New study reveals misconceptions about UTI prevention and treatment

When a therapy moves from niche option to likely standard of care, it usually happens quietly—then all at once. This week, enzymatic debridement is stepping into that spotlight. MediWound’s NexoBrid will be featured in 36 presentations at the European Burns Association Congress, covering pediatric, elderly, and critically burned populations. The accumulated evidence—spanning survival, scar outcomes, infection control, and long-term recovery—now points to superiority over surgical excision in many scenarios. The timing isn’t just scientific. Burn services across Europe face persistent OR constraints, staffing shortages, and capacity pressure. A therapy that can remove eschar, preserve viable tissue, and reduce OR reliance lands directly where clinical need meets system economics. If guideline committees, payers, and procurement authorities act on this signal, the burn care landscape could shift fast. Enzymatic debridement aligns with value-based models, mass casualty preparedness, and hospital efficiency priorities. For competitors, this isn’t just a wound care story—it’s a signal of how biologics can reshape procedure-heavy care pathways. The real question isn’t whether the data are strong. It’s whether system-level decisions—guidelines, DRGs, tenders, emergency stockpiles—will follow quickly enough to lock in durable adoption. Will enzymatic debridement redefine burn care economics, or just complement surgery at the margins? 𝐑𝐞𝐚𝐝 𝐌𝐨𝐫𝐞: https://lnkd.in/dqwmWTnn #MedTech #HealthSystems #ValueBasedCare #BurnCare #Biologics #HealthInnovation Ety Klinger Miri Kramer

🚨 One of the #commonerrors in surgical practice: treating a skin abscess as if it needs prophylactic antibiotics. ❓ Do you think an adult patient admitted with a #skinabscess who is going for incision and drainage actually needs prophylaxis? And if antibiotics are indicated, when is the most critical time to start them? 💡 Key Point: A skin abscess is a true infection, not a clean surgical wound—so antibiotics here are treatment, not prophylaxis. 🔬 Best Practice for Timing & Use ✅ Obtain cultures first and withhold antibiotics until after drainage/cultures to preserve accuracy. 💉 Initiate #antibiotics before #incision_and_drainage #onlywhen: • Prompt drainage cannot be performed • The patient needs parenteral therapy for severe or rapidly progressive illness (e.g., sepsis) • The patient has risk factors for infective endocarditis (prosthetic valve, prior endocarditis, certain congenital defects, transplanted heart with valve dysfunction) 📌 #Take-home: Avoid unnecessary “#prophylaxis.” Use antibiotics strategically and at the right time to improve outcomes and support antimicrobial stewardship. 📚 Need guidance on implementing Antimicrobial Stewardship (AMS)? I provide consultations on AMS implementation and offer online courses in English and hybrid English–Arabic formats. 📲 For more details, contact me on #WhatsApp: +971502048101 📖 Reference: Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America (IDSA). Clin Infect Dis. 2014;59(2):147–159. doi:10.1093/cid/ciu296 #AntimicrobialStewardship #SurgicalInfections #InfectiousDiseases #ClinicalPharmacy #EvidenceBasedPractice #AMS #HealthcareEducation

Development and implementation of an electronic admission-screening tool for Candidozyma auris (formerly Candida auris) at a large healthcare system in Miami, FL

News | Leicester-led review shows around one in three hospital infections involve antimicrobial resistance 👉 https://lnkd.in/eAYwjQhe Study shows antimicrobial resistance is common in hospitals and independently associated with a higher risk of death. The results were published in September 2025 in The Lancet’s eClinical Medicine. Dr Daniel Pan, infectious diseases clinician, National Institute for Health and Care Research (NIHR) Doctoral Research Fellow at the University of Leicester, said. “Hospitals are high-risk environments for acquiring drug-resistant infections because many patients receive antibiotics and have invasive procedures. #CitizensOfChange | NIHR (National Institute for Health and Care Research) | Daniel Pan

Breastfeeding until at least six months helps babies to fight off infections and reduces chronic inflammation, according to a new study. And better understanding the way specific nutrients in breast milk impact the immune system will improve health outcomes for all infants including those not breastfed. The study, led by Murdoch Children’s Research Institute (MCRI) and the Baker Heart and Diabetes Institute (Baker Institute), discovered more clues as to why infants who were breastfed to at least six months of age had fewer infections and less chronic inflammation. Preventing these infections could reduce the rates of many childhood conditions, such as allergies, diabetes and asthma. Published in BMC Medicine, the researchers identified several types of lipids (essential nutrients) in blood samples from breastfed babies that help reduce inflammation, which may reflect the unique nutritional composition of breastmilk. Source in comments.

