Peptides: The Next Frontier in Diagnostics 💪 📈 New research is showcasing the power of peptides as a non-invasive, highly precise diagnostic tool. Two recent studies highlight how peptides are revolutionizing our ability to detect disease. Recent research demonstrates the use of charge-changing peptides (CCPs) to detect gastrointestinal (GI) cancers. These peptides act as smart probes, changing their charge and glowing when cleaved by specific proteases that are often elevated in cancer patients. This method accurately profiles protease activity, offering a new path for early, non-invasive cancer screening. 🔗 https://lnkd.in/gZq6nd3x In another study, "Twinkling Peptide Nanoemulsions" were used  for the precision detection of atherosclerotic plaques. These specialized peptides target and accumulate in plaque-ridden areas. When activated by ultrasound, they produce a unique "twinkling" effect, allowing clinicians to identify and visualize vulnerable plaques. 🔗 https://lnkd.in/gGKy3_aA Together, these studies show that designing peptides with specific functionalities can provide non-invasive, accurate, and scalable solutions for diagnosing complex diseases,  a potential game-changer for early detection and personalized medicine. #Peptides #Biotechnology #Diagnostics #MedTech #Innovation #CancerResearch #Cardiology