E11 is looking for an experienced executive assistant to work with our CEO and COO and take on management of general operations. We'd be a great fit for someone with a passion for neurobiology and excitement about developing cutting-edge tech. Please pass this link along to the right person! https://lnkd.in/gA2xgV3v
E11 Bio
Biotechnology Research
Alameda, California 2,498 followers
E11 BIO is making single-cell brain circuit mapping a routine and accessible part of every neuroscientist’s toolbox.
About us
Building the Future of Brain Mapping E11 Bio is a non-profit philanthropically-funded Focused Research Organization developing next-generation technology to accelerate neuroscience and improve human health. We are a world-class team of scientists and engineers taking on one of the hardest problems in neuroscience: brain circuit architecture mapping. Through an open technology platform featuring unprecedented detail, speed, and scalable economics, and our unique emphasis on mapping circuit architecture, we are giving scientists an unparalleled look into brain organization and accelerating progress in fundamental neuroscience, neuropharmaceutical drug target discovery, and brain-inspired computing. E11 refers to the roughly one hundred billion (1e11) neurons characteristic of human brains.
- Website
-
http://e11.bio
External link for E11 Bio
- Industry
- Biotechnology Research
- Company size
- 11-50 employees
- Headquarters
- Alameda, California
- Type
- Nonprofit
- Founded
- 2021
Locations
-
Primary
Get directions
Alameda, California 94502, US
Employees at E11 Bio
Updates
-
E11 Bio is thrilled to welcome Will Patton as our newest Machine Learning Scientist!! Will has a broad background in image processing and machine learning with a focus on developing well documented, tested, and distributed code. Before starting at E11, Will worked at the Janelia Research Campus and provided Machine Learning software engineering support as an independent contractor. He has contributed significantly to the development of gunpowder, daisy and volara, three libraries that simplify the training and application of machine learning models on large microscopy volumes, and is passionate about making scientific code easily usable and accessible. We’re excited to unleash Will’s skills on E11’s neuronal tracing pipeline and look forward to making even more progress toward mammalian connectomics. Welcome, Will! 🧠 💻
-
-
All the DNA behind our PRISM technology is available on Addgene!
Scientists at E11 Bio have developed PRISM: a set of AAV tools to express protein-labeling barcodes for high-throughput reconstruction of individual neurons and other cell-labeling applications. Learn more about these plasmids and how you can use them: https://hubs.la/Q03LJq6C0
-
E11 Bio reposted this
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery. Link to paper: t.co/vaYDVtmULp Read more: http://e11.bio/blog/prism We partnered with Sam Rodriques (Francis Crick Institute, now Future House), Ed Boyden (MIT and HHMI (Boyden Lab), and Joergen Kornfeld (MPI) for this study. So proud of the team that accomplished this work: Sun Yung (Rosa) Park, Arlo Sheridan, Bobae An, Erin Jarvis, Julia Lyudchik, William Patton, Jun Axup Penman, Stephanie Chan, Hugo Damstra, Daniel Leible, Kylie Leung, Clarence Magno, Aashir Meeran, Julia Magdalena Michalska, Franz Rieger, Claire Wang, Michelle Wu, George Church, Jan Funke, Todd Huffman, Kathleen Leeper, Sven Truckenbrodt, Johan Winnubst, Joergen Kornfeld, Ed Boyden, Samuel G. Rodriques
-
E11 Bio is seeking a creative and passionate spatial ‘omics scientist to co-develop next-generation technology for high-throughput connectomic imaging using molecular barcodes. As a core member of the E11 team, you’ll develop innovative methods for highly-multiplexed imaging of protein barcodes at the scale of mammalian brains. Working closely with world experts in cellular barcoding and computational connectomic reconstruction, you’ll design spatial ‘omics and barcode detection experiments, collect, analyze, and interpret multiplexed image data, and present or publish open scientific results for public benefit. In addition to helping change the world and getting to work with some of the most talented and collaborative experts across scientific fields, E11 Bio offers excellent medical, dental, and vision insurance through a PPO plan, parental leave, generous time off and paid holidays, and ample healthy and energizing food including daily lunches. https://lnkd.in/gRHERZwZ
-
E11 is looking for a research associate for our sample preparation and sample processing pipeline. E11 is passionate about whole-brain connectomics and supports its team with great benefits. Please connect us with independent and resourceful associates with experience in fluorescence microscopy and tissue sectioning! https://lnkd.in/giPeY6nf
-
How to make frontier AI models safer and accelerate drug discovery with the connectome. We are featured in this IFP article by Adam Marblestone & Andrew Payne https://lnkd.in/gQDVz74x
-
E11 welcomes Michelle Wu to our brain mapping and molecular barcoding team! Michelle just finished her BASc in Biomedical Engineering at University of Toronto. Her research experience includes UofT, the Broad Institute of MIT and Harvard, and a previous year with us at E11!! We're super excited to have her back.
-
-
This week we’re thrilled to welcome Victor Holmes to the E11 team as our new Chief of Staff! Victor brings 20+ years of experience at Amyris, a leader in synthetic biology. We're excited to benefit from his deep experience in scientific operations, project strategy, and team management. He’ll be helping us build the connective tissue that supports fast, focused progress toward mammalian connectomics. Welcome, Victor! 🧠 🛠️
-
-
This summer we welcome Julia Lyudchik and Jakob Troidl to the team! Julia did her PhD at Institute of Science and Technology Austria (ISTA) where she developed methods for brain tissue visualization and reconstruction using light microscopy: LIONESS, CATS and LICONN. Jakob is a PhD candidate at Harvard University interested in data visualization and applied machine learning, especially for connectomics.
-