Expanded agreement with Oxford Nanopore for genetics portfolio

Exciting news! We have expanded our partnership with Oxford Nanopore Technologies to continue building our genetics portfolio. Leveraging ONT's cutting-edge platform, we continue to push the boundaries of genetic testing innovations. Our recent development, the AmplideX® Nanopore Carrier Plus Kit (RUO), is just the first in the portfolio. Read the full press release for more details: https://lnkd.in/djGYNXA6

Strengthen your genetic research with orthogonal loss-of-function approaches: Relying on a single method can leave gaps in your data. By combining orthogonal technologies like CRISPR-Cas9 and RNAi, researchers can cross-validate results and uncover deeper genetic insights. Explore how this dual approach can increase confidence in your findings and help navigate complex gene functions. Read the blog http://ms.spr.ly/6043spYl9 #CRISPR #RNAi #FunctionalGenomics #OrthogonalValidation #Revvity #Dharmacon

🧬 Feng Zhang – Pioneer of Genome Editing and Biotechnology 🔬Feng Zhang, a leading scientist in biotechnology and genetic engineering, has revolutionized genetic research and disease treatment through the development of CRISPR-Cas9 technology. With creativity and relentless dedication, he has inspired a new generation of researchers worldwide, demonstrating how science can improve the lives of millions. His achievements include: • Developing precise genome editing tools • Advancing cell therapy and personalized medicine • Making a significant impact in both fundamental and industrial research Zhang exemplifies how innovation and science together can transform our world. #FengZhang #CRISPR #Biotechnology #GeneEditing #Innovation #ScienceLeadership #Genetics #BioTechRevolution

Dr. Alexander Kel CEO & CSO geneXplain, presenting geneXplain’s progress at the ChromRare Annual Meeting 2025, held at the Nencki Institute of Experimental Biology PAS. The ChromRare consortium brings together Europe’s leading experts to uncover the molecular mechanisms of chromatinopathies rare genetic diseases that, despite their diversity, share a common cause: the inactivation of chromatin regulators controlling gene expression and 3D genome organization. At geneXplain, we are proud to serve as the bioinformatics core of this initiative. Our mission: to decode the regulatory circuits of chromatinopathies through integrated promoter and pathway analysis, and to identify master regulators and potential drug targets for these currently incurable disorders. The work presented by Dr. Kel today at the joint EMBO/ChromRare meeting highlights how computational systems biology can transform our understanding of gene regulation in rare diseases, turning complex molecular data into insights that one day may guide targeted therapies. 🔗 Learn more about the ChromRare project: https://lnkd.in/em7cKyuD #ChromRare Chrom Rare #GeneXplain #Bioinformatics #SystemsBiology #RareDiseases #Chromatinopathies #GeneRegulation #PathwayAnalysis #PromoterAnalysis #NenckiInstitute

Rare DNA elements, non-canonical fragments outside standard chromosomes, are increasingly recognized for their roles in gene regulation, genome stability, and disease. In this case study, we share how a multi-stage analytical framework was used to: - Combine Illumina and Nanopore sequencing data - Annotate rare DNA elements against known genomic features - Connect elements to transcriptional activity with RNA-seq - Compare across samples to identify conserved and context-specific elements The workflows produced high-confidence assemblies, motif enrichment results, and reproducible outputs that supported new biological insights. Read the full article: https://lnkd.in/eUkrxqQh #Genomics #Bioinformatics #Sequencing #DataScience #RNAseq #DNA

Happy Monday! New case study: how bench scientists can turn complex sequencing data into clear decisions with advanced informatics. #Bioinformatics #Genomics

🧬 New Seminar Recording: The 3D Regulatory Genome We're excited to share our latest virtual seminar featuring Dr. Axel Visel from the Joint Genome Institute! Dr. Visel presented ground-breaking research on enhancer function—a critical challenge in genomics. His team uses CRISPR editing, chromatin mapping, and large-scale transgenic mouse studies to understand how genetic variations affect gene regulation, with major implications for interpreting patient genome data. Watch the full recording to learn how cutting-edge approaches are unlocking the secrets of the non-coding genome: Explore Dr. Visel's research: http://enhancer.lbl.gov #Genomics #Epigenetics #GeneRegulation #CRISPR #Biotechnology

Imagine a future where therapeutic interventions are precisely tailored to an individual's genetic makeup. By analyzing a person's DNA, it's becoming possible to understand their predispositions and how treatments can alter their biochemistry. This allows for a revolutionary approach, where interventions can change the expression of genes, even in individuals with genetic predispositions. This personalized approach enables a deeper understanding of how treatments affect the body at a molecular level, opening new avenues for targeted and effective therapies. What if healthcare could anticipate and counteract genetic vulnerabilities? #personalizedmedicine #genetics #therapeutics #DNA #biochemistry #innovation

Ever wondered how we edit genes? It’s all about precision! A key player in the revolutionary CRISPR system is the guide RNA. Think of it as a biological GPS — this tiny molecule is specifically designed to lead the Cas9 protein to the exact spot in the DNA that needs to be edited. Without the right guide RNA, the system wouldn’t know where to go. This level of control is what makes CRISPR such a powerful tool for gene editing, with applications ranging from developing new therapies to improving crops. It’s a game-changer! #HVD #HVDLifeSciences #HVDEgypt Horizon Discovery #CRISPR #GeneEditing #GeneEdit #Cas9 #DNA #RNA

Welcome to our “Did you know?” series, where we share data driven facts and information about Neurofibromatosis (NF) as a means to bring a higher level of awareness, increased education, and a deeper understanding of NF. What is NF? Neurofibromatosis causes tumors to grow on nerves throughout the body. NF is caused by a change in a gene, a sequence of DNA, which is the genetic code passed down from parents to children.