Dr. Larouche on aggressive acromegaly: challenges and treatments

Anastomotic leaks remain one of the most serious complications in colorectal surgery, but recent advances are improving detection, treatment, and prevention. Key strategies shared by experts at #SAGES2025 include: -Postoperative evaluation: Air leak tests, flexible sigmoidoscopy, tissue perfusion assessment, and imaging -Endoscopic treatment: Closure (clips/sutures), diversion (stents), and drainage (EVT or pigtail stents) -Leak detection: Clinical monitoring, biomarkers (CRP, procalcitonin), and advanced imaging -Ileostomy-avoiding techniques: Optimized stapling, perfusion assessment, and intraluminal bypass devices While no single approach eliminates risk, combining vigilant assessment with innovation provides the best outcomes for patients. Read more here: https://lnkd.in/etW6UJy8 #ColorectalSurgery #PatientSafety #SurgicalEducation #InnovationInSurgery #Healthcare #hernia

Paradigm shift in the diagnosis and treatment of pelvic venous disease (PeVD): a long-term study presenting a personalized protocol guided by each patient’s venous map. We evaluated 175 women with chronic pelvic pain and followed interventions such as ovarian vein embolization and iliac and renal vein stenting, with follow-up exceeding 2 years. The results show clinically meaningful reductions in pain and improvements in quality of life, alongside acceptable safety and manageable retreatment rates. This work underscores the value of meticulous preoperative assessment to tailor therapeutic choices to the individual, moving beyond one-size-fits-all approaches. Open Access for full reading and deeper insights. Journal of Vascular Surgery #WomenHealth #PelvicVenousDisease #PeVD #PelvicVaricosities #ChronicPelvicPain #VascularMedicine #OpenAccess

I’m proud to share that our latest article, "Selective Appendectomy in Patients Undergoing Minimally Invasive Surgery for Endometriosis: A Retrospective Cohort Study," has just been published in the Journal of Clinical Medicine (JCM) MDPI! Endometriosis is a complex, chronic inflammatory disease that can often involve the bowel — including the appendix, where disease may mimic or coexist with chronic appendicitis. Yet, appendiceal involvement frequently goes undetected by visual inspection alone. In this study of 236 patients who underwent selective appendectomy during laparoscopic surgery for endometriosis, we found that: ✅ 91.5% had abnormal appendiceal pathology ✅ 14.4% had histologically confirmed appendiceal endometriosis ✅ 1.3% had neuroendocrine tumors (including one malignant) ✅ There were no intraoperative complications and favorable postoperative outcomes Our findings suggest that even when no visible implants are present, the appendix may contribute to symptoms in endometriosis patients. Selective appendectomy, when guided by intraoperative findings, can help ensure more comprehensive care while maintaining patient safety. 📄 Read the full article here: https://lnkd.in/dCajSAyS #Endometriosis #MinimallyInvasiveSurgery #Laparoscopy #RoboticSurgery #WomensHealth #Research #Surgery #Innovation #Appendectomy

This post is intended for U.S. audiences only Millions of people in the US live with the daily challenges of chronic rhinosinusitis with nasal polyps (CRSwNP). We’re proud to share that the FDA has approved a respiratory biologic for the treatment for CRSwNP. In the WAYPOINT Phase 3 trial, the treatment demonstrated a statistically significant and clinically meaningful reduction in nasal polyp severity, showed near-elimination of the need for surgery and significant reduction in systemic corticosteroid use. See announcement: https://bit.ly/49aQft1

Hemostemix expands its Phase 1 basket trial to include Refractory Angina. For patients living with daily chest pain despite every available drug or surgery, options are few and quality of life is often devastatingly reduced. Hemostemix has completed its clinical protocol for the treatment of Refractory Angina with ACP-01, our autologous stem-cell therapy designed to help restore circulation and regenerate micro-vessels. This addition strengthens our regenerative-cardiology program and advances our goal of transforming outcomes for “no-option” patients worldwide. As CEO Thomas Smeenk noted: “For patients living with daily chest pain who have no other options, this trial represents a meaningful step toward a restorative, rather than purely palliative, therapy.” 🔗 Read the full announcement: https://lnkd.in/gF-BBWFf #Biotech #RegenerativeMedicine #Cardiology #Angina #ClinicalTrials #Hemostemix $HEM $HMTXF $2VF0

