Praxis Precision Medicines, Inc.

We’re pleased to share positive topline results from two pivotal Phase 3 studies of ulixacaltamide, an investigational therapy being evaluated for essential tremor (ET) as part of our Essential3 program. In both studies, ulixacaltamide met its pre-specified primary endpoints and was generally well tolerated in patients with essential tremor. We’re deeply grateful to the patients, families, and investigators whose dedication made this research possible. For additional details, read our press release here: http://bit.ly/48AdtZk #PraxisMedicines #essentialtremor #tremor #MoreThanTremor #DareforMore The International Essential Tremor Foundation Diann Shaddox Foundation for Essential Tremor

Today is SUDEP Action Day. We join the epilepsy community in raising awareness about Sudden Unexpected Death in Epilepsy (#SUDEP). At Praxis, our work is rooted in translating genetic insights into therapies for people affected by neurological disorders. We believe everyone affected by epilepsy, and everyone who supports them, should have clear, accessible information about SUDEP. This year’s SUDEP Action Day theme, #BreakDownBarriers, highlights how stigma, lack of knowledge, and silence can prevent people from receiving the information and care they need. Learn more about SUDEP causes, risk factors, and steps that can help from the Epilepsy Foundation: https://lnkd.in/esCZ_eM6 #SUDEPActionDay2025 #BreakDownBarriers #Epilepsy #Neuroscience #PatientAdvocacy 

At Praxis, our culture is built on curiosity, collaboration, and the drive to make a difference. Every person here brings unique energy and expertise that push us to grow and evolve together. Today we’re spotlighting Megan Merlino, Accounting Manager, who shares what excites her most about being part of the team: “I feel like this is the place to be right now. I’m learning something new every single day, from my teammates to our scientists. I want to grow here, to see what we become, and to be part of the impact we’re going to have.” Megan’s words capture what makes Praxis such a special place, a community where curiosity leads to growth and every day brings a new opportunity to make an impact. Explore open opportunities at Praxis https://lnkd.in/dgPFijVP.  #LifeAtPraxis #WeArePraxis #Biotechcareers

Praxis is proud to be participating in the 54th Child Neurology Society Annual Meeting in Charlotte, NC! Stop by Booth #820 to meet our team and learn more about our precision epilepsy pipeline and how we’re working to advance treatments across developmental and epileptic encephalopathies (DEEs). We’re excited to connect with the child neurology community and share our commitment to patients and progress in the field. Learn more about Praxis https://lnkd.in/gdWDKFr #CNS2025 #ChildNeurology #PraxisMedicines #Neuroscience

#EssentialTremor can run in families. Each child of an affected parent has a 50% chance of inheriting the gene that causes ET. “I have a large extended family, so I'm aware that ET can be familial. Two of my sisters, one first cousin and my daughter also have ET.” – Barbara, living with ET It’s time to raise awareness. Let’s spread the word. To learn more and explore ET community stories and resources visit: https://lnkd.in/e9qxESN4. #essentialtremor #tremor #MoreThanTremor #DareforMore

Did you know #EssentialTremor is the most common movement disorder? An estimated 7 million people in the U.S. live with ET—that’s 8 times more than those with Parkinson’s.     “I want other people with ET to know that they aren’t alone. Parkinson’s disease gets talked about more than ET, and yet, far more people have ET.” – Allison, living with ET    It’s time to raise awareness. Let’s spread the word.    To learn more and explore ET community stories and resources visit: https://lnkd.in/e9qxESN4.    #essentialtremor #tremor #MoreThanTremor #DareforMore   

At Praxis, our mission begins with our people and our commitment to patients. We asked our Praxons why they chose Praxis and how being part of this team inspires them every day. Interested in joining our mission? Explore careers at Praxis: https://lnkd.in/dgPFijVP #LifeAtPraxis #BiotechCareers 

We are excited to be investigating 2 first-in-class potential DEE treatments developed to reduce seizures and improve quality of life for people living with DEEs. Take the online prescreener to see if our studies may be right for you or your child: https://lnkd.in/eMwP5RYv

Thank you for joining Praxis at IEC 2025! At this year’s meeting, in addition to showcasing topline results from the RADIANT study in focal onset seizures, we were proud to share progress across our epilepsy programs including the latest preclinical and clinical data, and rapidly enrolling trials across our precision epilepsy pipeline. Thank you to everyone who stopped by. We loved speaking with so many attendees and exploring new opportunities for collaboration. If you missed us in Lisbon, you can still check out our presentations on our resources page on our website. Catch up here: https://lnkd.in/eZVhXi_6

Brianna is a pianist, music instructor and proud #EssentialTremor advocate. For her, shaking hands aren’t just a daily reality — they’re also a powerful form of self-expression. Through music, she’s raising awareness and breaking the stigma around ET.    Her words remind us: “None of us are perfect and none of us are alone. Your ‘tremor,’ whatever it may be, is a part of how you exist in this life. And this world needs all of us.”    Thank you, Brianna, for using your voice — and your music — to inspire and uplift. At Praxis, it’s the lived experiences of people with ET that drive our daily work. Learn more at https://lnkd.in/e9qxESN4.    #essentialtremor #tremor #MoreThanTremor #DareforMore