AstraZeneca's $1.3B Bet Pays Off: Baxdrostat Wins Phase 3 Trial

View profile for Harry Reeve

Specialist in US Contract and Project Delivery | Life Science GxP

🚨 $1.3B Bet Pays Off: AstraZeneca Just Hit the Jackpot 🚨 AstraZeneca dropped $1.3 BILLION to acquire CinCor and its mid-phase hypertension drug baxdrostat in 2023 and they’ve just nailed a Phase 3 win. 📉 In patients with uncontrolled hypertension: ✅ Statistically significant drop in systolic BP ✅ Success across key secondary endpoints ✅ Well tolerated with a solid safety profile ✅ Signals major potential for resistant hypertension 📈 Baxdrostat also showed strong results in patients who reached SBP <130 mmHg in just 12 weeks. Why it matters: 🔬 Novel mechanism: selectively blocks aldosterone without impacting cortisol 🫀 First real innovation in blood pressure drugs in over 20 years 💥 Massive commercial potential in combo with Farxiga for CKD Remember… this came just months after a failed Phase 2 trial. That flop helped AZ secure better acquisition terms, and now they might be sitting on the next billion-dollar blockbuster. 🛎️I post weekly on major pharma moves, biotech breakthroughs, and validation trends across the U.S. Follow me to stay in the loop! 👇 What’s your take on this move, smart bet or lucky break? #AstraZeneca #CinCor #Baxdrostat #Hypertension #PharmaDeals #DrugDevelopment #ClinicalTrials #LifeSciences #CardiovascularHealth #PharmaNews #GxP #Validation

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Hamish Corson

Senior Business Manager | USA | GxP Contract Division

3mo

Thanks for sharing, Harry!

Thomas Kemper

Neuroscience Health & science professional

3mo

Awesome News

Maiza Dornelas

Research Technician II | Research Scientist| Trilingual English-Spanish-Portuguese

3mo

A first-in-class approach to aldosterone targeting is a big deal especially with such a clean safety profile. Curious to see how it shifts treatment paradigms for resistant hypertension.

Brian Lipworth

Professor of Allergy and Pulmonology at University of Dundee

3mo

Need to do phase 4 superiority study vs low dose spironolactone as add on Rx in refractory HT ?

Dr.M Haroon Siddiqi

Former Chairman at Epla Laboratories (Pvt) Limted

2mo

Thanks for sharing, Harry

Eshwari Kovoor, MD

Physician Scientist ★ Clinical Development & Operations Lead ★ 18+ yrs Leading 50+ Clinical Trials ★ Broad spectrum of Therapeutic Areas ★ Sr. Medical Director ★ Driving Continuous Advancement of Research Programs

3mo

Congratulations! Great news, thanks for sharing!👏

Julia Ivashina

Pharma R&D Business Technology Expert | Driven by Business Value, Innovation and Common Sense

3mo
gerard boyle

Ex Process Operator at Abbott Ireland Cootehill

3mo

Thanks for sharing, Harry

Yan (Kathy) Ling

Catalent Pharma Solution, BD Director, biologics, bioanalytics, gene and cell therapy

3mo

Congratulations! This is a great news!

Dr. Shailendra Vikram Singh

Head of Safety and Efficacy @ Sirius Pharma Consulting Limited | Pharmaceutical Physician | MBBS, MD | Pharmacovigilance | Medical Devices

3mo

Wow, what a fascinating development! AstraZeneca's strategic move to acquire CinCor seems to be paying off in a big way. It's impressive how they turned a Phase 2 setback into a major Phase 3 success.

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