#ESMO25: Potentially practice-changing phase III data with novel #immunotherapy combinations address unmet needs in #LiverCancers. Atezolizumab plus bevacizumab showed improved outcomes compared with transarterial chemoembolisation in intermediate-stage #HCC in the first interim analysis of the ABC-HCC #ClinicalTrial. Perioperative camrelizumab plus rivoceranib showed clinical benefit compared with surgery alone for resectable HCC at risk of recurrence in the CARES-009 study. Neoadjuvant ‘GOLP’ (gemcitabine, oxaliplatin, lenvatinib and toripalimab) also showed promise compared with resection alone for intrahepatic #cholangiocarcinoma (#ICC), but additional data are needed. 📌Learn more in the #ESMODailyReporter: https://ow.ly/jBSk50XeKCo Lorenza Rimassa #HepatocellularCarcinoma #ImmunoOncology

🩺 Case Insight: Fat-Poor Angiomyolipoma Mimicking RCC A middle-aged patient was incidentally diagnosed with a renal mass on CECT (done for altered bowel habits). Both CECT and PET-CT were highly suspicious for RCC, and radical nephrectomy was advised. On second opinion, after careful review and counseling, we proceeded with a robotic partial nephrectomy. Histopathology surprisingly revealed angiomyolipoma (fat-poor subtype). ✅ Kidney preserved ✅ Benign diagnosis ✅ Avoided unnecessary nephrectomy 📖 Learning point: Fat-poor angiomyolipomas can closely mimic RCC radiologically. Whenever technically feasible, nephron-sparing surgery (partial nephrectomy) should be prioritized over radical nephrectomy. This case reaffirms the importance of organ preservation in equivocal renal masses. #UroOncology #RoboticSurgery #RenalMass #OrganPreservation #ClinicalPearls

New Publication Alert 🚨 Excited to share our recently published ROSWOC Protocol in Impact Surgery. This project establishes a core outcome set (COS) for clinical trials focused on preventing surgical wound complications such as infections and dehiscence. By standardising outcomes, ROSWOC will strengthen evidence, reduce inconsistencies, and improve the design and reporting of future trials worldwide, ultimately leading to better prevention strategies and patient outcomes.

🩺 We’ve released a new clinical practice guideline emphasizing high-quality, risk-based endoscopic surveillance to help prevent cancer in patients with Barrett’s esophagus. 📊 The new guideline emphasizes risk-based, personalized surveillance, particularly for patients without dysplasia. 🕒 It also clarifies when surveillance may be unnecessary and when it can safely be discontinued. 💊 Daily PPI therapy remains the preferred approach over anti-reflux surgery. 📍 Patients with Barrett’s esophagus–related neoplasia should be referred to expert centers. ✅ Endoscopic surveillance is preferred for patients with non-dysplastic Barrett’s esophagus, 🚫 but not recommended for those with <1 cm of columnar-lined esophagus with intestinal metaplasia. Finally, the guideline highlights key evidence gaps and priorities for future research, paving the way for the next generation of gastroenterology practice. 📖 Read more here: https://ow.ly/ivA450XelVh Sachin Wani

Management of intravenous #leiomyomatosis: a comprehensive review of surgical and perioperative considerations 🤕 Clinical Manifestations 🔍 Diagnosis 🔪 Treatment: Surgery 🩸 Anti-coagulation 💊 Post-operative considerations: Hormonal therapy as adjuvant treatment 📌 https://bit.ly/4qwOOvo #IJGConline #Research #Prevention #Treatment #Diagnostic #GynCancer #GynOnc #WomenHealth #SoMe #SoMe4GynOnc