🚑💊Antibiotic-sparing treatment (ASPT) strategies, such as delayed prescribing and symptomatic treatment, are increasingly recognized as promising approaches to reduce antimicrobial consumption (AMC) in women with uncomplicated urinary tract infections (uUTIs). A new scoping review by Andreas Plate et al. (Infection, 2025) explored factors that may facilitate or hinder the use of ASPT. 🔍 Key insights: Main facilitator ➡️ the expectation of reduced antimicrobial consumption Main barriers ➡️ prolonged symptom duration & increased risk of disease progression Themes identified: AMC, clinical outcomes, healthcare utilisation, patient- and prescriber-related factors 📌 This review provides an important foundation for future research on patient-provider decision making and targeted interventions to promote wider implementation of ASPT. 👏 Congratulations to the authors on this valuable contribution to antimicrobial stewardship and patient-centered care! 🔗 Read the full paper here: https://lnkd.in/eYCGe-Ry #AntimicrobialStewardship #UTI #ScopingReview #HealthcareResearch #Infection

Newcastle University leads UK trial to redefine sepsis treatment. A major UK-wide study, led by Newcastle University, is investigating whether a shorter course of antibiotics could be just as safe and effective for sepsis treatment as the current standard. The research, known as the SHORTER trial, is testing if a five-day antibiotic regimen is as effective as the usual seven-day course. If successful, this could revolutionise how sepsis is managed in hospitals, reducing risks for patients while tackling a major global health threat – antibiotic resistance. https://lnkd.in/eqPbrgA2 #sepsis #antibiotics #health #healthresearch

🟣 𝐀𝐂𝐔𝐓𝐄 𝐎𝐓𝐈𝐓𝐈𝐒 𝐌𝐄𝐃𝐈𝐀 🟣 Acute Otitis Media (AOM) is a sudden infection of the middle ear, characterized by inflammation and fluid accumulation behind the eardrum. It is one of the most common pediatric infections, particularly affecting children between 6 months and 3 years of age. ▪️ Causes AOM is usually caused by bacterial or viral infections that follow an upper respiratory infection: 1️⃣ Bacteria: Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis 2️⃣ Viruses: Respiratory syncytial virus (RSV), influenza, adenovirus Symptoms ✔️ Ear Pain (otalgia) – often worse when lying down ✔️ Fever – may range from mild to high ✔️ Irritability or fussiness – especially in infants ✔️ Hearing difficulty – due to fluid in the middle ear ✔️ Otorrhea – fluid or pus draining if the eardrum ruptures ✔️ Other signs: Poor appetite, vomiting, diarrhea, or sleep disturbances ▪️ Diagnosis ✅ Otoscopy: Shows a bulging, red eardrum with reduced mobility. ✅ Pneumatic otoscopy or tympanometry: Confirms fluid in the middle ear. ✅ Clinical history: Recent upper respiratory infection, sudden onset of pain, and fever. ▪️ Treatment ✔️ Observation (Watchful Waiting): For children older than 2 years with mild symptoms, sometimes AOM resolves spontaneously. ✔️ Antibiotics: Amoxicillin is the first-line treatment for bacterial AOM. Duration: Typically 5–10 days, depending on age and severity. ✔️ Pain Management: Acetaminophen or ibuprofen to relieve pain and fever. ✔️ Surgical Intervention (for recurrent cases): Myringotomy with tympanostomy tubes may be considered for children with repeated infections or persistent fluid. ▪️ Prevention ✅ Vaccinations: Pneumococcal and influenza vaccines ✅ Avoiding secondhand smoke ✅ Breastfeeding for at least 6 months ✅ Minimizing exposure to respiratory infections in daycare or crowded settings . . . . . #AcuteOtitisMedia #Bacteria #Viruses #Otoscopy #Inflammation #FluidAccumulation

Antibiotic use and C. difficile risk: correlating prescribing with infection A new study in Infection Prevention in Practice from Bern University Hospital in Switzerland offers compelling insights into how antibiotic prescribing patterns correlate with Clostridioides difficile infection (CDI) rates across 17 clinical departments. Over 2.9 million patient-days were analyzed, revealing: -A significant association between overall antibiotic consumption and CDI incidence (no big surprise here!). - Departments like nephrology, pulmonary medicine, and haemato-oncology showed the highest CDI rates. - Specific antibiotics (carbapenems, ceftriaxone, cefepime, macrolides, and piperacillin/tazobactam) were linked to increased CDI risk. Interestingly, some departments with high antibiotic use (e.g., urology) had low CDI rates, suggesting that patient population characteristics and length of stay may also play a role (see image). The key message? Antibiotic stewardship must be tailored to departmental prescribing habits and patient profiles. Surveillance and targeted interventions will help reduce CDI rates and improve patient outcomes. Read the full open-access study here: https://lnkd.in/e_ba98Eg #AntibioticStewardship #InfectionPrevention #HealthcareQuality #CDI #HospitalEpidemiology #AntimicrobialResistance Healthcare Infection Society